Louis Guillou

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Gro
    Louis Guillou
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 31:1387-402. 2007
  2. doi Soft tissue sarcomas with complex genomic profiles
    Louis Guillou
    University Institute of Pathology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 25, Lausanne, Switzerland
    Virchows Arch 456:201-17. 2010
  3. ncbi Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group
    Carole Gengler
    Department of Pathology, University Institute of Pathology, Lausanne, Switzerland
    Cancer 109:1584-98. 2007
  4. ncbi Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two cases
    Jean François Egger
    University Institute of Pathology, Lausanne, Switzerland
    Mod Pathol 15:998-1004. 2002
  5. ncbi Identification of cancer stem cells in Ewing's sarcoma
    Mario Luca Suva
    Division of Experimental Pathology and Division of Clinical Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
    Cancer Res 69:1776-81. 2009
  6. ncbi Digestive PEComas: a solution when the diagnosis fails to "fit"
    Muriel Genevay
    Institut Universitaire de Pathologie, Lausanne, Switzerland
    Ann Diagn Pathol 8:367-72. 2004
  7. doi Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas
    Andrea T Deyrup
    Department of Pathology, University of South Carolina School of Medicine Greenville, Greenville, SC Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA Department of Pathology and INSERM U916 Institut Bergonié Laboratory of Pathology, Universite Victor Segalen Bordeaux 2, Bordeaux, France Department of Pathology, University Hospital, Lausanne, Switzerland
    Am J Surg Pathol 37:1373-8. 2013
  8. ncbi Primary clear cell sarcoma of the ileum: an uncommon and misleading site
    Lorenzo Taminelli
    Department of Pathology, University Hospital, Lausanne, Switzerland
    Virchows Arch 447:772-7. 2005
  9. ncbi Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group
    Sandra Gebhard
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 26:601-16. 2002
  10. doi Early prediction of response to sunitinib after imatinib failure by 18F-fluorodeoxyglucose positron emission tomography in patients with gastrointestinal stromal tumor
    John O Prior
    Nuclear Medicine Department, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Clin Oncol 27:439-45. 2009

Collaborators

Detail Information

Publications42

  1. ncbi Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Gro
    Louis Guillou
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 31:1387-402. 2007
    ..The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related...
  2. doi Soft tissue sarcomas with complex genomic profiles
    Louis Guillou
    University Institute of Pathology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 25, Lausanne, Switzerland
    Virchows Arch 456:201-17. 2010
    ..In this paper, we review the cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles. Features of diagnostic or prognostic relevance will be discussed when needed...
  3. ncbi Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group
    Carole Gengler
    Department of Pathology, University Institute of Pathology, Lausanne, Switzerland
    Cancer 109:1584-98. 2007
    ....
  4. ncbi Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two cases
    Jean François Egger
    University Institute of Pathology, Lausanne, Switzerland
    Mod Pathol 15:998-1004. 2002
    ..We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas...
  5. ncbi Identification of cancer stem cells in Ewing's sarcoma
    Mario Luca Suva
    Division of Experimental Pathology and Division of Clinical Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
    Cancer Res 69:1776-81. 2009
    ....
  6. ncbi Digestive PEComas: a solution when the diagnosis fails to "fit"
    Muriel Genevay
    Institut Universitaire de Pathologie, Lausanne, Switzerland
    Ann Diagn Pathol 8:367-72. 2004
    ..Other differential diagnoses include rhabdomyosarcoma, paraganglioma, leiomyosarcoma, and clear cell sarcoma...
  7. doi Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas
    Andrea T Deyrup
    Department of Pathology, University of South Carolina School of Medicine Greenville, Greenville, SC Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA Department of Pathology and INSERM U916 Institut Bergonié Laboratory of Pathology, Universite Victor Segalen Bordeaux 2, Bordeaux, France Department of Pathology, University Hospital, Lausanne, Switzerland
    Am J Surg Pathol 37:1373-8. 2013
    ....
  8. ncbi Primary clear cell sarcoma of the ileum: an uncommon and misleading site
    Lorenzo Taminelli
    Department of Pathology, University Hospital, Lausanne, Switzerland
    Virchows Arch 447:772-7. 2005
    ..This case demonstrates that the gastrointestinal tract is a potential site for primary clear cell sarcoma of soft tissues, and, furthermore, that cytogenetics and/or molecular techniques play a central role in the diagnosis...
  9. ncbi Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group
    Sandra Gebhard
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 26:601-16. 2002
    ..It shows a wide range of morphologic appearances, but tumor grade and histology have no effect on patient outcome...
  10. doi Early prediction of response to sunitinib after imatinib failure by 18F-fluorodeoxyglucose positron emission tomography in patients with gastrointestinal stromal tumor
    John O Prior
    Nuclear Medicine Department, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Clin Oncol 27:439-45. 2009
    ....
  11. ncbi [The place of the pathologist in the management of tumors of soft tissue]
    Carole Gengler
    Institut Universitaire de Pathologie, CHUV, 1011 Lausanne
    Rev Med Suisse 3:1726-32. 2007
    ..Optimal management of the patient depends on a close collaboration between pathologists, surgeons, radiologists, oncologist and radiotherapists...
  12. ncbi Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomas
    Pu Yan
    University Institute of Pathology, Lausanne, Switzerland
    Int J Cancer 98:851-6. 2002
    ..Few STSs that showed a TRF pattern suggestive of alternative lengthening of telomeres (ALT) may contain ALT subpopulations...
  13. doi Osteoid osteoma and osteoid osteoma-mimicking lesions: biopsy findings, distinctive MDCT features and treatment by radiofrequency ablation
    Fabio Becce
    Department of Diagnostic and Interventional Radiology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011, Lausanne, Switzerland
    Eur Radiol 20:2439-46. 2010
    ..To report the biopsy findings of osteoid osteoma (OO) and OO-mimicking lesions, assess their distinctive multidetector computed tomography (MDCT) features and evaluate treatment by radiofrequency ablation (RFA)...
  14. pmc Soft-tissue textiloma: a potential diagnostic pitfall
    Elyazid Mouhsine
    Departments of Orthopaedic Surgery and Traumatology, University Hospital, Lausanne, Switzerland
    Can J Surg 48:495-6. 2005
  15. doi Well-differentiated papillary mesothelioma of the tunica vaginalis testis: imaging on Tc-99m heat-denatured red blood cell scintigraphy
    Yves Chollet
    Department of Urology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    Clin Nucl Med 33:282-4. 2008
    ..The patient underwent resection and histopathology revealed a well-differentiated papillary mesothelioma. Inguinal orchidectomy was subsequently performed and the patient was free of recurrence at 18 months...
  16. ncbi De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin
    Samuel Rotman
    Institute of Pathology, University Hospital, Lausanne, Switzerland
    Hum Pathol 37:481-7. 2006
    ..To our knowledge, this is the first report of de novo concurrent papillary RCC and angiomyolipoma in a renal allograft...
  17. ncbi Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma
    Nicolò Riggi
    Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
    Cancer Res 66:7016-23. 2006
    ..Taken together, our observations suggest that expression of FUS-CHOP may be the initiating event in myxoid liposarcoma pathogenesis, and that MPCs may constitute one cell type from which these tumors originate...
  18. ncbi Treatment of penile carcinoma: to cut or not to cut?
    Mahmut Ozsahin
    Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Int J Radiat Oncol Biol Phys 66:674-9. 2006
    ..The aim of this study was to assess the outcome in patients with penile cancer...
  19. doi Metastatic choroidal paraganglioma
    Ann Schalenbourg
    Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland
    Ophthalmology 118:2238-41. 2011
    ..To describe a patient with metastatic choroidal paraganglioma that was locally controlled with radiotherapy...
  20. ncbi Primary intrathoracic synovial sarcoma: a clinicopathologic study of 40 t(X;18)-positive cases from the French Sarcoma Group and the Mesopath Group
    Hugues Begueret
    From the Department of Pathology, Hopital Haut Leveque, Pessac, France
    Am J Surg Pathol 29:339-46. 2005
    ..In conclusion, intrathoracic SS are rare but aggressive tumors with poor prognosis. In this unusual location, the detection of SYT-SSX fusion transcripts is a valuable diagnostic adjunct...
  21. ncbi Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Lab Invest 85:408-15. 2005
    ..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion...
  22. ncbi Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR
    Nicolas Sirvent
    Laboratoire de Génétique Somatique des Tumeurs Solides, Faculte de Medecine, CNRS UMR 6543, Nice University Hospital, Avenue de Valombrose, 06100 Nice, France
    Am J Surg Pathol 31:1476-89. 2007
    ..In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone...
  23. ncbi Molecular detection of the synovial sarcoma translocation t(X;18) by real-time polymerase chain reaction in paraffin-embedded material
    Isabelle Hostein
    Department of Molecular Oncology, Institut Curie, Paris, France
    Diagn Mol Pathol 11:16-21. 2002
    ..In addition, the t(X;18) can be detected not only on frozen but also on paraffin-embedded tumor samples...
  24. ncbi Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group
    Marie Josee Terrier-Lacombe
    Department of Pathology, Gustave Roussy Institute, Villejuif, France
    Am J Surg Pathol 27:27-39. 2003
    ....
  25. ncbi Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive cases
    Manuela Pelmus
    Bergonie Institute, Bordeaux, France
    Am J Surg Pathol 26:1434-40. 2002
    ....
  26. ncbi [Detection of chromosomal abnormalities in soft tissue sarcomas: which sarcomas? Which abnormalities? How? Why?]
    Muriel Genevay
    Service de pathologie clinique, Hopital Cantonal Universitaire, Geneve, Suisse
    Bull Cancer 94:781-92. 2007
    ....
  27. ncbi Elevated (> or = 10%) MIB-1 proliferative index correlates with poor outcome in gastric stromal tumor patients: a study of 35 cases
    Claire Toquet
    Department of Pathology, University Hospital of Nantes, France
    Dig Dis Sci 47:2247-53. 2002
    ....
  28. ncbi SYT-SSX fusion is absent in sarcomatoid mesothelioma allowing its distinction from synovial sarcoma of the pleura
    Nicolas Weinbreck
    Departement de Pathologie, CHU de Nancy and EMI 014, Nancy, France
    Mod Pathol 20:617-21. 2007
    ..This result confirms the usefulness of this analysis in differentiating sarcomatoid mesothelioma from synovial sarcoma...
  29. ncbi Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas
    Matthieu Bui Nguyen Binh
    Department of Pathology, Institut Bergonié and Université Victor Segalen, Bordeaux, France
    Am J Surg Pathol 31:1557-66. 2007
    ..Moreover, DLPS with a myogenic component have a low metastatic potential, similar to conventional DLPS and significantly lower to the metastatic potential of leiomyosarcomas...
  30. ncbi Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues: clinicopathologic and molecular analysis of 44 patients from the French sarcoma group
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Cancer 107:1055-64. 2006
    ..The diagnosis of CCS usually is easy but may be challenging in unusual sites, and the detection of EWS-ATF1 fusion transcripts is helpful to rule out a metastatic melanoma...
  31. ncbi The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylation
    Isabelle Guilleret
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Carcinogenesis 23:2025-30. 2002
    ..In conclusion, this study shows that hTERC expression is indeed regulated during carcinogenesis, but this regulation is unlikely to depend on hTERC methylation, cell proliferation rate, telomere length or hTERT expression...
  32. ncbi A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas
    Frederic Chibon
    Institut National de la Sante et de la Recherche Medicale, U509, Curie Institute, Cedex, Paris, France
    Cancer Genet Cytogenet 139:24-9. 2002
    ....
  33. ncbi [Recent entities in soft tissue tumor pathology. Part 2]
    Muriel Genevay
    Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
    Ann Pathol 23:135-48. 2003
    ..The role of immunohistochemistry and molecular pathology in the identification and delineation of these new entities is emphasized...
  34. ncbi Short- and long-term prognostic value of postoperative cardiac troponin I concentration in patients undergoing coronary artery bypass grafting
    Jean Luc Fellahi
    Departement d Anesthesie Reanimation, Centre Hospitalier Privé Saint Martin, Caen, France
    Anesthesiology 99:270-4. 2003
    ..The authors therefore assessed the long-term prognostic value of cTnI in patients undergoing elective coronary artery bypass grafting...
  35. ncbi Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 cases
    Jean Michel Coindre
    Department of Pathology, Bergonie Institute, Bordeaux, France
    Cancer 98:2700-7. 2003
    ....
  36. ncbi High expression of peptide receptors as a novel target in gastrointestinal stromal tumours
    Jean Claude Reubi
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Murtenstrasse 31, PO Box 62, 3010 Bern, Switzerland
    Eur J Nucl Med Mol Imaging 31:803-10. 2004
    ....
  37. ncbi Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    J Pathol 203:822-30. 2004
    ..Quantitative PCR showed amplification of MDM2 in six and of CDK4 in seven of nine inflammatory MFHs. In conclusion, this study strongly suggests that most so-called inflammatory MFHs are dedifferentiated liposarcomas...
  38. ncbi Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis
    Louis Guillou
    Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
    J Clin Oncol 22:4040-50. 2004
    ..To assess the prognostic value of SYT-SSX fusion type, in comparison with other factors, in a population of 165 patients with synovial sarcoma (SS)...
  39. ncbi Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimens
    Isabelle Hostein
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Cancer 101:2817-24. 2004
    ..Two specific translocations have been found in ARMS, and fusion transcripts can be detected by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of paraffin-embedded tissue (PET)...
  40. ncbi MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data
    Matthieu Bui Nguyen Binh
    Department of Pathology at the Curie Institute, Paris, France
    Am J Surg Pathol 29:1340-7. 2005
    ..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas...
  41. ncbi Reproducibility of MDM2 and CDK4 staining in soft tissue tumors
    Matthieu Bui Nguyen Binh
    Department of Pathology, Bergonié Institute and University Victor Segalen, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Am J Clin Pathol 125:693-7. 2006
    ..80) and CDK4 (kappa, 0.93). Immunostaining for MDM2 and CDK4 is a reproducible technique that may be exported to different laboratories for routine use. Tissue microarray is indicated for studying large series...
  42. ncbi Malignant peripheral nerve sheath tumors are t(X;18)-negative sarcomas. Molecular analysis of 25 cases occurring in neurofibromatosis type 1 patients, using two different RT-PCR-based methods of detection
    Jean Michel Coindre
    Bergonié Institute and the University of Bordeaux 2, France
    Mod Pathol 15:589-92. 2002
    ..Laboratories that use PCR-based techniques for diagnostic purposes would benefit from quality assurance programs...