Francois P Pralong

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland
    F P Pralong
    Division of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland
    Endocrinology 139:4264-8. 1998
  2. ncbi Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor
    F P Pralong
    Department of Medicine, University Hospital, Lausanne, Switzerland
    J Clin Endocrinol Metab 84:3811-6. 1999
  3. ncbi Food-dependent Cushing's syndrome: possible involvement of leptin in cortisol hypersecretion
    F P Pralong
    Department of Medicine, Institute of Pathology, University Hospital and Lausanne Medical School, Switzerland
    J Clin Endocrinol Metab 84:3817-22. 1999
  4. ncbi Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors
    F P Pralong
    Division of Endocrinology, Diabetology and Metabolism, Department of Medicine, Lausanne University Hospital, 1011, Lausanne, Switzerland
    Regul Pept 95:47-52. 2000
  5. ncbi Neuroendocrine effects of leptin
    F P Pralong
    Department of Medicine, University Hospital, Lausanne, Switzerland
    Pituitary 4:25-32. 2001
  6. ncbi The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions
    Francois P Pralong
    Division of Endocrinology, Diabetology and Metabolism, University of Lausanne Medical School, CH 1011 Lausanne, Switzerland
    FASEB J 16:712-4. 2002
  7. ncbi The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions
    Christine Gonzales
    Division of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland
    FASEB J 18:137-9. 2004
  8. ncbi The lack of effect of insulin on luteinizing hormone pulsatility in healthy male volunteers provides evidence of a sexual dimorphism in the metabolic regulation of reproductive hormones
    Marie Hélène Pesant
    Service of Endocrinology, Diabetology and Metabolism, Department of Medicine, Lausanne University Hospital, Switzerland
    Am J Clin Nutr 96:283-8. 2012
  9. ncbi Insulin and NPY pathways and the control of GnRH function and puberty onset
    Francois P Pralong
    Services of Endocrinology, Diabetology and Metabolism, University Hospitals of Lausanne and Geneva, Switzerland
    Mol Cell Endocrinol 324:82-6. 2010
  10. ncbi Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons
    Catherine Chau Van
    Service of Endocrinology, BH 19 709, University Hospital, 1011 Lausanne, Switzerland
    Endocrinology 148:507-11. 2007

Collaborators

Detail Information

Publications14

  1. ncbi Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland
    F P Pralong
    Division of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland
    Endocrinology 139:4264-8. 1998
    ..Therefore, leptin inhibits directly stimulated cortisol secretion from human and rat adrenal glands, and this may represent an important mechanism to modulate glucocorticoid levels in various metabolic states...
  2. ncbi Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor
    F P Pralong
    Department of Medicine, University Hospital, Lausanne, Switzerland
    J Clin Endocrinol Metab 84:3811-6. 1999
    ..In conclusion, we report the first mutation of the GnRH-R gene that can induce a total loss of function of this receptor and is associated with a phenotype of complete hypogonadotropic hypogonadism...
  3. ncbi Food-dependent Cushing's syndrome: possible involvement of leptin in cortisol hypersecretion
    F P Pralong
    Department of Medicine, Institute of Pathology, University Hospital and Lausanne Medical School, Switzerland
    J Clin Endocrinol Metab 84:3817-22. 1999
    ..Further studies in other cases of food-dependent Cushing's syndrome, however, will be necessary to better ascertain the pathophysiological significance of this finding...
  4. ncbi Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors
    F P Pralong
    Division of Endocrinology, Diabetology and Metabolism, Department of Medicine, Lausanne University Hospital, 1011, Lausanne, Switzerland
    Regul Pept 95:47-52. 2000
    ..They are entirely consistent with the proposed inhibition exerted by endogenous hypothalamic NPY before the onset of pubertal development. They also suggest that the Y1 subtype of NPY receptors is involved in this effect...
  5. ncbi Neuroendocrine effects of leptin
    F P Pralong
    Department of Medicine, University Hospital, Lausanne, Switzerland
    Pituitary 4:25-32. 2001
    ..The precise site of action and mode of regulation of the gonadotrope and somatotrope axes by leptin are reviewed...
  6. ncbi The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions
    Francois P Pralong
    Division of Endocrinology, Diabetology and Metabolism, University of Lausanne Medical School, CH 1011 Lausanne, Switzerland
    FASEB J 16:712-4. 2002
    ..Results point to a crucial role for the NPY Y1 receptor in mediating the NPY pathways situated downstream of leptin actions and controlling food intake, the onset of puberty, and the maintenance of reproductive functions...
  7. ncbi The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions
    Christine Gonzales
    Division of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland
    FASEB J 18:137-9. 2004
    ....
  8. ncbi The lack of effect of insulin on luteinizing hormone pulsatility in healthy male volunteers provides evidence of a sexual dimorphism in the metabolic regulation of reproductive hormones
    Marie Hélène Pesant
    Service of Endocrinology, Diabetology and Metabolism, Department of Medicine, Lausanne University Hospital, Switzerland
    Am J Clin Nutr 96:283-8. 2012
    ..This link is particularly important in healthy women, in whom insulin is a positive signal for the reproductive system. In contrast, very little is known regarding this relation in men...
  9. ncbi Insulin and NPY pathways and the control of GnRH function and puberty onset
    Francois P Pralong
    Services of Endocrinology, Diabetology and Metabolism, University Hospitals of Lausanne and Geneva, Switzerland
    Mol Cell Endocrinol 324:82-6. 2010
    ....
  10. ncbi Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons
    Catherine Chau Van
    Service of Endocrinology, BH 19 709, University Hospital, 1011 Lausanne, Switzerland
    Endocrinology 148:507-11. 2007
    ....
  11. ncbi Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients
    Mallory Moret
    Service of Endocrinology, Diabetology and Metabolism, University Hospital, University of Lausanne, Lausanne, Switzerland
    Neuroendocrinology 89:131-9. 2009
    ..This study was undertaken to further evaluate the role of insulin to modulate LH secretion in lean PCOS patients with normal insulin sensitivity and normal volunteers...
  12. ncbi Molecular characterization and phenotypic expression of mutations in genes for gonadotropins and their receptors in humans
    Roberto Salvi
    Service of Endocrinology, Diabetology and Metabolism, University Hospital, Lausanne, Switzerland
    Front Horm Res 39:1-12. 2010
    ..In this work, we describe briefly the known mutations in the genes for both gonadotropins and their receptors, and discuss their genotype/phenotype correlations in light of these important gender differences...
  13. ncbi Progressive onset of adrenal insufficiency and hypogonadism of pituitary origin caused by a complex genetic rearrangement within DAX-1
    Roberto Salvi
    Division of Endocrinology and Diabetology, University Hospital, 1011 Lausanne, Switzerland
    J Clin Endocrinol Metab 87:4094-100. 2002
    ..In vitro functional analyses confirm the absence of repressor activity exerted by such mutant protein. These studies expand the genotypic and phenotypic spectrum of DAX-1 insufficiency in humans...
  14. ncbi Phenotypic and molecular characterization of proliferating and differentiated GnRH-expressing GnV-3 cells
    Virginie Mansuy
    Service of Endocrinology, Diabetology and Metabolism, University Hospital and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
    Mol Cell Endocrinol 332:97-105. 2011
    ..Moreover, the genes differentially regulated between these two different states are providing novel pathways potentially important for a better understanding of the physiology of mature GnRH neurons...