Research Topics
| Simon L CroftSummaryAffiliation: Drugs for Neglected Diseases Initiative Country: Switzerland Publications
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Detail Information
Publications
Public-private partnership: from there to hereSimon L Croft
Drugs for Neglected Diseases Initiative DNDi, 1 place Saint Gervais, 1201 Geneva, Switzerland
Trans R Soc Trop Med Hyg 99:S9-14. 2005..The challenge is to ensure that the products are delivered to the people who need them and to ensure that scientists in endemic countries are involved in the whole process...- Current scenario of drug development for leishmaniasisSimon L Croft
Drugs for Neglected Diseases Initiative DNDi, Geneva, Switzerland
Indian J Med Res 123:399-410. 2006..The process for discovery and development of new antileishmanials would also benefit from improved models, for example, transfected parasites, and non invasive methods of measuring parasite load in rodent models of infection... 
Drug resistance in leishmaniasisSimon L Croft
Drugs for Neglected Diseases Initiative, 1 place Saint Gervais, CH 1201 Geneva, Switzerland
Clin Microbiol Rev 19:111-26. 2006....- Chemotherapy of trypanosomiases and leishmaniasisSimon L Croft
Drugs for Neglected Diseases Initiative, 1 place Saint Gervais, CH 1201 Geneva, Switzerland
Trends Parasitol 21:508-12. 2005..Financial constraints continue to represent a major hurdle to drug development. However, the appearance of not-for-profit product-development partnerships offers a new paradigm for bringing new drugs to patients... - Miltefosine--discovery of the antileishmanial activity of phospholipid derivativesSimon L Croft
Drugs for Neglected Diseases Initiative DNDi, 1 Place St Gervais, CH 1201 Geneva, Switzerland
Trans R Soc Trop Med Hyg 100:S4-8. 2006..Miltefosine is active against most Leishmania species, including those that cause cutaneous disease... - Leishmaniasis--current chemotherapy and recent advances in the search for novel drugsSimon L Croft
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Trends Parasitol 19:502-8. 2003 - Toxicity and antileishmanial activity of a new stable lipid suspension of amphotericin BMalika Larabi
Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, , , 92296 Chatenay Malabry Cedex, France
Antimicrob Agents Chemother 47:3774-9. 2003..It was unable to reverse the resistance of an AMB-resistant L. donovani strain. In vivo LC-AMB was less efficient than AmBisome against L. donovani... - In-vitro and in-vivo studies on a topical formulation of sitamaquine dihydrochloride for cutaneous leishmaniasisTracy Garnier
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
J Pharm Pharmacol 58:1043-54. 2006..Several formulations were tested in-vivo against Leishmania major cutaneous lesions in BALB/c mice. None of the sitamaquine dihydrochloride formulations tested appeared to either slow lesion progression or reduce parasite burden... - Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical useF Javier Pérez-Victoria
Instituto de Parasitologia y Biomedicina Lopez Neyra, Spanish Research Council C S I C, Technological Park of Health Sciences, Avda del Conocimiento s n, 18100 Armilla, Granada, Spain
Drug Resist Updat 9:26-39. 2006.... - Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquoneAntti Mäntylä
Department of Pharmaceutical Chemistry, University of Kuopio, PO Box, 1627, FIN 70211 Kuopio, Finland
J Med Chem 47:188-95. 2004..In addition, 4b easily released the parent drug in human skin homogenate and, therefore, is a promising prodrug candidate to deliver buparvaquone through the skin for the treatment of cutaneous leishmaniasis... - Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasisSilvia Orenes Lorente
Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, United Kingdom
Antimicrob Agents Chemother 48:2937-50. 2004..The compounds were also found to be active against the bloodstream form (trypomastigotes) of Trypanosoma brucei rhodesiense, a causative agent of African trypanosomiasis... - In vitro antiprotozoal and cytotoxic activities of some alkaloids, quinones, flavonoids, and coumarinsMaria del Rayo Camacho
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK
Planta Med 70:70-2. 2004 - Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoaSilvia Orenes Lorente
Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK
Bioorg Med Chem 13:3519-29. 2005..Some compounds also showed growth inhibition of T. brucei rhodesiense trypomastigotes, although in this case alternative modes of action other than inhibition of SQS are probably involved... - Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinateN P Dhammika Nanayakkara
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Antimicrob Agents Chemother 52:2130-7. 2008.... - The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosineVanessa Yardley
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Am J Trop Med Hyg 73:272-5. 2005..If this model can be correlated to therapeutic outcome, it may have implications for the interpretation of clinical trials... - Antimalarial drug discovery: efficacy models for compound screeningDavid A Fidock
Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Nat Rev Drug Discov 3:509-20. 2004 - In vitro and in vivo interactions between miltefosine and other antileishmanial drugsKarin Seifert
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
Antimicrob Agents Chemother 50:73-9. 2006..38). The potentiation of miltefosine in vivo was also achieved with the combination of miltefosine and paromomycin (AEI of up to 7.22)... - Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)Karin Seifert
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Int J Antimicrob Agents 22:380-7. 2003..Resistance was stable up to 12 weeks in drug-free culture medium. No amplification of specific genes, including the multidrug resistance P-glycoprotein gene, could be detected in the resistant parasites... - Chemotherapy of leishmaniasisSimon L Croft
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Curr Pharm Des 8:319-42. 2002..In short, there remains a pressing need for new anti-leishmanials and this chapter reviews the current status of chemotherapy, the various avenues being investigated by researchers and their potential application in the future... - Drug sensitivity of Leishmania species: some unresolved problemsSimon L Croft
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Trans R Soc Trop Med Hyg 96:S127-9. 2002..Reporter genes and the polymerase chain reaction will improve assays both in vitro and in vivo for the identification and evaluation of new drugs... - Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agendaPhilippe J Guerin
Norwegian Institute of Public Health, Norway
Lancet Infect Dis 2:494-501. 2002..This article reviews the current situation and perspectives for diagnosis, treatment, and control of visceral leishmaniasis, and lists some priorities for research and development... - Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin BPatricia Escobar
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Acta Trop 81:151-7. 2002..5-37.1 microM against amastigotes. Amphotericin B deoxycholate was used as the standard drug and gave submicromolar ED(50) values in all assays; L. mexicana was the least sensitive species to this drug... - Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivoKarin Seifert
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Int J Antimicrob Agents 30:229-35. 2007..90% inhibition in wild-type infections). No cross-resistance to other antileishmanial drugs was observed in M-mutR amastigotes... - Leishmaniasis: new approaches to disease controlClive R Davies
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT
BMJ 326:377-82. 2003 - Antiprotozoal activities of phospholipid analoguesSimon L Croft
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Mol Biochem Parasitol 126:165-72. 2003..This review will focus on the biological activities of phospholipid analogues. Biochemical and molecular targets and mechanism(s) of action have been studied extensively in tumor cells but have not been determined in protozoa... - Artemisone--a highly active antimalarial drug of the artemisinin classRichard K Haynes
Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China
Angew Chem Int Ed Engl 45:2082-8. 2006 - Development and validation of RP-HPLC-UV method for simultaneous determination of buparvaquone, atenolol, propranolol, quinidine and verapamil: a tool for the standardization of rat in situ intestinal permeability studiesGantala Venkatesh
Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia
J Pharm Biomed Anal 43:1546-51. 2007..Stability studies were carried out at different storage conditions and all the analytes were found to be stable. This method is simple, reliable and can be routinely used for accurate permeability characterization... - Antimalarial compounds from Kniphofia foliosa rootsAbraham Abebe Wube
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4/1, A-8010 Graz, Austria
Phytother Res 19:472-6. 2005..This is the first report of the inhibition of the growth of P. falciparum by anthraquinone-anthrone dimers and establishes them as a new class of potential antimalarial compounds with very little host cell toxicity... - Topical buparvaquone formulations for the treatment of cutaneous leishmaniasisTracy Garnier
School of Pharmacy, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK
J Pharm Pharmacol 59:41-9. 2007.... - Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinoneNikhil H Gokhale
Department of Chemistry, University of Pune, Ganeshkhind Road, Pune-411007, India
Bioorg Med Chem Lett 16:430-2. 2006..The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target... 
Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivoLivia Vivas
London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, London WC1E 7HT, United Kingdom
Acta Trop 105:222-8. 2008..The data suggest that the combination of pyronaridine and artesunate should have potential in areas of multi-drug resistant malaria...- Inhibition of Trypanosoma cruzi hexokinase by bisphosphonatesMichael P Hudock
Department of Biophysics, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, Illinois 61801, USA
J Med Chem 49:215-23. 2006..2 microM IC(50) versus the clinically relevant intracellular amastigote form of T. cruzi, but only a approximately 1-2 mM IC(50) versus Dictyostelium discoideum and a human cell line, indicating selective activity versus T. cruzi... - New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor actionLudovic Gros
Welsh School of Pharmacy, Cardiff University, UK
Antimicrob Agents Chemother 50:2595-601. 2006..Likewise, Western blot analysis and activity determinations evidenced the existence of active enzyme in both forms of the parasite. We conclude that the designed compounds act at sites other than 24-SMT in Trypanosoma brucei... - Neglected diseases: progress in drug developmentSimon L Croft
Curr Opin Investig Drugs 8:103-4. 2007 - Antileishmanial structure-activity relationships of synthetic phospholipids: in vitro and in vivo activities of selected derivativesKarin Seifert
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Antimicrob Agents Chemother 51:4525-8. 2007..Promising compounds were tested further in vivo. In vitro structure-activity relationships showed a positive contribution of head groups bearing ring systems (N-methylpiperidino and N-methylmorpholino) to antileishmanial activity... - Metallocene-based antimalarials: an exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparumMargaret A L Blackie
Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
Bioorg Med Chem 15:6510-6. 2007..Unexpectedly high activity for quinoline compounds lacking the 7-chloro substituent suggests the ferrocenyl moiety may have an additive and/or synergistic effect... - Optimization and validation of RP-HPLC-UV method with solid-phase extraction for determination of buparvaquone in human and rabbit plasma: application to pharmacokinetic studyGantala Venkatesh
Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia
Biomed Chromatogr 22:535-41. 2008..Partial validation studies were carried out using rabbit plasma and intra- and inter-day precision and accuracy were within 7%. This method is simple, reliable and can be routinely used for preclinical pharmacokinetic studies for BPQ... - Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasiticsSilvia Orenes Lorente
Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3XF, UK
Bioorg Med Chem 13:5435-53. 2005..donovani and T. cruzi, but no inhibition of the enzyme. In addition, some of the compounds had anti-proliferative activity against the bloodstream forms of Trypanosoma brucei rhodesiense, which causes African trypanosomiasis... - Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenaseRebecca Conners
Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
Mol Biochem Parasitol 142:137-48. 2005.... - Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruziFilippo Magaraci
Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3XF, UK
J Med Chem 46:4714-27. 2003..However, some azasterols which were not good inhibitors of 24-SMT also showed antiproliferative activity, suggesting that there may be other modes of actions of these compounds... - Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareiraIrama Ramírez
Faculty of Pharmacy, University of Los Andes, Mérida ZP 5101, Venezuela
Phytochemistry 64:645-7. 2003..This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line... - Structure-activity relationships of antileishmanial and antimalarial chalconesMei Liu
Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
Bioorg Med Chem 11:2729-38. 2003..Despite different requirements, two alkoxylated chalcones (8, 19) were identified which combined good antimalarial and antileishmanial activities... - Antileishmanial activity of two gamma-pyrones from Podolepsis hieracioides (Asteraceae)Oliver Kayser
Institute of Pharmacy Pharmaceutical Technology, Biopharmacy and Biotechnology, Freie Universitat Berlin, Kelchstrasse 31, D 112169 Berlin, Germany
Acta Trop 86:105-7. 2003..7, SKMel, and KB; IC(50)=11.5->25.0 microg/ml). Both compounds were not active against Trypanosoma cruzi or Trypanosoma br. brucei (IC(50)>30 microg/ml)... - Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal leadGérard Chauviere
Groupe de Chimie Organique Biologique, Laboratoire de Synthèse et Physicochimie de Molécules d Intérêt Biologique, Universite Paul Sabatier, UMR CNRS 5068, 31062 Toulouse, France
J Med Chem 46:427-40. 2003..The mutagenicity of this compound is at present being reevaluated, and metabolism is also under investigation prior to possible further developments... - Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanesMaria del Rayo Camacho
Centre for Pharmacognosy and Phytotherapy, and Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, UK
J Nat Prod 65:1457-61. 2002..2 microM against Trypanosoma brucei brucei, and 63.8 microM against Leishmania donovani. Quercetin was found to be inactive against KB cells (IC(50) = 295.8 microM)... - Synthesis, stability, and antimalarial activity of new hydrolytically stable and water-soluble (+)-deoxoartelinic acidMankil Jung
Department of Chemistry, Yonsei University, Seoul 120 749, Korea
J Med Chem 45:4940-4. 2002..66 h, 23 times more stable than clinically useful arteether in simulated stomach acid, and improved solubility, 4 times more soluble than artemisinin in water... - In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against Leishmania donovani and Trypanosoma brucei bruceiMaria del Rayo Camacho
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC 1N 1AX, UK
Phytother Res 16:432-6. 2002..Thalisopidine showed the strongest activity (IC(50) = 1.14 microM) against Trypanosoma brucei brucei blood stream form trypomastigotes, but was less active than pentamidine... - Topical treatment for cutaneous leishmaniasisTracy Garnier
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
Curr Opin Investig Drugs 3:538-44. 2002..The focus of this review is on recent developments in the field of topical treatment for cutaneous leishmaniasis and rational approaches to enhance topical drug absorption... - Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazinesHongyu Ren
Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA
Eur J Med Chem 38:949-57. 2003..cruzi infections. In addition, all but one of the new bicyclic hydrazine esters are virtually non-toxic, one of the most important drawbacks of currently available trypanocidal drugs... - Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasisAnjan Nan
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
J Control Release 94:115-27. 2004..0001) than nontargeted conjugate (47% inhibition). HPMA copolymers containing ManN in the side chains can potentially reduce the toxicity and increase efficacy of anti-leishmanial drugs for the treatment of VL... - Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivoSubhash Ghosh
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
J Med Chem 47:175-87. 2004..Taken together, these results show that bisphosphonates appear to be useful lead compounds for the development of novel antiamebic and antimalarial drugs... - Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of actionOnyeka Onyeibor
The School of Pharmacy, Department of Biomedical Sciences and Tom Connors Cancer Research Centre, University of Bradford, West Yorkshire, BD7 1DP, UK
J Med Chem 48:2701-9. 2005..No correlation was seen (r(2) = 0.0781) suggesting that the potent antimalarial activity of compounds such as 15 involves other mechanisms in addition to the inhibition of hemozoin formation... - In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeabilityDora Carrico
Department of Chemistry, Yale University, PO Box 208107, New Haven, CT 06520, USA
Bioorg Med Chem 12:6517-26. 2004.... - Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivityRichard K Haynes
Department of Chemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P.R. China
Angew Chem Int Ed Engl 43:1381-5. 2004 - Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activityKaren M Grant
Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom
Antimicrob Agents Chemother 48:3033-42. 2004..Thus, use of chemical inhibitors supports genetic studies to confirm CRK3 as a validated drug target in Leishmania and provides pharmacophores for further drug development... - Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agentsJunko Ohkanda
Department of Chemistry, Yale University, PO Box 208107, New Haven, Connecticut 06520, USA
J Med Chem 47:432-45. 2004..brucei cells were shown to be highly correlated. These studies validate TbPFT as a target for the development of novel therapeutics against African sleeping sickness... - Synthesis and antileishmanial activity of novel buparvaquone oxime derivativesAntti Mäntylä
Department of Pharmaceutical Chemistry, University of Kuopio, Finland
Bioorg Med Chem 12:3497-502. 2004..Further in vivo studies are needed to verify the biological activity of buparvaquone-oximes in the treatment of leishmaniasis... - Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazolesDenise M Cottrell
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA
Bioorg Med Chem 12:2815-24. 2004..doses at 5mg/kg and by 61% when administered orally for 5 days at 50 mg/kg. These results indicate that aromatic thiocyanates hold promise for the treatment of leishmanial infections if the selectivity of these compounds can be improved... - Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activityAngus Cameron
Department of Biochemistry and Molecular Recognition Centre, University of Bristol, Bristol BS8 1TD, United Kingdom
J Biol Chem 279:31429-39. 2004..In combination these studies also provide strong support for the validity of targeting the Plasmodium glycolytic pathway and, in particular, LDH in the search for novel anti-malarials... - Prediction of anti-plasmodial activity of Artemisia annua extracts: application of 1H NMR spectroscopy and chemometricsNigel J C Bailey
SCYNEXIS Europe Ltd, Fyfield Business and Research Park, Fyfield Road, Ongar, Essex CM5 0GS, UK
J Pharm Biomed Anal 35:117-26. 2004..8. This approach was also able to correlate 1H NMR spectra with cytotoxicity (R2=0.9, Q2=0.8). This work demonstrates the potential of NMR spectroscopy and chemometrics for the development of predictive models of anti-plasmodial activity... - In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondiiVanessa Yardley
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
Antimicrob Agents Chemother 46:929-31. 2002..donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice...
Research Grants
- Development of a low cost formulation of amphotericin BSHING CHANG; Fiscal Year: 2007....
- K777 for treatment of Chagas Disease: IND-enabling Studies and IND SubmissionSHING CHANG; Fiscal Year: 2010..This proposal is designed to complete all remaining requirements as agreed with the FDA to allow K777 to move into clinical trials. ..