L Guillou

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi request reprint Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma
    L Guillou
    University Institute of Pathology, Lausanne, Switzerland
    J Clin Oncol 15:350-62. 1997
  2. ncbi request reprint Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis
    Louis Guillou
    Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
    J Clin Oncol 22:4040-50. 2004
  3. ncbi request reprint Solitary fibrous tumour and haemangiopericytoma: evolution of a concept
    C Gengler
    University Institute of Pathology, Rue du Bugnon 25, CH 1011 Lausanne, Switzerland
    Histopathology 48:63-74. 2006
  4. ncbi request reprint Metastasizing fibrous histiocytoma of the skin: a clinicopathologic and immunohistochemical analysis of three cases
    L Guillou
    Institute of Pathology of Lausanne, Switzerland
    Mod Pathol 13:654-60. 2000
  5. ncbi request reprint Orbital and extraorbital giant cell angiofibroma: a giant cell-rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying concept
    L Guillou
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 24:971-9. 2000
  6. ncbi request reprint Limb salvage by neoadjuvant isolated perfusion with TNFalpha and melphalan for non-resectable soft tissue sarcoma of the extremities
    F J Lejeune
    Multidisciplinary Oncology Centre, and Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Eur J Surg Oncol 26:669-78. 2000
  7. ncbi request reprint Food-dependent Cushing's syndrome: possible involvement of leptin in cortisol hypersecretion
    F P Pralong
    Department of Medicine, Institute of Pathology, University Hospital and Lausanne Medical School, Switzerland
    J Clin Endocrinol Metab 84:3817-22. 1999
  8. pmc Soft-tissue textiloma: a potential diagnostic pitfall
    Elyazid Mouhsine
    Departments of Orthopaedic Surgery and Traumatology, University Hospital, Lausanne, Switzerland
    Can J Surg 48:495-6. 2005
  9. ncbi request reprint De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin
    Samuel Rotman
    Institute of Pathology, University Hospital, Lausanne, Switzerland
    Hum Pathol 37:481-7. 2006
  10. pmc Treatment of advanced soft-tissue sarcomas using a combined strategy of high-dose ifosfamide, high-dose doxorubicin and salvage therapies
    S Leyvraz
    Centre Pluridisciplinaire d Oncologie, University Hospital, CHUV BH06, Rue du Bugnon 46, Lausanne, Switzerland
    Br J Cancer 95:1342-7. 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma
    L Guillou
    University Institute of Pathology, Lausanne, Switzerland
    J Clin Oncol 15:350-62. 1997
    ....
  2. ncbi request reprint Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis
    Louis Guillou
    Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
    J Clin Oncol 22:4040-50. 2004
    ..To assess the prognostic value of SYT-SSX fusion type, in comparison with other factors, in a population of 165 patients with synovial sarcoma (SS)...
  3. ncbi request reprint Solitary fibrous tumour and haemangiopericytoma: evolution of a concept
    C Gengler
    University Institute of Pathology, Rue du Bugnon 25, CH 1011 Lausanne, Switzerland
    Histopathology 48:63-74. 2006
    ..In practice, any HPC-like lesion can be allocated to one of these categories, leaving the ill-defined "haemangiopericytoma" category empty...
  4. ncbi request reprint Metastasizing fibrous histiocytoma of the skin: a clinicopathologic and immunohistochemical analysis of three cases
    L Guillou
    Institute of Pathology of Lausanne, Switzerland
    Mod Pathol 13:654-60. 2000
    ..Risk factors for metastatic dissemination include large size, high cellularity, aneurysmal changes, marked cellular pleomorphism, high mitotic activity, tumor necrosis, and repeated local recurrences...
  5. ncbi request reprint Orbital and extraorbital giant cell angiofibroma: a giant cell-rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying concept
    L Guillou
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 24:971-9. 2000
    ..In addition, it shows that giant cell angiofibroma occurs equally in both sexes and has a wider distribution than initially thought, developing even more often in extraorbital locations than in the orbit...
  6. ncbi request reprint Limb salvage by neoadjuvant isolated perfusion with TNFalpha and melphalan for non-resectable soft tissue sarcoma of the extremities
    F J Lejeune
    Multidisciplinary Oncology Centre, and Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Eur J Surg Oncol 26:669-78. 2000
    ..In order to avoid major amputations, we tested isolated limb perfusion (ILP) with tumour necrosis factor alpha (TNF)+melphalan+/-interferon-gamma (IFN) as a pre-operative, neoadjuvant limb salvage treatment...
  7. ncbi request reprint Food-dependent Cushing's syndrome: possible involvement of leptin in cortisol hypersecretion
    F P Pralong
    Department of Medicine, Institute of Pathology, University Hospital and Lausanne Medical School, Switzerland
    J Clin Endocrinol Metab 84:3817-22. 1999
    ..Further studies in other cases of food-dependent Cushing's syndrome, however, will be necessary to better ascertain the pathophysiological significance of this finding...
  8. pmc Soft-tissue textiloma: a potential diagnostic pitfall
    Elyazid Mouhsine
    Departments of Orthopaedic Surgery and Traumatology, University Hospital, Lausanne, Switzerland
    Can J Surg 48:495-6. 2005
  9. ncbi request reprint De novo concurrent papillary renal cell carcinoma and angiomyolipoma in a kidney allograft: evidence of donor origin
    Samuel Rotman
    Institute of Pathology, University Hospital, Lausanne, Switzerland
    Hum Pathol 37:481-7. 2006
    ..To our knowledge, this is the first report of de novo concurrent papillary RCC and angiomyolipoma in a renal allograft...
  10. pmc Treatment of advanced soft-tissue sarcomas using a combined strategy of high-dose ifosfamide, high-dose doxorubicin and salvage therapies
    S Leyvraz
    Centre Pluridisciplinaire d Oncologie, University Hospital, CHUV BH06, Rue du Bugnon 46, Lausanne, Switzerland
    Br J Cancer 95:1342-7. 2006
    ..This high-dose regimen is toxic but nonetheless feasible in multicentre settings in non elderly patients with good performance status. A high response rate was obtained. Prolonged survival was mainly a function of salvage therapies...
  11. ncbi request reprint A gene expression signature that distinguishes desmoid tumours from nodular fasciitis
    M Bacac
    Division of Experimental Pathology, University Institute of Pathology, Lausanne, Switzerland
    J Pathol 208:543-53. 2006
    ....
  12. ncbi request reprint Newly described adipocytic lesions
    L Guillou
    University Institute of Pathology, Lausanne, Switzerland
    Semin Diagn Pathol 18:238-49. 2001
    ....
  13. ncbi request reprint Digestive PEComas: a solution when the diagnosis fails to "fit"
    Muriel Genevay
    Institut Universitaire de Pathologie, Lausanne, Switzerland
    Ann Diagn Pathol 8:367-72. 2004
    ..Other differential diagnoses include rhabdomyosarcoma, paraganglioma, leiomyosarcoma, and clear cell sarcoma...
  14. ncbi request reprint Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group
    Sandra Gebhard
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 26:601-16. 2002
    ..It shows a wide range of morphologic appearances, but tumor grade and histology have no effect on patient outcome...
  15. ncbi request reprint Primary heterologous carcinosarcoma (metaplastic carcinoma) of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literature
    L Perret
    University Institute of Pathology, Lausanne, Switzerland
    Cancer 82:1535-49. 1998
    ..Histogenetically, some heterologous carcinosarcomas should be regarded as a variant of sarcomatoid carcinoma (metaplastic carcinoma) that shows prominent heterologous differentiation...
  16. ncbi request reprint Pathologic fracture of the femur neck as first manifestation of a minute columnar cell carcinoma of the thyroid gland
    C Y Genton
    Institute of Pathology, Orthopedic Hospital, University Hospital CHUV, Lausanne, Switzerland
    Pathol Res Pract 194:861-3; discussion 865-6. 1998
    ....
  17. ncbi request reprint Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two cases
    Jean François Egger
    University Institute of Pathology, Lausanne, Switzerland
    Mod Pathol 15:998-1004. 2002
    ..We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas...
  18. ncbi request reprint Primary clear cell sarcoma of the ileum: an uncommon and misleading site
    Lorenzo Taminelli
    Department of Pathology, University Hospital, Lausanne, Switzerland
    Virchows Arch 447:772-7. 2005
    ..This case demonstrates that the gastrointestinal tract is a potential site for primary clear cell sarcoma of soft tissues, and, furthermore, that cytogenetics and/or molecular techniques play a central role in the diagnosis...
  19. ncbi request reprint Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer
    A Marti
    Department of Urology, University Hospital, Lausanne, Switzerland
    J Urol 170:428-32. 2003
    ....
  20. ncbi request reprint Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Gro
    Louis Guillou
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 31:1387-402. 2007
    ..The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related...
  21. ncbi request reprint Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma
    Nicolò Riggi
    Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
    Cancer Res 66:7016-23. 2006
    ..Taken together, our observations suggest that expression of FUS-CHOP may be the initiating event in myxoid liposarcoma pathogenesis, and that MPCs may constitute one cell type from which these tumors originate...
  22. doi request reprint [Fibroblastic and myofibroblastic tumors of the head and neck]
    Essia Saiji
    CHU Vaudois, Institut Universitaire de Pathologie, Universite de Lausanne, Rue du Bugnon 25, 1011 Lausanne, Suisse
    Ann Pathol 29:335-46. 2009
    ....
  23. ncbi request reprint Treatment of penile carcinoma: to cut or not to cut?
    Mahmut Ozsahin
    Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Int J Radiat Oncol Biol Phys 66:674-9. 2006
    ..The aim of this study was to assess the outcome in patients with penile cancer...
  24. ncbi request reprint [The place of the pathologist in the management of tumors of soft tissue]
    Carole Gengler
    Institut Universitaire de Pathologie, CHUV, 1011 Lausanne
    Rev Med Suisse 3:1726-32. 2007
    ..Optimal management of the patient depends on a close collaboration between pathologists, surgeons, radiologists, oncologist and radiotherapists...
  25. ncbi request reprint [Recent entities in soft tissue tumor pathology. Part 2]
    Muriel Genevay
    Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
    Ann Pathol 23:135-48. 2003
    ..The role of immunohistochemistry and molecular pathology in the identification and delineation of these new entities is emphasized...
  26. ncbi request reprint Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomas
    Pu Yan
    University Institute of Pathology, Lausanne, Switzerland
    Int J Cancer 98:851-6. 2002
    ..Few STSs that showed a TRF pattern suggestive of alternative lengthening of telomeres (ALT) may contain ALT subpopulations...
  27. ncbi request reprint Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive cases
    Manuela Pelmus
    Bergonie Institute, Bordeaux, France
    Am J Surg Pathol 26:1434-40. 2002
    ....
  28. ncbi request reprint Molecular detection of the synovial sarcoma translocation t(X;18) by real-time polymerase chain reaction in paraffin-embedded material
    Isabelle Hostein
    Department of Molecular Oncology, Institut Curie, Paris, France
    Diagn Mol Pathol 11:16-21. 2002
    ..In addition, the t(X;18) can be detected not only on frozen but also on paraffin-embedded tumor samples...
  29. ncbi request reprint Primary intrathoracic synovial sarcoma: a clinicopathologic study of 40 t(X;18)-positive cases from the French Sarcoma Group and the Mesopath Group
    Hugues Begueret
    From the Department of Pathology, Hopital Haut Leveque, Pessac, France
    Am J Surg Pathol 29:339-46. 2005
    ..In conclusion, intrathoracic SS are rare but aggressive tumors with poor prognosis. In this unusual location, the detection of SYT-SSX fusion transcripts is a valuable diagnostic adjunct...
  30. ncbi request reprint Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Lab Invest 85:408-15. 2005
    ..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion...
  31. ncbi request reprint [Detection of chromosomal abnormalities in soft tissue sarcomas: which sarcomas? Which abnormalities? How? Why?]
    Muriel Genevay
    Service de pathologie clinique, Hopital Cantonal Universitaire, Geneve, Suisse
    Bull Cancer 94:781-92. 2007
    ....
  32. pmc Determination of the threshold of cardiac troponin I associated with an adverse postoperative outcome after cardiac surgery: a comparative study between coronary artery bypass graft, valve surgery, and combined cardiac surgery
    Jean Luc Fellahi
    Centre Hospitalier Privé Saint Martin, 18 rue des Roquemonts, 14050 Caen Cedex 4, France
    Crit Care 11:R106. 2007
    ....
  33. ncbi request reprint SYT-SSX fusion is absent in sarcomatoid mesothelioma allowing its distinction from synovial sarcoma of the pleura
    Nicolas Weinbreck
    Departement de Pathologie, CHU de Nancy and EMI 014, Nancy, France
    Mod Pathol 20:617-21. 2007
    ..This result confirms the usefulness of this analysis in differentiating sarcomatoid mesothelioma from synovial sarcoma...
  34. ncbi request reprint Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR
    Nicolas Sirvent
    Laboratoire de Génétique Somatique des Tumeurs Solides, Faculte de Medecine, CNRS UMR 6543, Nice University Hospital, Avenue de Valombrose, 06100 Nice, France
    Am J Surg Pathol 31:1476-89. 2007
    ..In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone...
  35. ncbi request reprint Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas
    Matthieu Bui Nguyen Binh
    Department of Pathology, Institut Bergonié and Université Victor Segalen, Bordeaux, France
    Am J Surg Pathol 31:1557-66. 2007
    ..Moreover, DLPS with a myogenic component have a low metastatic potential, similar to conventional DLPS and significantly lower to the metastatic potential of leiomyosarcomas...
  36. ncbi request reprint Malignant peripheral nerve sheath tumors are t(X;18)-negative sarcomas. Molecular analysis of 25 cases occurring in neurofibromatosis type 1 patients, using two different RT-PCR-based methods of detection
    Jean Michel Coindre
    Bergonié Institute and the University of Bordeaux 2, France
    Mod Pathol 15:589-92. 2002
    ..Laboratories that use PCR-based techniques for diagnostic purposes would benefit from quality assurance programs...
  37. ncbi request reprint Elevated (> or = 10%) MIB-1 proliferative index correlates with poor outcome in gastric stromal tumor patients: a study of 35 cases
    Claire Toquet
    Department of Pathology, University Hospital of Nantes, France
    Dig Dis Sci 47:2247-53. 2002
    ....
  38. ncbi request reprint Comparison of neoadjuvant cisplatin-based chemotherapy versus radiochemotherapy followed by resection for stage III (N2) NSCLC
    Edgardo Pezzetta
    Department of Thoracic Surgery, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH 1011 Lausanne, Switzerland
    Eur J Cardiothorac Surg 27:1092-8. 2005
    ....
  39. ncbi request reprint Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimens
    Isabelle Hostein
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Cancer 101:2817-24. 2004
    ..Two specific translocations have been found in ARMS, and fusion transcripts can be detected by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of paraffin-embedded tissue (PET)...
  40. ncbi request reprint MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data
    Matthieu Bui Nguyen Binh
    Department of Pathology at the Curie Institute, Paris, France
    Am J Surg Pathol 29:1340-7. 2005
    ..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas...
  41. ncbi request reprint Motility-related protein 1 (MRP-1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progression
    Paulette Mhawech
    Department of Pathology, Geneva University Hospital, Geneva, Switzerland
    Cancer 98:1649-57. 2003
    ....
  42. ncbi request reprint Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 cases
    Jean Michel Coindre
    Department of Pathology, Bergonie Institute, Bordeaux, France
    Cancer 98:2700-7. 2003
    ....
  43. ncbi request reprint Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group
    Marie Josee Terrier-Lacombe
    Department of Pathology, Gustave Roussy Institute, Villejuif, France
    Am J Surg Pathol 27:27-39. 2003
    ....
  44. ncbi request reprint Reproducibility of MDM2 and CDK4 staining in soft tissue tumors
    Matthieu Bui Nguyen Binh
    Department of Pathology, Bergonié Institute and University Victor Segalen, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Am J Clin Pathol 125:693-7. 2006
    ..80) and CDK4 (kappa, 0.93). Immunostaining for MDM2 and CDK4 is a reproducible technique that may be exported to different laboratories for routine use. Tissue microarray is indicated for studying large series...
  45. ncbi request reprint Alpha-methyl CoA racemase expression in renal cell carcinomas
    Vincent Molinie
    Department of Pathology, Hopital Saint Joseph, 75014 Paris Cedex, France
    Hum Pathol 37:698-703. 2006
    ....
  46. ncbi request reprint Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues: clinicopathologic and molecular analysis of 44 patients from the French sarcoma group
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Cancer 107:1055-64. 2006
    ..The diagnosis of CCS usually is easy but may be challenging in unusual sites, and the detection of EWS-ATF1 fusion transcripts is helpful to rule out a metastatic melanoma...