Rene Gysin

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. doi request reprint Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia
    Rene Gysin
    Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Site de Cery, Prilly, Lausanne, Switzerland
    Antioxid Redox Signal 15:2003-10. 2011
  2. pmc Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence
    Rene Gysin
    Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, 1008 Prilly Lausanne, Switzerland
    Proc Natl Acad Sci U S A 104:16621-6. 2007
  3. doi request reprint Skin fibroblast model to study an impaired glutathione synthesis: consequences of a genetic polymorphism on the proteome
    Rene Gysin
    Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Switzerland
    Brain Res Bull 79:46-52. 2009
  4. doi request reprint Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit
    Suzie Lavoie
    Department of Psychiatry, Center for Psychiatric Neuroscience, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    J Neurochem 108:1410-22. 2009
  5. doi request reprint Interaction of GAG trinucleotide repeat and C-129T polymorphisms impairs expression of the glutamate-cysteine ligase catalytic subunit gene
    Christophe Butticaz
    Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center of Lausanne, CH 1008 Prilly Lausanne, Switzerland
    Free Radic Biol Med 50:617-23. 2011
  6. doi request reprint A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons
    Pascal Steullet
    Center for Psychiatric Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Prilly Lausanne, Switzerland
    Free Radic Biol Med 44:1042-54. 2008

Collaborators

Detail Information

Publications6

  1. doi request reprint Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia
    Rene Gysin
    Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Site de Cery, Prilly, Lausanne, Switzerland
    Antioxid Redox Signal 15:2003-10. 2011
    ..This altered pattern potentially contributes to the development of a biomarker profile useful for early diagnosis and monitoring the effectiveness of novel drugs targeting redox dysregulation in schizophrenia...
  2. pmc Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence
    Rene Gysin
    Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, 1008 Prilly Lausanne, Switzerland
    Proc Natl Acad Sci U S A 104:16621-6. 2007
    ..Taken together, the study provides genetic and functional evidence that an impaired capacity to synthesize GSH under conditions of oxidative stress is a vulnerability factor for schizophrenia...
  3. doi request reprint Skin fibroblast model to study an impaired glutathione synthesis: consequences of a genetic polymorphism on the proteome
    Rene Gysin
    Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Switzerland
    Brain Res Bull 79:46-52. 2009
    ..Furthermore, the study corroborates the use of fibroblasts as an additional mean to study vulnerability factors of psychiatric diseases...
  4. doi request reprint Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit
    Suzie Lavoie
    Department of Psychiatry, Center for Psychiatric Neuroscience, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    J Neurochem 108:1410-22. 2009
    ..Our results indicate that GCLM is essential for the up-regulation of GCL activity induced by curcumin, quercetin and tBHQ...
  5. doi request reprint Interaction of GAG trinucleotide repeat and C-129T polymorphisms impairs expression of the glutamate-cysteine ligase catalytic subunit gene
    Christophe Butticaz
    Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center of Lausanne, CH 1008 Prilly Lausanne, Switzerland
    Free Radic Biol Med 50:617-23. 2011
    ..These results provide evidence that interaction of the two variations can efficiently impair GCLC expression and thus suggest its involvement in the pathogenesis of diseases related to GSH metabolism...
  6. doi request reprint A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons
    Pascal Steullet
    Center for Psychiatric Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Prilly Lausanne, Switzerland
    Free Radic Biol Med 44:1042-54. 2008
    ..This represents a mechanism by which dopaminergic systems could be dysfunctional under conditions of impaired glutathione synthesis as in schizophrenia...