D Moradpour

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. doi request reprint Hepatitis C virus proteins: from structure to function
    Darius Moradpour
    Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Curr Top Microbiol Immunol 369:113-42. 2013
  2. ncbi request reprint [Therapy of chronic hepatitis C]
    D Moradpour
    Service de Gastroentérologie et d Hépatologie, CHUV, Lausanne
    Praxis (Bern 1994) 95:1451-7. 2006
  3. ncbi request reprint [Hepatitis D: forgotten but not gone]
    Darius Moradpour
    Service de gastro entérologie et d hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 6:1656-9. 2010
  4. ncbi request reprint Replication of hepatitis C virus
    Darius Moradpour
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH 1011 Lausanne, Switzerland
    Nat Rev Microbiol 5:453-63. 2007
  5. doi request reprint [Viral hepatitis]
    Darius Moradpour
    Service de Gastroentérologie et d Hépatologie, Centre Hospitalier Universitaire Vaudois, Lausanne
    Ther Umsch 68:175-81. 2011
  6. ncbi request reprint [Management of chronic hepatitis B]
    C Doerig
    Service de gastro entérologie et d hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 6:168-70, 172-3. 2010
  7. ncbi request reprint [Management of hepatocellular carcinoma]
    I Pache
    Service de gastro entérologie et d hépatologie, CHUV, Lausanne
    Rev Med Suisse 6:198-202. 2010
  8. ncbi request reprint [An update on the management of chronic hepatitis C]
    F Bihl
    Service de gastro entérologie et d hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 6:174, 176-9. 2010
  9. ncbi request reprint [Hepatology]
    D Mondada
    Service de Gastro entérologie et d Hépatologie CHUV, 1011 Lausanne
    Rev Med Suisse 2:218-20, 223-6, 228-30. 2006
  10. ncbi request reprint [Highlights in hepatology]
    I Pache
    Service de Gastroentérologie et d Hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 5:195-6, 198, 200-2. 2009

Collaborators

Detail Information

Publications58

  1. doi request reprint Hepatitis C virus proteins: from structure to function
    Darius Moradpour
    Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Curr Top Microbiol Immunol 369:113-42. 2013
    ..This review summarizes current knowledge of the structure and function of the HCV proteins and highlights recent advances in the field...
  2. ncbi request reprint [Therapy of chronic hepatitis C]
    D Moradpour
    Service de Gastroentérologie et d Hépatologie, CHUV, Lausanne
    Praxis (Bern 1994) 95:1451-7. 2006
    ..Comprehensive management of chronic hepatitis C takes into account cofactors of disease progression. Novel antiviral strategies will likely complement existing therapeutic modalities in the near future...
  3. ncbi request reprint [Hepatitis D: forgotten but not gone]
    Darius Moradpour
    Service de gastro entérologie et d hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 6:1656-9. 2010
    ..Liver transplantation should be considered in patients with advanced cirrhosis or limited hepatocellular carcinoma. Preventive measures for hepatitis D are the same as for hepatitis B...
  4. ncbi request reprint Replication of hepatitis C virus
    Darius Moradpour
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH 1011 Lausanne, Switzerland
    Nat Rev Microbiol 5:453-63. 2007
    ..These efforts have already translated into the identification of novel antiviral targets and the development of new therapeutic strategies, some of which are currently undergoing clinical evaluation...
  5. doi request reprint [Viral hepatitis]
    Darius Moradpour
    Service de Gastroentérologie et d Hépatologie, Centre Hospitalier Universitaire Vaudois, Lausanne
    Ther Umsch 68:175-81. 2011
    ..Here, we briefly review current understanding and new developments in the virology and epidemiology, diagnosis, natural history, therapy and prevention of viral hepatitis...
  6. ncbi request reprint [Management of chronic hepatitis B]
    C Doerig
    Service de gastro entérologie et d hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 6:168-70, 172-3. 2010
    ..The purpose of this review is to provide a concise overview of the diagnosis and management of chronic hepatitis B...
  7. ncbi request reprint [Management of hepatocellular carcinoma]
    I Pache
    Service de gastro entérologie et d hépatologie, CHUV, Lausanne
    Rev Med Suisse 6:198-202. 2010
    ..A multidisciplinary approach is mandatory to offer to each patient the best treatment...
  8. ncbi request reprint [An update on the management of chronic hepatitis C]
    F Bihl
    Service de gastro entérologie et d hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 6:174, 176-9. 2010
    ..Several new antiviral drugs are currently being evaluated in advanced clinical trials, with very promising results. These new drugs should greatly broaden treatment options for chronic hepatitis C in the near future...
  9. ncbi request reprint [Hepatology]
    D Mondada
    Service de Gastro entérologie et d Hépatologie CHUV, 1011 Lausanne
    Rev Med Suisse 2:218-20, 223-6, 228-30. 2006
    ..In the treatment of nonalcoholic fatty liver disease, thiazolidinediones show considerable promise, but further clinical studies are required in order to prove their efficacity and safety...
  10. ncbi request reprint [Highlights in hepatology]
    I Pache
    Service de Gastroentérologie et d Hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 5:195-6, 198, 200-2. 2009
    ..These new developments will be summarized and discussed critically, with a particular emphasis on their potential implications for current and future clinical practice...
  11. ncbi request reprint [Management of chronic viral hepatitis]
    Isabelle Pache
    Service de gastro entérologie et d hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 3:215, 217-8, 221-3. 2007
    ..Finally, recent studies using pegylated interferon-alpha have shown promising results for the treatment of chronic hepatitis D...
  12. ncbi request reprint [Liver transplantation: new organ allocation system in Switzerland]
    Massimiliano Fontana
    Centre de transplantation d organes, CHUV, 1011 Lausanne
    Rev Med Suisse 4:221-3. 2008
    ..Advantages and limitations of the MELD score are discussed. Finally the West Switzerland joint liver transplantation program is briefly introduced...
  13. ncbi request reprint [Highlights in hepatology]
    Isabelle Pache
    Service de gastro entérologie et d hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 4:214, 216, 218-20. 2008
    ..Finally, we will briefly comment new findings in alcoholic hepatitis as well as acetaminophen hepatotoxicity and summarize revised criteria for the diagnosis and management of hepatorenal syndrome...
  14. doi request reprint Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus
    K Morikawa
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Viral Hepat 18:305-15. 2011
    ..This review provides a concise update on the biochemical and structural aspects of NS3-4A, its role in the pathogenesis of chronic hepatitis C and the clinical development of NS3-4A protease inhibitors...
  15. ncbi request reprint [Highlights in gastroenterology and hepatology 2010]
    A Schoepfer
    Service de Gastroentérologie et d Hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 7:25-9. 2011
    ..These new developments will be summarized and discussed critically, with a particular emphasis on their potential implications for current and future clinical practice...
  16. doi request reprint Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C
    Pierre Yves Bochud
    Department of Internal Medicine, Infectious Diseases Service, CHUV, Lausanne, Switzerland
    J Hepatol 51:655-66. 2009
    ..The aim of this study was to assess independent predictors for fibrosis progression...
  17. ncbi request reprint Hepatitis C virus comes full circle: production of recombinant infectious virus in tissue culture
    Jan Martin Berke
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
    Hepatology 42:1264-9. 2005
  18. ncbi request reprint [A primer on the management of antiviral resistance in chronic hepatitis B]
    C Doerig
    Service de Gastroentérologie et d Hépatologie, CHUV, 1011 Lausanne
    Rev Med Suisse 5:203-4, 206-8,. 2009
    ..The purpose of this concise review is to provide an introduction to the prevention, diagnosis and management of antiviral resistance in chronic hepatitis B...
  19. ncbi request reprint [Complications of liver cirrhosis: oesophageal varices, ascites and hepato-cellular carcinoma]
    F X Troillet
    Service de Chirurgie Viscerale, CHUV, Lausanne
    Rev Med Suisse 1:249-50, 252-5. 2005
    ..Surgery is only possible in a small number of cases. Percutaneous destruction techniques have nearly the same survival rate as that obtained by surgery and should be proposed to patients where surgery is not an option...
  20. pmc An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association
    Jérôme Gouttenoire
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, BU44 07 2421, Rue du Bugnon 44, CH 1011 Lausanne, Switzerland
    J Virol 83:11378-84. 2009
    ..Here, we describe an amphipathic alpha-helix at the C terminus of NS4B (amino acid residues 229 to 253) that mediates membrane association and is involved in the formation of a functional HCV replication complex...
  21. pmc Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication
    Darius Moradpour
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 44, CH 1011 Lausanne, Switzerland
    J Virol 78:13278-84. 2004
    ..These results have implications for the functional architecture of the HCV replication complex and provide new insights into the expanding spectrum of tail-anchored proteins...
  22. doi request reprint Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory
    Jérôme Gouttenoire
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Rev Med Virol 20:117-29. 2010
    ....
  23. pmc Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein
    Rainer Gosert
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
    J Virol 79:7911-7. 2005
    ..This feature may provide the nonstructural proteins with a certain flexibility to perform their multiple functions during HCV replication...
  24. doi request reprint Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference
    Pantxika Bellecave
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Hepatology 50:46-55. 2009
    ..These findings provide new insights into the pathogenesis of HBV-HCV coinfection and may contribute to its clinical management in the future...
  25. ncbi request reprint Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 437:1167-72. 2005
    ..Cardif thus functions as an adaptor, linking the cytoplasmic dsRNA receptor RIG-I to the initiation of antiviral programmes...
  26. pmc Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B
    Jérôme Gouttenoire
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Virol 83:6257-68. 2009
    ..These results provide the first atomic resolution structure of an essential membrane-associated determinant of HCV NS4B...
  27. ncbi request reprint Function follows form: the structure of the N-terminal domain of HCV NS5A
    Darius Moradpour
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Hepatology 42:732-5. 2005
    ..5-A resolution, which contains a novel fold, a new zinc-coordination motif, and a disulfide bond. We use molecular surface analysis to suggest the location of protein-, RNA-, and membrane-interaction sites...
  28. ncbi request reprint [Hepatocellular carcinoma: a multidisciplinary approach]
    Adrien A Tempia-Caliera
    Service de Chirurgie Viscerale, CHUV, 1011 Lausanne
    Rev Med Suisse 1:1621-4, 1627-9. 2005
    ..Follow-up is crucial as recurrences can be treated by following similar algorithms. The efficacy of oncological adjuvant and neoadjuvant treatment is not yet proved...
  29. doi request reprint Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system
    Pantxika Bellecave
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Hepatology 51:1127-36. 2010
    ..We conclude that the pre-activation status of the endogenous IFN system in the liver of patients with CHC is in part regulated by cleavage of MAVS...
  30. ncbi request reprint Combined antiviral therapy for recurrent hepatitis C virus after liver transplantation
    Massimiliano Fontana
    Transplantation 83:525-6. 2007
  31. ncbi request reprint Hepatitis C virus infection in haemodialysis and kidney transplant patients
    Seema Baid-Agrawal
    Department of Nephrology and Medical Intensive Care, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Rev Med Virol 18:97-115. 2008
    ..Large multi-centre clinical trials are required in HCV-infected haemodialysis and kidney transplant patients in order to define optimal therapeutic strategies before and after transplantation...
  32. ncbi request reprint Structural biology of hepatitis C virus
    Francois Penin
    Institut de Biologie et Chimie des Proteines, Lyon, France
    Hepatology 39:5-19. 2004
    ..This article reviews the current knowledge of HCV structural biology...
  33. ncbi request reprint Of mice and men: a small animal model of hepatitis C virus replication
    Volker Brass
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Hepatology 35:722-4. 2002
  34. pmc Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    Denise Egger
    Institute for Medical Microbiology, University of Basel, CH 4003 Basel, Switzerland
    J Virol 76:5974-84. 2002
    ..Virchows Arch. B., 33:233-243, 1980). In view of this finding and the observation that all HCV proteins accumulate on the membranous web, we propose that the membranous web forms the viral replication complex in HCV-infected cells...
  35. ncbi request reprint Hepatitis C: molecular virology and antiviral targets
    Darius Moradpour
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, Germany
    Trends Mol Med 8:476-82. 2002
    ..Moreover, in vitro and in vivo model systems have been developed that allow systematic evaluation of new therapeutic strategies. This review details current concepts in molecular virology and emerging therapies for hepatitis C...
  36. ncbi request reprint Viral pathogenesis of hepatocellular carcinoma
    Hubert E Blum
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Gastroenterol Hepatol 17:S413-20. 2002
  37. ncbi request reprint Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice
    Alex Blindenbacher
    Department of Research, University Hospital Basel, Switzerland
    Gastroenterology 124:1465-75. 2003
    ..Interference of viral proteins with the Jak-STAT pathway could be responsible for interferon resistance in patients with chronic HCV...
  38. pmc Cytotoxic T lymphocytes derived from patients with chronic hepatitis C virus infection kill bystander cells via Fas-FasL interaction
    Christel Gremion
    Clinic for Rheumatology and Clinical Immunology Allergology, University of Bern, CH 3010 Bern, Switzerland
    J Virol 78:2152-7. 2004
    ..Our data underscore the role of the Fas pathway in HCV-related liver injury and support the exploration of Fas-based treatment strategies for patients with chronic hepatitis C virus infection...
  39. ncbi request reprint Recent developments in target identification against hepatitis C virus
    Volker Brass
    Department of Medicine II, University of Freiburg, D 79106 Freiburg, Germany
    Expert Opin Ther Targets 8:295-307. 2004
    ..These and other novel antiviral strategies may complement existing therapeutic modalities in the future...
  40. ncbi request reprint Pathogenesis of hepatocellular carcinoma
    Darius Moradpour
    Department of Medicine II, University of Freiburg, Germany
    Eur J Gastroenterol Hepatol 17:477-83. 2005
    ..New technologies, including gene expression profiling and proteomic analyses, should allow us to further elucidate the molecular events underlying HCC development and identify novel diagnostic markers as well as therapeutic targets...
  41. ncbi request reprint A primer on the molecular virology of hepatitis C
    Darius Moradpour
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Liver Int 24:519-25. 2004
    ..Here, we provide a primer on the molecular virology of hepatitis C, with particular reference to novel antiviral targets and therapeutic strategies...
  42. ncbi request reprint Interaction of hepatitis C virus proteins with host cell membranes and lipids
    Jean Dubuisson
    CNRS UPR2511, Institut de Biologie de Lille, 1 rue Calmette, BP447, 59021 Lille Cedex, France
    Trends Cell Biol 12:517-23. 2002
    ....
  43. ncbi request reprint A new twist to translation initiation of the hepatitis C virus
    Rainer Gosert
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Hepatology 35:724-6. 2002
  44. ncbi request reprint Oral valganciclovir for cytomegalovirus colitis after liver transplantation
    Oriol Manuel
    Transplantation 83:239-40. 2007
  45. ncbi request reprint An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A
    Volker Brass
    Department of Medicine II, University of Freiburg, D 79106 Freiburg, Germany
    J Biol Chem 277:8130-9. 2002
    ..These findings have important implications for the structural and functional organization of the HCV replication complex and may define novel targets for antiviral intervention...
  46. pmc Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1
    Francois H T Duong
    Department of Research and Division of Gastroenterology and Hepatology, University Hospital Basel, CH 4031 Basel, Switzerland
    J Virol 79:15342-50. 2005
    ..We conclude that up-regulation of PP2A might be crucial for the efficient replication of HCV and propose PP2A as a potential target for anti-HCV treatment strategies...
  47. pmc The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment
    Natalia Ivashkina
    Department of Medicine II, University Hospital, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Virol 76:13088-93. 2002
    ..These findings have important implications for the functional architecture of the HCV replication complex...
  48. ncbi request reprint Stable human lymphoblastoid cell lines constitutively expressing hepatitis C virus proteins
    Benno Wölk
    Department of Medicine II, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    J Gen Virol 86:1737-46. 2005
    ..In conclusion, these cell lines represent a unique tool to study the cellular immune response, as well as to evaluate novel vaccine and immunotherapeutic strategies against HCV...
  49. ncbi request reprint Antiviral treatment of patients with HBV-related cirrhosis
    Hubert E Blum
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Gastroenterol Hepatol 17:S306-10. 2002
  50. ncbi request reprint A liposomal peptide vaccine inducing CD8+ T cells in HLA-A2.1 transgenic mice, which recognise human cells encoding hepatitis C virus (HCV) proteins
    Olivier B Engler
    Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, Bern, Switzerland
    Vaccine 23:58-68. 2004
    ..In conclusion, such liposome formulations represent a safe and promising strategy to stimulate the CD8(+) T cell against HCV...
  51. pmc Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons
    Rainer Gosert
    Department of Medicine II, University of Freiburg, Germany
    J Virol 77:5487-92. 2003
    ..Metabolic labeling with 5-bromouridine 5'-triphosphate in the presence of actinomycin D revealed that the membranous web is the site of viral RNA synthesis and therefore represents the replication complex of HCV...
  52. ncbi request reprint Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stress
    Claudia Piccoli
    Department of Biomedical Sciences, University of Foggia, Foggia, Italy
    Hepatology 46:58-65. 2007
    ..These observations provide new insights into the pathogenesis of hepatitis C and may offer new opportunities for therapeutic intervention...
  53. ncbi request reprint Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex
    Darius Moradpour
    Department of Medicine II, University of Freiburg, D 79106 Freiburg, Germany
    Antiviral Res 60:103-9. 2003
    ..These findings add to our current understanding of the HCV life cycle and may ultimately allow to design novel antiviral strategies against hepatitis C...
  54. ncbi request reprint Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase
    Darius Moradpour
    Department of Medicine II, University of Freiburg, D 79106 Freiburg, Germany
    J Biol Chem 277:593-601. 2002
    ..More important, detailed knowledge of the mAb 5B-12B7 contact sites on the enzyme may facilitate the development of small molecule RdRp inhibitors as novel antiviral agents...
  55. pmc Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes
    Darius Moradpour
    Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10021, USA
    J Virol 78:7400-9. 2004
    ..These findings reveal an unexpected flexibility of the C-terminal domain of NS5A and provide tools for studying the formation and turnover of HCV replication complexes in living cells...
  56. pmc Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
    Volker Brass
    Department of Medicine II, University of Freiburg, D 79106 Freiburg, Germany
    Proc Natl Acad Sci U S A 105:14545-50. 2008
    ..This model has implications for the functional architecture of the HCV replication complex, proteolytic targeting of host factors, and drug design...
  57. pmc A dynamic view of hepatitis C virus replication complexes
    Benno Wölk
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    J Virol 82:10519-31. 2008
    ..We suggest that this MT-dependent transport sustains two distinct RC populations, which are both required during the HCV life cycle...
  58. pmc euHCVdb: the European hepatitis C virus database
    Christophe Combet
    Institut de Biologie et Chimie des Protéines UMR5086, CNRS, University of Lyon 1, IFR 128 BioSciences, Lyon Gerland, France
    Nucleic Acids Res 35:D363-6. 2007
    ..As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses...