Murielle Bochud

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. doi request reprint CYP3A5 and ABCB1 genes and hypertension
    Murielle Bochud
    Institute of Social and Preventive Medicine, Centre hospitalier universitaire vaudois CHUV et Université de Lausanne, Rue du Bugnon 17, CH 1005 Lausanne, Switzerland
    Pharmacogenomics 10:477-87. 2009
  2. doi request reprint The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test
    Beatrice Oneda
    Unit of Biochemistry and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry CHUV, University of Lausanne, Hospital of Cery, Prilly Lausanne, Switzerland
    Pharmacogenet Genomics 19:877-83. 2009
  3. pmc Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study
    Tanica Lyngdoh
    Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 6:e19901. 2011
  4. pmc Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach
    Tanica Lyngdoh
    Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital, Lausanne, Switzerland
    PLoS ONE 7:e39321. 2012
  5. doi request reprint Gene-environment interactions of selected pharmacogenes in arterial hypertension
    Murielle Bochud
    Institute of Social and Preventive Medicine, Lausanne University Hospital, Switzerland
    Expert Rev Clin Pharmacol 5:677-86. 2012
  6. ncbi request reprint [Population reduction of salt consumption: opportunities, impact and strategies]
    M Bochud
    Unité de prévention communautaire, Institut Universitaire de Medecine Sociale et Preventive, CHUV, 1011 Lausanne
    Rev Med Suisse 8:1443-7. 2012
  7. ncbi request reprint Genetics for clinicians: from candidate genes to whole genome scans (technological advances)
    Murielle Bochud
    Community Prevention Unit, Institute of Social and Preventive Medicine, Switzerland
    Best Pract Res Clin Endocrinol Metab 26:119-32. 2012
  8. ncbi request reprint [Are genetic tests useful for cardiovascular prevention?]
    Murielle Bochud
    Unité de prévention communautaire, Institut de Medecine Sociale et Preventive, CHUV, 1011 Lausanne
    Rev Med Suisse 8:519-20, 522-4. 2012
  9. doi request reprint Estimating heritability from nuclear family and pedigree data
    Murielle Bochud
    Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland
    Methods Mol Biol 850:171-86. 2012
  10. pmc Usefulness of Mendelian randomization in observational epidemiology
    Murielle Bochud
    University Institute of Social and Preventive Medicine, Rue du Bugnon 17, Lausanne, Switzerland
    Int J Environ Res Public Health 7:711-28. 2010

Detail Information

Publications64

  1. doi request reprint CYP3A5 and ABCB1 genes and hypertension
    Murielle Bochud
    Institute of Social and Preventive Medicine, Centre hospitalier universitaire vaudois CHUV et Université de Lausanne, Rue du Bugnon 17, CH 1005 Lausanne, Switzerland
    Pharmacogenomics 10:477-87. 2009
    ..If the role of these genes in blood pressure control is confirmed in other populations and other ethnic groups, these findings would point toward a new pathway for blood pressure control in humans...
  2. doi request reprint The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test
    Beatrice Oneda
    Unit of Biochemistry and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Department of Psychiatry CHUV, University of Lausanne, Hospital of Cery, Prilly Lausanne, Switzerland
    Pharmacogenet Genomics 19:877-83. 2009
    ..CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about 50% of drugs on the market, with a large overlap in their specificities. We investigated the genetic bases that contribute to the variation of CYP3A activity...
  3. pmc Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study
    Tanica Lyngdoh
    Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 6:e19901. 2011
    ..We analyzed the association between SUA and circulating levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor- α (TNF-α) and C-reactive protein (CRP)...
  4. pmc Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach
    Tanica Lyngdoh
    Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital, Lausanne, Switzerland
    PLoS ONE 7:e39321. 2012
    ..We used a bidirectional Mendelian randomization approach to explore the nature and direction of causality between SUA and adiposity in a population-based study of Caucasians aged 35 to 75 years...
  5. doi request reprint Gene-environment interactions of selected pharmacogenes in arterial hypertension
    Murielle Bochud
    Institute of Social and Preventive Medicine, Lausanne University Hospital, Switzerland
    Expert Rev Clin Pharmacol 5:677-86. 2012
    ..This review will discuss the respective role of population-based primary prevention and personalized medicine for arterial hypertension, taking a pharmacogenomics' perspective focusing on selected pharmacogenes...
  6. ncbi request reprint [Population reduction of salt consumption: opportunities, impact and strategies]
    M Bochud
    Unité de prévention communautaire, Institut Universitaire de Medecine Sociale et Preventive, CHUV, 1011 Lausanne
    Rev Med Suisse 8:1443-7. 2012
    ..Regular population-based surveys will be needed to monitor the impact of current measures on salt consumption, hypertension prevalence as well as cardiovascular morbidity and mortality in the years to come...
  7. ncbi request reprint Genetics for clinicians: from candidate genes to whole genome scans (technological advances)
    Murielle Bochud
    Community Prevention Unit, Institute of Social and Preventive Medicine, Switzerland
    Best Pract Res Clin Endocrinol Metab 26:119-32. 2012
    ..This review will therefore concentrate on human genetic variation analysis...
  8. ncbi request reprint [Are genetic tests useful for cardiovascular prevention?]
    Murielle Bochud
    Unité de prévention communautaire, Institut de Medecine Sociale et Preventive, CHUV, 1011 Lausanne
    Rev Med Suisse 8:519-20, 522-4. 2012
    ..It is therefore currently not recommended to conducted genetic testing to guide cardiovascular prevention neither in clinical nor in public health settings...
  9. doi request reprint Estimating heritability from nuclear family and pedigree data
    Murielle Bochud
    Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland
    Methods Mol Biol 850:171-86. 2012
    ..Assortative mating, nonrandom ascertainment of families and failure to account for key confounding factors may bias heritability estimates...
  10. pmc Usefulness of Mendelian randomization in observational epidemiology
    Murielle Bochud
    University Institute of Social and Preventive Medicine, Rue du Bugnon 17, Lausanne, Switzerland
    Int J Environ Res Public Health 7:711-28. 2010
    ....
  11. ncbi request reprint Association between C-reactive protein and adiposity in women
    Murielle Bochud
    Department of Medicine, University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1005 Lausanne, Switzerland
    J Clin Endocrinol Metab 94:3969-77. 2009
    ..The link between C-reactive protein (CRP) and adiposity deserves to be further explored, considering the controversial diabetogenic role of CRP...
  12. ncbi request reprint [The example of cystic fibrosis to highlight the complexity of genetic screening]
    Murielle Bochud
    Unité de prévention communautaire, IUMSP, CHUV, Lausanne
    Rev Med Suisse 6:1395-9. 2010
    ..We also present some ethical and economic issues related to cystic fibrosis genetic screening...
  13. ncbi request reprint [Contribution of the CoLaus study to decipher the determinants of serum uric acid]
    M Bochud
    Institut de Medecine Sociale et Preventive, CHUV, Route de la Corniche 2, 1066 Epalinges
    Rev Med Suisse 7:2142, 2144-5. 2011
    ..A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far...
  14. ncbi request reprint [Reducing dietary salt intake: an important public health strategy in Switzerland]
    Murielle Bochud
    Unité de prévention communautaire, Institut Universitaire de Medecine Sociale et Preventive, Departement de Medecine Interne, CHUV et Universite de Lausanne
    Rev Med Suisse 6:494, 496-8. 2010
    ..The Swiss Federal Office of Public Health is currently running a strategy aiming at reducing dietary salt intake in the Swiss population to less than 5 g per day on the long run (Salz Strategie 2008-2012)...
  15. doi request reprint Association between inflammatory and obesity markers in a Swiss population-based sample (CoLaus Study)
    Pedro Marques-Vidal
    Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital, Lausanne, Switzerland
    Obes Facts 5:734-44. 2012
    ....
  16. doi request reprint Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations
    Isabelle Anne Rossi
    Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital and University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Switzerland
    Eur J Epidemiol 27:379-84. 2012
    ..All these relationship were similar in Caucasians and Africans. This is the first report on a non-linear relation, stratified by gender, between hs-CRP and adiposity...
  17. doi request reprint Not all inflammatory markers are linked to kidney function: results from a population-based study
    Menno Pruijm
    Department of Nephrology, University Hospital of Lausanne, Switzerland
    Am J Nephrol 35:288-94. 2012
    ..In this study, we assessed levels of the inflammatory markers C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), interleukin (IL)-1β and IL-6 across all ranges of renal function...
  18. doi request reprint Smoking offsets the metabolic benefits of parental longevity in women: the CoLaus study
    Jerome Jaunin
    University Institute of Social and Preventive Medicine IUMSP, University of Lausanne, Switzerland
    Prev Med 48:224-31. 2009
    ..We evaluated whether subjects with long-lived parents show lower levels of cardiovascular risk factors, including the metabolic syndrome...
  19. pmc Prevalence of obesity and abdominal obesity in the Lausanne population
    Pedro Marques-Vidal
    CardioMet, CHUV, Lausanne, Switzerland
    BMC Public Health 8:330. 2008
    ..Little information exists regarding its prevalence and determinants in Switzerland. Hence, we assessed the levels of obesity as defined by BMI or waist circumference in a Swiss population-based sample...
  20. doi request reprint Short-term increase in particulate matter blunts nocturnal blood pressure dipping and daytime urinary sodium excretion
    Dai Hua Tsai
    Institute of Social and Preventive Medicine, Department of Medicine, Lausanne University Hospital, Biopôle 2, Route de la Corniche 10, CH 1010 Lausanne, Switzerland
    Hypertension 60:1061-9. 2012
    ..The underlying mechanism linking air pollution to increased cardiovascular risk may include disturbed circadian rhythms of renal sodium handling and blood pressure...
  21. doi request reprint Association between white-coat effect and blunted dipping of nocturnal blood pressure
    Murielle Bochud
    Institut Universitaire de Medecine Sociale et Preventive, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Am J Hypertens 22:1054-61. 2009
    ..In this study, we assessed whether the white-coat effect (difference between office and daytime blood pressure (BP)) is associated with nondipping (absence of BP decrease at night)...
  22. ncbi request reprint Predictive accuracy and usefulness of calibration of the ESC SCORE in Switzerland
    Pedro Marques-Vidal
    Centre for Cardiovascular and Metabolic Research Cardiomet, University of Lausanne, Lausanne, Switzerland
    Eur J Cardiovasc Prev Rehabil 15:402-8. 2008
    ..Prevention of cardiovascular disease (CVD) at the individual level should rely on the assessment of absolute risk using population-specific risk tables...
  23. doi request reprint Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension
    Idris Guessous
    Community Prevention Unit, University Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital, Lausanne, Switzerland
    Hum Mol Genet 21:3283-92. 2012
    ..22, -2.91) mmHg]. The associations of CYP1A2 variants with BP were modified by reported caffeine intake. These observational and quasi-experimental results strongly support a causal role of CYP1A2 in BP control via caffeine intake...
  24. ncbi request reprint Associations between alcohol consumption and selected cytokines in a Swiss population-based sample (CoLaus study)
    Pedro Marques-Vidal
    Institute of Social and Preventive Medicine IUMSP, CHUV and Faculty of Biology and Medicine, 1066 Epalinges, Switzerland
    Atherosclerosis 222:245-50. 2012
    ..To assess the associations between alcohol consumption and cytokine levels (interleukin-1beta - IL-1β; interleukin-6 - IL-6 and tumor necrosis factor-α - TNF-α) in a Caucasian population...
  25. pmc Associations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based study
    Tanica Lyngdoh
    Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital CHUV, Lausanne, Switzerland
    PLoS ONE 8:e76336. 2013
    ..We explored the relationship between SUA and subtypes of major depressive disorder (MDD) and specific anxiety disorders. Additionally, we examined the association of SLC2A9 rs6855911 variant with anxiety disorders...
  26. pmc Adipocytokines, hepatic and inflammatory biomarkers and incidence of type 2 diabetes. the CoLaus study
    Pedro Marques-Vidal
    Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital, Lausanne, Switzerland
    PLoS ONE 7:e51768. 2012
    ....
  27. doi request reprint Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis
    Tao Cai
    Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Switzerland
    J Hepatol 55:529-35. 2011
    ....
  28. pmc The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome
    Mathieu Firmann
    Department of Medicine, Internal Medicine, CHUV, Lausanne, Switzerland
    BMC Cardiovasc Disord 8:6. 2008
    ..A secondary aim of the CoLaus study will be to determine new genetic determinants associated with CVRFs...
  29. pmc Effects of particulate matter on inflammatory markers in the general adult population
    Dai Hua Tsai
    Institute of Social and Preventive Medicine, Lausanne University Hospital, Switzerland
    Part Fibre Toxicol 9:24. 2012
    ..Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway...
  30. pmc IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction
    Stephanie Bibert
    Infectious Diseases Service, Department of Medicine and Hepatology, University Hospital and University of Lausanne, 1011 Lausanne, Switzerland
    J Exp Med 210:1109-16. 2013
    ..This novel step in understanding the genetic regulation of IL28B may have important implications for clinical practice, as the use of TT/G genotyping instead of rs12979860 would improve patient management...
  31. pmc Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study
    Franziska Marti
    University Institute of Social and Preventive Medicine, University of Lausanne and Centre Hospitalier Universitaire Vaudois, 1005 Lausanne, Switzerland
    BMC Public Health 11:733. 2011
    ..We also investigated the association of MTHFR polymorphisms related to homocysteine with albuminuria to get further insight into causality...
  32. pmc Serum calcium levels are associated with novel cardiometabolic risk factors in the population-based CoLaus study
    Idris Guessous
    Community Prevention Unit, Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 6:e18865. 2011
    ..We analyzed the association of albumin-corrected serum calcium levels with conventional and non-conventional cardio-metabolic risk factors in a general adult population...
  33. ncbi request reprint Marked association between obesity and glomerular hyperfiltration: a cross-sectional study in an African population
    Gregoire Wuerzner
    Department of Medicine, Service of Nephrology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Am J Kidney Dis 56:303-12. 2010
    ..Obesity and African American ethnicity are established independent risk factors for the development of chronic kidney disease. No data exist about the association between obesity and renal hemodynamics in the African region...
  34. ncbi request reprint Clinical and biological determinants of kidney outcomes in a population-based cohort study
    Idris Guessous
    Community Prevention Unit, Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne University Hospital, Lausanne, Switzerland
    Kidney Blood Press Res 39:74-85. 2014
    ..Conclusion: In addition to age and diabetes, education and CRP levels are associated with adverse kidney outcomes independently of baseline kidney function. © 2014 S. Karger AG, Basel. ..
  35. doi request reprint Heritability, determinants and reference values of renal length: a family-based population study
    Menno Pruijm
    Department of Nephrology, Lausanne University Hospital CHUV, Lausanne, Switzerland
    Eur Radiol 23:2899-905. 2013
    ..In this population-based study, reference values were generated for renal length, and the heritability and factors associated with kidney length were assessed...
  36. pmc Association between variants of the leptin receptor gene (LEPR) and overweight: a systematic review and an analysis of the CoLaus study
    Nicole Bender
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    PLoS ONE 6:e26157. 2011
    ..We performed a systematic review and meta-analysis on the association of the three LEPR variants with BMI. In addition, we analysed 15 SNPs within the LEPR gene in the CoLaus study, assessing the interaction of the variants with sex...
  37. doi request reprint Measurement of glomerular filtration rate in obese patients: pitfalls and potential consequences on drug therapy
    Gregoire Wuerzner
    Service of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Obes Facts 4:238-43. 2011
    ..This may be particularly relevant for drugs known to have a narrow therapeutic range or excreted by the kidney...
  38. ncbi request reprint Patients' sibling history was sensitive for hypertension and specific for diabetes
    Murielle Bochud
    University Institute for Social and Preventive Medicine, Rue du Bugnon 17, 1005 Lausanne, Switzerland
    J Clin Epidemiol 57:497-501. 2004
    ..We examined the analytic validity of reported family history of hypertension and diabetes among siblings in the Seychelles...
  39. doi request reprint Use of a Mendelian randomization approach to assess the causal relation of gamma-Glutamyltransferase with blood pressure and serum insulin levels
    David Conen
    Department of Medicine, University Hospital Basel, Basel, Switzerland
    Am J Epidemiol 172:1431-41. 2010
    ..Using MR, the authors also observed a positive association of GGT with insulin (β = 0.19, 95% CI: 0.01, 0.37; P = 0.04). In conclusion, the authors found evidence for a direct causal relation of GGT with fasting insulin but not with BP...
  40. doi request reprint Factors associated with 24-hour urinary volume: the Swiss salt survey
    Tobias Schoen
    Department of Medicine, University Hospital, Basel, Switzerland
    BMC Nephrol 14:246. 2013
    ..Low 24-hour urine volume (24 UV) may be a significant risk factor for decline in kidney function. We therefore aimed to study associated markers and possible determinants of 24 UV in a sample of the Swiss population...
  41. pmc Epidemiology of masked and white-coat hypertension: the family-based SKIPOGH study
    Heba Alwan
    Institute of Social and Preventive Medicine IUMSP, University Hospital of Lausanne, Lausanne, Switzerland
    PLoS ONE 9:e92522. 2014
    ..We investigated factors associated with masked and white-coat hypertension in a Swiss population-based sample...
  42. doi request reprint Step count is associated with lower nighttime systolic blood pressure and increased dipping
    Gregoire Wuerzner
    Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland
    Am J Hypertens 26:527-34. 2013
    ..However, the determinants of the loss of nocturnal BP dipping are only beginning to be understood. We investigated whether different indicators of physical activity were associated with the loss of nocturnal dipping of BP...
  43. pmc Levels and determinants of inflammatory biomarkers in a Swiss population-based sample (CoLaus study)
    Pedro Marques-Vidal
    Institute of Social and Preventive Medicine, CHUV and Faculty of Biology and Medicine, Lausanne, Switzerland
    PLoS ONE 6:e21002. 2011
    ..to assess the levels and determinants of interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF)-α and C-reactive protein (CRP) in a healthy Caucasian population...
  44. doi request reprint Relation between high-sensitivity C-reactive protein and cardiovascular and renal markers in a middle-income country in the African region
    Isabelle Anne Rossi
    University Institute of Social and Preventive Medicine, University Hospital Center CHUV, University of Lausanne, Rue du Bugnon 17, 1011 Lausanne, Switzerland
    Int J Cardiol 156:203-8. 2012
    ..We analyzed the distribution of hs-CRP and the relationship with a broad set of CVRF, renal markers and carotid intima-media thickness (IMT), in the Seychelles (African region)...
  45. ncbi request reprint Gender difference in the response to an angiotensin-converting enzyme inhibitor and a diuretic in hypertensive patients of African descent
    Catherine Falconnet
    Division of Hypertension and Vascular Medicine, CHUV, Lausanne, University Institute for Social and Preventive Medicine, Lausanne, Switzerland
    J Hypertens 22:1213-20. 2004
    ..The efficacy of angiotensin-converting enzyme (ACE) inhibitors in decreasing blood pressure in African patients is controversial...
  46. pmc Ethnic differences in proximal and distal tubular sodium reabsorption are heritable in black and white populations
    Murielle Bochud
    Community Prevention Unit, University Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland
    J Hypertens 27:606-12. 2009
    ..Segmental handling of sodium along the proximal and distal nephron might be heritable and different between black and white participants...
  47. doi request reprint Methods for testing association between uncertain genotypes and quantitative traits
    Zoltan Kutalik
    Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, 1005 Lausanne, Switzerland
    Biostatistics 12:1-17. 2011
    ..5 M single nucleotide polymorphisms and 5000 individuals...
  48. ncbi request reprint The association of aldosterone with obesity-related hypertension and the metabolic syndrome
    Bruno Vogt
    Department of Medecine, Service of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Semin Nephrol 27:529-37. 2007
    ..Because aldosterone also is associated with blood glucose and blood lipids, selective aldosterone blockade may represent a particularly attractive therapeutic strategy in obese patients with a clustering of cardiovascular risk factors...
  49. ncbi request reprint Association of education and receiving social transfers with allostatic load in the Swiss population-based CoLaus study
    Edouard Nicod
    Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital, Lausanne, Switzerland
    Prev Med 63:63-71. 2014
    ..It is hypothesized that people with low socioeconomic status (SES) are exposed to higher chronic stress and have therefore greater levels of allostatic load...
  50. doi request reprint Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C
    Pierre Yves Bochud
    Department of Internal Medicine, Infectious Diseases Service, CHUV, Lausanne, Switzerland
    J Hepatol 51:655-66. 2009
    ..The aim of this study was to assess independent predictors for fibrosis progression...
  51. ncbi request reprint Renal sodium handling and nighttime blood pressure
    Michel Burnier
    Division of Nephrology and Hypertension Consultation, Department of Medicine, University Hospital, Lausanne, Switzerland
    Semin Nephrol 27:565-71. 2007
    ..These observations would suggest that renal function, and most importantly the ability to eliminate sodium during the day, is indeed a key determinant of the circadian rhythm of blood pressure...
  52. ncbi request reprint Proximal tubular function and salt sensitivity
    Michel Burnier
    Service de Nephrologie, CHUV, Rue du Bugnon 17, 1011 Lausanne, Switzerland
    Curr Hypertens Rep 8:8-15. 2006
    ..In this paper, we review the experimental, clinical, genetic, and epidemiologic evidence suggesting that proximal tubular function is also an important determinant of the blood pressure response to salt, which deserves greater attention...
  53. doi request reprint No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels
    Pedro Marques-Vidal
    Centre for Cardiovascular and Metabolic Research Cardiomet, Switzerland
    Atherosclerosis 211:551-7. 2010
    ..To assess the relationships and possible interactions between polymorphisms related to HDL levels and alcohol consumption...
  54. doi request reprint Predictive accuracy of original and recalibrated Framingham risk score in the Swiss population
    Pedro Marques-Vidal
    Centre for Cardiovascular and Metabolic Research, CardioMet, Switzerland
    Int J Cardiol 133:346-53. 2009
    ..To compare the predictive accuracy of the original and recalibrated Framingham risk function on current morbidity from coronary heart disease (CHD) and mortality data from the Swiss population...
  55. doi request reprint Distribution of plasma levels of adiponectin and leptin in an adult Caucasian population
    Pedro Marques-Vidal
    Centre for Cardiovascular and Metabolic Research Cardiomet, GlaxoSmithKline, Philadelphia, PA, USA
    Clin Endocrinol (Oxf) 72:38-46. 2010
    ..Little is known regarding the distribution and the determinants of leptin and adiponectin levels in the general population...
  56. doi request reprint Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population
    Eva Choong
    Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland
    JAMA Psychiatry 70:1011-9. 2013
    ..The CREB-regulated transcription coactivator 1 (CRTC1) gene is involved in energy balance and obesity in animal models, but its role in human obesity is unknown...
  57. ncbi request reprint A new technique for simultaneous validation of two manual nonmercury auscultatory sphygmomanometers (A&D UM-101 and Accoson Greenlight 300) based on the International protocol
    Menno T Pruijm
    Service of Nephrology, University Hospital of Lausanne CHUV, Rue du Bugnon 17, Lausanne, Switzerland
    Blood Press Monit 15:322-5. 2010
    ..The aim of this study was to validate a new technique capable of testing two devices simultaneously, based on the International protocol of the European Society of Hypertension...
  58. pmc Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene
    Karen Kapur
    Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 6:e1001035. 2010
    ..This study highlights the key role of CASR in calcium regulation...
  59. pmc A comparison of three methods of Mendelian randomization when the genetic instrument, the risk factor and the outcome are all binary
    Philippe Vuistiner
    University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Epalinges, Switzerland
    PLoS ONE 7:e35951. 2012
    ..g., intention-to-treat) approach. We thus conclude that the need to find stronger instruments is probably as important as the need to develop a methodology allowing to consistently estimate a causal odds-ratio...
  60. ncbi request reprint Use of constant denaturant capillary electrophoresis of pooled blood samples to identify single-nucleotide polymorphisms in the genes (Scnn1a and Scnn1b) encoding the alpha and beta subunits of the epithelial sodium channel
    Ming Zhan Xue
    Institute of Pharmacology and Toxicology, Rue du Bugnon 27, 1005 Lausanne, Switzerland
    Clin Chem 48:718-28. 2002
    ..The contribution of genetic variants within the Scnn1a gene, which codes for the alpha subunit, has not been investigated...
  61. ncbi request reprint A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease
    Pascal Renner
    Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    FASEB J 26:907-16. 2012
    ..09 and P=0.09 for MIF production). Taken together, these data suggest that polymorphisms of the MIF gene affecting MIF expression are associated with the occurrence, severity, and outcome of meningococcal disease in children...
  62. ncbi request reprint Are internists in an non-prescriptive setting favourable to guidelines? A survey in a Department of Internal Medicine in Switzerland
    Murielle Bochud
    Health Care Evaluation Unit, Institute of Social and Preventive Medicine, 17 rue du Bugnon, CH 1005 Lausanne, Switzerland
    Swiss Med Wkly 132:201-6. 2002
    ..Despite generally positive attitudes towards guidelines, the opinion of senior staff physicians constitute a barrier to their dissemination and implementation...