Research Topics
| L GuillouSummaryAffiliation: Centre Hospitalier Universitaire Vaudois Country: Switzerland Publications
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Detail Information
Publications
Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcomaL Guillou
University Institute of Pathology, Lausanne, Switzerland
J Clin Oncol 15:350-62. 1997....- Solitary fibrous tumour and haemangiopericytoma: evolution of a conceptC Gengler
University Institute of Pathology, Rue du Bugnon 25, CH 1011 Lausanne, Switzerland
Histopathology 48:63-74. 2006..In practice, any HPC-like lesion can be allocated to one of these categories, leaving the ill-defined "haemangiopericytoma" category empty... - Orbital and extraorbital giant cell angiofibroma: a giant cell-rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying conceptL Guillou
University Institute of Pathology, Lausanne, Switzerland
Am J Surg Pathol 24:971-9. 2000..In addition, it shows that giant cell angiofibroma occurs equally in both sexes and has a wider distribution than initially thought, developing even more often in extraorbital locations than in the orbit... - Metastasizing fibrous histiocytoma of the skin: a clinicopathologic and immunohistochemical analysis of three casesL Guillou
Institute of Pathology of Lausanne, Switzerland
Mod Pathol 13:654-60. 2000..Risk factors for metastatic dissemination include large size, high cellularity, aneurysmal changes, marked cellular pleomorphism, high mitotic activity, tumor necrosis, and repeated local recurrences... - Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysisLouis Guillou
Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
J Clin Oncol 22:4040-50. 2004..To assess the prognostic value of SYT-SSX fusion type, in comparison with other factors, in a population of 165 patients with synovial sarcoma (SS)... - Limb salvage by neoadjuvant isolated perfusion with TNFalpha and melphalan for non-resectable soft tissue sarcoma of the extremitiesF J Lejeune
Multidisciplinary Oncology Centre, and Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
Eur J Surg Oncol 26:669-78. 2000..In order to avoid major amputations, we tested isolated limb perfusion (ILP) with tumour necrosis factor alpha (TNF)+melphalan+/-interferon-gamma (IFN) as a pre-operative, neoadjuvant limb salvage treatment... - Food-dependent Cushing's syndrome: possible involvement of leptin in cortisol hypersecretionF P Pralong
Department of Medicine, Institute of Pathology, University Hospital and Lausanne Medical School, Switzerland
J Clin Endocrinol Metab 84:3817-22. 1999..Further studies in other cases of food-dependent Cushing's syndrome, however, will be necessary to better ascertain the pathophysiological significance of this finding... - Soft-tissue textiloma: a potential diagnostic pitfallElyazid Mouhsine
Departments of Orthopaedic Surgery and Traumatology, University Hospital, Lausanne, Switzerland
Can J Surg 48:495-6. 2005 - De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor originSamuel Rotman
Institute of Pathology, University Hospital, Lausanne, Switzerland
Hum Pathol 37:481-7. 2006..To our knowledge, this is the first report of de novo concurrent papillary RCC and angiomyolipoma in a renal allograft... - Treatment of advanced soft-tissue sarcomas using a combined strategy of high-dose ifosfamide, high-dose doxorubicin and salvage therapiesS Leyvraz
Centre Pluridisciplinaire d Oncologie, University Hospital, CHUV BH06, Rue du Bugnon 46, Lausanne, Switzerland
Br J Cancer 95:1342-7. 2006..This high-dose regimen is toxic but nonetheless feasible in multicentre settings in non elderly patients with good performance status. A high response rate was obtained. Prolonged survival was mainly a function of salvage therapies... - Newly described adipocytic lesionsL Guillou
University Institute of Pathology, Lausanne, Switzerland
Semin Diagn Pathol 18:238-49. 2001.... - Digestive PEComas: a solution when the diagnosis fails to "fit"Muriel Genevay
Institut Universitaire de Pathologie, Lausanne, Switzerland
Ann Diagn Pathol 8:367-72. 2004..Other differential diagnoses include rhabdomyosarcoma, paraganglioma, leiomyosarcoma, and clear cell sarcoma... - Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma GroupSandra Gebhard
University Institute of Pathology, Lausanne, Switzerland
Am J Surg Pathol 26:601-16. 2002..It shows a wide range of morphologic appearances, but tumor grade and histology have no effect on patient outcome... - Primary heterologous carcinosarcoma (metaplastic carcinoma) of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literatureL Perret
University Institute of Pathology, Lausanne, Switzerland
Cancer 82:1535-49. 1998..Histogenetically, some heterologous carcinosarcomas should be regarded as a variant of sarcomatoid carcinoma (metaplastic carcinoma) that shows prominent heterologous differentiation... - A gene expression signature that distinguishes desmoid tumours from nodular fasciitisM Bacac
Division of Experimental Pathology, University Institute of Pathology, Lausanne, Switzerland
J Pathol 208:543-53. 2006.... - Pathologic fracture of the femur neck as first manifestation of a minute columnar cell carcinoma of the thyroid glandC Y Genton
Institute of Pathology, Orthopedic Hospital, University Hospital CHUV, Lausanne, Switzerland
Pathol Res Pract 194:861-3; discussion 865-6. 1998.... - Primary clear cell sarcoma of the ileum: an uncommon and misleading siteLorenzo Taminelli
Department of Pathology, University Hospital, Lausanne, Switzerland
Virchows Arch 447:772-7. 2005..This case demonstrates that the gastrointestinal tract is a potential site for primary clear cell sarcoma of soft tissues, and, furthermore, that cytogenetics and/or molecular techniques play a central role in the diagnosis... - Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancerA Marti
Department of Urology, University Hospital, Lausanne, Switzerland
J Urol 170:428-32. 2003..This approach allows us to optimize PpIX tissue distribution for photodynamic therapy in superficial bladder cancer... - Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma GroLouis Guillou
University Institute of Pathology, Lausanne, Switzerland
Am J Surg Pathol 31:1387-402. 2007..The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related... - [Fibroblastic and myofibroblastic tumors of the head and neck]Essia Saiji
CHU Vaudois, Institut Universitaire de Pathologie, Universite de Lausanne, Rue du Bugnon 25, 1011 Lausanne, Suisse
Ann Pathol 29:335-46. 2009.... - Treatment of penile carcinoma: to cut or not to cut?Mahmut Ozsahin
Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Int J Radiat Oncol Biol Phys 66:674-9. 2006..However, there is no difference in survival between patients treated with surgery and those treated with definitive RT, with 52% organ preservation... - [The place of the pathologist in the management of tumors of soft tissue]Carole Gengler
Institut Universitaire de Pathologie, CHUV, 1011 Lausanne
Rev Med Suisse 3:1726-32. 2007..Optimal management of the patient depends on a close collaboration between pathologists, surgeons, radiologists, oncologist and radiotherapists... - [Recent entities in soft tissue tumor pathology. Part 2]Muriel Genevay
Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
Ann Pathol 23:135-48. 2003..The role of immunohistochemistry and molecular pathology in the identification and delineation of these new entities is emphasized... - Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomasPu Yan
University Institute of Pathology, Lausanne, Switzerland
Int J Cancer 98:851-6. 2002..Few STSs that showed a TRF pattern suggestive of alternative lengthening of telomeres (ALT) may contain ALT subpopulations... - Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive casesManuela Pelmus
, Bordeaux, France
Am J Surg Pathol 26:1434-40. 2002.... - Molecular detection of the synovial sarcoma translocation t(X;18) by real-time polymerase chain reaction in paraffin-embedded materialIsabelle Hostein
Department of Molecular Oncology, Institut Curie, Paris, France
Diagn Mol Pathol 11:16-21. 2002..In addition, the t(X;18) can be detected not only on frozen but also on paraffin-embedded tumor samples... - Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion geneFredrik Mertens
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
Lab Invest 85:408-15. 2005..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion... - [Detection of chromosomal abnormalities in soft tissue sarcomas: which sarcomas? Which abnormalities? How? Why?]Muriel Genevay
Service de pathologie clinique, Hopital Cantonal Universitaire, Geneve, Suisse
Bull Cancer 94:781-92. 2007.... - Determination of the threshold of cardiac troponin I associated with an adverse postoperative outcome after cardiac surgery: a comparative study between coronary artery bypass graft, valve surgery, and combined cardiac surgeryJean Luc Fellahi
Centre Hospitalier Privé Saint Martin, 18 rue des Roquemonts, 14050 Caen Cedex 4, France
Crit Care 11:R106. 2007.... - SYT-SSX fusion is absent in sarcomatoid mesothelioma allowing its distinction from synovial sarcoma of the pleuraNicolas Weinbreck
Departement de Pathologie, CHU de Nancy and EMI 014, Nancy, France
Mod Pathol 20:617-21. 2007..This result confirms the usefulness of this analysis in differentiating sarcomatoid mesothelioma from synovial sarcoma... - Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCRNicolas Sirvent
Laboratoire de Génétique Somatique des Tumeurs Solides, Faculte de Medecine, CNRS UMR 6543, Nice University Hospital, Avenue de Valombrose, 06100 Nice, France
Am J Surg Pathol 31:1476-89. 2007..In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone... - Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomasMatthieu Bui Nguyen Binh
Department of Pathology, Institut Bergonié and Université Victor Segalen, Bordeaux, France
Am J Surg Pathol 31:1557-66. 2007..Moreover, DLPS with a myogenic component have a low metastatic potential, similar to conventional DLPS and significantly lower to the metastatic potential of leiomyosarcomas... - Malignant peripheral nerve sheath tumors are t(X;18)-negative sarcomas. Molecular analysis of 25 cases occurring in neurofibromatosis type 1 patients, using two different RT-PCR-based methods of detectionJean-Michel Coindre
, France
Mod Pathol 15:589-92. 2002..Laboratories that use PCR-based techniques for diagnostic purposes would benefit from quality assurance programs... - Elevated (> or = 10%) MIB-1 proliferative index correlates with poor outcome in gastric stromal tumor patients: a study of 35 casesClaire Toquet
Department of Pathology, University Hospital of Nantes, France
Dig Dis Sci 47:2247-53. 2002.... - Comparison of neoadjuvant cisplatin-based chemotherapy versus radiochemotherapy followed by resection for stage III (N2) NSCLCEdgardo Pezzetta
Department of Thoracic Surgery, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1011 Lausanne, Switzerland
Eur J Cardiothorac Surg 27:1092-8. 2005.... - Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimensIsabelle Hostein
Department of Pathology, Institut Bergoni, Bordeaux, France
Cancer 101:2817-24. 2004..Although RT-PCR analysis appears not to possess diagnostic value in tumors with < 50% tumor cell immunopositivity, it is strongly recommended for the diagnosis of tumors containing > 50% myogenin-positive cells... - MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic dataMatthieu Bui Nguyen Binh
Department of Pathology at the Curie Institute, Paris, France
Am J Surg Pathol 29:1340-7. 2005..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas... - Motility-related protein 1 (MRP-1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progressionPaulette Mhawech
Department of Pathology, Geneva University Hospital, Geneva, Switzerland
Cancer 98:1649-57. 2003.... - Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 casesJean-Michel Coindre
Department of Pathology, , Bordeaux, France
Cancer 98:2700-7. 2003.... - Reproducibility of MDM2 and CDK4 staining in soft tissue tumorsMatthieu Bui Nguyen Binh
Department of Pathology, , 229 cours de l'Argonne, , France
Am J Clin Pathol 125:693-7. 2006..80) and CDK4 (kappa, 0.93). Immunostaining for MDM2 and CDK4 is a reproducible technique that may be exported to different laboratories for routine use. Tissue microarray is indicated for studying large series... - Alpha-methyl CoA racemase expression in renal cell carcinomasVincent Molinie
Department of Pathology, Hopital Saint Joseph, 75014 Paris Cedex, France
Hum Pathol 37:698-703. 2006.... - Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues: clinicopathologic and molecular analysis of 44 patients from the French sarcoma groupJean Michel Coindre
Department of Pathology, Institut Bergonie, Bordeaux, France
Cancer 107:1055-64. 2006..The diagnosis of CCS usually is easy but may be challenging in unusual sites, and the detection of EWS-ATF1 fusion transcripts is helpful to rule out a metastatic melanoma...