D Moradpour

..This review summarizes current knowledge of the structure and function of the HCV proteins and highlights recent advances in the field...

..Comprehensive management of chronic hepatitis C takes into account cofactors of disease progression. Novel antiviral strategies will likely complement existing therapeutic modalities in the near future...

..Liver transplantation should be considered in patients with advanced cirrhosis or limited hepatocellular carcinoma. Preventive measures for hepatitis D are the same as for hepatitis B...

..These efforts have already translated into the identification of novel antiviral targets and the development of new therapeutic strategies, some of which are currently undergoing clinical evaluation...

..Here, we briefly review current understanding and new developments in the virology and epidemiology, diagnosis, natural history, therapy and prevention of viral hepatitis...

..The purpose of this review is to provide a concise overview of the diagnosis and management of chronic hepatitis B...

..A multidisciplinary approach is mandatory to offer to each patient the best treatment...

..Several new antiviral drugs are currently being evaluated in advanced clinical trials, with very promising results. These new drugs should greatly broaden treatment options for chronic hepatitis C in the near future...

..In the treatment of nonalcoholic fatty liver disease, thiazolidinediones show considerable promise, but further clinical studies are required in order to prove their efficacity and safety...

..These new developments will be summarized and discussed critically, with a particular emphasis on their potential implications for current and future clinical practice...

..Finally, recent studies using pegylated interferon-alpha have shown promising results for the treatment of chronic hepatitis D...

..Advantages and limitations of the MELD score are discussed. Finally the West Switzerland joint liver transplantation program is briefly introduced...

..Finally, we will briefly comment new findings in alcoholic hepatitis as well as acetaminophen hepatotoxicity and summarize revised criteria for the diagnosis and management of hepatorenal syndrome...

..This review provides a concise update on the biochemical and structural aspects of NS3-4A, its role in the pathogenesis of chronic hepatitis C and the clinical development of NS3-4A protease inhibitors...

..These new developments will be summarized and discussed critically, with a particular emphasis on their potential implications for current and future clinical practice...

..The aim of this study was to assess independent predictors for fibrosis progression...

..The purpose of this concise review is to provide an introduction to the prevention, diagnosis and management of antiviral resistance in chronic hepatitis B...

..Surgery is only possible in a small number of cases. Percutaneous destruction techniques have nearly the same survival rate as that obtained by surgery and should be proposed to patients where surgery is not an option...

..Here, we describe an amphipathic alpha-helix at the C terminus of NS4B (amino acid residues 229 to 253) that mediates membrane association and is involved in the formation of a functional HCV replication complex...

..These results have implications for the functional architecture of the HCV replication complex and provide new insights into the expanding spectrum of tail-anchored proteins...

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..This feature may provide the nonstructural proteins with a certain flexibility to perform their multiple functions during HCV replication...

..These findings provide new insights into the pathogenesis of HBV-HCV coinfection and may contribute to its clinical management in the future...

..Cardif thus functions as an adaptor, linking the cytoplasmic dsRNA receptor RIG-I to the initiation of antiviral programmes...

..These results provide the first atomic resolution structure of an essential membrane-associated determinant of HCV NS4B...

..5-A resolution, which contains a novel fold, a new zinc-coordination motif, and a disulfide bond. We use molecular surface analysis to suggest the location of protein-, RNA-, and membrane-interaction sites...

..Follow-up is crucial as recurrences can be treated by following similar algorithms. The efficacy of oncological adjuvant and neoadjuvant treatment is not yet proved...

..We conclude that the pre-activation status of the endogenous IFN system in the liver of patients with CHC is in part regulated by cleavage of MAVS...

..Large multi-centre clinical trials are required in HCV-infected haemodialysis and kidney transplant patients in order to define optimal therapeutic strategies before and after transplantation...

..This article reviews the current knowledge of HCV structural biology...

..Virchows Arch. B., 33:233-243, 1980). In view of this finding and the observation that all HCV proteins accumulate on the membranous web, we propose that the membranous web forms the viral replication complex in HCV-infected cells...

..Moreover, in vitro and in vivo model systems have been developed that allow systematic evaluation of new therapeutic strategies. This review details current concepts in molecular virology and emerging therapies for hepatitis C...

..Interference of viral proteins with the Jak-STAT pathway could be responsible for interferon resistance in patients with chronic HCV...

..Our data underscore the role of the Fas pathway in HCV-related liver injury and support the exploration of Fas-based treatment strategies for patients with chronic hepatitis C virus infection...

..These and other novel antiviral strategies may complement existing therapeutic modalities in the future...

..New technologies, including gene expression profiling and proteomic analyses, should allow us to further elucidate the molecular events underlying HCC development and identify novel diagnostic markers as well as therapeutic targets...

..Here, we provide a primer on the molecular virology of hepatitis C, with particular reference to novel antiviral targets and therapeutic strategies...

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..These findings have important implications for the structural and functional organization of the HCV replication complex and may define novel targets for antiviral intervention...

..We conclude that up-regulation of PP2A might be crucial for the efficient replication of HCV and propose PP2A as a potential target for anti-HCV treatment strategies...

..These findings have important implications for the functional architecture of the HCV replication complex...

..In conclusion, these cell lines represent a unique tool to study the cellular immune response, as well as to evaluate novel vaccine and immunotherapeutic strategies against HCV...

..In conclusion, such liposome formulations represent a safe and promising strategy to stimulate the CD8(+) T cell against HCV...

..Metabolic labeling with 5-bromouridine 5'-triphosphate in the presence of actinomycin D revealed that the membranous web is the site of viral RNA synthesis and therefore represents the replication complex of HCV...

..These observations provide new insights into the pathogenesis of hepatitis C and may offer new opportunities for therapeutic intervention...

..These findings add to our current understanding of the HCV life cycle and may ultimately allow to design novel antiviral strategies against hepatitis C...

..More important, detailed knowledge of the mAb 5B-12B7 contact sites on the enzyme may facilitate the development of small molecule RdRp inhibitors as novel antiviral agents...

..These findings reveal an unexpected flexibility of the C-terminal domain of NS5A and provide tools for studying the formation and turnover of HCV replication complexes in living cells...

..This model has implications for the functional architecture of the HCV replication complex, proteolytic targeting of host factors, and drug design...

..We suggest that this MT-dependent transport sustains two distinct RC populations, which are both required during the HCV life cycle...

..As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses...