Paul J Dyson

Summary

Country: Switzerland

Publications

  1. ncbi request reprint Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms
    Carsten A Vock
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Med Chem 50:2166-75. 2007
  2. ncbi request reprint Amide bond formation via C(sp3)-H bond functionalization and CO insertion
    Huizhen Liu
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Chem Commun (Camb) 50:341-3. 2014
  3. doi request reprint Non-essential metals in chemical biology
    Paul J Dyson
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Chimia (Aarau) 65:839-42. 2011
  4. ncbi request reprint Organometallic chemistry in non-classical environments
    Paul J Dyson
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne
    Chimia (Aarau) 65:730-3. 2011
  5. ncbi request reprint An octahedral rhodium cluster with six phosphine and 12 hydride ligands and 10 too few electrons
    Paul J Dyson
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, EPFL BCH, 1015 Lausanne, Switzerland
    Angew Chem Int Ed Engl 43:6028-30. 2004
  6. ncbi request reprint Nitrile-functionalized pyrrolidinium ionic liquids as solvents for cross-coupling reactions involving in situ generated nanoparticle catalyst reservoirs
    Yugang Cui
    , , CH 1015 Lausanne, Switzerland
    Phys Chem Chem Phys 12:1834-41. 2010
  7. ncbi request reprint The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapy
    Isam Khalaila
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, EPFL, CH 1015 Lausanne, Switzerland
    Int J Oncol 29:261-8. 2006
  8. ncbi request reprint Synthesis, characterization, and in vitro evaluation of novel ruthenium(II) eta6-arene imidazole complexes
    Carsten A Vock
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Med Chem 49:5552-61. 2006
  9. ncbi request reprint Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis
    Wee Han Ang
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Inorg Chem 45:9006-13. 2006
  10. doi request reprint Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds
    Alexey A Nazarov
    Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology EPFL, 1015 Lausanne, Switzerland
    Inorg Chem 51:3633-9. 2012

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms
    Carsten A Vock
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Med Chem 50:2166-75. 2007
    ..Moreover, because the complex is fluorescent, its uptake in cells was studied, and relative to the free anthracene-based ligand, uptake of the complex is accelerated and accumulation of the complex in the cell nucleus is observed...
  2. ncbi request reprint Amide bond formation via C(sp3)-H bond functionalization and CO insertion
    Huizhen Liu
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Chem Commun (Camb) 50:341-3. 2014
    ..An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp(3))-H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes. ..
  3. doi request reprint Non-essential metals in chemical biology
    Paul J Dyson
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Chimia (Aarau) 65:839-42. 2011
    ....
  4. ncbi request reprint Organometallic chemistry in non-classical environments
    Paul J Dyson
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne
    Chimia (Aarau) 65:730-3. 2011
    ..The role of organometallic compounds in both catalysis and medicinal chemistry are briefly described...
  5. ncbi request reprint An octahedral rhodium cluster with six phosphine and 12 hydride ligands and 10 too few electrons
    Paul J Dyson
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, EPFL BCH, 1015 Lausanne, Switzerland
    Angew Chem Int Ed Engl 43:6028-30. 2004
  6. ncbi request reprint Nitrile-functionalized pyrrolidinium ionic liquids as solvents for cross-coupling reactions involving in situ generated nanoparticle catalyst reservoirs
    Yugang Cui
    , , CH 1015 Lausanne, Switzerland
    Phys Chem Chem Phys 12:1834-41. 2010
    ..The ability to use the nitrile-functionalized pyrrolidinium-based ionic liquids diluted in other (non-functionalized) ionic liquids is also described...
  7. ncbi request reprint The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapy
    Isam Khalaila
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, EPFL, CH 1015 Lausanne, Switzerland
    Int J Oncol 29:261-8. 2006
    ....
  8. ncbi request reprint Synthesis, characterization, and in vitro evaluation of novel ruthenium(II) eta6-arene imidazole complexes
    Carsten A Vock
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Med Chem 49:5552-61. 2006
    ..Thus, two of the compounds, [Ru(eta6-p-cymene)Cl(vinylimid)2][Cl] (vinylimid = N-vinylimidazole) and [Ru(eta6-benzene)(mimid)3][BF4]2 (mimid = N-methylimidazole), have been selected for a more detailed in vivo evaluation...
  9. ncbi request reprint Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis
    Wee Han Ang
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Inorg Chem 45:9006-13. 2006
    ....
  10. doi request reprint Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds
    Alexey A Nazarov
    Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology EPFL, 1015 Lausanne, Switzerland
    Inorg Chem 51:3633-9. 2012
    ..Similar IC(50) values were obtained in cell proliferation assays, and similar levels of uptake and accumulation were also established. The X-ray structure of [{Ru(η(6)-C(6)H(5)CH(2)NHCO-anthracene)Cl(2)(pta)] is also reported...
  11. doi request reprint Synthesis, characterisation and biological properties of gold(III) compounds with modified bipyridine and bipyridylamine ligands
    Angela Casini
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Dalton Trans 39:2239-45. 2010
    ..Reactivity studies with biomolecules, such as reducing agents, plasmid DNA and a model protein (ubiquitin) were also performed to provide tentative insights into the mode of action of the complexes...
  12. ncbi request reprint Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(eta6-p-cymene)Cl2(pta)]
    Claudine Scolaro
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    J Inorg Biochem 102:1743-8. 2008
    ..Hydrolysis is suppressed at high chloride concentrations. These results have important implications on the mode of action of the RAPTA drug candidates...
  13. ncbi request reprint Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT
    Angela Casini
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Dalton Trans 39:5556-63. 2010
    ..Initial structure-activity relationships have been defined with the calculated binding energies of the M-S bonds correlating well with the observed inhibition properties of the compounds...
  14. doi request reprint Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin
    Michael Groessl
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Metallomics 3:591-9. 2011
    ....
  15. doi request reprint Synthesis of gold nanoparticle catalysts based on a new water-soluble ionic polymer
    Ilaria Biondi
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Inorg Chem 50:8038-45. 2011
    ..The aqueous gold nanoparticle solutions were employed as catalysts in the reduction of p-nitrophenol and in the hydrogenation of cinnamaldehyde and were found to exhibit excellent activity under mild conditions...
  16. doi request reprint Rational design of an organometallic glutathione transferase inhibitor
    Wee Han Ang
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Angew Chem Int Ed Engl 48:3854-7. 2009
    ..The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods...
  17. doi request reprint Ruthenium porphyrin compounds for photodynamic therapy of cancer
    Frederic Schmitt
    Institute of Pathology, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland
    J Med Chem 51:1811-6. 2008
    ..Thus, the porphyrin areneruthenium(II) derivatives represent a promising new class of organometallic photosensitizers able to combine chemotherapeutic activity with photodynamic therapeutic treatment of cancer...
  18. ncbi request reprint Bioanalytical and biophysical techniques for the elucidation of the mode of action of metal-based drugs
    Michael Groessl
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Curr Top Med Chem 11:2632-46. 2011
    ..The current state of these techniques, their strengths and limitations, and the information they can provide for achieving this demanding goal, are described in this review...
  19. doi request reprint Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action
    Angela Casini
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Metallomics 1:434-41. 2009
    ..The mechanistic implications of these results are discussed...
  20. doi request reprint Use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumor targeting
    Anna K Renfrew
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Inorg Chem 49:2239-46. 2010
    ..Incubation at 42 degrees C for 2 h resulted in improved cytotoxicities for two of the complexes...
  21. ncbi request reprint Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry
    Michael Groessl
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, Switzerland
    J Biol Inorg Chem 15:677-88. 2010
    ..A strong preference for guanine residues was established...
  22. doi request reprint A viable hydrogen-storage system based on selective formic acid decomposition with a ruthenium catalyst
    Céline Fellay
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Angew Chem Int Ed Engl 47:3966-8. 2008
  23. ncbi request reprint Strategy to tether organometallic ruthenium-arene anticancer compounds to recombinant human serum albumin
    Wee Han Ang
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Inorg Chem 46:9048-50. 2007
    ..The approach involves the design of a drug fragment capable of conjugating to linker molecules on a modified carrier protein via hydrazone bond formation. The proof-of-concept using recombinant human serum albumin is described...
  24. doi request reprint Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death
    Alexey A Nazarov
    Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland
    Dalton Trans 42:2347-50. 2013
    ....
  25. doi request reprint Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound
    Angela Casini
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Biol Inorg Chem 14:761-70. 2009
    ..In addition, competition studies between cisplatin and RAPTA-C showed that the two metallodrugs have affinities for the same amino acid residues on protein binding...
  26. ncbi request reprint Metabolization of [Ru(eta(6)-C (6)H (5)CF (3))(pta)Cl (2)]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand
    Alexander E Egger
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015, Lausanne, Switzerland
    J Biol Inorg Chem 15:919-27. 2010
    ..Consequently, facile arene loss appears to be responsible for the increased cytotoxicity of RAPTA-CF3...
  27. ncbi request reprint Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach
    Christian G Hartinger
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015, Lausanne, Switzerland
    Inorg Chem 47:17-9. 2008
    ....
  28. doi request reprint Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: relevance to antitumour activity
    Christian G Hartinger
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Inorg Biochem 102:2136-41. 2008
    ..In addition, the ability of glutathione to cleave ruthenium-ubiquitin bonds was assayed and it was shown that GSH is capable of removing the Ru moiety from the protein, although no ternary adducts were identified...
  29. ncbi request reprint Influence of the interaction between hydrogen sulfide and ionic liquids on solubility: experimental and theoretical investigation
    Christian Silvio Pomelli
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Swizerland
    J Phys Chem B 111:13014-9. 2007
    ..Quantum chemical calculations have been used to investigate at a molecular level the interaction between H2S and the [bmim](+)-based ILs...
  30. ncbi request reprint Ruthenium(II) and osmium(II) 1,2,3-triazolylidene organometallics: a preliminary investigation into the biological activity of 'click' carbene complexes
    Kelly J Kilpin
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Dalton Trans 43:1443-8. 2014
    ..85 μM in A2780 ovarian cancer cells versus 435 μM in human embryonic kidney cells in one case)...
  31. ncbi request reprint Electrostatic and non-covalent interactions in dicationic imidazolium-sulfonium salts with mixed anions
    Zhaofu Fei
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne Switzerland
    Chemistry 20:4273-83. 2014
    ..Electrospray ionization mass spectrometry and quantum-chemical calculations were used to rationalise the relative strength of these interactions. ..
  32. ncbi request reprint Discovery of a highly tumor-selective organometallic ruthenium(II)-arene complex
    Catherine M Clavel
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Med Chem 57:3546-58. 2014
    ..The lead compound was then evaluated in vivo for antiangiogenic activity in the CAM model and in a xenografted ovarian carcinoma tumor (A2780) grown on the CAM. A 90% reduction in the tumor growth was observed. ..
  33. ncbi request reprint Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: influence of the ligands on drug efficacies and uptake
    Wee Han Ang
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Med Chem 48:8060-9. 2005
    ..The functionalization of the aromatic carboxylate ligand was found to have a profound influence on the uptake, and hence, efficacy, of this class of complex...
  34. doi request reprint Organometallic ruthenium(II) arene compounds with antiangiogenic activity
    Patrycja Nowak-Sliwinska
    Institute of Bio Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland
    J Med Chem 54:3895-902. 2011
    ....
  35. ncbi request reprint Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds
    Antoine Dorcier
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Inorg Biochem 102:1066-76. 2008
    ..The X-ray structures of the precursor complexes, [(eta5-C10H15)RhCl(pta-Me)2]Cl2, [(eta6-C10H14)OsCl(pta)2]Cl, and [(eta6-C6H6)OsCl2(CH3CN)], are also reported...
  36. ncbi request reprint A nearly planar water sheet sandwiched between strontium-imidazolium carboxylate coordination polymers
    Zhaofu Fei
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Inorg Chem 44:5200-2. 2005
    ..The two-dimensional polymer is separated by water sheets in which the water molecules form near-planar hexagons...
  37. doi request reprint Ruthenium(II) arene PTA (RAPTA) complexes: impact of enantiomerically pure chiral ligands
    Kelly J Kilpin
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Dalton Trans 42:2008-14. 2013
    ....
  38. ncbi request reprint Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs
    Wee Han Ang
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    ChemMedChem 2:1799-806. 2007
    ..They are highly effective against the GST Pi-positive A2780 and A2780cisR ovarian carcinoma cell lines, are among the most effective ruthenium complexes reported so far, and target ubiquitous GST Pi overexpressed in many cancers...
  39. ncbi request reprint Determination of drug binding sites to proteins by electrospray ionisation mass spectrometry: the interaction of cisplatin with transferrin
    Claire S Allardyce
    Institut de Chimie Minérale et Analytique, Ecole Polytechnique Federale de Lausanne, EPFL BCH, CH 1015 Lausanne, Switzerland
    Rapid Commun Mass Spectrom 16:933-5. 2002
    ..The studies indicate that cisplatin initially docks with, and subsequently bonds covalently to, the hydroxyl functional group of threonine 457, with the loss of HCl affording a transferrin-O-PtCl(NH3)2 adduct...
  40. ncbi request reprint Enhanced conversion of carbohydrates to the platform chemical 5-hydroxymethylfurfural using designer ionic liquids
    Sviatlana Siankevich
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015, Lausanne Switzerland, Fax 41 21 693 97 80
    ChemSusChem 7:1647-54. 2014
    ..In Situ NMR spectroscopy and computational modeling pinpoint the key interactions between the IL, catalyst, and substrate that account for the enhanced reactivities observed. ..
  41. doi request reprint Bioorganometallic chemistry--from teaching paradigms to medicinal applications
    Christian G Hartinger
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015, Lausanne, Switzerland
    Chem Soc Rev 38:391-401. 2009
    ..It is also shown how rational ligand design has led to new improved therapies much in the same way that an organometallic chemist working in catalysis will design new ligands for improved activities...
  42. ncbi request reprint A strategy for the synthesis of transition-metal nanoparticles and their transfer between liquid phases
    Dongbin Zhao
    Ecole Polytechnique Federale de Lausanne EPFL, Institut des Sciences et Ingenierie Chimiques, 1015 Lausanne, Switzerland
    Small 2:879-83. 2006
  43. ncbi request reprint Application of Ionic Liquids Containing Tricyanomethanide [C(CN)(3)](-) or Tetracyanoborate [B(CN)(4)](-) Anions in Dye-Sensitized Solar Cells
    Magdalena Marszalek
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Inorg Chem 50:11561-7. 2011
    ..35 and 7.85% under 100 and 10% Sun, respectively, in combination with the standard Z907 dye...
  44. ncbi request reprint Selective formic acid decomposition for high-pressure hydrogen generation: a mechanistic study
    Céline Fellay
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Chemistry 15:3752-60. 2009
    ..Overall, the method proposed overcomes the limitations of other catalysts for the decomposition of formic acid making it a viable hydrogen-storage material...
  45. ncbi request reprint Mass spectrometric and theoretical study of polyiodides: the connection between solid state, solution, and gas phases
    Michael Groessl
    Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, CH 1015 Lausanne, Switzerland
    Inorg Chem 50:9728-33. 2011
    ..This study demonstrates the utility of mass spectrometry to provide structural information in the absence of other spectroscopic handles...
  46. ncbi request reprint Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance
    Wee Han Ang
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, EPFL BCH, CH 1015 Lausanne, Switzerland
    J Am Chem Soc 127:1382-3. 2005
    ..Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described...
  47. doi request reprint Efficient synthesis of β-chlorovinylketones from acetylene in chloroaluminate ionic liquids
    Dennis J M Snelders
    Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Org Lett 13:4048-51. 2011
    ..Consequently, the products can be isolated using a simpler purification procedure, giving a range of aromatic and aliphatic β-chlorovinyl ketones in high yield and purity...
  48. ncbi request reprint Acid-free regioselective aminocarbonylation of alkenes
    Huizhen Liu
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Chem Commun (Camb) 50:7848-51. 2014
    ..An efficient method for the synthesis of N-aryl monosubstituted carboxamides via the Pd-catalyzed carbonylation of alkenes with CO and amines is described. Mechanistic insights for this highly selective reaction are provided. ..
  49. pmc Direct synthesis of formic acid from carbon dioxide by hydrogenation in acidic media
    Séverine Moret
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Nat Commun 5:4017. 2014
    ....
  50. ncbi request reprint A mass spectrometric and molecular modelling study of cisplatin binding to transferrin
    Isam Khalaila
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Chembiochem 6:1788-95. 2005
    ....
  51. pmc Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis
    João Neres
    Global Health Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Sci Transl Med 4:150ra121. 2012
    ..Our structural and kinetic analysis provides both insight into a critical epimerization reaction and a platform for structure-based design of improved inhibitors...
  52. doi request reprint The making of iLiquids--the chemist's equivalent of the iPhone
    Zhaofu Fei
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Chem Commun (Camb) 49:2594-6. 2013
    ..The multitude of 'apps' of ILs warrants an analogy with the iPhone and our use of the term iLiquids...
  53. ncbi request reprint A remarkable anion effect on palladium nanoparticle formation and stabilization in hydroxyl-functionalized ionic liquids
    Xiao Yuan
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Phys Chem Chem Phys 14:6026-33. 2012
    ..DFT calculations were employed to rationalize the interactions between Pd NPs and the [C(2)OHmim](+) cation and the various anions...
  54. ncbi request reprint pH-Sensitive gold nanoparticle catalysts for the aerobic oxidation of alcohols
    Yuan Yuan
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Inorg Chem 50:11069-74. 2011
    ..The mechanism of the precipitation process has been studied. Due to the efficiency of this process, the NPs may be reused as catalysts by readjusting their pH...
  55. ncbi request reprint Enhanced rate of arene hydrogenation with imidazolium functionalized bipyridine stabilized rhodium nanoparticle catalysts
    Ryan R Dykeman
    Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Inorg Chem 50:717-9. 2011
    ....
  56. ncbi request reprint In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes
    Claudine Scolaro
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
    J Med Chem 48:4161-71. 2005
    ..Pharmacokinetic studies of RAPTA-C indicate that ruthenium is rapidly lost from the organs and the bloodstream...
  57. doi request reprint Direct, in situ determination of pH and solute concentrations in formic acid dehydrogenation and CO(2) hydrogenation in pressurised aqueous solutions using (1)H and (13)C NMR spectroscopy
    Séverine Moret
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Dalton Trans 42:4353-6. 2013
    ..These data facilitate kinetic and mechanistic studies for H(2) storage/delivery in the carbon dioxide-formic acid systems under H(2) and CO(2) pressures...
  58. ncbi request reprint Rhodium nanoparticle catalysts stabilized with a polymer that enhances stability without compromising activity
    Ning Yan
    Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Chem Commun (Camb) 47:2529-31. 2011
    ..Rh NPs coated with a PVP-derived polymer, that combines several distinct protective interactions, exhibit superior thermal and catalytic stability compared to analogue NPs coated with PVP...
  59. ncbi request reprint Ferrocenoyl pyridine arene ruthenium complexes with anticancer properties: synthesis, structure, electrochemistry, and cytotoxicity
    Mathieu Auzias
    Institut de Chimie, Universite de Neuchatel, Case Postale 158, CH 2009 Neuchatel, Switzerland
    Inorg Chem 47:578-83. 2008
    ..Cyclic voltammetry revealed a good correlation of the RuII/RuIII redox potentials of 1-4 and the number of alkyl substituents in the arene ligand...
  60. doi request reprint CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP
    Michael Groessl
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Street 42, A 1090 Vienna, Austria
    J Inorg Biochem 102:1060-5. 2008
    ..RAPTA-C was found to hydrolyze fastest and showed the highest reactivity toward the DNA model compound, whereas KP418 was the most stable compound in both these respects...
  61. ncbi request reprint ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes
    Angela Casini
    Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
    ChemMedChem 2:631-5. 2007
  62. ncbi request reprint Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action
    Angela Casini
    Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy
    J Inorg Biochem 102:564-75. 2008
    ..The mechanistic relevance of gold(III)-induced oxidative protein damage and of direct gold coordination to protein sidechains is specifically assessed. Perspectives for the future of this topics are briefly outlined...
  63. doi request reprint The "complex-in-a-complex" cations [(acac)2M subset Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: A trojan horse for cancer cells
    Bruno Therrien
    Institut de Chimie, Universite de Neuchatel, Case Postale 158, 2009 Neuchatel, Switzerland
    Angew Chem Int Ed Engl 47:3773-6. 2008