Research Topics
Species | C B EapSummaryAffiliation: Centre Hospitalier Universitaire Vaudois Country: Switzerland Publications
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Publications
Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizersC B Eap
Unit of Biochemistry and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, University Department of Psychiatry CHUV, Hospital of Cery, Prilly Lausanne, Switzerland
Clin Pharmacol Ther 81:719-28. 2007..2-17.7; P=0.03). This study reports the first genetic factor implicated in methadone metabolism that may increase the risk of cardiac arrhythmias and sudden death. This risk could be reduced by the administration of (R)-methadone...- [Addiction]J Besson
Departement de Psychiatrie, Service de psychiatrie communautaire, CHUV, Lausanne
Rev Med Suisse 4:8-13. 2008..Initiation and maintenance of cannabis use. 2. Methadone and heart toxicity. 3. Suicidal behaviour in gambling. 4. Treatment of addictive disorders via internet: present and future perspectives... 
Could pharmacogenetic data explain part of the interindividual sensitivity to methadone-induced respiratory depression?Severine Crettol
Unit of Biochemistry and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, University Psychiatry Department, Cery Hospital, CH 1008 Prilly Lausanne, Switzerland
Crit Care 11:119. 2007..Here, we discuss whether recent pharmacogenetic data could help us to understand interindividual variability in sensitivity to respiratory depression and, ultimately, to predict which patients are most likely to be affected...- Light-induced racemization: artifacts in the analysis of the diastereoisomeric pairs of thioridazine 5-sulfoxide in the plasma and urine of patients treated with thioridazineC B Eap
Departement universitaire de psychiatrie adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
Ther Drug Monit 13:356-62. 1991.... 
β-Arrestin2 influences the response to methadone in opioid-dependent patientsB Oneda
Unit of Biochemistry and Clinical Psychopharmacology, Department of Psychiatry, CHUV, Center of Psychiatric Neurosciences, Hospital of Cery, University of Lausanne, Lausanne, Switzerland
Pharmacogenomics J 11:258-66. 2011..2-5.1, P=0.02) also illustrated by a 12-fold shorter period of negative urine screening (P=0.01). The ARRB2 genotype may thus contribute to the interindividual variability in the response to MMT and help to predict response to treatment...- Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoinC B Eap
Departement universitaire de psychiatrie adulte, Prilly Lausanne, Switzerland
Clin Pharmacol Ther 59:322-31. 1996..087), and 67.2 +/- 66.2 (range, 16.8 to 248), respectively. CYP2D6 is apparently involved in the formation of (S)-thioridazine 2-SO(FE), (R)-thioridazine 2-SO(SE), and also probably (S)-thioridazine 5-SO(FE) and (R)-thioridazine 5-SO(SE)... - [New psychopharmacologic studies on methadone: implications for the treatment of opiate dependency]C B Eap
Département Universitaire de Psychiatre Adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
Rev Med Suisse Romande 120:111-6. 2000..This choice must not result from an administrative standardization, as it is essential for patients that, with an adequate social and psychological treatment, an adequate pharmacological treatment should be associated... - Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patientsC B Eap
Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Prilly Lausanne, Switzerland
Ther Drug Monit 22:209-14. 2000..The CYP2D6 poor metabolizer had the highest (L)-DTRI and (D)-DTRI concentrations to dose-to-weight ratios, and the CYP2C19 poor metabolizer had the highest (L)-TRI and (D)-TRI concentrations to dose-to-weight ratios of the group... - Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizersC B Eap
Département Universitaire de Psychiatre Adulte, Hĵpital de Cery, Prilly Lausanne, Switzerland
J Clin Psychopharmacol 21:330-4. 2001..The data also clearly show that the CYP2D6 genotype has an important influence on the concentrations of the (S)- but not of the (R)-enantiomer of FLX and NFLX after multiple doses... - Determination of trimipramine and its demethylated and hydroxylated metabolites in plasma by gas chromatography-mass spectrometryC B Eap
Unite de Biochimie et Psychopharmacologie Clinique, Départment Universitaire de Psychiatrie Adulte DUPA, Prilly Lausanne, Switzerland
J Chromatogr 652:97-103. 1994..This specific detection method is useful, as polymedication is a usual practice in clinical situations, and its sensitivity allows its use for single-dose pharmacokinetic studies... - Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatmentC B Eap
Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Hôpital de Cery, CH 1008, Prilly Lausanne, Switzerland
Drug Alcohol Depend 61:47-54. 2000..This demonstrates the importance of individualizing methadone treatment... - Marked increase of venlafaxine enantiomer concentrations as a consequence of metabolic interactions: a case reportC B Eap
Unite de Biochimie et Psychopharmacologie Clinique, Département universitaire de psychiatrie, Adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
Pharmacopsychiatry 33:112-5. 2000..This case report shows the importance of performing studies on the effects of either genetically determined or acquired deficiency of metabolism on the kinetics of venlafaxine... - Influence of quinidine on the pharmacokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers. A pilot study on two subjectsC B Eap
Departement universitaire de psychiatrie adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
Neuropsychobiology 25:214-20. 1992..Since cytochrome P-450IID6 is deficient in 5-10% of Caucasian subjects, this may have consequences in trimipramine-treated subjects, especially with regard to the effects of the drug on the EEG... - [Follow-up of the metabolic syndrome induced by atypical antipsychotics: recommendations and pharmacogenetics perspectives]E Choong
Departement de Psychiatrie, Centre de Neurosciences Psychiatriques, Unite de Biochimie et Psychopharmacologie Clinique, CHUV, Prilly
Rev Med Suisse 4:1994-6, 1998-9. 2008..Such studies should allow, in the near future, to adapt the treatment for each patient... - Simultaneous determination of human plasma levels of citalopram, paroxetine, sertraline, and their metabolites by gas chromatography-mass spectrometryC B Eap
Departement universitaire de psychiatrie adulte, Hôpital de Cery, Prilly Lausanne, Switzerland
J Chromatogr Sci 36:365-71. 1998..It is also useful for therapeutic drug monitoring of these three drugs and could possibly be adapted for the quantitation of the two other selective serotonin reuptake inhibitors on the market, namely fluoxetine and fluvoxamine... - Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin testC B Eap
Unit of Biochemistry and Clinical Psychopharmacology, University Department of Adult Psychiatry, Cery Hospital, CH Prilly Lausanne, Switzerland
Ther Drug Monit 23:228-31. 2001..The reported increase of clozapine concentrations by risperidone can therefore not be explained by an inhibition of CYP1A2, CYP2D6, CYP2C19 or by any combination of the three... - Cytochrome P450 2D6 genotype and methadone steady-state concentrationsC B Eap
Departement universitaire de psychiatrie adulte, H pital de Cery, Prilly Lausanne, Switzerland
J Clin Psychopharmacol 21:229-34. 2001..More studies are needed to examine the influence of the ultrarapid metabolizer status on the outcome of the MMT... - Adherence to antidepressant treatment: what the doctor thinks and what the patient saysN Loayza
Department of Psychiatry, Section Karl Jaspers, Lausanne University Hospital, Hospital of Cery, Prilly Lausanne, Switzerland
Pharmacopsychiatry 45:204-7. 2012..Finally, the patients' and the doctors' Helping Alliance scores were not related to adherence self-report... - Therapeutic monitoring of antidepressants in the era of pharmacogenetics studiesC B Eap
Unite de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Departement universitaire de psychiatrie adulte, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
Ther Drug Monit 26:152-5. 2004..Therapeutic drug monitoring and genotyping are thus complementary, and their combined use contributes to improve pharmacotherapy with antidepressants and other drugs... - Impact of smoking, smoking cessation, and genetic polymorphisms on CYP1A2 activity and inducibilityM Dobrinas
Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neurosciences, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly, Switzerland
Clin Pharmacol Ther 90:117-25. 2011..002). After quitting smoking, only CYP1A2*1F (P = 0.017) and the use of contraceptives (P = 0.05) had an influence. No influence of CYP1A2 polymorphisms on the inducibility of CYP1A2 was observed... - Methadone blood concentrations are decreased by the administration of abacavir plus amprenavirP A Bart
Division of Immunology and Allergy, University Hospital of Lausanne, Switzerland
Ther Drug Monit 23:553-5. 2001..Because amprenavir is a cytochrome P4503A4 substrate and is involved in the metabolism of methadone, reduction of methadone concentrations could be explained by an induction of cytochrome P4503A4... - Methadone maintenance treatment and St. John's Wort - a case reportD Eich-Höchli
Pharmacopsychiatry 36:35-7. 2003.... - Over- and underreporting of recent drug use in subjects entering an inpatient detoxification unitDaniele F Zullino
Division of Substance Abuse, University Hospitals of Geneva, Switzerland
Eur J Med Res 13:15-20. 2008..Underreporting of drug use is commonly found more often than overreporting. Overreporting may, however, occur in particular settings, e.g. in subjects entering a detoxification program... - Determination of human plasma levels of levo-alpha-acetylmethadol and its metabolites by gas chromatography-mass spectrometryC B Eap
Unite de Biochimie et Psychopharmacologie Clinique, Departement universitaire de psychiatrie adulte, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
J Chromatogr B Analyt Technol Biomed Life Sci 805:141-6. 2004..No interference was noted from methadone. This sensitive and specific analytical method could be useful for assessing the in vivo relationship between LAAM's blood levels, clinical efficacy and/or cardiotoxicity.. - The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychotic patientsG Bondolfi
Dépatrement universitaire de psychiatrie adulte, Site de Cery, Pirlly Lausanne, Switzerland
Pharmacopsychiatry 35:50-6. 2002..The severity and incidence of extrapyramidal symptoms and adverse events did not significantly increase when fluoxetine was added... - No influence of ABCB1 haplotypes on methadone dosage requirementS Crettol
Clin Pharmacol Ther 83:668-9; author reply 669-70. 2008 - Pharmacogenetics of acenocoumarol: CYP2C9, CYP2C19, CYP1A2, CYP3A4, CYP3A5 and ABCB1 gene polymorphisms and dose requirementsR B Saraeva
Department of Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria
J Clin Pharm Ther 32:641-9. 2007.... - Increase of oral methadone dose in methadone injecting patients: a pilot studyC B Eap
Unite de Biochimie et Psychopharmacologie Clinique, Hôpital de Cery, CH 1008 Prilly Lausanne, Switzerland
J Addict Dis 22:7-17. 2003.... - Prevalence of methadone injection in three Swiss citiesA E Chevalley
Division d'abus de substances, , Geneva, Switzerland
Presse Med 34:776-80. 2005..This information is especially necessary when maintenance therapy is provided in the same center, or city as injectable methadone maintenance... - Using saccadic eye movements as objective measures of tolerance in methadone dependent individuals during the hydromorphone challenge testJ K Melichar
Psychopharmacology Unit, School of Medical Sciences, University of Bristol, Bristol, UK
Addict Biol 8:59-66. 2003..Such studies may help in refining our understanding of the actions of methadone and the SEM measure could help in defining the degree of tolerance in individuals using street heroin...