Olivier Braissant

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. doi request reprint Ammonia toxicity to the brain
    Olivier Braissant
    Service of Biomedicine, Lausanne University Hospital, Avenue Pierre Decker 2, CI 02 33, CH 1011 Lausanne, Switzerland
    J Inherit Metab Dis 36:595-612. 2013
  2. doi request reprint AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: a review
    O Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    J Inherit Metab Dis 31:230-9. 2008
  3. doi request reprint Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers
    Olivier Braissant
    Inborn Errors of Metabolism, Service of Biomedicine, Lausanne University Hospital, Avenue Pierre Decker 2, CI 02 33, CH 1011, Lausanne, Switzerland
    J Inherit Metab Dis 35:655-64. 2012
  4. pmc Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
    Antoinette Defaux
    Department of Physiology, University of Lausanne, CH 1005 Lausanne, Switzerland
    J Neuroinflammation 6:15. 2009
  5. doi request reprint Dissociation of AGAT, GAMT and SLC6A8 in CNS: relevance to creatine deficiency syndromes
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Neurobiol Dis 37:423-33. 2010
  6. doi request reprint Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH 1011 Lausanne, Switzerland
    Eur J Neurosci 27:1673-85. 2008
  7. doi request reprint Current concepts in the pathogenesis of urea cycle disorders
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CI 02 33, Lausanne, Switzerland
    Mol Genet Metab 100:S3-S12. 2010
  8. pmc Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1
    Olivier Braissant
    Clinical Chemistry Laboratory, University Hospital, CH 1011 Lausanne, Switzerland
    BMC Dev Biol 5:9. 2005
  9. doi request reprint Ammonia toxicity to the brain: effects on creatine metabolism and transport and protective roles of creatine
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Center Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Mol Genet Metab 100:S53-8. 2010
  10. doi request reprint Creatine deficiency syndromes and the importance of creatine synthesis in the brain
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Avenue Pierre Decker 2, Lausanne, Switzerland
    Amino Acids 40:1315-24. 2011

Collaborators

Detail Information

Publications25

  1. doi request reprint Ammonia toxicity to the brain
    Olivier Braissant
    Service of Biomedicine, Lausanne University Hospital, Avenue Pierre Decker 2, CI 02 33, CH 1011 Lausanne, Switzerland
    J Inherit Metab Dis 36:595-612. 2013
    ..Magnetic resonance imaging and spectroscopy will ultimately be a powerful tool to measure the effects of these neuroprotective approaches. ..
  2. doi request reprint AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: a review
    O Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    J Inherit Metab Dis 31:230-9. 2008
    ....
  3. doi request reprint Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers
    Olivier Braissant
    Inborn Errors of Metabolism, Service of Biomedicine, Lausanne University Hospital, Avenue Pierre Decker 2, CI 02 33, CH 1011, Lausanne, Switzerland
    J Inherit Metab Dis 35:655-64. 2012
    ..No uptake of guanidinoacetate from periphery occurs at BBB except under GAMT deficiency, but a net exit of guanidinoacetate seems to occur from CSF to blood at BCSFB, predominantly through the taurine transporter TauT...
  4. pmc Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
    Antoinette Defaux
    Department of Physiology, University of Lausanne, CH 1005 Lausanne, Switzerland
    J Neuroinflammation 6:15. 2009
    ..GW 501516, a specific PPAR-beta agonist, was examined for its capacity to protect from antibody-mediated demyelination and to prevent inflammatory responses induced by IFN-gamma and LPS...
  5. doi request reprint Dissociation of AGAT, GAMT and SLC6A8 in CNS: relevance to creatine deficiency syndromes
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Neurobiol Dis 37:423-33. 2010
    ..This suggests that in most brain regions, guanidinoacetate is transported from AGAT- to GAMT-expressing cells through SLC6A8 to allow creatine synthesis, thereby explaining creatine deficiency in SLC6A8-deficient CNS...
  6. doi request reprint Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH 1011 Lausanne, Switzerland
    Eur J Neurosci 27:1673-85. 2008
    ..This is normally limited due to the absence of SLC6A8 from the astrocyte feet lining microcapillary endothelial cells, and thus creatine supplementation may protect the developing CNS of hyperammonemic patients...
  7. doi request reprint Current concepts in the pathogenesis of urea cycle disorders
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CI 02 33, Lausanne, Switzerland
    Mol Genet Metab 100:S3-S12. 2010
    ..Better understanding the pathophysiology of ammonium toxicity to the brain under UCD will allow the development of new strategies for neuroprotection...
  8. pmc Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1
    Olivier Braissant
    Clinical Chemistry Laboratory, University Hospital, CH 1011 Lausanne, Switzerland
    BMC Dev Biol 5:9. 2005
    ..To investigate the involvement of Cr synthesis and uptake pathways during embryonic development, we determined the spatiotemporal expression of AGAT, GAMT and CT1 during the rat embryogenesis, at the mRNA and protein level...
  9. doi request reprint Ammonia toxicity to the brain: effects on creatine metabolism and transport and protective roles of creatine
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Center Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Mol Genet Metab 100:S53-8. 2010
    ..This article focuses on the effects of ammonia exposure on creatine metabolism and transport in developing brain cells, and on the potential neuroprotective properties of creatine in the brain exposed to ammonium...
  10. doi request reprint Creatine deficiency syndromes and the importance of creatine synthesis in the brain
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Avenue Pierre Decker 2, Lausanne, Switzerland
    Amino Acids 40:1315-24. 2011
    ....
  11. pmc Ammonium accumulation and cell death in a rat 3D brain cell model of glutaric aciduria type I
    Paris Jafari
    Inborn Errors of Metabolism, Molecular Pediatrics, Lausanne University Hospital, Lausanne, Switzerland
    PLoS ONE 8:e53735. 2013
    ..They suggest that intracerebral ammonium accumulation might be an important target for the development of more effective treatment strategies to prevent brain damage in patients with glutaric aciduria type I...
  12. ncbi request reprint Tumor necrosis factor-alpha and alphaB-crystallin up-regulation during antibody-mediated demyelination in vitro: a putative protective mechanism in oligodendrocytes
    Cécile Besson Duvanel
    Neurochemistry Laboratory, Department of Pediatrics, CHUV, Lausanne, Switzerland
    J Neurosci Res 78:711-22. 2004
    ..These results suggest that TNF-alpha, often regarded as a promoter of oligodendroglial death, could alternatively mediate a protective pathway through alphaB-crystallin up-regulation...
  13. pmc Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures
    Paris Jafari
    Inborn Errors of Metabolism, Molecular Pediatrics, Lausanne University Hospital, 1011 Lausanne, Switzerland
    Orphanet J Rare Dis 8:4. 2013
    ..Early diagnosis and current treatment strategies aimed at limiting the production of these metabolites are only partially effective in preventing neurological damage...
  14. doi request reprint Methods to assess neuroinflammation
    Florianne Monnet-Tschudi
    Department of Physiology, University of Lausanne, Switzerland
    Curr Protoc Toxicol . 2011
    ....
  15. doi request reprint CNTF protects oligodendrocytes from ammonia toxicity: intracellular signaling pathways involved
    Laurène Cagnon
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Neurobiol Dis 33:133-42. 2009
    ..Co-treatment with exogenous CNTF demonstrated strong protective effects on oligodendrocytes, but not on neurons, against ammonia toxicity. These protective effects involved JAK/STAT, SAPK/JNK and c-jun proteins...
  16. ncbi request reprint Ammonium-induced impairment of axonal growth is prevented through glial creatine
    Olivier Braissant
    Clinical Chemistry Laboratory, University Hospital, CH 1011 Lausanne, Switzerland
    J Neurosci 22:9810-20. 2002
    ..Our findings suggest that the means to efficiently sustain CNS creatine concentration in hyperammonemic neonates and infants should be assessed to prevent impairment of axonogenesis and irreversible brain damage...
  17. doi request reprint Synthesis and transport of creatine in the CNS: importance for cerebral functions
    Elidie Beard
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    J Neurochem 115:297-313. 2010
    ..Emphasis is also given to the importance of creatine for cerebral function...
  18. ncbi request reprint Expression and function of AGAT, GAMT and CT1 in the mammalian brain
    Olivier Braissant
    Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Subcell Biochem 46:67-81. 2007
    ..The potential role of CT1 as guanidinoacetate transporter between "AGAT-only" and "GAMT-only" expressing cells will also be explored...
  19. doi request reprint Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells
    Laurène Cagnon
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    Neurobiol Dis 32:281-92. 2008
    ..Thus, cdk5 appears as a promising therapeutic target for treating hyperammonemic newborns and infants, especially if one develops specific cdk5/p25 inhibitors...
  20. ncbi request reprint Hyperammonemia-induced toxicity for the developing central nervous system
    Laurène Cagnon
    Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CI 02 33, Avenue Pierre Decker 2, CH 1011 Lausanne, Switzerland
    Brain Res Rev 56:183-97. 2007
    ..Unraveling the molecular mechanisms involved in the chain of events leading to neuronal dysfunction under hyperammonemia may be useful to develop new potential strategies for neuroprotection...
  21. doi request reprint The unsolved puzzle of neuropathogenesis in glutaric aciduria type I
    Paris Jafari
    Inborn Errors of Metabolism, Molecular Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland
    Mol Genet Metab 104:425-37. 2011
    ..Here, we review the experimental evidence and try to delineate possible pathogenetic models and approaches for future studies...
  22. ncbi request reprint P-glycoprotein modulation by valspodar and cyclosporin does not increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases
    Andrea Kuemmerle
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University Hospital, BH18 218, CH 1011 Lausanne, Switzerland
    Anticancer Res 31:2121-8. 2011
    ..The aim of this study was to assess whether tumor uptake of doxorubicin, administered locoregionally by ILP, would be increased by the administration of P-glycoprotein (P-gp) modulators...
  23. ncbi request reprint Measurement of nitric oxide-related enzymes in the brain by in situ hybridization
    Olivier Braissant
    Clinical Chemistry Laboratory, University Hospital, Lausanne, Switzerland
    Methods Mol Biol 279:113-24. 2004
    ....
  24. ncbi request reprint Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha
    Raphael Genolet
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 280:24143-52. 2005
    ..Overall, these data indicate a species-specific regulation by PPARalpha of GRHPR, a key gene of the glyoxylate cycle...
  25. ncbi request reprint Ammonia toxicity to the brain and creatine
    Claude Bachmann
    Laboratoire Central de Chimie Clinique, Centre Hospitalier Universitaire Vaudois, University of Lausanne, LCC, CHUV, Bugnon 46, 1011 Lausanne, Switzerland
    Mol Genet Metab 81:S52-7. 2004
    ..Adequate arginine substitution is essential in the treatment of urea cycle defects as creatine is inefficiently transported into the brain...