Francois Spertini

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. pmc Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice
    Celine Pellaton
    R and D Laboratory of the Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Int J Inflam 2012:686739. 2012
  2. pmc The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial
    Regine Audran
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS ONE 4:e7304. 2009
  3. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  4. pmc Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides
    Celine Pellaton
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon, Lausanne, 1011, Switzerland
    Clin Transl Allergy 3:17. 2013
  5. doi request reprint The candidate tuberculosis vaccine Mtb72F/AS02 in PPD positive adults: a randomized controlled phase I/II study
    Francois Spertini
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois CHUV BH19, Rue du Bugnon, CH 1011 Lausanne, Switzerland
    Tuberculosis (Edinb) 93:179-88. 2013
  6. ncbi request reprint [What to expect from allergy tests?]
    F Spertini
    Service d immunologie et d allergie CHUV, 1011 Lausanne
    Rev Med Suisse 7:856-9. 2011
  7. ncbi request reprint [New concepts for the therapy of systemic lupus erythematosus]
    Francois Spertini
    Service d immunologie et d allergie, CHUV, Lausanne
    Rev Med Suisse 3:98-102. 2007
  8. ncbi request reprint Allergen-specific immunotherapy of allergy and asthma: current and future trends
    Francois Spertini
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Expert Rev Respir Med 3:37-51. 2009
  9. pmc Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen
    Regine Audran
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, BH 19, Rue du Bugnon, 1011 Lausanne, Switzerland
    Infect Immun 73:8017-26. 2005
  10. ncbi request reprint Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: results of a phase I trial
    Jean Marc Fellrath
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Allergy Clin Immunol 111:854-61. 2003

Collaborators

Detail Information

Publications38

  1. pmc Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice
    Celine Pellaton
    R and D Laboratory of the Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Int J Inflam 2012:686739. 2012
    ..Conclusion. A concerted selection of intervention schedule, doses, and administration routes (intranasal versus intragastric) may markedly contribute to modulate airway inflammation in a probiotic strain-specific manner...
  2. pmc The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial
    Regine Audran
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS ONE 4:e7304. 2009
    ....
  3. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  4. pmc Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides
    Celine Pellaton
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon, Lausanne, 1011, Switzerland
    Clin Transl Allergy 3:17. 2013
    ..In combination, COPs encompass the entire allergen sequence, providing all potential T cell epitopes, while preventing IgE conformational epitopes of the native allergen...
  5. doi request reprint The candidate tuberculosis vaccine Mtb72F/AS02 in PPD positive adults: a randomized controlled phase I/II study
    Francois Spertini
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois CHUV BH19, Rue du Bugnon, CH 1011 Lausanne, Switzerland
    Tuberculosis (Edinb) 93:179-88. 2013
    ..IFN-γ was detectable in serum one day post each vaccination. Further evaluation of the candidate vaccine, Mtb72F/AS02, is warranted. Trial registration: ClinicalTrials.gov identifier: NCT00146744...
  6. ncbi request reprint [What to expect from allergy tests?]
    F Spertini
    Service d immunologie et d allergie CHUV, 1011 Lausanne
    Rev Med Suisse 7:856-9. 2011
    ..However these new technologies are expensive, and will have to be carefully analyzed in terms of medical usefulness and public health costs...
  7. ncbi request reprint [New concepts for the therapy of systemic lupus erythematosus]
    Francois Spertini
    Service d immunologie et d allergie, CHUV, Lausanne
    Rev Med Suisse 3:98-102. 2007
    ..Further information is expected from the inhibitor of T cell/B cell co-stimulation CTLA4-Ig, or from strategies aiming to inhibit key cytokines in SLE pathogenesis such as interferon-alpha, IL-1 or IL-6...
  8. ncbi request reprint Allergen-specific immunotherapy of allergy and asthma: current and future trends
    Francois Spertini
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Expert Rev Respir Med 3:37-51. 2009
    ..The simultaneous use of adjuvants with immunomodulatory properties may contribute to improve both the safety and efficacy of allergen-SIT of allergy and asthma...
  9. pmc Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen
    Regine Audran
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, BH 19, Rue du Bugnon, 1011 Lausanne, Switzerland
    Infect Immun 73:8017-26. 2005
    ..e., the type of anti-MSP3 antibodies involved in antibody-dependent, monocyte-mediated protective mechanisms in areas where malaria is endemic)...
  10. ncbi request reprint Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: results of a phase I trial
    Jean Marc Fellrath
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Allergy Clin Immunol 111:854-61. 2003
    ..There is a need to improve the safety and efficacy of allergen-specific immunotherapy. Long synthetic peptide-based immunotherapy was proven safe, immunogenic, and protective in preclinical trials...
  11. pmc Ex vivo monitoring of antigen-specific CD4+ T cells after recall immunization with tetanus toxoid
    Catherine Barbey
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011 Lausanne, Switzerland
    Clin Vaccine Immunol 14:1108-16. 2007
    ....
  12. ncbi request reprint [Use of autoantibodies in clinical practice]
    Stéphanie Petitpierre
    Departement de Medecine Interne, CHUV, Lausanne
    Rev Med Suisse 5:823-31. 2009
    ..Due to its high sensitivity indirect immunofluorescence is used as a screening test; when positive, ELISA is performed to search for antibodies more specifically associated with certain auto-immune diseases...
  13. ncbi request reprint Predictive value of antineutrophil cytoplasmic antibodies in small-vessel vasculitis
    Floriana Lurati-Ruiz
    Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Rheumatol 32:2167-72. 2005
    ..We reviewed the outcome of patients with ANCA-associated vasculitis from a single center and evaluated the predictive value of ANCA as markers of relapse...
  14. doi request reprint CD4+CD25-mTGFbeta+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma
    Céline Pellaton-Longaretti
    Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Int Immunol 23:17-27. 2011
    ..Intranasal administration of high amount of allergen was shown to induce tolerance and to reverse the allergic phenotype. However, mechanisms of tolerance induction via the mucosal route are still unclear...
  15. doi request reprint Malaria vaccine candidate: design of a multivalent subunit α-helical coiled coil poly-epitope
    Sope Olugbile
    Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Vaccine 29:7090-9. 2011
    ..Naturally induced antigen-specific human antibodies were at high titers and associated with clinical protection from malaria in longitudinal follow-up studies in Senegal...
  16. ncbi request reprint Levocetirizine better protects than desloratadine in a nasal provocation with allergen
    Cédric Déruaz
    Division of Allergy and Immunology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011 Lausanne, Switzerland
    J Allergy Clin Immunol 113:669-76. 2004
    ..Newly available antihistamine preparations, levocetirizine, the R-enantiomer of racemate cetirizine, and desloratadine, an active metabolite of loratadine, have been recently released for allergic rhinitis...
  17. ncbi request reprint Safety and immunogenicity of the M72/AS01 candidate tuberculosis vaccine in HIV-infected adults on combination antiretroviral therapy: a phase I/II, randomized trial
    Eleonora G Thacher
    aDivision of Immunology and Allergy bService of Infectious Diseases, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland cGlaxoSmithKline Vaccines, Rixensart, Belgium The authors Eleonora G Thacher and Matthias Cavassini contributed equally to the writing of this article Opokua Ofori Anyinam and François Spertini are equal senior authors
    AIDS 28:1769-81. 2014
    ..We evaluated the safety and immunogenicity of the candidate TB vaccine M72/AS01 in adults with well controlled HIV infection on cART...
  18. ncbi request reprint [Therapeutic strategies in idiopatic inflammatory myopathies]
    Reza Chakour
    Service d immunologie et d allergie, CHUV, 1011 Lausanne
    Rev Med Suisse 5:812-8. 2009
    ..In case of therapeutic resistance, a rescue treatment (ciclosporine, immunoglobulins, rituximab, cyclophosphamide) could be considered...
  19. ncbi request reprint Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells
    Jacques Rey
    Laboratoire de Recherche et Développement, du Service d Immunologie et d Allergie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunol 172:3026-33. 2004
    ..Thus, although immune exclusion represents the main function of SIgA, transport of the Ab by M cells might promote Ag sampling under neutralizing conditions essential to the homeostasis of mucosal surfaces...
  20. doi request reprint Unsatisfactory outcomes in myasthenia gravis: influence by care providers
    Murielle Dunand
    Nerve Muscle Unit, Neurology Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011, Lausanne, Switzerland
    J Neurol 257:338-43. 2010
    ..The differential UO rates at follow-up, their dependency on the degree to which the management was specialized and their correlation with final outcomes suggest that specialized MG care improves outcomes...
  21. ncbi request reprint Fondaparinux is a safe alternative in case of heparin intolerance during pregnancy
    Lucia Mazzolai
    Service of Vascular Medicine, University Hospital of Lausanne CHUV, Av Pierre Decker 5, 1011 Lausanne, Switerland
    Blood 108:1569-70. 2006
    ..This report describes the successful management with fondaparinux, during 150 days, of a pregnant patient with protein S deficiency and prior deep vein thrombosis (DVT) who developed heparin and danaparoid hypersensitivity...
  22. ncbi request reprint Prevention of cryoprecipitation during cardiopulmonary bypass in a patient with HIV-HCV co-infections
    Massimiliano Fontana
    Division of Immunology and Allergy, CHUV, 1011 Lausanne, Switzerland
    Perfusion 21:263-5. 2006
    ..There are no guidelines for the management of patients with cryoglobulins during cardiopulmonary bypass (CPB) necessitating core hypothermia...
  23. ncbi request reprint Simplified procedure to recover recombinant antigenized secretory IgA to be used as a vaccine vector
    Laurent I Favre
    R and D Laboratory, Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, HO 05 1542, Avenue Pierre Decker 4, 1005, Lausanne, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 786:143-51. 2003
    ..Such preparations are currently used to immunize mice to induce mucosal and systemic responses...
  24. ncbi request reprint [Allergic rhinoconjunctivitis and immunotherapy: an update]
    Annette Leimgruber
    Service d immunologie et d allergie, CHUV, 1011 Lausanne
    Rev Med Suisse 5:88-93. 2009
    ....
  25. ncbi request reprint Malaria vaccines - The long synthetic peptide approach: Technical and conceptual advancements
    Sope Olugbile
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Curr Opin Mol Ther 12:64-76. 2010
    ..Finally, new approaches to exploit the abundance of genomic data and the flexibility and speed of peptide synthesis are proposed...
  26. ncbi request reprint [Mastocytosis: when should it be considered?]
    Sophie Comte-Perret
    Service d immunologie et d allergie, CHUV, 1011 Lausanne
    Rev Med Suisse 5:837-42. 2009
    ..Treatment is based on control of the symptoms triggered by mast cell degranulation. Moreover, novel treatment options targeting mast cell proliferation become available for clinical use...
  27. ncbi request reprint Immune responses induced by lower airway mucosal immunisation with a human papillomavirus type 16 virus-like particle vaccine
    Denise Nardelli-Haefliger
    Department of Gynecology, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Vaccine 23:3634-41. 2005
    ..Our data suggest that aerosol administration of HPV VLPs may represent a potential alternative to parenteral injection...
  28. ncbi request reprint Microaerophilic conditions permit to mimic in vitro events occurring during in vivo Helicobacter pylori infection and to identify Rho/Ras-associated proteins in cellular signaling
    Sandra Cottet
    Division of Immunology and Allergy, R and D Laboratory, Centre Hospitalier Universitaire Vaudois, 1005 Lausanne, Switzerland
    J Biol Chem 277:33978-86. 2002
    ....
  29. ncbi request reprint Oxidized low-density lipoproteins activate CD4+ T cell apoptosis in patients with end-stage renal disease through Fas engagement
    Pascal Meier
    Service of Nephrology, Centre Hospitalier Universitaire Vaudois CHUV, 17 rue du Bugnon, 1011 Lausanne, Suisse
    J Am Soc Nephrol 18:331-42. 2007
    ..Subsequently, this may favor activation of mitochondria-dependent apoptotic pathways, leading to activated CD4+ T cell dysfunction...
  30. ncbi request reprint Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses
    Laurent Favre
    Research and Development Laboratory, Division of Immunology and Allergy, Département de Médecine Interne Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunol 175:2793-800. 2005
    ..These results provide evidence that mucosal SIgA re-entering the body exerts a function of Ag delivery that contributes to effector and/or regulatory pathways characteristic of the intestinal mucosal compartment...
  31. ncbi request reprint [Large vessel vasculitis: giant cell arteritis and Takayasu arteritis]
    Stéphanie Petitpierre
    Service d immunologie et d allergie CHUV, 1011 Lausanne
    Rev Med Suisse 3:1056-60, 1062-3. 2007
    ..Corticosteroids still represent the basis of treatment, most often alone in GCA and usually in association with another immunosuppressive drug in TA...
  32. ncbi request reprint [Allergy to radiographic contrast media]
    Julien Vionnet
    Service d immunologie et d allergie, CHUV, 1011 Lausanne
    Rev Med Suisse 9:812-8. 2013
    ..Practical recommendations are presented in this article. For gadolinium-based contrast agents, data in the literature is not sufficient for suggesting guidelines...
  33. ncbi request reprint [Allergic and toxic cutaneous reactions to plants]
    Eleonora Gambillara
    Service d immunologie et d allergie CHUV, 1011 Lausanne
    Rev Med Suisse 6:824-9. 2010
    ..The role of UV (phytophotodermatosis), as well as the contact allergy to wood is also evoked in this paper...
  34. pmc Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells
    Francois Spertini
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Immunology 113:441-52. 2004
    ..This model strongly suggests that CD45 extracytoplasmic tail multimerization may contribute to the modulation T-cell functions...
  35. doi request reprint Improved diagnoses of autoimmune hepatitis using an anti-actin ELISA
    Vincent Aubert
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Lab Anal 22:340-5. 2008
    ..1 vs 37.1%). Although frequently positive in HCV samples, a comparable sensitivity but better specificity makes the anti-actin ELISA a useful tool in combination with ASMA IIFA for the screening and diagnosis of autoimmune hepatitis...
  36. ncbi request reprint [Severe delayed drug hypersensitivity reactions]
    Christa Maria Maniu
    Service d immunologie et d allergie, CHUV, 1011 Lausanne
    Rev Med Suisse 9:803-4, 806-11. 2013
    ..Early detection of warning signs and symptoms may help to take appropriate measures precociously...
  37. pmc Carriers of the fragile X mental retardation 1 (FMR1) premutation allele present with increased levels of cytokine IL-10
    Diana Marek
    Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, Lausanne, 1005, Switzerland
    J Neuroinflammation 9:238. 2012
    ..Abnormal immunological patterns are often associated with neurodegenerative disorders and implicated in their etiology. We therefore investigated the immune status of FXTAS patients, which had not been assessed prior to this study...
  38. ncbi request reprint [Peripheral blood eosinophilia: diagnostic value and further assessment]
    Samuel Chappuis
    Service d immunologie et d allergie, CHUV, 1011 Lausanne
    Rev Med Suisse 9:819-25. 2013
    ..The scope of this article is to detail pathologies associated with peripheral eosinophilia by order of frequency and to guide further investigations...