Research Topics
| Paul J DysonSummaryCountry: Switzerland Publications
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Publications
Development of ruthenium antitumor drugs that overcome multidrug resistance mechanismsCarsten A Vock
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
J Med Chem 50:2166-75. 2007..Moreover, because the complex is fluorescent, its uptake in cells was studied, and relative to the free anthracene-based ligand, uptake of the complex is accelerated and accumulation of the complex in the cell nucleus is observed...
The making of iLiquids--the chemist's equivalent of the iPhoneZhaofu Fei
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Chem Commun (Camb) 49:2594-6. 2013..The multitude of 'apps' of ILs warrants an analogy with the iPhone and our use of the term iLiquids...- Ruthenium(II) arene PTA (RAPTA) complexes: impact of enantiomerically pure chiral ligandsKelly J Kilpin
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Dalton Trans 42:2008-14. 2013.... - Non-essential metals in chemical biologyPaul J Dyson
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Chimia (Aarau) 65:839-42. 2011.... - An octahedral rhodium cluster with six phosphine and 12 hydride ligands and 10 too few electronsPaul J Dyson
, , EPFL-BCH, 1015 Lausanne, Switzerland
Angew Chem Int Ed Engl 43:6028-30. 2004 - Nitrile-functionalized pyrrolidinium ionic liquids as solvents for cross-coupling reactions involving in situ generated nanoparticle catalyst reservoirsYugang Cui
, , CH 1015 Lausanne, Switzerland
Phys Chem Chem Phys 12:1834-41. 2010..The ability to use the nitrile-functionalized pyrrolidinium-based ionic liquids diluted in other (non-functionalized) ionic liquids is also described... - Organometallic chemistry in non-classical environmentsPaul J Dyson
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne
Chimia (Aarau) 65:730-3. 2011..The role of organometallic compounds in both catalysis and medicinal chemistry are briefly described... - Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compoundsAlexey A Nazarov
Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology EPFL, 1015 Lausanne, Switzerland
Inorg Chem 51:3633-9. 2012..Similar IC(50) values were obtained in cell proliferation assays, and similar levels of uptake and accumulation were also established. The X-ray structure of [{Ru(η(6)-C(6)H(5)CH(2)NHCO-anthracene)Cl(2)(pta)] is also reported... - Synthesis, characterisation and biological properties of gold(III) compounds with modified bipyridine and bipyridylamine ligandsAngela Casini
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Dalton Trans 39:2239-45. 2010..Reactivity studies with biomolecules, such as reducing agents, plasmid DNA and a model protein (ubiquitin) were also performed to provide tentative insights into the mode of action of the complexes... - Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(eta6-p-cymene)Cl2(pta)]Claudine Scolaro
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
J Inorg Biochem 102:1743-8. 2008..Hydrolysis is suppressed at high chloride concentrations. These results have important implications on the mode of action of the RAPTA drug candidates... - Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFTAngela Casini
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Dalton Trans 39:5556-63. 2010..Initial structure-activity relationships have been defined with the calculated binding energies of the M-S bonds correlating well with the observed inhibition properties of the compounds... - Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatinMichael Groessl
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Metallomics 3:591-9. 2011.... - Synthesis, characterization, and in vitro evaluation of novel ruthenium(II) eta6-arene imidazole complexesCarsten A Vock
, , CH-1015 Lausanne, Switzerland
J Med Chem 49:5552-61. 2006..Thus, two of the compounds, [Ru(eta6-p-cymene)Cl(vinylimid)2][Cl] (vinylimid = N-vinylimidazole) and [Ru(eta6-benzene)(mimid)3][BF4]2 (mimid = N-methylimidazole), have been selected for a more detailed in vivo evaluation... - Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysisWee Han Ang
, , CH-1015 Lausanne, Switzerland
Inorg Chem 45:9006-13. 2006.... - Synthesis of gold nanoparticle catalysts based on a new water-soluble ionic polymerIlaria Biondi
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Inorg Chem 50:8038-45. 2011..The aqueous gold nanoparticle solutions were employed as catalysts in the reduction of p-nitrophenol and in the hydrogenation of cinnamaldehyde and were found to exhibit excellent activity under mild conditions... - Rational design of an organometallic glutathione transferase inhibitorWee Han Ang
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Angew Chem Int Ed Engl 48:3854-7. 2009..The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods... - Ruthenium porphyrin compounds for photodynamic therapy of cancerFrederic Schmitt
Institute of Pathology, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland
J Med Chem 51:1811-6. 2008..Thus, the porphyrin areneruthenium(II) derivatives represent a promising new class of organometallic photosensitizers able to combine chemotherapeutic activity with photodynamic therapeutic treatment of cancer... - Bioanalytical and biophysical techniques for the elucidation of the mode of action of metal-based drugsMichael Groessl
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Curr Top Med Chem 11:2632-46. 2011..The current state of these techniques, their strengths and limitations, and the information they can provide for achieving this demanding goal, are described in this review... - The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapyIsam Khalaila
, , EPFL, CH-1015 Lausanne, Switzerland
Int J Oncol 29:261-8. 2006.... - Use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumor targetingAnna K Renfrew
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Inorg Chem 49:2239-46. 2010..Incubation at 42 degrees C for 2 h resulted in improved cytotoxicities for two of the complexes... - Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of actionAngela Casini
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Metallomics 1:434-41. 2009..The mechanistic implications of these results are discussed... - Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometryMichael Groessl
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, Switzerland
J Biol Inorg Chem 15:677-88. 2010..A strong preference for guanine residues was established... - Strategy to tether organometallic ruthenium-arene anticancer compounds to recombinant human serum albuminWee Han Ang
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Inorg Chem 46:9048-50. 2007..The approach involves the design of a drug fragment capable of conjugating to linker molecules on a modified carrier protein via hydrazone bond formation. The proof-of-concept using recombinant human serum albumin is described... - Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compoundAngela Casini
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
J Biol Inorg Chem 14:761-70. 2009..In addition, competition studies between cisplatin and RAPTA-C showed that the two metallodrugs have affinities for the same amino acid residues on protein binding... - Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: relevance to antitumour activityChristian G Hartinger
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
J Inorg Biochem 102:2136-41. 2008..In addition, the ability of glutathione to cleave ruthenium-ubiquitin bonds was assayed and it was shown that GSH is capable of removing the Ru moiety from the protein, although no ternary adducts were identified... - Metabolization of [Ru(eta(6)-C (6)H (5)CF (3))(pta)Cl (2)]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligandAlexander E Egger
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015, Lausanne, Switzerland
J Biol Inorg Chem 15:919-27. 2010..Consequently, facile arene loss appears to be responsible for the increased cytotoxicity of RAPTA-CF3... - Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approachChristian G Hartinger
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015, Lausanne, Switzerland
Inorg Chem 47:17-9. 2008.... - Organometallic ruthenium(II) arene compounds with antiangiogenic activityPatrycja Nowak-Sliwinska
Institute of Bio Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland
J Med Chem 54:3895-902. 2011.... - A viable hydrogen-storage system based on selective formic acid decomposition with a ruthenium catalystCéline Fellay
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Angew Chem Int Ed Engl 47:3966-8. 2008 - Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugsWee Han Ang
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
ChemMedChem 2:1799-806. 2007..They are highly effective against the GST Pi-positive A2780 and A2780cisR ovarian carcinoma cell lines, are among the most effective ruthenium complexes reported so far, and target ubiquitous GST Pi overexpressed in many cancers... - Determination of drug binding sites to proteins by electrospray ionisation mass spectrometry: the interaction of cisplatin with transferrinClaire S Allardyce
, , EPFL - BCH, CH-1015 Lausanne, Switzerland
Rapid Commun Mass Spectrom 16:933-5. 2002..The studies indicate that cisplatin initially docks with, and subsequently bonds covalently to, the hydroxyl functional group of threonine 457, with the loss of HCl affording a transferrin-O-PtCl(NH3)2 adduct... - Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: influence of the ligands on drug efficacies and uptakeWee Han Ang
, , CH 1015 Lausanne, Switzerland
J Med Chem 48:8060-9. 2005..The functionalization of the aromatic carboxylate ligand was found to have a profound influence on the uptake, and hence, efficacy, of this class of complex... - Bioorganometallic chemistry--from teaching paradigms to medicinal applicationsChristian G Hartinger
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015, Lausanne, Switzerland
Chem Soc Rev 38:391-401. 2009..It is also shown how rational ligand design has led to new improved therapies much in the same way that an organometallic chemist working in catalysis will design new ligands for improved activities... - A strategy for the synthesis of transition-metal nanoparticles and their transfer between liquid phasesDongbin Zhao
, , 1015 Lausanne, Switzerland
Small 2:879-83. 2006 - Application of Ionic Liquids Containing Tricyanomethanide [C(CN)(3)](-) or Tetracyanoborate [B(CN)(4)](-) Anions in Dye-Sensitized Solar CellsMagdalena Marszalek
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Inorg Chem 50:11561-7. 2011..35 and 7.85% under 100 and 10% Sun, respectively, in combination with the standard Z907 dye... - Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compoundsAntoine Dorcier
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
J Inorg Biochem 102:1066-76. 2008..The X-ray structures of the precursor complexes, [(eta5-C10H15)RhCl(pta-Me)2]Cl2, [(eta6-C10H14)OsCl(pta)2]Cl, and [(eta6-C6H6)OsCl2(CH3CN)], are also reported... - Influence of the interaction between hydrogen sulfide and ionic liquids on solubility: experimental and theoretical investigationChristian Silvio Pomelli
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Swizerland
J Phys Chem B 111:13014-9. 2007..Quantum chemical calculations have been used to investigate at a molecular level the interaction between H2S and the [bmim](+)-based ILs... - In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexesClaudine Scolaro
, , Switzerland
J Med Chem 48:4161-71. 2005..Pharmacokinetic studies of RAPTA-C indicate that ruthenium is rapidly lost from the organs and the bloodstream... - Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell deathAlexey A Nazarov
Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland
Dalton Trans 42:2347-50. 2013.... - Mass spectrometric and theoretical study of polyiodides: the connection between solid state, solution, and gas phasesMichael Groessl
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, CH 1015 Lausanne, Switzerland
Inorg Chem 50:9728-33. 2011..This study demonstrates the utility of mass spectrometry to provide structural information in the absence of other spectroscopic handles... - A nearly planar water sheet sandwiched between strontium-imidazolium carboxylate coordination polymersZhaofu Fei
, , CH-1015 Lausanne, Switzerland
Inorg Chem 44:5200-2. 2005..The two-dimensional polymer is separated by water sheets in which the water molecules form near-planar hexagons... - Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistanceWee Han Ang
, , EPFL-BCH, CH 1015 Lausanne, Switzerland
J Am Chem Soc 127:1382-3. 2005..Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described... - Selective formic acid decomposition for high-pressure hydrogen generation: a mechanistic studyCéline Fellay
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Chemistry 15:3752-60. 2009..Overall, the method proposed overcomes the limitations of other catalysts for the decomposition of formic acid making it a viable hydrogen-storage material... - A remarkable anion effect on palladium nanoparticle formation and stabilization in hydroxyl-functionalized ionic liquidsXiao Yuan
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Phys Chem Chem Phys 14:6026-33. 2012..DFT calculations were employed to rationalize the interactions between Pd NPs and the [C(2)OHmim](+) cation and the various anions... - Enhanced rate of arene hydrogenation with imidazolium functionalized bipyridine stabilized rhodium nanoparticle catalystsRyan R Dykeman
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Inorg Chem 50:717-9. 2011.... - pH-Sensitive gold nanoparticle catalysts for the aerobic oxidation of alcoholsYuan Yuan
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Inorg Chem 50:11069-74. 2011..The mechanism of the precipitation process has been studied. Due to the efficiency of this process, the NPs may be reused as catalysts by readjusting their pH... - A mass spectrometric and molecular modelling study of cisplatin binding to transferrinIsam Khalaila
, , 1015 Lausanne, Switzerland
Chembiochem 6:1788-95. 2005.... - Efficient synthesis of β-chlorovinylketones from acetylene in chloroaluminate ionic liquidsDennis J M Snelders
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Org Lett 13:4048-51. 2011..Consequently, the products can be isolated using a simpler purification procedure, giving a range of aromatic and aliphatic β-chlorovinyl ketones in high yield and purity... - Rhodium nanoparticle catalysts stabilized with a polymer that enhances stability without compromising activityNing Yan
Institut des Sciences et Ingenierie Chimiques, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Chem Commun (Camb) 47:2529-31. 2011..Rh NPs coated with a PVP-derived polymer, that combines several distinct protective interactions, exhibit superior thermal and catalytic stability compared to analogue NPs coated with PVP... - CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMPMichael Groessl
Institute of Inorganic Chemistry, University of Vienna, Waehringer Street 42, A 1090 Vienna, Austria
J Inorg Biochem 102:1060-5. 2008..RAPTA-C was found to hydrolyze fastest and showed the highest reactivity toward the DNA model compound, whereas KP418 was the most stable compound in both these respects... - Ferrocenoyl pyridine arene ruthenium complexes with anticancer properties: synthesis, structure, electrochemistry, and cytotoxicityMathieu Auzias
Institut de Chimie, Universite de Neuchatel, Case Postale 158, CH 2009 Neuchatel, Switzerland
Inorg Chem 47:578-83. 2008..Cyclic voltammetry revealed a good correlation of the RuII/RuIII redox potentials of 1-4 and the number of alkyl substituents in the arene ligand... - ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexesAngela Casini
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
ChemMedChem 2:631-5. 2007 - The "complex-in-a-complex" cations [(acac)2M subset Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: A trojan horse for cancer cellsBruno Therrien
Institut de Chimie, , Case Postale 158, , Switzerland
Angew Chem Int Ed Engl 47:3773-6. 2008 - Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of actionAngela Casini
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy
J Inorg Biochem 102:564-75. 2008..The mechanistic relevance of gold(III)-induced oxidative protein damage and of direct gold coordination to protein sidechains is specifically assessed. Perspectives for the future of this topics are briefly outlined...