Research Topics
Species | Michel GillietSummaryAffiliation: Dermatologische Klinik Country: Switzerland Publications
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Detail Information
Publications
Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligationAndre Boonstra
Division of Immunoregulation, The National Institute for Medical Research NIMR, NW7 1AA London, United Kingdom
J Exp Med 197:101-9. 2003..Thus, the net effect of antigen dose, the state of maturation of the DCs together with the stimulation of DCs by pathogen-derived products, will determine whether a Th1 or Th2 response develops...
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursorsMichel Gilliet
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Arch Dermatol 140:1490-5. 2004..It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this...
Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha productionFrank O Nestle
Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland
J Exp Med 202:135-43. 2005..These findings uncover a novel innate immune pathway for triggering a common human autoimmune disease and suggest that PDCs and PDC-derived IFN-alpha represent potential early targets for the treatment of psoriasis...- Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatmentMirjana Urosevic
Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
J Natl Cancer Inst 97:1143-53. 2005..We focused on plasmacytoid predendritic cells (PDCs), the primary producer of interferon alpha (IFN-alpha) after imiquimod activation in vitro... - The pathogenic role of tissue-resident immune cells in psoriasisOnur Boyman
Division of Immunology and Allergy, University Hospital of Lausanne CHUV, CH 1011 Lausanne, Switzerland
Trends Immunol 28:51-7. 2007..This concept focuses attention on local, rather than systemic, components of the immune system for rationalized therapeutic approaches of psoriasis and possibly also other chronic inflammatory diseases... - Intra-lesional low-dose interferon alpha2a therapy for primary cutaneous marginal zone B-cell lymphomaAntonio Cozzio
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Leuk Lymphoma 47:865-9. 2006..All other patients remained free of disease. Thus, intra-lesional IFNalpha2a may represent a valuable alternative to surgery and radiotherapy as first-line treatment of pcMZL... - Febrile ulceronecrotic Mucha-Habermann disease with clonality: a cutaneous T-cell lymphoma entity?Antonio Cozzio
Department of Dermatology, University Hospital of Zurich, Switzerland
J Am Acad Dermatol 51:1014-7. 2004..Here, we report two cases of FUMHD with monoclonal T-cell population, as detected by Southern blot analysis. We propose that clonal FUMHD represents a cutaneous T-cell lymphoma entity... - Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigenMichel Gilliet
Department of Dermatology, , Gloriastrasse 31, , Switzerland
Blood 102:36-42. 2003..Our results indicate that intranodal vaccination with semimature DCs can prime strong, long-lasting CD4 T-cell responses with a TH1-type cytokine profile in cancer patients... - Defining upstream elements of psoriasis pathogenesis: an emerging role for interferon alphaFrank O Nestle
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
J Invest Dermatol 125:xiv-xv. 2005 
Type I IFNs at the interface between cutaneous immunity and epidermal remodelingCurdin Conrad
Department of Dermatology, Lausanne University Hospital of Lausanne, Lausanne, Switzerland
J Invest Dermatol 132:1759-62. 2012....- Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphomaMartin Kleinhans
Department of Dermatology, University of Zurich Medical School, Switzerland
Blood 101:1487-93. 2003..These results suggest that expression of CCR3 and its ligand eotaxin/CCL11 plays a role in the recruitment and retention of CD30(+) malignant T cells to the skin... - Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cellsMichel Gilliet
DNAX Research Institute, Palo Alto, CA 94304, USA
J Exp Med 197:1059-63. 2003.... - Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseasesMichel Gilliet
Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Nat Rev Immunol 8:594-606. 2008..Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis... - Two functional subsets of FOXP3+ regulatory T cells in human thymus and peripheryTomoki Ito
Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Immunity 28:870-80. 2008.... - Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptideRoberto Lande
Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
Nature 449:564-9. 2007..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis... - Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligandTomoki Ito
Department of Immunology, M D Anderson Cancer Center, Graduate School of Biomedical Sciences at Houston, The University of Texas, Houston, TX 77030, USA
J Exp Med 204:105-15. 2007..Our findings demonstrate that mDC and pDCs are intrinsically different in the expression of costimulatory molecules that drive distinct types of T cell responses... - OX40 ligand shuts down IL-10-producing regulatory T cellsTomoki Ito
Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, 77030 1903, USA
Proc Natl Acad Sci U S A 103:13138-43. 2006..These two novel functions of OX40L shed light on the mechanism by which OX40/OX40L regulates immunity and tolerance... - Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cellsYui-Hsi Wang
Department of Immunology, Center of Cancer Immunology Research, Graduate School of Biomedical Science, Houston, Texas 77030, USA
Immunity 24:827-38. 2006.... - The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factorMichel Gilliet
DNAX Research Institute, Palo Alto, CA 94304, USA
J Exp Med 195:953-8. 2002..Human IPCs and mouse IPCs display different ability to produce IL-12p70. Large numbers of mouse IPCs can now be obtained from total bone marrow culture... - Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLPVassili Soumelis
DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
Nat Immunol 3:673-80. 2002..TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation... - Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cellsMichel Gilliet
DNAX Research Institute, Palo Alto, California, USA
Hum Immunol 63:1149-55. 2002..DC2 can be used as tool to drive potent antigen specific Tr-cell differentiation and expansion in vitro and in vivo... - Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunityJean Francois Fonteneau
Laboratory of Molecular Neuro Oncology, Rockefeller University, New York, NY, USA
Blood 101:3520-6. 2003..Our results pinpoint a new role of pDCs in the induction of antiviral T-cell responses and suggest that these DCs play a prominent role in the adaptive immune response against viruses... - Mature dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15JoAnn Castelli
Department of Medicine, Division of Hematology Oncology, University of California, San Francisco 94143 1270, USA
Blood 103:2699-704. 2004..These studies provide another potential approach by which the immune system in HIV infection could be restored by cytokine therapy, particularly IL-15 administration... - Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cellsMichel Gilliet
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
J Exp Med 195:695-704. 2002....