Sami Damak

Summary

Country: Switzerland

Publications

  1. pmc Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice
    Sami Damak
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York, 10029, USA
    BMC Neurosci 9:96. 2008
  2. pmc Quinine controls body weight gain without affecting food intake in male C57BL6 mice
    Philippe Cettour-Rose
    Nestle Research Center, Vers chez les Blanc, Lausanne 1000, Switzerland
    BMC Physiol 13:5. 2013
  3. pmc Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25
    Tod R Clapp
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    BMC Biol 4:7. 2006
  4. ncbi request reprint Umami taste responses are mediated by alpha-transducin and alpha-gustducin
    Wei He
    Department of Physiology and Biophysics, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 24:7674-80. 2004
  5. ncbi request reprint Signal transduction of umami taste: insights from knockout mice
    Minqing Rong
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Chem Senses 30:i33-4. 2005
  6. ncbi request reprint Trpm5 null mice respond to bitter, sweet, and umami compounds
    Sami Damak
    Department of Neuroscience, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Chem Senses 31:253-64. 2006
  7. doi request reprint Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne, Switzerland
    J Neurosci 29:2654-62. 2009
  8. doi request reprint Taste preference for fatty acids is mediated by GPR40 and GPR120
    Cristina Cartoni
    Nestle Research Center, Lausanne 1000, Switzerland
    J Neurosci 30:8376-82. 2010
  9. ncbi request reprint Detection of sweet and umami taste in the absence of taste receptor T1r3
    Sami Damak
    Department of Biophysics and Physiology, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA
    Science 301:850-3. 2003
  10. doi request reprint The capsaicin receptor participates in artificial sweetener aversion
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, Perception Physiology, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Biochem Biophys Res Commun 376:653-7. 2008

Collaborators

Detail Information

Publications14

  1. pmc Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice
    Sami Damak
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York, 10029, USA
    BMC Neurosci 9:96. 2008
    ..To determine how WGA produced in T1r3-expressing taste cells is transported into gustatory neurons, transgenic mice expressing WGA-IRES-GFP driven by the T1r3 promoter were generated...
  2. pmc Quinine controls body weight gain without affecting food intake in male C57BL6 mice
    Philippe Cettour-Rose
    Nestle Research Center, Vers chez les Blanc, Lausanne 1000, Switzerland
    BMC Physiol 13:5. 2013
    ..The objective of this work is to determine the effect of diet supplementation with quinine on body weight and body composition in male mice, to investigate its mechanism of action, and whether the effect is mediated through Trpm5...
  3. pmc Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25
    Tod R Clapp
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    BMC Biol 4:7. 2006
    ....
  4. ncbi request reprint Umami taste responses are mediated by alpha-transducin and alpha-gustducin
    Wei He
    Department of Physiology and Biophysics, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 24:7674-80. 2004
    ..Umami detection involving alpha-gustducin and alpha(t-rod) occurs in anteriorly placed taste buds, however taste cells at the back of the tongue respond to umami compounds independently of these two G-protein subunits...
  5. ncbi request reprint Signal transduction of umami taste: insights from knockout mice
    Minqing Rong
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Chem Senses 30:i33-4. 2005
  6. ncbi request reprint Trpm5 null mice respond to bitter, sweet, and umami compounds
    Sami Damak
    Department of Neuroscience, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Chem Senses 31:253-64. 2006
    ..Thus, while Trpm5 is an important factor in many taste responses, its absence does not eliminate all taste responses. We conclude that Trpm5-dependent and Trpm5-independent pathways underlie bitter, sweet, and umami tastes...
  7. doi request reprint Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne, Switzerland
    J Neurosci 29:2654-62. 2009
    ....
  8. doi request reprint Taste preference for fatty acids is mediated by GPR40 and GPR120
    Cristina Cartoni
    Nestle Research Center, Lausanne 1000, Switzerland
    J Neurosci 30:8376-82. 2010
    ..These results show that GPR40 and GPR120 mediate the taste of fatty acids...
  9. ncbi request reprint Detection of sweet and umami taste in the absence of taste receptor T1r3
    Sami Damak
    Department of Biophysics and Physiology, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA
    Science 301:850-3. 2003
    ..These results indicate that T1r3-independent sweet- and umami-responsive receptors and/or pathways exist in taste cells...
  10. doi request reprint The capsaicin receptor participates in artificial sweetener aversion
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, Perception Physiology, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Biochem Biophys Res Commun 376:653-7. 2008
    ....
  11. ncbi request reprint Contribution of alpha-gustducin to taste-guided licking responses of mice
    John I Glendinning
    Department of Biological Science, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Chem Senses 30:299-316. 2005
    ..There was no significant effect of deleting alpha-gustducin on licking responses to NH4Cl or HCl...
  12. ncbi request reprint Claudin-based permeability barriers in taste buds
    Stéphanie Michlig
    Nestle Research Center, Vers chez les Blanc, Lausanne 1000, Switzerland
    J Comp Neurol 502:1003-11. 2007
    ..With the ion permeability features of the different claudins, a highly specific permeability pattern for paracellular diffusion is apparent, which indicates a peripheral mechanism for taste coding...
  13. ncbi request reprint Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells
    Carole Bezençon
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    Chem Senses 32:41-9. 2007
    ..The data suggest that these duodenal cells are possibly involved in sensing amino acids...
  14. ncbi request reprint Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducin
    Wei He
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, NY 10029, USA
    Chem Senses 27:719-27. 2002
    ..Our results also suggest that alpha-transducin and alpha-gustducin may differ, at least in part, in their function in these cells, although this conclusion must be qualified because of the limited fidelity of the transgene expression...