Michel Gilliet

Summary

Affiliation: Dermatologische Klinik
Country: Switzerland

Publications

  1. pmc Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation
    Andre Boonstra
    Division of Immunoregulation, The National Institute for Medical Research NIMR, NW7 1AA London, United Kingdom
    J Exp Med 197:101-9. 2003
  2. ncbi Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors
    Michel Gilliet
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Arch Dermatol 140:1490-5. 2004
  3. pmc Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland
    J Exp Med 202:135-43. 2005
  4. ncbi Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatment
    Mirjana Urosevic
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    J Natl Cancer Inst 97:1143-53. 2005
  5. ncbi The pathogenic role of tissue-resident immune cells in psoriasis
    Onur Boyman
    Division of Immunology and Allergy, University Hospital of Lausanne CHUV, CH 1011 Lausanne, Switzerland
    Trends Immunol 28:51-7. 2007
  6. ncbi Intra-lesional low-dose interferon alpha2a therapy for primary cutaneous marginal zone B-cell lymphoma
    Antonio Cozzio
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Leuk Lymphoma 47:865-9. 2006
  7. ncbi Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen
    Michel Gilliet
    Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Blood 102:36-42. 2003
  8. ncbi Febrile ulceronecrotic Mucha-Habermann disease with clonality: a cutaneous T-cell lymphoma entity?
    Antonio Cozzio
    Department of Dermatology, University Hospital of Zurich, Switzerland
    J Am Acad Dermatol 51:1014-7. 2004
  9. ncbi Defining upstream elements of psoriasis pathogenesis: an emerging role for interferon alpha
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    J Invest Dermatol 125:xiv-xv. 2005
  10. doi Type I IFNs at the interface between cutaneous immunity and epidermal remodeling
    Curdin Conrad
    Department of Dermatology, Lausanne University Hospital of Lausanne, Lausanne, Switzerland
    J Invest Dermatol 132:1759-62. 2012

Collaborators

Detail Information

Publications24

  1. pmc Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation
    Andre Boonstra
    Division of Immunoregulation, The National Institute for Medical Research NIMR, NW7 1AA London, United Kingdom
    J Exp Med 197:101-9. 2003
    ..Thus, the net effect of antigen dose, the state of maturation of the DCs together with the stimulation of DCs by pathogen-derived products, will determine whether a Th1 or Th2 response develops...
  2. ncbi Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors
    Michel Gilliet
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Arch Dermatol 140:1490-5. 2004
    ..It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this...
  3. pmc Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland
    J Exp Med 202:135-43. 2005
    ..These findings uncover a novel innate immune pathway for triggering a common human autoimmune disease and suggest that PDCs and PDC-derived IFN-alpha represent potential early targets for the treatment of psoriasis...
  4. ncbi Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatment
    Mirjana Urosevic
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    J Natl Cancer Inst 97:1143-53. 2005
    ..We focused on plasmacytoid predendritic cells (PDCs), the primary producer of interferon alpha (IFN-alpha) after imiquimod activation in vitro...
  5. ncbi The pathogenic role of tissue-resident immune cells in psoriasis
    Onur Boyman
    Division of Immunology and Allergy, University Hospital of Lausanne CHUV, CH 1011 Lausanne, Switzerland
    Trends Immunol 28:51-7. 2007
    ..This concept focuses attention on local, rather than systemic, components of the immune system for rationalized therapeutic approaches of psoriasis and possibly also other chronic inflammatory diseases...
  6. ncbi Intra-lesional low-dose interferon alpha2a therapy for primary cutaneous marginal zone B-cell lymphoma
    Antonio Cozzio
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Leuk Lymphoma 47:865-9. 2006
    ..All other patients remained free of disease. Thus, intra-lesional IFNalpha2a may represent a valuable alternative to surgery and radiotherapy as first-line treatment of pcMZL...
  7. ncbi Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen
    Michel Gilliet
    Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Blood 102:36-42. 2003
    ..Our results indicate that intranodal vaccination with semimature DCs can prime strong, long-lasting CD4 T-cell responses with a TH1-type cytokine profile in cancer patients...
  8. ncbi Febrile ulceronecrotic Mucha-Habermann disease with clonality: a cutaneous T-cell lymphoma entity?
    Antonio Cozzio
    Department of Dermatology, University Hospital of Zurich, Switzerland
    J Am Acad Dermatol 51:1014-7. 2004
    ..Here, we report two cases of FUMHD with monoclonal T-cell population, as detected by Southern blot analysis. We propose that clonal FUMHD represents a cutaneous T-cell lymphoma entity...
  9. ncbi Defining upstream elements of psoriasis pathogenesis: an emerging role for interferon alpha
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    J Invest Dermatol 125:xiv-xv. 2005
  10. doi Type I IFNs at the interface between cutaneous immunity and epidermal remodeling
    Curdin Conrad
    Department of Dermatology, Lausanne University Hospital of Lausanne, Lausanne, Switzerland
    J Invest Dermatol 132:1759-62. 2012
    ....
  11. ncbi Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma
    Martin Kleinhans
    Department of Dermatology, University of Zurich Medical School, Switzerland
    Blood 101:1487-93. 2003
    ..These results suggest that expression of CCR3 and its ligand eotaxin/CCL11 plays a role in the recruitment and retention of CD30(+) malignant T cells to the skin...
  12. pmc Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 197:1059-63. 2003
    ....
  13. doi Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
    ..Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis...
  14. pmc Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
    Tomoki Ito
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:870-80. 2008
    ....
  15. ncbi Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    Roberto Lande
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Nature 449:564-9. 2007
    ..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis...
  16. pmc Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand
    Tomoki Ito
    Department of Immunology, M D Anderson Cancer Center, Graduate School of Biomedical Sciences at Houston, The University of Texas, Houston, TX 77030, USA
    J Exp Med 204:105-15. 2007
    ..Our findings demonstrate that mDC and pDCs are intrinsically different in the expression of costimulatory molecules that drive distinct types of T cell responses...
  17. pmc OX40 ligand shuts down IL-10-producing regulatory T cells
    Tomoki Ito
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, 77030 1903, USA
    Proc Natl Acad Sci U S A 103:13138-43. 2006
    ..These two novel functions of OX40L shed light on the mechanism by which OX40/OX40L regulates immunity and tolerance...
  18. ncbi Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells
    Yui Hsi Wang
    Department of Immunology, Center of Cancer Immunology Research, Graduate School of Biomedical Science, Houston, Texas 77030, USA
    Immunity 24:827-38. 2006
    ....
  19. pmc The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 195:953-8. 2002
    ..Human IPCs and mouse IPCs display different ability to produce IL-12p70. Large numbers of mouse IPCs can now be obtained from total bone marrow culture...
  20. ncbi Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    Vassili Soumelis
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Immunol 3:673-80. 2002
    ..TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation...
  21. ncbi Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells
    Michel Gilliet
    DNAX Research Institute, Palo Alto, California, USA
    Hum Immunol 63:1149-55. 2002
    ..DC2 can be used as tool to drive potent antigen specific Tr-cell differentiation and expansion in vitro and in vivo...
  22. ncbi Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity
    Jean Francois Fonteneau
    Laboratory of Molecular Neuro Oncology, Rockefeller University, New York, NY, USA
    Blood 101:3520-6. 2003
    ..Our results pinpoint a new role of pDCs in the induction of antiviral T-cell responses and suggest that these DCs play a prominent role in the adaptive immune response against viruses...
  23. ncbi Mature dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15
    JoAnn Castelli
    Department of Medicine, Division of Hematology Oncology, University of California, San Francisco 94143 1270, USA
    Blood 103:2699-704. 2004
    ..These studies provide another potential approach by which the immune system in HIV infection could be restored by cytokine therapy, particularly IL-15 administration...
  24. pmc Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells
    Michel Gilliet
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Exp Med 195:695-704. 2002
    ....