Jean Rene Cardinaux
Affiliation: Centre Hospitalier Universitaire Vaudois
KovÃ¡cs K, Steinmann M, Halfon O, Magistretti P, Cardinaux J. Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2. Cell Signal. 2015;27:2252-60 pubmed publisher
..Our findings thus highlight a complex regulation of CBP activity by HIPK2, which might be relevant for the control of specific sets of target genes involved in cellular proliferation, differentiation and apoptosis. ..
Meylan E, Halfon O, Magistretti P, Cardinaux J. The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression. Neuropharmacology. 2016;107:111-121 pubmed publisher
..These findings suggest that CRTC1 alterations may be associated with treatment-resistant depression, and support the interesting possibility that targeting HDACs may be a useful therapeutic strategy in antidepressant development. ..
Saura C, Cardinaux J. Emerging Roles of CREB-Regulated Transcription Coactivators in Brain Physiology and Pathology. Trends Neurosci. 2017;40:720-733 pubmed publisher
..We also discuss how CRTCs deregulation in cognitive and emotional disorders may provide the basis for potential clinical and therapeutic applications in neurodegenerative and psychiatric diseases. ..
Rossetti C, Sciarra D, Petit J, Eap C, Halfon O, Magistretti P, et al
. Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression. Transl Psychiatry. 2017;7:1269 pubmed publisher
..Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity. ..