Research Topics
Species | Louis GuillouSummaryAffiliation: Centre Hospitalier Universitaire Vaudois Country: Switzerland Publications
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Publications
Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma GroLouis Guillou
University Institute of Pathology, Lausanne, Switzerland
Am J Surg Pathol 31:1387-402. 2007..The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related...
Soft tissue sarcomas with complex genomic profilesLouis Guillou
University Institute of Pathology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 25, Lausanne, Switzerland
Virchows Arch 456:201-17. 2010..In this paper, we review the cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles. Features of diagnostic or prognostic relevance will be discussed when needed...- Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma GroupCarole Gengler
Department of Pathology, University Institute of Pathology, Lausanne, Switzerland
Cancer 109:1584-98. 2007.... - Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two casesJean François Egger
University Institute of Pathology, Lausanne, Switzerland
Mod Pathol 15:998-1004. 2002..We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas... - Identification of cancer stem cells in Ewing's sarcomaMario Luca Suva
Division of Experimental Pathology and Division of Clinical Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
Cancer Res 69:1776-81. 2009.... - Digestive PEComas: a solution when the diagnosis fails to "fit"Muriel Genevay
Institut Universitaire de Pathologie, Lausanne, Switzerland
Ann Diagn Pathol 8:367-72. 2004..Other differential diagnoses include rhabdomyosarcoma, paraganglioma, leiomyosarcoma, and clear cell sarcoma... - Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma GroupSandra Gebhard
University Institute of Pathology, Lausanne, Switzerland
Am J Surg Pathol 26:601-16. 2002..It shows a wide range of morphologic appearances, but tumor grade and histology have no effect on patient outcome... - Early prediction of response to sunitinib after imatinib failure by 18F-fluorodeoxyglucose positron emission tomography in patients with gastrointestinal stromal tumorJohn O Prior
Nuclear Medicine Department, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
J Clin Oncol 27:439-45. 2009.... - Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomasPu Yan
University Institute of Pathology, Lausanne, Switzerland
Int J Cancer 98:851-6. 2002..Few STSs that showed a TRF pattern suggestive of alternative lengthening of telomeres (ALT) may contain ALT subpopulations... - Primary clear cell sarcoma of the ileum: an uncommon and misleading siteLorenzo Taminelli
Department of Pathology, University Hospital, Lausanne, Switzerland
Virchows Arch 447:772-7. 2005..This case demonstrates that the gastrointestinal tract is a potential site for primary clear cell sarcoma of soft tissues, and, furthermore, that cytogenetics and/or molecular techniques play a central role in the diagnosis... - [The place of the pathologist in the management of tumors of soft tissue]Carole Gengler
Institut Universitaire de Pathologie, CHUV, 1011 Lausanne
Rev Med Suisse 3:1726-32. 2007..Optimal management of the patient depends on a close collaboration between pathologists, surgeons, radiologists, oncologist and radiotherapists... 
Soft-tissue textiloma: a potential diagnostic pitfallElyazid Mouhsine
Departments of Orthopaedic Surgery and Traumatology, University Hospital, Lausanne, Switzerland
Can J Surg 48:495-6. 2005- Well-differentiated papillary mesothelioma of the tunica vaginalis testis: imaging on Tc-99m heat-denatured red blood cell scintigraphyYves Chollet
Department of Urology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
Clin Nucl Med 33:282-4. 2008..The patient underwent resection and histopathology revealed a well-differentiated papillary mesothelioma. Inguinal orchidectomy was subsequently performed and the patient was free of recurrence at 18 months... - Osteoid osteoma and osteoid osteoma-mimicking lesions: biopsy findings, distinctive MDCT features and treatment by radiofrequency ablationFabio Becce
Department of Diagnostic and Interventional Radiology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, 1011, Lausanne, Switzerland
Eur Radiol 20:2439-46. 2010..To report the biopsy findings of osteoid osteoma (OO) and OO-mimicking lesions, assess their distinctive multidetector computed tomography (MDCT) features and evaluate treatment by radiofrequency ablation (RFA)... - De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor originSamuel Rotman
Institute of Pathology, University Hospital, Lausanne, Switzerland
Hum Pathol 37:481-7. 2006..To our knowledge, this is the first report of de novo concurrent papillary RCC and angiomyolipoma in a renal allograft... - Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcomaNicolò Riggi
Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
Cancer Res 66:7016-23. 2006..Taken together, our observations suggest that expression of FUS-CHOP may be the initiating event in myxoid liposarcoma pathogenesis, and that MPCs may constitute one cell type from which these tumors originate... - Metastatic choroidal paragangliomaAnn Schalenbourg
Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland
Ophthalmology 118:2238-41. 2011..To describe a patient with metastatic choroidal paraganglioma that was locally controlled with radiotherapy... - Treatment of penile carcinoma: to cut or not to cut?Mahmut Ozsahin
Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Int J Radiat Oncol Biol Phys 66:674-9. 2006..The aim of this study was to assess the outcome in patients with penile cancer... - Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma GroupMarie Josee Terrier-Lacombe
Department of Pathology, Gustave Roussy Institute, Villejuif, France
Am J Surg Pathol 27:27-39. 2003.... - Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive casesManuela Pelmus
, Bordeaux, France
Am J Surg Pathol 26:1434-40. 2002.... - Primary intrathoracic synovial sarcoma: a clinicopathologic study of 40 t(X;18)-positive cases from the French Sarcoma Group and the Mesopath GroupHugues Begueret
From the Department of Pathology, Hopital Haut Leveque, Pessac, France
Am J Surg Pathol 29:339-46. 2005..In conclusion, intrathoracic SS are rare but aggressive tumors with poor prognosis. In this unusual location, the detection of SYT-SSX fusion transcripts is a valuable diagnostic adjunct... - Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion geneFredrik Mertens
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
Lab Invest 85:408-15. 2005..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion... - Molecular detection of the synovial sarcoma translocation t(X;18) by real-time polymerase chain reaction in paraffin-embedded materialIsabelle Hostein
Department of Molecular Oncology, Institut Curie, Paris, France
Diagn Mol Pathol 11:16-21. 2002..In addition, the t(X;18) can be detected not only on frozen but also on paraffin-embedded tumor samples... - Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCRNicolas Sirvent
Laboratoire de Génétique Somatique des Tumeurs Solides, Faculte de Medecine, CNRS UMR 6543, Nice University Hospital, Avenue de Valombrose, 06100 Nice, France
Am J Surg Pathol 31:1476-89. 2007..In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone... - The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylationIsabelle Guilleret
Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
Carcinogenesis 23:2025-30. 2002..In conclusion, this study shows that hTERC expression is indeed regulated during carcinogenesis, but this regulation is unlikely to depend on hTERC methylation, cell proliferation rate, telomere length or hTERT expression... - [Detection of chromosomal abnormalities in soft tissue sarcomas: which sarcomas? Which abnormalities? How? Why?]Muriel Genevay
Service de pathologie clinique, Hopital Cantonal Universitaire, Geneve, Suisse
Bull Cancer 94:781-92. 2007.... - Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomasMatthieu Bui Nguyen Binh
Department of Pathology, Institut Bergonié and Université Victor Segalen, Bordeaux, France
Am J Surg Pathol 31:1557-66. 2007..Moreover, DLPS with a myogenic component have a low metastatic potential, similar to conventional DLPS and significantly lower to the metastatic potential of leiomyosarcomas... - Elevated (> or = 10%) MIB-1 proliferative index correlates with poor outcome in gastric stromal tumor patients: a study of 35 casesClaire Toquet
Department of Pathology, University Hospital of Nantes, France
Dig Dis Sci 47:2247-53. 2002.... - Malignant peripheral nerve sheath tumors are t(X;18)-negative sarcomas. Molecular analysis of 25 cases occurring in neurofibromatosis type 1 patients, using two different RT-PCR-based methods of detectionJean-Michel Coindre
, France
Mod Pathol 15:589-92. 2002..Laboratories that use PCR-based techniques for diagnostic purposes would benefit from quality assurance programs... - A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomasFrederic Chibon
Institut National de la Sante et de la Recherche Medicale, U509, Curie Institute, Cedex, Paris, France
Cancer Genet Cytogenet 139:24-9. 2002.... - SYT-SSX fusion is absent in sarcomatoid mesothelioma allowing its distinction from synovial sarcoma of the pleuraNicolas Weinbreck
Departement de Pathologie, CHU de Nancy and EMI 014, Nancy, France
Mod Pathol 20:617-21. 2007..This result confirms the usefulness of this analysis in differentiating sarcomatoid mesothelioma from synovial sarcoma... - Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entityJean Michel Coindre
Department of Pathology, Institut Bergonie, Bordeaux, France
J Pathol 203:822-30. 2004..Quantitative PCR showed amplification of MDM2 in six and of CDK4 in seven of nine inflammatory MFHs. In conclusion, this study strongly suggests that most so-called inflammatory MFHs are dedifferentiated liposarcomas... - High expression of peptide receptors as a novel target in gastrointestinal stromal tumoursJean Claude Reubi
Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Murtenstrasse 31, PO Box 62, 3010 Bern, Switzerland
Eur J Nucl Med Mol Imaging 31:803-10. 2004.... - MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic dataMatthieu Bui Nguyen Binh
Department of Pathology at the Curie Institute, Paris, France
Am J Surg Pathol 29:1340-7. 2005..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas... - Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 casesJean Michel Coindre
Department of Pathology, Bergonie Institute, Bordeaux, France
Cancer 98:2700-7. 2003.... - Short- and long-term prognostic value of postoperative cardiac troponin I concentration in patients undergoing coronary artery bypass graftingJean Luc Fellahi
Departement d Anesthesie Reanimation, Centre Hospitalier Privé Saint Martin, Caen, France
Anesthesiology 99:270-4. 2003..The authors therefore assessed the long-term prognostic value of cTnI in patients undergoing elective coronary artery bypass grafting... - Reproducibility of MDM2 and CDK4 staining in soft tissue tumorsMatthieu Bui Nguyen Binh
Department of Pathology, , 229 cours de l'Argonne, , France
Am J Clin Pathol 125:693-7. 2006..80) and CDK4 (kappa, 0.93). Immunostaining for MDM2 and CDK4 is a reproducible technique that may be exported to different laboratories for routine use. Tissue microarray is indicated for studying large series... - Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysisLouis Guillou
Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
J Clin Oncol 22:4040-50. 2004..To assess the prognostic value of SYT-SSX fusion type, in comparison with other factors, in a population of 165 patients with synovial sarcoma (SS)... - Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues: clinicopathologic and molecular analysis of 44 patients from the French sarcoma groupJean Michel Coindre
Department of Pathology, Institut Bergonie, Bordeaux, France
Cancer 107:1055-64. 2006..The diagnosis of CCS usually is easy but may be challenging in unusual sites, and the detection of EWS-ATF1 fusion transcripts is helpful to rule out a metastatic melanoma... - [Recent entities in soft tissue tumor pathology. Part 2]Muriel Genevay
Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
Ann Pathol 23:135-48. 2003..The role of immunohistochemistry and molecular pathology in the identification and delineation of these new entities is emphasized... - Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimensIsabelle Hostein
Department of Pathology, Institut Bergoni, Bordeaux, France
Cancer 101:2817-24. 2004..Although RT-PCR analysis appears not to possess diagnostic value in tumors with < 50% tumor cell immunopositivity, it is strongly recommended for the diagnosis of tumors containing > 50% myogenin-positive cells...