Affiliation: Centre Hospitalier Universitaire Vaudois
- Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidenceRene Gysin
Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, 1008 Prilly Lausanne, Switzerland
Proc Natl Acad Sci U S A 104:16621-6. 2007..Taken together, the study provides genetic and functional evidence that an impaired capacity to synthesize GSH under conditions of oxidative stress is a vulnerability factor for schizophrenia...
- Skin fibroblast model to study an impaired glutathione synthesis: consequences of a genetic polymorphism on the proteomeRene Gysin
Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Switzerland
Brain Res Bull 79:46-52. 2009..Furthermore, the study corroborates the use of fibroblasts as an additional mean to study vulnerability factors of psychiatric diseases...
- Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophreniaRene Gysin
Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Site de Cery, Prilly, Lausanne, Switzerland
Antioxid Redox Signal 15:2003-10. 2011..This altered pattern potentially contributes to the development of a biomarker profile useful for early diagnosis and monitoring the effectiveness of novel drugs targeting redox dysregulation in schizophrenia...
- Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunitSuzie Lavoie
Department of Psychiatry, Center for Psychiatric Neuroscience, University Hospital Center and University of Lausanne, Lausanne, Switzerland
J Neurochem 108:1410-22. 2009..Our results indicate that GCLM is essential for the up-regulation of GCL activity induced by curcumin, quercetin and tBHQ...
- Interaction of GAG trinucleotide repeat and C-129T polymorphisms impairs expression of the glutamate-cysteine ligase catalytic subunit geneChristophe Butticaz
Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center of Lausanne, CH 1008 Prilly Lausanne, Switzerland
Free Radic Biol Med 50:617-23. 2011..These results provide evidence that interaction of the two variations can efficiently impair GCLC expression and thus suggest its involvement in the pathogenesis of diseases related to GSH metabolism...
- A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neuronsPascal Steullet
Center for Psychiatric Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Prilly Lausanne, Switzerland
Free Radic Biol Med 44:1042-54. 2008..This represents a mechanism by which dopaminergic systems could be dysfunctional under conditions of impaired glutathione synthesis as in schizophrenia...