A Muhlethaler-Mottet

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. pmc Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma
    Gilda Raguenez
    Centre National de Recherche Scientifique, Unité Mixte de Recherche 8126, Institut Fédératif de Recherche 54, Institut Gustave Roussy, Villejuif, France
    BMC Cancer 9:97. 2009
  2. pmc Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio
    Annick Muhlethaler-Mottet
    Paediatric Oncology Research, Paediatric Department, University Hospital CHUV, CH 1011 Lausanne, Switzerland
    BMC Cancer 6:214. 2006
  3. pmc Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells
    Annick Muhlethaler-Mottet
    Paediatric Oncology Research, Paediatric Department, University Hospital CHUV, CH 1011 Lausanne, Switzerland
    Mol Cancer 7:55. 2008
  4. pmc Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis
    A Muhlethaler-Mottet
    Department of Paediatrics, Paediatric Oncology Research, University Hospital CHUV, CH 1011 Lausanne, Switzerland
    Cell Death Dis 2:e125. 2011
  5. ncbi request reprint Persistent inhibition of FLIP(L) expression by lentiviral small hairpin RNA delivery restores death-receptor-induced apoptosis in neuroblastoma cells
    M Flahaut
    Paediatric Oncology Research, Paediatric Department, University Hospital CHUV, CH 1011, Lausanne
    Apoptosis 11:255-63. 2006
  6. doi request reprint The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway
    M Flahaut
    Department of Paediatrics, University Hospital CHUV, Lausanne, Switzerland
    Oncogene 28:2245-56. 2009
  7. ncbi request reprint Molecular cytogenetic characterization of doxorubicin-resistant neuroblastoma cell lines: evidence that acquired multidrug resistance results from a unique large amplification of the 7q21 region
    Marjorie Flahaut
    Paediatric Oncology Research, Paediatric Department, University Hospital CHUV, Lausanne, Switzerland
    Genes Chromosomes Cancer 45:495-508. 2006
  8. pmc The chemokine receptor CXCR4 strongly promotes neuroblastoma primary tumour and metastatic growth, but not invasion
    Roland Meier
    Department of Paediatrics, Paediatric Oncology Research, University Hospital Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Switzerland
    PLoS ONE 2:e1016. 2007

Collaborators

Detail Information

Publications8

  1. pmc Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma
    Gilda Raguenez
    Centre National de Recherche Scientifique, Unité Mixte de Recherche 8126, Institut Fédératif de Recherche 54, Institut Gustave Roussy, Villejuif, France
    BMC Cancer 9:97. 2009
    ..As the role of caspase-8 appears to be critical in preventing metastasis, we aimed at studying the effect of 4-HPR on caspase-8 expression in metastatic neuroblasts...
  2. pmc Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio
    Annick Muhlethaler-Mottet
    Paediatric Oncology Research, Paediatric Department, University Hospital CHUV, CH 1011 Lausanne, Switzerland
    BMC Cancer 6:214. 2006
    ..Although HDACIs were recently shown to increase death induced by TRAIL in weakly TRAIL-sensitive tumour cells, the precise involved sensitisation mechanisms have not been fully identified...
  3. pmc Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells
    Annick Muhlethaler-Mottet
    Paediatric Oncology Research, Paediatric Department, University Hospital CHUV, CH 1011 Lausanne, Switzerland
    Mol Cancer 7:55. 2008
    ..Neuroblastoma (NB) is the second most common solid tumour in children still associated with poor outcome in higher stages and, thus NB strongly requires novel treatment modalities...
  4. pmc Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis
    A Muhlethaler-Mottet
    Department of Paediatrics, Paediatric Oncology Research, University Hospital CHUV, CH 1011 Lausanne, Switzerland
    Cell Death Dis 2:e125. 2011
    ..These data highlight in several tumour cell types, a differential pro- or anti-apoptotic role for the distinct caspase-10 isoforms in DR signalling, which may be relevant for fine tuning of apoptosis initiation...
  5. ncbi request reprint Persistent inhibition of FLIP(L) expression by lentiviral small hairpin RNA delivery restores death-receptor-induced apoptosis in neuroblastoma cells
    M Flahaut
    Paediatric Oncology Research, Paediatric Department, University Hospital CHUV, CH 1011, Lausanne
    Apoptosis 11:255-63. 2006
    ..Combining such tools with other therapeutic modalities may improve treatment of resistant tumours such as neuroblastoma...
  6. doi request reprint The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway
    M Flahaut
    Department of Paediatrics, University Hospital CHUV, Lausanne, Switzerland
    Oncogene 28:2245-56. 2009
    ..Our data represent the first implication of the Wnt/beta-catenin pathway in NB chemoresistance and identify potential new targets to treat aggressive and resistant NB...
  7. ncbi request reprint Molecular cytogenetic characterization of doxorubicin-resistant neuroblastoma cell lines: evidence that acquired multidrug resistance results from a unique large amplification of the 7q21 region
    Marjorie Flahaut
    Paediatric Oncology Research, Paediatric Department, University Hospital CHUV, Lausanne, Switzerland
    Genes Chromosomes Cancer 45:495-508. 2006
    ..These results could lead to the identification of relevant target genes for the development of new therapeutic modalities...
  8. pmc The chemokine receptor CXCR4 strongly promotes neuroblastoma primary tumour and metastatic growth, but not invasion
    Roland Meier
    Department of Paediatrics, Paediatric Oncology Research, University Hospital Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Switzerland
    PLoS ONE 2:e1016. 2007
    ..In conclusion, this study reveals a yet unreported NB-specific predominant growth and survival-promoting role of CXCR4, which warrants a critical reconsideration of the role of CXCR4 in the malignant behaviour of NB and other cancers...