C B Eap

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt
    Chin B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Centre des Neurosciences Psychiatriques, Département de Psychiatrie Centre Hospitalier Universitaire Vaudois, Prilly, Switzerland
    Hypertension 49:1007-14. 2007
  2. ncbi Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans
    Chin B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Hôpital de Cery, Lausanne, Switzerland
    Pharmacogenetics 13:39-47. 2003
  3. ncbi Cytochrome P450 2D6 genotype and methadone steady-state concentrations
    C B Eap
    Departement universitaire de psychiatrie adulte, H pital de Cery, Prilly Lausanne, Switzerland
    J Clin Psychopharmacol 21:229-34. 2001
  4. ncbi Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test
    C B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, University Department of Adult Psychiatry, Cery Hospital, CH Prilly Lausanne, Switzerland
    Ther Drug Monit 23:228-31. 2001
  5. ncbi Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers
    C B Eap
    Département Universitaire de Psychiatre Adulte, Hĵpital de Cery, Prilly Lausanne, Switzerland
    J Clin Psychopharmacol 21:330-4. 2001
  6. ncbi Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects
    Chin B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neurosciences, University Department of Adult Psychiatry, Hôpital de Cery, 1008 Prilly Lausanne, Switzerland
    Eur J Clin Pharmacol 60:231-6. 2004
  7. ncbi Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity
    Chin B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neurosciences, University Department of Adult Psychiatry, Prilly Lausanne, Switzerland
    Eur J Clin Pharmacol 60:237-46. 2004
  8. ncbi CYP3A activity measured by the midazolam test is not related to 3435 C >T polymorphism in the multiple drug resistance transporter gene
    Chin B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neurosciences, University Department of Adult Psychiatry, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    Pharmacogenetics 14:255-60. 2004
  9. ncbi Determination of picogram levels of midazolam, and 1- and 4-hydroxymidazolam in human plasma by gas chromatography-negative chemical ionization-mass spectrometry
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Département universitaire, de Psychiatrie Adulte, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 802:339-45. 2004
  10. ncbi Increase of oral methadone dose in methadone injecting patients: a pilot study
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    J Addict Dis 22:7-17. 2003

Detail Information

Publications76

  1. ncbi CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt
    Chin B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Centre des Neurosciences Psychiatriques, Département de Psychiatrie Centre Hospitalier Universitaire Vaudois, Prilly, Switzerland
    Hypertension 49:1007-14. 2007
    ....
  2. ncbi Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans
    Chin B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Hôpital de Cery, Lausanne, Switzerland
    Pharmacogenetics 13:39-47. 2003
    ..In contrast, data obtained on the partial metabolic clearance of (R)- and (S)-venlafaxine to N-demethylated metabolites, a reaction which is mediated by CYP3A4, suggest a lack of stereoselectivity of this enzyme...
  3. ncbi Cytochrome P450 2D6 genotype and methadone steady-state concentrations
    C B Eap
    Departement universitaire de psychiatrie adulte, H pital de Cery, Prilly Lausanne, Switzerland
    J Clin Psychopharmacol 21:229-34. 2001
    ..More studies are needed to examine the influence of the ultrarapid metabolizer status on the outcome of the MMT...
  4. ncbi Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test
    C B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, University Department of Adult Psychiatry, Cery Hospital, CH Prilly Lausanne, Switzerland
    Ther Drug Monit 23:228-31. 2001
    ..The reported increase of clozapine concentrations by risperidone can therefore not be explained by an inhibition of CYP1A2, CYP2D6, CYP2C19 or by any combination of the three...
  5. ncbi Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers
    C B Eap
    Département Universitaire de Psychiatre Adulte, Hĵpital de Cery, Prilly Lausanne, Switzerland
    J Clin Psychopharmacol 21:330-4. 2001
    ..The data also clearly show that the CYP2D6 genotype has an important influence on the concentrations of the (S)- but not of the (R)-enantiomer of FLX and NFLX after multiple doses...
  6. ncbi Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects
    Chin B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neurosciences, University Department of Adult Psychiatry, Hôpital de Cery, 1008 Prilly Lausanne, Switzerland
    Eur J Clin Pharmacol 60:231-6. 2004
    ..We investigated whether differences in pharmacokinetics of midazolam, a CYP3A probe, could be demonstrated between subjects with different CYP3A4 and CYP3A5 genotypes...
  7. ncbi Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity
    Chin B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neurosciences, University Department of Adult Psychiatry, Prilly Lausanne, Switzerland
    Eur J Clin Pharmacol 60:237-46. 2004
    ..We investigated whether the oral administration of a low dose (75 micro g) of midazolam, a CYP3A probe, can be used to measure the in vivo CYP3A activity...
  8. ncbi CYP3A activity measured by the midazolam test is not related to 3435 C >T polymorphism in the multiple drug resistance transporter gene
    Chin B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neurosciences, University Department of Adult Psychiatry, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    Pharmacogenetics 14:255-60. 2004
    ..The existence of a strong association between the activity of CYP3A and MDR13435 C >T and 2677 G >T polymorphisms appears unlikely, at least in Caucasian populations and/or in the absence of specific environmental factors...
  9. ncbi Determination of picogram levels of midazolam, and 1- and 4-hydroxymidazolam in human plasma by gas chromatography-negative chemical ionization-mass spectrometry
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Département universitaire, de Psychiatrie Adulte, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 802:339-45. 2004
    ..This method can be used for phenotyping cytochrome P4503A in humans following the administration of a very low oral dose of midazolam (75 microg), without central nervous system side-effects...
  10. ncbi Increase of oral methadone dose in methadone injecting patients: a pilot study
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    J Addict Dis 22:7-17. 2003
    ....
  11. ncbi Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence
    Chin B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, University Department of Adult Psychiatry, Cery Hospital, Prilly Lausanne, Switzerland
    Clin Pharmacokinet 41:1153-93. 2002
    ..However, therapeutic drug monitoring can be useful in particular situations. In the case of non-response trough plasma concentrations of 400 microg/L for (R,S)-methadone or 250 microg/L for (R)-methadone might be used as target values...
  12. ncbi Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Hôpital de Cery, CH 1008, Prilly Lausanne, Switzerland
    Drug Alcohol Depend 61:47-54. 2000
    ..This demonstrates the importance of individualizing methadone treatment...
  13. ncbi Marked increase of venlafaxine enantiomer concentrations as a consequence of metabolic interactions: a case report
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Département universitaire de psychiatrie, Adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
    Pharmacopsychiatry 33:112-5. 2000
    ..This case report shows the importance of performing studies on the effects of either genetically determined or acquired deficiency of metabolism on the kinetics of venlafaxine...
  14. ncbi Nonresponse to clozapine and ultrarapid CYP1A2 activity: clinical data and analysis of CYP1A2 gene
    Chin B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
    J Clin Psychopharmacol 24:214-9. 2004
    ..Due to the high frequency of smokers among patients with schizophrenia and to the high frequency of the -164C > A polymorphism, CYP1A2 genotyping could have important clinical implications for the treatment of patients with CLO...
  15. ncbi [New psychopharmacologic studies on methadone: implications for the treatment of opiate dependency]
    C B Eap
    Département Universitaire de Psychiatre Adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
    Rev Med Suisse Romande 120:111-6. 2000
    ..This choice must not result from an administrative standardization, as it is essential for patients that, with an adequate social and psychological treatment, an adequate pharmacological treatment should be associated...
  16. ncbi Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers
    C B Eap
    Departement universitaire de psychiatrie adulte, Hôpital de Cery, Prilly, Lausanne, Switzerland
    Clin Pharmacol Ther 64:52-7. 1998
    ..It is known that CYP2E1 is involved in the activation of many low-molecular-weight toxins and carcinogens and may be involved in the development of alcohol-induced liver disease...
  17. ncbi Simultaneous determination of human plasma levels of citalopram, paroxetine, sertraline, and their metabolites by gas chromatography-mass spectrometry
    C B Eap
    Departement universitaire de psychiatrie adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
    J Chromatogr Sci 36:365-71. 1998
    ..It is also useful for therapeutic drug monitoring of these three drugs and could possibly be adapted for the quantitation of the two other selective serotonin reuptake inhibitors on the market, namely fluoxetine and fluvoxamine...
  18. ncbi Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Departement universitaire de psychiatrie adulte, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    Ther Drug Monit 26:152-5. 2004
    ..Therapeutic drug monitoring and genotyping are thus complementary, and their combined use contributes to improve pharmacotherapy with antidepressants and other drugs...
  19. ncbi Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin
    C B Eap
    Departement universitaire de psychiatrie adulte, Prilly Lausanne, Switzerland
    Clin Pharmacol Ther 59:322-31. 1996
    ..087), and 67.2 +/- 66.2 (range, 16.8 to 248), respectively. CYP2D6 is apparently involved in the formation of (S)-thioridazine 2-SO(FE), (R)-thioridazine 2-SO(SE), and also probably (S)-thioridazine 5-SO(FE) and (R)-thioridazine 5-SO(SE)...
  20. doi Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals
    M Arab-Alameddine
    Division of Clinical Pharmacology and Toxicology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    Clin Pharmacol Ther 85:485-94. 2009
    ..Therefore, dosage adjustment in accordance with the type of polymorphism (CYP2B6, CYP2A6, or CYP3A4) is required in order to maintain EFV within the therapeutic target levels...
  21. ncbi Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Prilly Lausanne, Switzerland
    Ther Drug Monit 22:209-14. 2000
    ..The CYP2D6 poor metabolizer had the highest (L)-DTRI and (D)-DTRI concentrations to dose-to-weight ratios, and the CYP2C19 poor metabolizer had the highest (L)-TRI and (D)-TRI concentrations to dose-to-weight ratios of the group...
  22. doi β-Arrestin2 influences the response to methadone in opioid-dependent patients
    B Oneda
    Unit of Biochemistry and Clinical Psychopharmacology, Department of Psychiatry, CHUV, Center of Psychiatric Neurosciences, Hospital of Cery, University of Lausanne, Lausanne, Switzerland
    Pharmacogenomics J 11:258-66. 2011
    ..2-5.1, P=0.02) also illustrated by a 12-fold shorter period of negative urine screening (P=0.01). The ARRB2 genotype may thus contribute to the interindividual variability in the response to MMT and help to predict response to treatment...
  23. ncbi ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment
    Severine Crettol
    Unite de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Département de Psychiatrie Centre Hospitalier Universitaire Vaudois, Hôpital de Cery, Prilly Lausanne, Switzerland
    Clin Pharmacol Ther 80:668-81. 2006
    ..The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear. We aimed to thoroughly examine the genetic factors influencing methadone kinetics and response to treatment...
  24. ncbi Light-induced racemization: artifacts in the analysis of the diastereoisomeric pairs of thioridazine 5-sulfoxide in the plasma and urine of patients treated with thioridazine
    C B Eap
    Departement universitaire de psychiatrie adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
    Ther Drug Monit 13:356-62. 1991
    ....
  25. ncbi Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers
    C B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, University Department of Psychiatry CHUV, Hospital of Cery, Prilly Lausanne, Switzerland
    Clin Pharmacol Ther 81:719-28. 2007
    ..2-17.7; P=0.03). This study reports the first genetic factor implicated in methadone metabolism that may increase the risk of cardiac arrhythmias and sudden death. This risk could be reduced by the administration of (R)-methadone...
  26. ncbi Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment
    Severine Crettol
    Unite de Biochimie et Psychopharmacologie Clinique, Centre des Neurosciences Psychiatriques, Departement universitaire de psychiatrie adulte, Hôpital de Cery, Lausanne, Switzerland
    Clin Pharmacol Ther 78:593-604. 2005
    ..We aimed to determine the influence of CYP2B6, CYP2C9, and CYP2C19 genetic polymorphism on methadone pharmacokinetics and on the response to treatment...
  27. ncbi Influence of quinidine on the pharmacokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers. A pilot study on two subjects
    C B Eap
    Departement universitaire de psychiatrie adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
    Neuropsychobiology 25:214-20. 1992
    ..Since cytochrome P-450IID6 is deficient in 5-10% of Caucasian subjects, this may have consequences in trimipramine-treated subjects, especially with regard to the effects of the drug on the EEG...
  28. ncbi Plasma levels of trimipramine and metabolites in four patients: determination of the enantiomer concentrations of the hydroxy metabolites
    C B Eap
    Département Universitaire de Psychiatrie Adulte DUPA, Hôpital de Cery, Lausanne, Switzerland
    Ther Drug Monit 14:380-5. 1992
    ....
  29. doi Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibility
    M Dobrinas
    Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly, Switzerland
    Clin Pharmacol Ther 90:117-25. 2011
    ..002). After quitting smoking, only CYP1A2*1F (P = 0.017) and the use of contraceptives (P = 0.05) had an influence. No influence of CYP1A2 polymorphisms on the inducibility of CYP1A2 was observed...
  30. ncbi CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients
    Severine Crettol
    Unité de Biochimie et de Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Departement de Psychiatrie, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Hôpital de Cery, Prilly Lausanne, Switzerland
    Ther Drug Monit 30:689-99. 2008
    ....
  31. ncbi Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein
    C B Eap
    Clinique Psychiatrique Universitaire de Lausanne, Hôpital de Cery, Prilly, Switzerland
    Naunyn Schmiedebergs Arch Pharmacol 337:220-4. 1988
    ..The selectivity (binding to S- vs. F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin...
  32. ncbi Determination of trimipramine and its demethylated and hydroxylated metabolites in plasma by gas chromatography-mass spectrometry
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Départment Universitaire de Psychiatrie Adulte DUPA, Prilly Lausanne, Switzerland
    J Chromatogr 652:97-103. 1994
    ..This specific detection method is useful, as polymedication is a usual practice in clinical situations, and its sensitivity allows its use for single-dose pharmacokinetic studies...
  33. ncbi Determination of human plasma levels of levo-alpha-acetylmethadol and its metabolites by gas chromatography-mass spectrometry
    C B Eap
    Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 805:141-6. 2004
    ..No interference was noted from methadone. This sensitive and specific analytical method could be useful for assessing the in vivo relationship between LAAM's blood levels, clinical efficacy and/or cardiotoxicity..
  34. ncbi Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
    Jacques Fellay
    Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland
    Lancet 359:30-6. 2002
    ..This variability could have a genetic basis. We did a pharmacogenetics study to analyse the association between response to antiretroviral treatment and allelic variants of several genes...
  35. ncbi Tobacco and cannabis smoking cessation can lead to intoxication with clozapine or olanzapine
    D F Zullino
    Unit of Biochemistry and Clinical Psychopharmacology, University Department of Adult Psychiatry, Prilly, Lausanne, Switzerland
    Int Clin Psychopharmacol 17:141-3. 2002
    ....
  36. doi The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test
    Beatrice Oneda
    Unit of Biochemistry and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry CHUV, University of Lausanne, Hospital of Cery, Prilly Lausanne, Switzerland
    Pharmacogenet Genomics 19:877-83. 2009
    ..CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about 50% of drugs on the market, with a large overlap in their specificities. We investigated the genetic bases that contribute to the variation of CYP3A activity...
  37. ncbi Routine therapeutic drug monitoring in patients treated with 10-360 mg/day citalopram
    Yves Le Bloc'h
    University Department of Adult Psychiatry, CH 1008 Prilly Lausanne, Switzerland
    Ther Drug Monit 25:600-8. 2003
    ..In conclusion, there is a highly linear correlation between CIT plasma concentrations and CIT doses, well above the usual dose range...
  38. ncbi Enantiomers' potential in psychopharmacology--a critical analysis with special emphasis on the antidepressant escitalopram
    Pierre Baumann
    Departement universitaire de psychiatrie adulte, Unite de Biochimie et Psychopharmacologie Clinique, Hôpitalde Cery, CH 1008, Prilly Lausanne, Switzerland
    Eur Neuropsychopharmacol 12:433-44. 2002
    ....
  39. pmc Could pharmacogenetic data explain part of the interindividual sensitivity to methadone-induced respiratory depression?
    Severine Crettol
    Unit of Biochemistry and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, University Psychiatry Department, Cery Hospital, CH 1008 Prilly Lausanne, Switzerland
    Crit Care 11:119. 2007
    ..Here, we discuss whether recent pharmacogenetic data could help us to understand interindividual variability in sensitivity to respiratory depression and, ultimately, to predict which patients are most likely to be affected...
  40. doi Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment
    Severine Crettol
    Unité de Biochimie et de Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Departement de Psychiatrie, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
    Prog Neuropsychopharmacol Biol Psychiatry 32:1722-7. 2008
    ..Genetic variations of the dopamine and opioid receptors could influence the response to methadone maintenance treatment (MMT)...
  41. ncbi Combination therapy with venlafaxine and carbamazepine in depressive patients not responding to venlafaxine: pharmacokinetic and clinical aspects
    Elio Ciusani
    Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Prilly Lausanne, Switzerland
    J Psychopharmacol 18:559-66. 2004
    ..However, these findings should be verified in a more comprehensive study...
  42. ncbi Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone
    Messaoud Benmebarek
    Service of Medicine and Penitentiary Psychiatry, University Department of Adult Psychiatry, Lausanne, Switzerland
    Clin Pharmacol Ther 76:55-63. 2004
    ..Cytochrome P450 (CYP) 3A4 is the main CYP isozyme involved in methadone metabolism. We investigated the influence of grapefruit juice, which contains inhibitors of intestinal CYP3A, on the steady-state pharmacokinetics of methadone...
  43. ncbi [Follow-up of the metabolic syndrome induced by atypical antipsychotics: recommendations and pharmacogenetics perspectives]
    E Choong
    Departement de Psychiatrie, Centre de Neurosciences Psychiatriques, Unite de Biochimie et Psychopharmacologie Clinique, CHUV, Prilly
    Rev Med Suisse 4:1994-6, 1998-9. 2008
    ..Such studies should allow, in the near future, to adapt the treatment for each patient...
  44. doi Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients
    Severine Crettol
    Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neuroscience, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly, Switzerland
    Pharmacogenet Genomics 18:307-15. 2008
    ..The expression on lymphocytes of P-glycoprotein, an efflux transporter encoded by the ABCB1 gene, might influence cyclosporine intracellular concentration...
  45. doi Validation and long-term evaluation of a modified on-line chiral analytical method for therapeutic drug monitoring of (R,S)-methadone in clinical samples
    Nicolas Ansermot
    Unit of Biochemistry and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry CHUV, University of Lausanne, Hospital of Cery, Prilly, Lausanne, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2301-7. 2009
    ..During this period, 257 trough concentration and 54 peak concentration plasma samples of patients undergoing (R,S)-methadone treatment were successfully analysed for routine therapeutic drug monitoring...
  46. ncbi Risperidone-induced symptomatic hyperprolactinaemia in adolescents
    Laurent Holzer
    Service universitaire de psychiatrie de l enfant et de l adolescent, Centre Thérapeutique de Jour pour Adolescents, Lausanne, Switzerland
    J Clin Psychopharmacol 26:167-71. 2006
    ....
  47. ncbi In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites
    Severine Crettol
    Unite de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Departement de Psychiatrie, Centre Hospitalier Universitaire Vaudois et Universite de Lausanne, Hôpital de Cery, Prilly Lausanne, Suisse
    Pharmacology 80:304-11. 2007
    ..05), thus indicating that they are substrates of P-gp. A weak stereoselectivity in methadone transport was observed towards the (S)-enantiomer. P-gp may therefore affect the pharmacokinetics and pharmacodynamics of methadone and LAAM...
  48. doi The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution
    Eva Choong
    University of Lausanne, Centre for Psychiatric Neurosciences, Department of Psychiatry, CHUV, Hospital of Cery, Prilly, Switzerland
    Expert Opin Drug Metab Toxicol 6:953-65. 2010
    ..P-gp can have a major impact on the distribution of drugs in selected organs, including the brain. Polymorphisms of the ABCB1 gene, which encodes for P-gp, can influence the kinetics of several drugs...
  49. ncbi Adherence to antidepressant treatment: what the doctor thinks and what the patient says
    N Loayza
    Department of Psychiatry, Section Karl Jaspers, Lausanne University Hospital, Hospital of Cery, Prilly Lausanne, Switzerland
    Pharmacopsychiatry 45:204-7. 2012
    ..Finally, the patients' and the doctors' Helping Alliance scores were not related to adherence self-report...
  50. pmc Population pharmacokinetics of imatinib and the role of alpha-acid glycoprotein
    N Widmer
    Division of Clinical Pharmacology, University Hospital, Lausanne, Switzerland
    Br J Clin Pharmacol 62:97-112. 2006
    ....
  51. doi In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function
    Julia Di Iulio
    Institute of Microbiology Division of Clinical Pharmacology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    Pharmacogenet Genomics 19:300-9. 2009
    ..We hypothesize that genetic variability in this gene may contribute to the particularly high, unexplained variability in EFV exposure in individuals with limited CYP2B6 function...
  52. doi Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS
    Eva Choong
    Unit of Biochemistry and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly Lausanne, Switzerland
    J Pharm Biomed Anal 50:1000-8. 2009
    ..For all investigated compounds, good performance in terms of recoveries, selectivity, stability, repeatability, intermediate precision, trueness and accuracy, was obtained. Real patient plasma samples were then successfully analysed...
  53. ncbi Chirality in the new generation of antidepressants: stereoselective analysis of the enantiomers of mirtazapine, N-demethylmirtazapine, and 8-hydroxymirtazapine by LC-MS
    Erik Paus
    Unite de Biochimie et Psychopharmacologie Clinique, University Department of Adult Psychiatry, Site de Cery, CH 1008 Prilly Lausanne, Switzerland
    Ther Drug Monit 26:366-74. 2004
    ..Therefore, this method seems to be suitable for the stereoselective assay of MIR and its metabolites in plasma of patients comedicated with MIR and other drugs for routine and research purposes...
  54. ncbi Determination and distribution of clotiapine (Entumine) in human plasma, post-mortem blood and tissue samples from clotiapine-treated patients and from autopsy cases
    Frank Sporkert
    Institut Universitaire de Medecine Legale, Lausanne, Switzerland
    Forensic Sci Int 170:193-9. 2007
    ..Concentrations ranged for the clotiapine-treated patients between 6 and 155 microg/L (mean 46 microg/L), and for the autopsy cases between 22 and 341 microg/L (mean 123 microg/L)...
  55. ncbi Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation
    Sara Colombo
    Division of Clinical Pharmacology and Toxicology, University Hospital of Lausanne, Institute of Microbiology, Lausanne, Switzerland
    Clin Pharmacol Ther 80:307-18. 2006
    ..Efavirenz, mainly bound to albumin, was included as a control drug...
  56. ncbi Aripiprazole and suicidality
    Laurent Holzer
    Service Universitaire de Psychiatrie de l Enfant et de l Adolescent SUPEA, Centre Thérapeutique de Jour pour Adolescents, Lausanne, Switzerland
    Int Clin Psychopharmacol 21:125-6. 2006
    ....
  57. doi Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval
    Nicolas Ansermot
    Center for Psychiatric Neurosciences, Department of Psychiatry, Hospital of Cery, Prilly Lausanne, Switzerland
    Arch Intern Med 170:529-36. 2010
    ....
  58. ncbi Prevalence of substance use in a Swiss psychiatric hospital: interview reports and urine screening
    Charles Bonsack
    Unité de recherche évaluative et clinique, Departement universitaire de psychiatrie adulte, Hôpital de Cery, 1008 Prilly, Suisse
    Addict Behav 31:1252-8. 2006
    ..Co-morbid substance misuse is common in psychiatric disorders, has potentially severe adverse consequences and may be frequently undetected...
  59. ncbi Carbamazepine augmentation in depressive patients non-responding to citalopram: a pharmacokinetic and clinical pilot study
    Lina Steinacher
    Praxis am Zweierplatz, Badenerstrasse 67, CH 8004 Zurich, Switzerland
    Eur Neuropsychopharmacol 12:255-60. 2002
    ....
  60. ncbi Disposition of venlafaxine enantiomers in rats with hepatic encephalopathy after chronic drug treatment
    Cecilia Wikell
    Department of Clinical Pharmacology, Lund University, Lund, Sweden
    Chirality 14:347-50. 2002
    ..4) and brain compartments (S/R = l.0-1.1). These findings may have clinical relevance for the safety of venlafaxine in chronic hepatic encephalopathy...
  61. ncbi Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers
    Stefan Begré
    Psychiatrische Universitätsklinik Basel, Basel, Switzerland
    J Clin Psychopharmacol 22:211-5. 2002
    ..Because paroxetine is a mild inhibitor of CYP1A2, CYP2C9, CYP2C19, and CYP3A4, increase of (S)-methadone concentrations in both EMs and PMs could be mediated by inhibition of any of these isozymes...
  62. ncbi Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda, Germany
    Int J Neuropsychopharmacol 8:403-10. 2005
    ..Significant NPY and CRH changes in CSF following treatment as well as correlations to changes in HAMD support the hypothesis that these two peptides play a role in affective disorders and are markers of therapeutic response...
  63. ncbi Cytochrome P4503A4 metabolic activity, methadone blood concentrations, and methadone doses
    Marc Shinderman
    Center for Addictive Problems, 609 North Wells, Chicago, IL, USA
    Drug Alcohol Depend 69:205-11. 2003
    ..This, however, must be confirmed by a prospective study...
  64. ncbi Time course of response to paroxetine: influence of plasma level
    Marianne Gex-Fabry
    Service of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Prog Neuropsychopharmacol Biol Psychiatry 31:892-900. 2007
    ..005). The present study supports the hypothesis that higher paroxetine concentration might contribute to hasten relief of depressive symptoms in severely depressed patients...
  65. ncbi Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients
    Claude Uehlinger
    Centre psychosocial, Unité de Traitement des Addictions, Fribourg, Switzerland
    J Clin Psychopharmacol 27:273-8. 2007
    ..No signs of overmedication caused by increased methadone plasma concentrations were noticed by the staff or reported by the patients...
  66. pmc Identification of a novel splice-site mutation in the CYP1A2 gene
    Delphine Allorge
    EA 2679, Faculté de Médecine Pôle Recherche, 1 place de Verdun, F 59045 Lille Cedex, France
    Br J Clin Pharmacol 56:341-4. 2003
    ....
  67. ncbi Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients
    Carlos A de Mendonça Lima
    Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 29:952-6. 2005
    ..01), and CIT+DCIT plasma levels (r=0.44, p<0.001), and thus accounts for 18% of the variability of CIT plasma levels, with no influence of gender. The recommended dose reduction of CIT in elderly patients seems therefore justified...
  68. ncbi Epileptiform seizure after sertraline treatment in an adolescent experiencing obsessive-compulsive disorder and presenting a rare pharmacogenetic status
    Pierre Baumann
    J Clin Psychopharmacol 26:679-81. 2006
  69. ncbi Increased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patients
    Guido Bondolfi
    Hopitaux Universitaires de Geneve, Departement de Psychiatrie, Service de Psychiatrie Adulte, Boulevard St Georges 16 18, 1205 Geneve, Switzerland
    Ther Drug Monit 27:539-43. 2005
    ....
  70. ncbi Association of CYP3A5 genotypes with blood pressure and renal function in African families
    Murielle Bochud
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    J Hypertens 24:923-9. 2006
    ..We determined whether CYP3A5 polymorphisms are associated with ambulatory blood pressure (ABP) and with glomerular filtration rate (GFR) in African families...
  71. ncbi Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients
    Jacques Fellay
    Division of Infectious Diseases, University Hospital of Lausanne, Switzerland
    Eur J Clin Pharmacol 60:865-73. 2005
    ..To measure the in vivo variations of CYP3A activity induced by anti-HIV drugs in human immunodeficiency virus (HIV)1-positive patients...
  72. ncbi Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Klinikum Fulda, P O Box 2364, 36013, Fulda, Germany
    Psychopharmacology (Berl) 181:751-60. 2005
    ..A dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a well-documented neurobiological finding in major depression. Moreover, clinically effective therapy with antidepressant drugs may normalize the HPA axis activity...
  73. ncbi Therapeutic drug monitoring and pharmacogenetic tests as tools in pharmacovigilance
    Eveline Jaquenoud Sirot
    Psychiatrische Dienste Aargau AG, MEDIQ, Klinik Königsfelden, Brugg, Switzerland
    Drug Saf 29:735-68. 2006
    ..Databases on drug-drug interactions and the impact of pharmacogenetic polymorphisms and adverse drug reaction information systems will be helpful to guide clinicians in individualised treatment choices...
  74. ncbi Stereoselective metabolism of citalopram in plasma and cerebrospinal fluid of depressive patients: relationship with 5-HIAA in CSF and clinical response
    Georg Nikisch
    Department of Psychiatry and Psychotherapy, Box 2364, Klinikum Fulda, D 36013 Fulda, Germany
    J Clin Psychopharmacol 24:283-90. 2004
    ..572, P = 0.01). The demonstrated correlations between pharmacokinetic parameters and the clinical outcome as well as 5-HIAA changes indicate that monitoring of plasma S-CIT, CSF S-CIT and CSF S-CIT-PROP may be of clinical relevance...
  75. ncbi Very long half-life of paroxetine following intoxication in an extensive cytochrome P4502D6 metabolizer
    Henriette Hilleret
    University Department of Psychiatry, Belle Idee, Chene Bourg, Geneva, Switzerland
    Ther Drug Monit 24:567-9. 2002
    ....
  76. ncbi Brain dopamine response in human opioid addiction
    Mark R C Daglish
    Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, UK
    Br J Psychiatry 193:65-72. 2008
    ..Drugs of dependence cause dopamine release in the rat striatum. Human neuroimaging studies have shown an increase in dopamine in the equivalent region in response to stimulants and other drugs...