C Bonny

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi request reprint IB1 reduces cytokine-induced apoptosis of insulin-secreting cells
    C Bonny
    Division of Medical Genetics and the Department of Internal Medicine, CHUV University Hospital, 1011 Lausanne Switzerland
    J Biol Chem 275:16466-72. 2000
  2. ncbi request reprint Blocking stress signaling pathways with cell permeable peptides
    Christophe Bonny
    Unit of Molecular Genetics, CHUV Lausanne, Switzerland
    Adv Exp Med Biol 588:133-43. 2006
  3. ncbi request reprint Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death
    C Bonny
    Division of Medical Genetics, Centre Hospitalier Universitaire Vaudois University Hospital, Lausanne, Switzerland
    Diabetes 50:77-82. 2001
  4. ncbi request reprint [Role of intracellular signalling pathways in the development of type 1 diabetes]
    Christophe Bonny
    Unité de Génétique Moléculaire, Service de Genetique Medicale, CHUV, 1011 Lausanne
    Rev Med Suisse 1:1153-6. 2005
  5. ncbi request reprint cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein
    S Negri
    Division of Medical Genetics, CHUV University Hospital, Lausanne, 1011, Switzerland
    Genomics 64:324-30. 2000
  6. pmc The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1)
    A Abderrahmani
    Department of Internal Medicine, CHUV University Hospital, Lausanne, Switzerland
    Mol Cell Biol 21:7256-67. 2001
  7. ncbi request reprint The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
    G Waeber
    Department of Internal Medicine, CHUV University Hospital, Lausanne, Switzerland
    Nat Genet 24:291-5. 2000
  8. pmc Characterization of the promoter region of the mouse Xist gene
    N Pillet
    Unit of Molecular Genetics, University of Lausanne, Switzerland
    Proc Natl Acad Sci U S A 92:12515-9. 1995
  9. ncbi request reprint Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene
    V Mooser
    Department of Pathology, CHUV University Hospital, Lausanne, CH 1011, Switzerland
    Genomics 55:202-8. 1999
  10. ncbi request reprint IB1, a JIP-1-related nuclear protein present in insulin-secreting cells
    C Bonny
    Department of Internal Medicine B, University Hospital, Lausanne, Switzerland
    J Biol Chem 273:1843-6. 1998

Collaborators

Detail Information

Publications40

  1. ncbi request reprint IB1 reduces cytokine-induced apoptosis of insulin-secreting cells
    C Bonny
    Division of Medical Genetics and the Department of Internal Medicine, CHUV University Hospital, 1011 Lausanne Switzerland
    J Biol Chem 275:16466-72. 2000
    ..These data indicate that IB1 plays an anti-apoptotic function in insulin-producing cells probably by controlling the activity of the JNK signaling pathway...
  2. ncbi request reprint Blocking stress signaling pathways with cell permeable peptides
    Christophe Bonny
    Unit of Molecular Genetics, CHUV Lausanne, Switzerland
    Adv Exp Med Biol 588:133-43. 2006
    ..We will discuss how we may interfere with MAPK signaling by using short cell-permeable peptides able to block, through a competitive mechanisms, relevant protein-protein contacts, and their effects on signaling and cell function...
  3. ncbi request reprint Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death
    C Bonny
    Division of Medical Genetics, Centre Hospitalier Universitaire Vaudois University Hospital, Lausanne, Switzerland
    Diabetes 50:77-82. 2001
    ..These data establish these bioactive cell-permeable peptides as potent pharmacological compounds that decrease intracellular JNK signaling and confer long-term protection to pancreatic beta-cells from IL-1beta-induced apoptosis...
  4. ncbi request reprint [Role of intracellular signalling pathways in the development of type 1 diabetes]
    Christophe Bonny
    Unité de Génétique Moléculaire, Service de Genetique Medicale, CHUV, 1011 Lausanne
    Rev Med Suisse 1:1153-6. 2005
    ..The pivotal role that the insulin-secreting cells play in their own destruction starts to be uncovered, and these new mechanisms are the target for a whole battery of future drugs...
  5. ncbi request reprint cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein
    S Negri
    Division of Medical Genetics, CHUV University Hospital, Lausanne, 1011, Switzerland
    Genomics 64:324-30. 2000
    ..These data establish IB2 as a novel scaffold protein that regulates the JNK signaling pathway in brain and pancreatic beta-cells and indicate that IB2 represents a novel candidate gene for diabetes...
  6. pmc The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1)
    A Abderrahmani
    Department of Internal Medicine, CHUV University Hospital, Lausanne, Switzerland
    Mol Cell Biol 21:7256-67. 2001
    ..Taken together, these data establish a critical role for REST in the control of the tissue-specific expression of the human IB1 gene...
  7. ncbi request reprint The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
    G Waeber
    Department of Internal Medicine, CHUV University Hospital, Lausanne, Switzerland
    Nat Genet 24:291-5. 2000
    ..Identification of this novel non-maturity onset diabetes of the young (MODY) form of diabetes demonstrates that IB1 is a key regulator of 3-cell function...
  8. pmc Characterization of the promoter region of the mouse Xist gene
    N Pillet
    Unit of Molecular Genetics, University of Lausanne, Switzerland
    Proc Natl Acad Sci U S A 92:12515-9. 1995
    ..A third region from -82 to -41 is needed for correct expression. Deletion of the segment -441 to -231 is associated with an increase in CAT activity and may represent a silencer element...
  9. ncbi request reprint Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene
    V Mooser
    Department of Pathology, CHUV University Hospital, Lausanne, CH 1011, Switzerland
    Genomics 55:202-8. 1999
    ..Our data indicate that the sequence and expression pattern of IB1 are highly conserved between rodent and human and provide the necessary tools to investigate whether IB1 is involved in human diseases...
  10. ncbi request reprint IB1, a JIP-1-related nuclear protein present in insulin-secreting cells
    C Bonny
    Department of Internal Medicine B, University Hospital, Lausanne, Switzerland
    J Biol Chem 273:1843-6. 1998
    ..These data demonstrate that IB1 is a DNA-binding protein related to JIP-1, which is highly expressed in pancreatic beta-cells where it functions as a transactivator of the GLUT2 gene...
  11. ncbi request reprint The loss of GLUT2 expression in the pancreatic beta-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors
    C Bonny
    Department of Internal Medicine B 19 135, University Hospital, CHUV, Lausanne, Switzerland
    Mol Cell Endocrinol 135:59-65. 1997
    ..These data suggest that the decreased activity of GTIIa, in contrast to PDX-1, may be a major initial step in the development of the beta-cell dysfunction in this model of diabetes...
  12. ncbi request reprint Methylation status of CpG sites and methyl-CpG binding proteins are involved in the promoter regulation of the mouse Xist gene
    N Allaman-Pillet
    Division of Medical Genetics and Unit of Molecular Genetics, CHUV, Lausanne, Switzerland
    Gene Expr 7:61-73. 1998
    ..Therefore, we suggest that Xist repression involves its promoter methylation and two distinct methylated DNA binding proteins...
  13. ncbi request reprint The 5' repeat elements of the mouse Xist gene inhibit the transcription of X-linked genes
    N Allaman-Pillet
    Division of Medical Genetics, CHUV, Lausanne, Switzerland
    Gene Expr 9:93-101. 2000
    ..This Xcr effect on X-linked genes suggests that Xcr transcript recognizes the genes to be silenced and is involved in the spreading of X inactivation...
  14. doi request reprint JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis
    S Abdelli
    Service of Medical Genetics, CHUV Hospital, Chemin des Falaises 1, 1011, Lausanne, Switzerland
    Diabetologia 52:1871-80. 2009
    ..This report aims to characterise the expression and role in apoptosis of the three JNK isoforms in insulin-secreting cells exposed to cytokines...
  15. ncbi request reprint Genomic characterization and embryonic expression of the mouse Bigh3 (Tgfbi) gene
    D F Schorderet
    Division Autonome de Génétique Médicale, CHUV, 1101 Lausanne, Switzerland
    Biochem Biophys Res Commun 274:267-74. 2000
    ..The characterization of the murine structure is a prerequisite for the making of such models...
  16. ncbi request reprint Circadian regulation of islet genes involved in insulin production and secretion
    N Allaman-Pillet
    Service of Medical Genetics and Unit of Molecular Genetics, Centre Hospitalier Universitaire Vaudois CHUV, CH 1011 Lausanne, Switzerland
    Mol Cell Endocrinol 226:59-66. 2004
    ..The circadian deregulation of these genes could therefore participate in the diabetic state development...
  17. ncbi request reprint Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
    G Waeber
    Department of Internal Medicine B, University Hospital, Lausanne, Switzerland
    Mol Endocrinol 10:1327-34. 1996
    ..These data demonstrate that the murine GLUT2 promoter is controlled by the PDX-1 homeobox factor through the identified GLUT2TAAT motif...
  18. ncbi request reprint A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo
    Giuseppina Milano
    Departments of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 292:H1828-35. 2007
    ..01). In conclusion, d-JNKI-1 is an important compound that can be used in preclinical models to investigate the role of JNK signaling in vivo. Inhibition of JNK during I/R is cardioprotective in anesthetized rats in vivo...
  19. ncbi request reprint Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals
    Jing Wang
    INSERM U 583, 80 rue Augustin Fliche, 34295 Montpellier, France
    Mol Pharmacol 71:654-66. 2007
    ..Blocking this signaling pathway with RWM delivery of d-JNKI-1 may have significant therapeutic value as a therapeutic intervention to protect the human cochlea from the effects of sound trauma...
  20. ncbi request reprint Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity
    Adrien A Eshraghi
    Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB 3160, Miami, FL 33136 1015, USA
    Hear Res 226:168-77. 2007
    ..This unique therapeutic approach may have clinical application for preventing: (1) hearing loss caused by neomycin ototoxicity; and (2) the progressive component of electrode insertion trauma-induced hearing loss...
  21. pmc Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase
    J David Beckham
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Virol 81:6984-92. 2007
    ..Given the efficacy of the inhibitor in protecting mice from viral encephalitis, JNK inhibition represents a promising and novel treatment strategy for viral encephalitis...
  22. doi request reprint Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases
    Kathrin Maedler
    Larry L Hillblom Islet Research Center, University of California, Los Angeles, California, USA
    FASEB J 22:1905-13. 2008
    ..Therefore, JNK inhibition may protect beta-cells from the deleterious effects of high glucose and leptin in diabetes...
  23. ncbi request reprint D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma
    Adrien A Eshraghi
    Department of Otolaryngology, University of Miami Ear Institute, Miami, Florida 33136 1015, USA
    Otol Neurotol 27:504-11. 2006
    ....
  24. ncbi request reprint Brief reoxygenation episodes during chronic hypoxia enhance posthypoxic recovery of LV function: role of mitogen-activated protein kinase signaling pathways
    Sandrine Morel
    Department of Cardiology, University of Lausanne, CHUV, BH10 1011, Lausanne, Switzerland, and Department of Cardiac Surgery, Alder Hey Royal Children Hospital, Liverpool, UK
    Basic Res Cardiol 101:336-45. 2006
    ..Brief normoxic episodes during chronic hypoxia prevent p38-MAPK activation and restore posthypoxic recovery of myocardial function...
  25. ncbi request reprint A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    Zhi Ye Zhuang
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3551-60. 2006
    ..Targeting the JNK pathway in spinal astroglia may present a new and efficient way to treat neuropathic pain symptoms...
  26. ncbi request reprint A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
    Tiziana Borsello
    Institut de Biologie Cellulaire et de Morphologie, Universite de Lausanne, Rue du Bugnon 9, CH 1005, Switzerland
    Nat Med 9:1180-6. 2003
    ..Protection correlated with prevention of an increase in c-Jun activation and c-Fos transcription. In view of its potency and long therapeutic window, this protease-resistant peptide is a promising neuroprotective agent for stroke...
  27. pmc A unique set of SH3-SH3 interactions controls IB1 homodimerization
    Ole Kristensen
    Biostructural Research, Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
    EMBO J 25:785-97. 2006
    ..Taken together, these results indicate that IB1 homodimerization through its SH3 domain has pleiotropic effects including regulation of the insulin secretion process...
  28. ncbi request reprint Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases
    Christophe Bonny
    Universite de Lausanne, Lausanne, Switzerland
    Rev Neurosci 16:57-67. 2005
    ....
  29. ncbi request reprint Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1
    Nathalie Allaman-Pillet
    Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    J Biol Chem 278:48720-6. 2003
    ..These data indicate that calcium influx initiated by cytokines mediates ubiquitination and degradation of IB1/JIP1 and may, therefore, provide a link between calcium influx and JNK-mediated apoptosis in pancreatic beta-cells...
  30. ncbi request reprint Use of cell-permeable peptides to prevent neuronal degeneration
    Tiziana Borsello
    IBCM, University of Lausanne, Lausanne, Switzerland
    Trends Mol Med 10:239-44. 2004
    ..Here, the recent findings that highlight the potential of this approach for therapeutic application are reviewed...
  31. ncbi request reprint D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia
    Lorenz Hirt
    Service de Neurologie, CHUV, Lausanne, Switzerland
    Stroke 35:1738-43. 2004
    ..In 2 models of severe ischemic injury, we have evaluated the neuroprotective action of D-JNKI1, a cell-penetrating and protease-resistant peptide selectively inhibiting the c-Jun-N-terminal kinase (JNK)...
  32. ncbi request reprint Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure
    Saida Abdelli
    Service of Medical Genetics, 1011 Lausanne CHUV, Switzerland
    Diabetes 53:2815-23. 2004
    ..Therefore, strategies might be rationally developed to avoid possible synergistic activation of these pathways in mediating islet loss during isolation and following grafting...
  33. ncbi request reprint Antitumorigenic effect of proteasome inhibitors on insulinoma cells
    Joachim Størling
    DMSc, Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Endocrinology 146:1718-26. 2005
    ..Our findings demonstrate that proteasome inhibitors possess antitumorigenic and antiinsulinogenic effects on insulinoma cells...
  34. ncbi request reprint A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells
    David Michod
    Department of Cellular Biology and Morphology, Lausanne University, Switzerland
    Oncogene 23:8971-8. 2004
    ..Our results demonstrate the feasibility in enhancing the efficacy of currently used drugs to selectively kill cancer cells using peptides derived from pro-apoptotic caspase substrate fragments...
  35. ncbi request reprint Homogeneous and nonradioactive high-throughput screening platform for the characterization of kinase inhibitors in cell lysates
    Sylvie Guenat
    Service of Medical Genetics, CHUV, Lausanne, Switzerland
    J Biomol Screen 11:1015-26. 2006
    ....
  36. ncbi request reprint Profiling treatment-specific post-translational modifications in a complex proteome with subtractive substrate phage display
    Angela Tenzer
    Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland
    Proteomics 4:2796-804. 2004
    ..Novel, selected peptide substrates were investigated in vitro and in vivo and showed high substrate specificity and functional biological significance...
  37. ncbi request reprint Induction of apoptosis in human corneal and HeLa cells by mutated BIGH3
    Sabine Morand
    Division of Medical Genetics, and Unit of Oculogenetics, Sion, Switzerland
    Invest Ophthalmol Vis Sci 44:2973-9. 2003
    ..To determine the effects of overexpression of mutated BIGH3 in HeLa and human corneal epithelial (HCE) cells...
  38. ncbi request reprint Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein
    Imran Dar
    Structural Chemistry Group, Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100, Denmark
    Acta Crystallogr D Biol Crystallogr 59:2300-2. 2003
    ..These crystals are orthorhombic (P2(1)2(1)2(1)), with unit-cell parameters a = 45.9, b = 57.0, c = 145.5 A. These are the first crystallographic data on a scaffold molecule such as IB1 to be reported...
  39. ncbi request reprint Cell-permeable peptides induce dose- and length-dependent cytotoxic effects
    Alessandra K Cardozo
    The Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Biochim Biophys Acta 1768:2222-34. 2007
    ....
  40. doi request reprint Modulation of the c-Jun N-terminal kinase activity in the embryonic heart in response to anoxia-reoxygenation: involvement of the Ca2+ and mitoKATP channels
    Alexandre Sarre
    Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Mol Cell Biochem 313:133-8. 2008
    ....