Lucas Liaudet

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi request reprint [Hypertension: early detection of target organ damage]
    Abigael Heim
    Division de physiopathologie, Departement de Medecine, CHUV et Universite de Lausanne, 1011 Lausanne
    Rev Med Suisse 3:1996, 1999-2002. 2007
  2. pmc Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction
    Joelle Rolli
    Department of Intensive Care Medicine, University Hospital Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland
    PLoS ONE 5:e12687. 2010
  3. pmc Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo
    Jianhui Li
    Department of Hepatobiliary Surgery, The First Affiliated Hospital, Zhejiang University, College of Medicine, Hangzhou, China
    PLoS ONE 8:e70331. 2013
  4. ncbi request reprint Role of peroxynitrite in the cardiovascular dysfunction of septic shock
    Lucas Liaudet
    Department of Intensive Care Medicine, BH 08 621 University Hospital Medical, Center, Lausanne, Switzerland
    Curr Vasc Pharmacol 11:196-207. 2013
  5. ncbi request reprint Role of innate immunity in cardiac inflammation after myocardial infarction
    Lucas Liaudet
    Department of Intensive Care Medicine and Burn Center, University Hospital Medical Center, Faculty of Biology and Medicine, Lausanne 1010, Switzerland
    Front Biosci (Schol Ed) 5:86-104. 2013
  6. ncbi request reprint [Oxidative biology and clinical implications of peroxynitrite]
    Lucas Liaudet
    Service de médecine intensive adulte, Chuv BH
    Rev Med Suisse 3:2840-3. 2007
  7. pmc Role of peroxynitrite in the redox regulation of cell signal transduction pathways
    Lucas Liaudet
    Department of Intensive Care Medicine, University Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland
    Front Biosci (Landmark Ed) 14:4809-14. 2009
  8. pmc Comparison of skin microvascular reactivity with hemostatic markers of endothelial dysfunction and damage in type 2 diabetes
    Sandra Beer
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Lausanne, Switzerland
    Vasc Health Risk Manag 4:1449-58. 2008
  9. pmc Endotoxin impairs cardiac hemodynamics by affecting loading conditions but not by reducing cardiac inotropism
    Li Jianhui
    Dept of Intensive Care Medicine, Univ Hospital Center and Faculty of Biology and Medicine, CHUV BH 08 621, 1011 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 299:H492-501. 2010
  10. pmc Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner
    Noureddine Loukili
    Department of Intensive Care Medicine, Division of Pathophysiology, Faculty of Biology and Medicine, University MedicalCenter, 1011 Lausanne, Switzerland
    J Biol Chem 285:15746-52. 2010

Collaborators

Detail Information

Publications64

  1. ncbi request reprint [Hypertension: early detection of target organ damage]
    Abigael Heim
    Division de physiopathologie, Departement de Medecine, CHUV et Universite de Lausanne, 1011 Lausanne
    Rev Med Suisse 3:1996, 1999-2002. 2007
    ..Microalbuminuria should not only be regarded as a marker of renal damage, but also as a strong indicator of increased cardiovascular risk...
  2. pmc Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction
    Joelle Rolli
    Department of Intensive Care Medicine, University Hospital Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland
    PLoS ONE 5:e12687. 2010
    ..Here, we determined the ability of bacterial flagellin, the ligand of mammalian TLR5, to trigger myocardial inflammation and contractile dysfunction...
  3. pmc Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo
    Jianhui Li
    Department of Hepatobiliary Surgery, The First Affiliated Hospital, Zhejiang University, College of Medicine, Hangzhou, China
    PLoS ONE 8:e70331. 2013
    ..Thus, peroxynitrite formed in the myocardium during PostC induces cardioprotective mechanisms improving both structural and functional integrity of the left ventricle exposed to ischemia and reperfusion in vivo. ..
  4. ncbi request reprint Role of peroxynitrite in the cardiovascular dysfunction of septic shock
    Lucas Liaudet
    Department of Intensive Care Medicine, BH 08 621 University Hospital Medical, Center, Lausanne, Switzerland
    Curr Vasc Pharmacol 11:196-207. 2013
    ..Therefore, these findings support the development of peroxynitrite decomposition catalysts as potentially useful novel therapeutic agents to restore cardiovascular function in sepsis...
  5. ncbi request reprint Role of innate immunity in cardiac inflammation after myocardial infarction
    Lucas Liaudet
    Department of Intensive Care Medicine and Burn Center, University Hospital Medical Center, Faculty of Biology and Medicine, Lausanne 1010, Switzerland
    Front Biosci (Schol Ed) 5:86-104. 2013
    ..This review presents the current state of knowledge on the process of immune activation within the infarcted myocardium and its consequences...
  6. ncbi request reprint [Oxidative biology and clinical implications of peroxynitrite]
    Lucas Liaudet
    Service de médecine intensive adulte, Chuv BH
    Rev Med Suisse 3:2840-3. 2007
    ..In such circumstances, various synthetic metalloporphyrins, able to degrade peroxynitrite, disclose important beneficial effects in animal models, and might therefore represent novel pharmacological agents in the future...
  7. pmc Role of peroxynitrite in the redox regulation of cell signal transduction pathways
    Lucas Liaudet
    Department of Intensive Care Medicine, University Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland
    Front Biosci (Landmark Ed) 14:4809-14. 2009
    ....
  8. pmc Comparison of skin microvascular reactivity with hemostatic markers of endothelial dysfunction and damage in type 2 diabetes
    Sandra Beer
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Lausanne, Switzerland
    Vasc Health Risk Manag 4:1449-58. 2008
    ....
  9. pmc Endotoxin impairs cardiac hemodynamics by affecting loading conditions but not by reducing cardiac inotropism
    Li Jianhui
    Dept of Intensive Care Medicine, Univ Hospital Center and Faculty of Biology and Medicine, CHUV BH 08 621, 1011 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 299:H492-501. 2010
    ..Therefore, the alterations of cardiac function induced by LPS are entirely due to altered loading conditions, but not to reduced contractility, which may instead be slightly increased...
  10. pmc Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner
    Noureddine Loukili
    Department of Intensive Care Medicine, Division of Pathophysiology, Faculty of Biology and Medicine, University MedicalCenter, 1011 Lausanne, Switzerland
    J Biol Chem 285:15746-52. 2010
    ..Our findings provide a new conceptual framework to understand the role of oxidant stress during inflammatory processes...
  11. pmc Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo
    Noureddine Loukili
    Department of Intensive Care Medicine, University Hospital Center and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
    Cardiovasc Res 89:586-94. 2011
    ..Here, we investigated the possible involvement of peroxynitrite, a potent cytotoxic oxidant formed during myocardial infarction, on these processes...
  12. doi request reprint Early predictors of outcome in comatose survivors of ventricular fibrillation and non-ventricular fibrillation cardiac arrest treated with hypothermia: a prospective study
    Mauro Oddo
    Department of Critical Care Medicine, Lausanne University Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland
    Crit Care Med 36:2296-301. 2008
    ..Additional studies are needed to evaluate the benefit of this treatment in more heterogeneous groups of patients, including those with non-VF rhythms and/or shock and to identify early predictors of outcome in this setting...
  13. pmc Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice
    Joelle Rolli
    Department of Intensive Care Medicine, University Hospital Medical Center and Faculty of Biology and Medicine, Rue du Bugnon 46, Lausanne 1010, Switzerland
    Crit Care 14:R160. 2010
    ..Therefore, we determined TLR5 expression and the ability of flagellin to trigger prototypical innate immune responses and apoptosis in major organs from mice...
  14. doi request reprint The vasodilatory response of skin microcirculation to local heating is subject to desensitization
    Meral Ciplak
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Lausanne, Switzerland
    Microcirculation 16:265-75. 2009
    ..Because the vascular effects of NO may be subject to desensitization, we examined whether a first local thermal stimulus would attenuate the hyperemic response to a second one applied later...
  15. pmc Homocysteine induces cell death in H9C2 cardiomyocytes through the generation of peroxynitrite
    Sandra Levrand
    Department of Intensive Care Medicine, University Hospital Center, 1011 Lausanne, Switzerland
    Biochem Biophys Res Commun 359:445-50. 2007
    ..These results provide the first demonstration that HCY kills cardiomyocytes through the generation of peroxynitrite and can activate key signaling cascades in the myocardium...
  16. ncbi request reprint Dose-dependent vasodilatory effects of acetylcholine and local warming on skin microcirculation
    Samuel Christen
    Division of Clinical Pathophysiology, University Hospital, Lausanne, Switzerland
    J Cardiovasc Pharmacol 44:659-64. 2004
    ..These techniques represent a unique means to investigate noninvasively the functional vasodilatory capacity of the skin microvasculature...
  17. ncbi request reprint Acetylcholine-induced vasodilation and reactive hyperemia are not affected by acute cyclo-oxygenase inhibition in human skin
    Anne Dalle-Ave
    Division of Clinical Pathophysiology and Medical Teaching, University Hospital, Lausanne, Switzerland
    Microcirculation 11:327-36. 2004
    ..To examine whether prostaglandins are involved in endothelium-dependent vasodilatory responses of the skin microcirculation...
  18. ncbi request reprint Endurance training enhances vasodilation induced by nitric oxide in human skin
    Yann Boegli
    Division de Physiopathologic Clinique, Center Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Invest Dermatol 121:1197-204. 2003
    ..Therefore, the augmentation of nitric oxide bioactivity in the dermal microcirculation might be one mechanism whereby endurance training modifies the thermoregulatory control of skin blood flow...
  19. ncbi request reprint Acute inflammation decreases the expression of connexin 40 in mouse lung
    Stéphanie Rignault
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Shock 28:78-85. 2007
    ....
  20. pmc Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo
    Sandra Levrand
    Department of Intensive Care Medicine, BH 10 982, University Hospital, 1011 Lausanne, Switzerland
    Free Radic Biol Med 41:886-95. 2006
    ..These results provide important novel information on the mechanisms of myocardial toxicity of peroxynitrite...
  21. doi request reprint No implication of thromboxane prostanoid receptors in reactive hyperemia of skin and skeletal muscle in human forearm
    Antoine Pasche
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois and Université de Lausanne, Lausanne, Switzerland
    J Cardiovasc Pharmacol 61:127-32. 2013
    ..These results do not support that thromboxane prostanoid receptor activation could exert a moderating influence on reactive hyperemia in human skin and skeletal muscle, at least in young subjects...
  22. doi request reprint Muscarinic receptor M1 and phosphodiesterase 1 are key determinants in pulmonary vascular dysfunction following perinatal hypoxia in mice
    Anne Christine Peyter
    Neonatal Research Laboratory, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Am J Physiol Lung Cell Mol Physiol 295:L201-13. 2008
    ..This raises the possibility that muscarinic receptors could be key determinants in pulmonary vascular diseases in relation to "perinatal imprinting."..
  23. doi request reprint Moderate hypercapnia exerts beneficial effects on splanchnic energy metabolism during endotoxemia
    Alex Gnaegi
    Division of Clinical Pathophysiology and Medical Teaching, Faculty of Biology and Medicine, University Hospital Center, CHUV BH 08 621, 1011, Lausanne, Switzerland
    Intensive Care Med 35:1297-304. 2009
    ..We therefore determined the effects of moderate hypercapnia on markers of systemic and splanchnic oxidative metabolism in an animal model of endotoxemia...
  24. doi request reprint Preserved capillary density of dorsal finger skin in treated hypertensive patients with or without type 2 diabetes
    Jerome Aellen
    Division de physiopathologie clinique, Universite de Lausanne, Lausanne, Switzerland
    Microcirculation 19:554-62. 2012
    ..Despite the frequent association of diabetes with hypertension, nothing is known on the capillary density of treated diabetic patients with hypertension...
  25. doi request reprint Major impact of body position on arterial stiffness indices derived from radial applanation tonometry in pregnant and nonpregnant women
    Letitia Jaccoud
    Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Hypertens 30:1161-8. 2012
    ..To evaluate the impact of body position on the arterial stiffness indices provided by radial applanation tonometry in pregnant and nonpregnant women...
  26. ncbi request reprint Profound impact of uncomplicated pregnancy on diastolic, but not systolic pulse contour of aortic pressure
    Anne Delachaux
    Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Hypertens 24:1641-8. 2006
    ..To evaluate the impact of uncomplicated pregnancy on the pulse contour of central aortic pressure...
  27. doi request reprint Body temperature regulation and outcome after cardiac arrest and therapeutic hypothermia
    Jakobea Benz-Woerner
    Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne University Hospital and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
    Resuscitation 83:338-42. 2012
    ..However, body temperature (BT) regulation has not been extensively studied in this setting. We investigated BT variation in CA patients treated with therapeutic hypothermia (TH) and analyzed its impact on outcome...
  28. pmc Caspase-3 protects stressed organs against cell death
    Hadi Khalil
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Mol Cell Biol 32:4523-33. 2012
    ..Our results provide evidence for the relevance of caspase-3 as a stress intensity sensor that controls cell fate by either initiating a RasGAP cleavage-dependent cell resistance program or a cell suicide response...
  29. ncbi request reprint [Pathophysiological mechanisms of organ dysfunction in sepsis]
    Belinda Calderari
    Service d anesthésiologie, CHUV, 1011 Lausanne
    Rev Med Suisse 6:2406-9. 2010
    ..In this article, we review the major mechanisms involved in organ dysfunction during sepsis, and also present the concept of organ dysfunction as an adaptive response to the septic process...
  30. doi request reprint Hypertension and microvascular remodelling
    Francois Feihl
    Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois and Université de Lausanne, Rue du Bugnon 46, BH10 701, CH 1011 Lausanne, Switzerland
    Cardiovasc Res 78:274-85. 2008
    ..We terminate by considering the potential role of remodelling in the pathogenesis of end-organ damage and in the perpetuation of hypertension...
  31. doi request reprint Whole-body vibration training elevates creatine kinase levels in sedentary subjects
    Boris Gojanovic
    Sports Medicine Unit, CHUV, Pierre Decker 4, CH 1011 Lausanne, Switzerland
    Swiss Med Wkly 141:w13222. 2011
    ..We hypothesised that the vigorous muscle contractions elicited by WBV can cause muscle damage expressed as an elevation in muscle enzymes...
  32. ncbi request reprint Hypertension: a disease of the microcirculation?
    Francois Feihl
    Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Hypertension 48:1012-7. 2006
  33. ncbi request reprint From evidence to clinical practice: effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest
    Mauro Oddo
    Department of Intensive Care Medicine, Lausanne University Hospital Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Crit Care Med 34:1865-73. 2006
    ....
  34. ncbi request reprint Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium
    Stéphanie Rignault
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Crit Care Med 33:1302-10. 2005
    ..e., Cx37, Cx40, and Cx43). We also examined a possible association between such changes and endothelial dysfunction in this model...
  35. ncbi request reprint Carboxyhemoglobin formation as an unexpected side effect of inhaled nitric oxide therapy in severe acute respiratory distress syndrome
    Marco Rusca
    Division of Critical Care, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Crit Care Med 32:2537-9. 2004
    ..To report an unexpected cause of carboxyhemoglobinemia associated with inhaled nitric oxide therapy in severe acute respiratory distress syndrome...
  36. doi request reprint Brachial or wrist blood pressure in obese patients: which is the best?
    Olivier de Senarclens
    Division of Clinical Pathophysiology, University Hospital and University of Lausanne, Lausanne, Switzerland
    Blood Press Monit 13:149-51. 2008
    ..Blood pressure (BP) measured in obese patients with a large arm circumference using a cuff of standard width may be overestimated...
  37. doi request reprint Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia
    Andrea O Rossetti
    Service de Neurologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Neurology 72:744-9. 2009
    ..The aim of this study was to identify favorable predictors for awakening beyond vegetative state in PSE...
  38. doi request reprint Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension
    Boris Gojanovic
    Division of Clinical Pathophysiology, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Lausanne, Switzerland
    J Renin Angiotensin Aldosterone Syst 9:1-9. 2008
    ..They are expected not only to improve BP control, but also to facilitate long-term adherence with antihypertensive therapy, thereby providing maximal protection against the cardiovascular and renal damage caused by high BP...
  39. ncbi request reprint Relapsing acute respiratory failure induced by minocycline
    Mauro Oddo
    Critical Care Division, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Chest 123:2146-8. 2003
    ..We now report a particularly severe case of minocycline-related pulmonary toxicity that was characterized by a relapsing form of hypersensitivity eosinophilic pneumonia complicated by acute respiratory failure...
  40. doi request reprint Three short perioperative infusions of n-3 PUFAs reduce systemic inflammation induced by cardiopulmonary bypass surgery: a randomized controlled trial
    Mette M Berger
    Services of Adult Intensive Care Medicine and Burns, Lausanne University Hospital, Lausanne, Switzerland
    Am J Clin Nutr 97:246-54. 2013
    ..Fish oil (FO) has antiinflammatory effects, which might reduce systemic inflammation induced by a cardiopulmonary bypass (CPB)...
  41. pmc Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines
    Sandra Levrand
    Division of Critical Care, Division of Clinical Pathophysiology, Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland
    J Biol Chem 280:34878-87. 2005
    ..These findings offer new perspectives for the understanding of the relationships between redox stress and inflammation...
  42. ncbi request reprint The hemodynamics of septic shock: a historical perspective
    Francois Feihl
    Division de physiopathologie clinique, Departement de Medecine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Curr Vasc Pharmacol 11:133-8. 2013
    ..Siegel, which introduced the concept of deficient peripheral utilization of oxygen, inspiring later work on the microvascular disturbances of septic shock...
  43. ncbi request reprint Role of poly(adenosine diphosphate-ribose) polymerase 1 in septic peritonitis
    Lucas Liaudet
    Critical Care Division, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Curr Opin Crit Care 9:152-8. 2003
    ....
  44. ncbi request reprint Images in cardiovascular medicine. Rapid resolution of massive lung abscesses complicating tricuspid-valve endocarditis
    Yok Ai Que
    Department of Intensive Care Medicine, University Hospital, 1011 Lausanne, Switzerland
    Circulation 114:e523-4. 2006
  45. ncbi request reprint Endothelium-dependent vasodilation in the skin microcirculation of patients with septic shock
    Sandrine Kubli
    Division of Clinical Pathophysiology, University Hospital, CH 1011, Lausanne, Switzerland
    Shock 19:274-80. 2003
    ..These results suggest that the capacity of the endothelium to produce signals for vasorelaxation remains intact in the skin microcirculation of patients with septic shock...
  46. ncbi request reprint [Inotropic agents for treatment of acute heart failure syndromes in intensive care]
    Marco Rusca
    Service de médecine intensive adulte, CHUV, 1011 Lausanne
    Rev Med Suisse 5:2512-5. 2009
    ..In this article, we summarize the mechanisms of action of these different classes of drugs, and also discuss important issues regarding their clinical indications and the potential risks associated with their use...
  47. ncbi request reprint Poly(adenosine 5'-diphosphate) ribose polymerase activation as a cause of metabolic dysfunction in critical illness
    Lucas Liaudet
    Critical Care Division, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Curr Opin Clin Nutr Metab Care 5:175-84. 2002
    ....
  48. ncbi request reprint [New therapeutic strategies in severe sepsis and septic shock]
    Mauro Oddo
    Division des soins intensifs, Departement de Medecine, Interne CHUV, Lausanne
    Rev Med Suisse Romande 124:329-32. 2004
    ..This review will focus on these recently acquired therapeutic modalities, that are presently available to clinicians for the treatment of severe sepsis and septic shock...
  49. ncbi request reprint Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice
    Francisco Garcia Soriano
    Inotek Corporation, Beverly, Massachusetts 01915, USA
    Shock 17:286-92. 2002
    ..Thus, PARP activation has an important role in systemic inflammation and organ damage in the present model of polymicrobial septic shock...
  50. pmc Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure
    Pal Pacher
    National Institute on Alcohol Abuse and Alcoholism, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892 8115, USA
    Am J Physiol Heart Circ Physiol 287:H2132-7. 2004
    ..P-V analysis is a sensitive method to determine cardiac function in rats...
  51. pmc Nitrosative stress and pharmacological modulation of heart failure
    Pal Pacher
    Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2S24, Bethesda, MD 20892 9413, USA
    Trends Pharmacol Sci 26:302-10. 2005
    ....
  52. ncbi request reprint Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shock
    Oleg V Evgenov
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Curr Vasc Pharmacol 3:293-9. 2005
    ..Innovative therapeutic strategies based on the pharmacological inhibition of PARP-1 catalytic activity might provide benefits by preventing tissue injury, organ dysfunction, and lethality associated with these conditions...
  53. pmc A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging
    Pal Pacher
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park Bldg Rm 445, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892 8115, USA
    J Pharmacol Exp Ther 311:485-91. 2004
    ..Thus, pharmacological inhibition of PARP may represent a novel approach to improve cardiac and vascular dysfunction associated with aging...
  54. ncbi request reprint Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite-poly(ADP-ribose) polymerase connection
    Lucas Liaudet
    Inotek Pharmaceuticals Corporation, Beverly, Massachusetts 01915, USA
    Coron Artery Dis 14:115-22. 2003
  55. ncbi request reprint [Heart arrest: which reality and which training for the practitioner?]
    Vincent Ribordy
    Division des Soins Intensifs de médecin CHUV, Lausanne
    Rev Med Suisse Romande 124:321-4. 2004
    ....
  56. pmc Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
    ..Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review...
  57. ncbi request reprint Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity
    Peter Bai
    Inotek Pharmaceuticals Corporation, 100 Cummings Center, Suite 419E, Beverly, MA 01915, USA
    Oncol Rep 11:505-8. 2004
    ..These results demonstrate that MMP activation is an early event in DOX-induced cardiotoxicity and raises the possibility that MMP inhibitors may influence the outcome of this severe complication...
  58. pmc Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
    Mohanraj Rajesh
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
    J Leukoc Biol 82:1382-9. 2007
    ..These findings suggest that selective CB(2) receptor agonists may represent a novel, protective strategy against I/R injury by attenuating oxidative stress, inflammatory response, and apoptosis...
  59. ncbi request reprint Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging
    Pal Pacher
    Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    Int J Mol Med 9:659-64. 2002
    ..Thus, PARP activation contributes to the pathogenesis of endothelial dysfunction associated with hypertension and aging, but not in the current experimental model of atherosclerosis...
  60. ncbi request reprint Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents
    Pal Pacher
    Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    Biochem Pharmacol 64:1785-91. 2002
    ..Thus, PARP activation in the cardiovascular system is an important contributory factor to the cardiac collapse and death associated with endotoxin shock...
  61. pmc Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis
    Jon G Mabley
    Inotek Pharmaceuticals Corporation, Cummings Center, Beverly, Massachusetts 01905, USA
    Mol Med 8:581-90. 2002
    ..Here, using a novel peroxynitrite decomposition catalyst, FP15, we directly investigate the role of peroxynitrite in the pathogenesis of arthritis and colitis in rodent models...
  62. ncbi request reprint Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction
    Pal Pacher
    Inotek Pharmaceuticals Corp, Beverly, Mass 01915, USA
    Circulation 107:896-904. 2003
    ....
  63. pmc Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure
    Pal Pacher
    National Institutes of Health, NAAA, Bethesda, MD 20892 9413, USA
    Int J Mol Med 17:369-75. 2006
    ..The current data strengthen the view that PARP inhibition may represent an effective approach for the experimental therapy of various forms of acute and chronic heart failure...
  64. ncbi request reprint Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents
    Prakash Jagtap
    Inotek Corporation, Beverly, MA 01915, USA
    Crit Care Med 30:1071-82. 2002
    ....