Research Topics
Genomes and Genes | Lucas LiaudetSummaryAffiliation: Centre Hospitalier Universitaire Vaudois Country: Switzerland Publications
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Publications
[Hypertension: early detection of target organ damage]Abigael Heim
Division de physiopathologie, Departement de Medecine, CHUV et Universite de Lausanne, 1011 Lausanne
Rev Med Suisse 3:1996, 1999-2002. 2007..Microalbuminuria should not only be regarded as a marker of renal damage, but also as a strong indicator of increased cardiovascular risk...- Role of peroxynitrite in the cardiovascular dysfunction of septic shockLucas Liaudet
Department of Intensive Care Medicine, BH 08 621 University Hospital Medical, Center, Lausanne, Switzerland
Curr Vasc Pharmacol 11:196-207. 2013..Therefore, these findings support the development of peroxynitrite decomposition catalysts as potentially useful novel therapeutic agents to restore cardiovascular function in sepsis... - Role of innate immunity in cardiac inflammation after myocardial infarctionLucas Liaudet
Department of Intensive Care Medicine and Burn Center, University Hospital Medical Center, Faculty of Biology and Medicine, Lausanne 1010, Switzerland
Front Biosci (Schol Ed) 5:86-104. 2013..This review presents the current state of knowledge on the process of immune activation within the infarcted myocardium and its consequences... - [Oxidative biology and clinical implications of peroxynitrite]Lucas Liaudet
Service de médecine intensive adulte, Chuv BH
Rev Med Suisse 3:2840-3. 2007..In such circumstances, various synthetic metalloporphyrins, able to degrade peroxynitrite, disclose important beneficial effects in animal models, and might therefore represent novel pharmacological agents in the future... 
Role of peroxynitrite in the redox regulation of cell signal transduction pathwaysLucas Liaudet
Department of Intensive Care Medicine, University Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland
Front Biosci 14:4809-14. 2009....- Endotoxin impairs cardiac hemodynamics by affecting loading conditions but not by reducing cardiac inotropismLi Jianhui
Dept of Intensive Care Medicine, Univ Hospital Center and Faculty of Biology and Medicine, CHUV BH 08 621, 1011 Lausanne, Switzerland
Am J Physiol Heart Circ Physiol 299:H492-501. 2010..Therefore, the alterations of cardiac function induced by LPS are entirely due to altered loading conditions, but not to reduced contractility, which may instead be slightly increased... - Comparison of skin microvascular reactivity with hemostatic markers of endothelial dysfunction and damage in type 2 diabetesSandra Beer
Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Lausanne, Switzerland
Vasc Health Risk Manag 4:1449-58. 2008.... - Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunctionJoelle Rolli
Department of Intensive Care Medicine, University Hospital Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland
PLoS ONE 5:e12687. 2010..Here, we determined the ability of bacterial flagellin, the ligand of mammalian TLR5, to trigger myocardial inflammation and contractile dysfunction... - Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent mannerNoureddine Loukili
Department of Intensive Care Medicine, Division of Pathophysiology, Faculty of Biology and Medicine, University MedicalCenter, 1011 Lausanne, Switzerland
J Biol Chem 285:15746-52. 2010..Our findings provide a new conceptual framework to understand the role of oxidant stress during inflammatory processes... - Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivoNoureddine Loukili
Department of Intensive Care Medicine, University Hospital Center and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
Cardiovasc Res 89:586-94. 2011..Here, we investigated the possible involvement of peroxynitrite, a potent cytotoxic oxidant formed during myocardial infarction, on these processes... - Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in miceJoelle Rolli
Department of Intensive Care Medicine, University Hospital Medical Center and Faculty of Biology and Medicine, Rue du Bugnon 46, Lausanne 1010, Switzerland
Crit Care 14:R160. 2010..Therefore, we determined TLR5 expression and the ability of flagellin to trigger prototypical innate immune responses and apoptosis in major organs from mice... 
Preserved capillary density of dorsal finger skin in treated hypertensive patients with or without type 2 diabetesJerome Aellen
Division de physiopathologie clinique, Universite de Lausanne, Lausanne, Switzerland
Microcirculation 19:554-62. 2012..Despite the frequent association of diabetes with hypertension, nothing is known on the capillary density of treated diabetic patients with hypertension...- Homocysteine induces cell death in H9C2 cardiomyocytes through the generation of peroxynitriteSandra Levrand
Department of Intensive Care Medicine, University Hospital Center, 1011 Lausanne, Switzerland
Biochem Biophys Res Commun 359:445-50. 2007..These results provide the first demonstration that HCY kills cardiomyocytes through the generation of peroxynitrite and can activate key signaling cascades in the myocardium... - Body temperature regulation and outcome after cardiac arrest and therapeutic hypothermiaJakobea Benz-Woerner
Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne University Hospital and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
Resuscitation 83:338-42. 2012..However, body temperature (BT) regulation has not been extensively studied in this setting. We investigated BT variation in CA patients treated with therapeutic hypothermia (TH) and analyzed its impact on outcome... - The vasodilatory response of skin microcirculation to local heating is subject to desensitizationMeral Ciplak
Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Lausanne, Switzerland
Microcirculation 16:265-75. 2009..Because the vascular effects of NO may be subject to desensitization, we examined whether a first local thermal stimulus would attenuate the hyperemic response to a second one applied later... - Caspase-3 protects stressed organs against cell deathHadi Khalil
Department of Physiology, University of Lausanne, Lausanne, Switzerland
Mol Cell Biol 32:4523-33. 2012..Our results provide evidence for the relevance of caspase-3 as a stress intensity sensor that controls cell fate by either initiating a RasGAP cleavage-dependent cell resistance program or a cell suicide response... - No implication of thromboxane prostanoid receptors in reactive hyperemia of skin and skeletal muscle in human forearmAntoine Pasche
Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois and Université de Lausanne, Lausanne, Switzerland
J Cardiovasc Pharmacol 61:127-32. 2013..These results do not support that thromboxane prostanoid receptor activation could exert a moderating influence on reactive hyperemia in human skin and skeletal muscle, at least in young subjects... - Moderate hypercapnia exerts beneficial effects on splanchnic energy metabolism during endotoxemiaAlex Gnaegi
Division of Clinical Pathophysiology and Medical Teaching, Faculty of Biology and Medicine, University Hospital Center, CHUV BH 08 621, 1011, Lausanne, Switzerland
Intensive Care Med 35:1297-304. 2009..We therefore determined the effects of moderate hypercapnia on markers of systemic and splanchnic oxidative metabolism in an animal model of endotoxemia... - Hypertension and microvascular remodellingFrancois Feihl
Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois and Université de Lausanne, Rue du Bugnon 46, BH10 701, CH 1011 Lausanne, Switzerland
Cardiovasc Res 78:274-85. 2008..We terminate by considering the potential role of remodelling in the pathogenesis of end-organ damage and in the perpetuation of hypertension... - Whole-body vibration training elevates creatine kinase levels in sedentary subjectsBoris Gojanovic
Sports Medicine Unit, CHUV, Pierre Decker 4, CH 1011 Lausanne, Switzerland
Swiss Med Wkly 141:w13222. 2011..We hypothesised that the vigorous muscle contractions elicited by WBV can cause muscle damage expressed as an elevation in muscle enzymes... - [Pathophysiological mechanisms of organ dysfunction in sepsis]Belinda Calderari
Service d anesthésiologie, CHUV, 1011 Lausanne
Rev Med Suisse 6:2406-9. 2010..In this article, we review the major mechanisms involved in organ dysfunction during sepsis, and also present the concept of organ dysfunction as an adaptive response to the septic process... - Major impact of body position on arterial stiffness indices derived from radial applanation tonometry in pregnant and nonpregnant womenLetitia Jaccoud
Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
J Hypertens 30:1161-8. 2012..To evaluate the impact of body position on the arterial stiffness indices provided by radial applanation tonometry in pregnant and nonpregnant women... - Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertensionBoris Gojanovic
Division of Clinical Pathophysiology, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Lausanne, Switzerland
J Renin Angiotensin Aldosterone Syst 9:1-9. 2008..They are expected not only to improve BP control, but also to facilitate long-term adherence with antihypertensive therapy, thereby providing maximal protection against the cardiovascular and renal damage caused by high BP... - Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermiaAndrea O Rossetti
Service de Neurologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Neurology 72:744-9. 2009..The aim of this study was to identify favorable predictors for awakening beyond vegetative state in PSE... - Hypertension: a disease of the microcirculation?Francois Feihl
Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Hypertension 48:1012-7. 2006 - Acute inflammation decreases the expression of connexin 40 in mouse lungStéphanie Rignault
Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Shock 28:78-85. 2007.... - Brachial or wrist blood pressure in obese patients: which is the best?Olivier de Senarclens
Division of Clinical Pathophysiology, University Hospital and University of Lausanne, Lausanne, Switzerland
Blood Press Monit 13:149-51. 2008..Blood pressure (BP) measured in obese patients with a large arm circumference using a cuff of standard width may be overestimated... - Profound impact of uncomplicated pregnancy on diastolic, but not systolic pulse contour of aortic pressureAnne Delachaux
Division de physiopathologie clinique, , Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
J Hypertens 24:1641-8. 2006..In contrast, the amplitude of reflection waves reaching the aortic root in diastole progressively decreases with advancing pregnancy... - Three short perioperative infusions of n-3 PUFAs reduce systemic inflammation induced by cardiopulmonary bypass surgery: a randomized controlled trialMette M Berger
Services of Adult Intensive Care Medicine and Burns, Lausanne University Hospital, Lausanne, Switzerland
Am J Clin Nutr 97:246-54. 2013..Fish oil (FO) has antiinflammatory effects, which might reduce systemic inflammation induced by a cardiopulmonary bypass (CPB)... - The hemodynamics of septic shock: a historical perspectiveFrancois Feihl
Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Curr Vasc Pharmacol 11:133-8. 2013..Siegel, which introduced the concept of deficient peripheral utilization of oxygen, inspiring later work on the microvascular disturbances of septic shock... - Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell linesSandra Levrand
Division of Critical Care, Division of Clinical Pathophysiology, Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland
J Biol Chem 280:34878-87. 2005..These findings offer new perspectives for the understanding of the relationships between redox stress and inflammation... - Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivoSandra Levrand
Department of Intensive Care Medicine, BH 10-982, University Hospital, 1011 Lausanne, Switzerland
Free Radic Biol Med 41:886-95. 2006..These results provide important novel information on the mechanisms of myocardial toxicity of peroxynitrite... - Early predictors of outcome in comatose survivors of ventricular fibrillation and non-ventricular fibrillation cardiac arrest treated with hypothermia: a prospective studyMauro Oddo
Department of Critical Care Medicine, Lausanne University Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland
Crit Care Med 36:2296-301. 2008..Additional studies are needed to evaluate the benefit of this treatment in more heterogeneous groups of patients, including those with non-VF rhythms and/or shock and to identify early predictors of outcome in this setting... - [Inotropic agents for treatment of acute heart failure syndromes in intensive care]Marco Rusca
Service de médecine intensive adulte, CHUV, 1011 Lausanne
Rev Med Suisse 5:2512-5. 2009..In this article, we summarize the mechanisms of action of these different classes of drugs, and also discuss important issues regarding their clinical indications and the potential risks associated with their use... - From evidence to clinical practice: effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrestMauro Oddo
Department of Intensive Care Medicine, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Crit Care Med 34:1865-73. 2006.... - Muscarinic receptor M1 and phosphodiesterase 1 are key determinants in pulmonary vascular dysfunction following perinatal hypoxia in miceAnne Christine Peyter
Neonatal Research Laboratory, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Am J Physiol Lung Cell Mol Physiol 295:L201-13. 2008..This raises the possibility that muscarinic receptors could be key determinants in pulmonary vascular diseases in relation to "perinatal imprinting.".. - Endothelium-dependent vasodilation in the skin microcirculation of patients with septic shockSandrine Kubli
Division of Clinical Pathophysiology, University Hospital, CH-1011, Lausanne, Switzerland
Shock 19:274-80. 2003..These results suggest that the capacity of the endothelium to produce signals for vasorelaxation remains intact in the skin microcirculation of patients with septic shock... - Role of poly(adenosine diphosphate-ribose) polymerase 1 in septic peritonitisLucas Liaudet
Critical Care Division, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
Curr Opin Crit Care 9:152-8. 2003.... - Endurance training enhances vasodilation induced by nitric oxide in human skinYann Boegli
Division de Physiopathologic Clinique, Center Hospitalier Universitaire Vaudois, Lausanne, Switzerland
J Invest Dermatol 121:1197-204. 2003..Therefore, the augmentation of nitric oxide bioactivity in the dermal microcirculation might be one mechanism whereby endurance training modifies the thermoregulatory control of skin blood flow... - Poly(adenosine 5'-diphosphate) ribose polymerase activation as a cause of metabolic dysfunction in critical illnessLucas Liaudet
Critical Care Division, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 5:175-84. 2002.... - Acetylcholine-induced vasodilation and reactive hyperemia are not affected by acute cyclo-oxygenase inhibition in human skinAnne Dalle-Ave
Division of Clinical Pathophysiology and Medical Teaching, University Hospital, Lausanne, Switzerland
Microcirculation 11:327-36. 2004..In this vascular bed, local anesthesia seems to amplify acetylcholine-induced vasodilation via a prostaglandin-independent mechanism... - Dose-dependent vasodilatory effects of acetylcholine and local warming on skin microcirculationSamuel Christen
Division of Clinical Pathophysiology, University Hospital, Lausanne, Switzerland
J Cardiovasc Pharmacol 44:659-64. 2004..These techniques represent a unique means to investigate noninvasively the functional vasodilatory capacity of the skin microvasculature... - Carboxyhemoglobin formation as an unexpected side effect of inhaled nitric oxide therapy in severe acute respiratory distress syndromeMarco Rusca
Division of Critical Care, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
Crit Care Med 32:2537-9. 2004..This observation does not support the use of inhaled nitric oxide in the treatment of acute respiratory distress syndrome... - Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient miceFrancisco Garcia Soriano
Inotek Corporation, Beverly, Massachusetts 01915, USA
Shock 17:286-92. 2002..Thus, PARP activation has an important role in systemic inflammation and organ damage in the present model of polymicrobial septic shock... - Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agentsPrakash Jagtap
Inotek Corporation, Beverly, MA 01915, USA
Crit Care Med 30:1071-82. 2002..CONCLUSIONS: The novel series of phenanthridinone PARS inhibitors have potent cytoprotective effects in vitro and significant protective effects in shock and reperfusion injury in rodent models in vivo... - Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and agingPal Pacher
Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
Int J Mol Med 9:659-64. 2002..Thus, PARP activation contributes to the pathogenesis of endothelial dysfunction associated with hypertension and aging, but not in the current experimental model of atherosclerosis... - Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodentsPal Pacher
Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
Biochem Pharmacol 64:1785-91. 2002..Thus, PARP activation in the cardiovascular system is an important contributory factor to the cardiac collapse and death associated with endotoxin shock... - Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitisJon G Mabley
Inotek Pharmaceuticals Corporation, Cummings Center, Beverly, Massachusetts 01905, USA
Mol Med 8:581-90. 2002..Further work is needed to determine whether neutralization of peroxynitrite also represents a promising strategy to treat human inflammatory diseases such as arthritis and colitis... - Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunctionPal Pacher
Inotek Pharmaceuticals Corp, Beverly, Mass 01915, USA
Circulation 107:896-904. 2003.... - Nitric oxide and peroxynitrite in health and diseasePal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Physiol Rev 87:315-424. 2007..Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review... - Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite-poly(ADP-ribose) polymerase connectionLucas Liaudet
Inotek Pharmaceuticals Corporation, Beverly, Massachusetts 01915, USA
Coron Artery Dis 14:115-22. 2003 - Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosisMohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
J Leukoc Biol 82:1382-9. 2007..These findings suggest that selective CB(2) receptor agonists may represent a novel, protective strategy against I/R injury by attenuating oxidative stress, inflammatory response, and apoptosis... - Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failurePal Pacher
National Institutes of Health, NAAA, Bethesda, MD 20892 9413, USA
Int J Mol Med 17:369-75. 2006..The current data strengthen the view that PARP inhibition may represent an effective approach for the experimental therapy of various forms of acute and chronic heart failure... - Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicityPeter Bai
Inotek Pharmaceuticals Corporation, 100 Cummings Center, Suite 419E, Beverly, MA 01915, USA
Oncol Rep 11:505-8. 2004..These results demonstrate that MMP activation is an early event in DOX-induced cardiotoxicity and raises the possibility that MMP inhibitors may influence the outcome of this severe complication... - Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shockOleg V Evgenov
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
Curr Vasc Pharmacol 3:293-9. 2005..Innovative therapeutic strategies based on the pharmacological inhibition of PARP-1 catalytic activity might provide benefits by preventing tissue injury, organ dysfunction, and lethality associated with these conditions... - Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failurePal Pacher
National Institute on Alcohol Abuse and Alcoholism, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892 8115, USA
Am J Physiol Heart Circ Physiol 287:H2132-7. 2004..P-V analysis is a sensitive method to determine cardiac function in rats... - Nitrosative stress and pharmacological modulation of heart failurePal Pacher
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2S24, Bethesda, MD 20892 9413, USA
Trends Pharmacol Sci 26:302-10. 2005.... - [Heart arrest: which reality and which training for the practitioner?]Vincent Ribordy
Division des Soins Intensifs de médecin CHUV, Lausanne
Rev Med Suisse Romande 124:321-4. 2004.... - [New therapeutic strategies in severe sepsis and septic shock]Mauro Oddo
Division des soins intensifs, Departement de Medecine, Interne CHUV, Lausanne
Rev Med Suisse Romande 124:329-32. 2004..This review will focus on these recently acquired therapeutic modalities, that are presently available to clinicians for the treatment of severe sepsis and septic shock... - A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced agingPal Pacher
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park Bldg Rm 445, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892 8115, USA
J Pharmacol Exp Ther 311:485-91. 2004..Thus, pharmacological inhibition of PARP may represent a novel approach to improve cardiac and vascular dysfunction associated with aging...