J Bille

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi request reprint Efficacy, tolerability and development of resistance in HIV-positive patients treated with fluconazole for secondary prevention of oropharyngeal candidiasis: a randomized, double-blind, placebo-controlled trial
    Jean Luc Pagani
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Antimicrob Chemother 50:231-40. 2002
  2. ncbi request reprint Laboratory diagnosis of infections in febrile neutropenic or immunocompromised patients
    J Bille
    Clinical Microbiology Laboratory, University Hospital CHUV, 1011 Lausanne, Switzerland
    Int J Antimicrob Agents 16:87-9. 2000
  3. ncbi request reprint Changing face of health-care associated fungal infections
    Jacques Bille
    Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Curr Opin Infect Dis 18:314-9. 2005
  4. ncbi request reprint [Diagnosis of invasive fungal infections]
    Jacques Bille
    Institut de Microbiologie, CHUV, 1011 Lausanne
    Rev Med Suisse 1:904-6, 909. 2005
  5. pmc The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois CHUV, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 43:2753-65. 1999
  6. pmc Typing of Pneumocystis carinii f. sp. hominis by single-strand conformation polymorphism of four genomic regions
    P M Hauser
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Microbiol 35:3086-91. 1997
  7. pmc Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 40:2300-5. 1996
  8. pmc Rapid detection of Candida albicans in clinical samples by DNA amplification of common regions from C. albicans-secreted aspartic proteinase genes
    M Flahaut
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Microbiol 36:395-401. 1998
  9. ncbi request reprint Comparison of hospital-wide and unit-specific cumulative antibiograms in hospital- and community-acquired infection
    F Lamoth
    Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Infection 38:249-53. 2010
  10. pmc Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 42:241-53. 1998

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Efficacy, tolerability and development of resistance in HIV-positive patients treated with fluconazole for secondary prevention of oropharyngeal candidiasis: a randomized, double-blind, placebo-controlled trial
    Jean Luc Pagani
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Antimicrob Chemother 50:231-40. 2002
    ..Development of resistant candidiasis (clinical and/or microbiological) was rarely seen in either group and its incidence was not significantly different...
  2. ncbi request reprint Laboratory diagnosis of infections in febrile neutropenic or immunocompromised patients
    J Bille
    Clinical Microbiology Laboratory, University Hospital CHUV, 1011 Lausanne, Switzerland
    Int J Antimicrob Agents 16:87-9. 2000
    ....
  3. ncbi request reprint Changing face of health-care associated fungal infections
    Jacques Bille
    Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Curr Opin Infect Dis 18:314-9. 2005
    ..The purpose of this review was to evaluate recent publications on the epidemiology, diagnosis and management of invasive fungal infections...
  4. ncbi request reprint [Diagnosis of invasive fungal infections]
    Jacques Bille
    Institut de Microbiologie, CHUV, 1011 Lausanne
    Rev Med Suisse 1:904-6, 909. 2005
    ..Among these still experimental methods, the serial detection of galactomannane in the serum of at risk patients is now considered as a useful adjunct for the early diagnosis of invasive aspergillosis...
  5. pmc The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois CHUV, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 43:2753-65. 1999
    ..This study demonstrates for the first time the determinant role of an ABC transporter gene in the acquisition of resistance to azole antifungals by C. glabrata clinical isolates...
  6. pmc Typing of Pneumocystis carinii f. sp. hominis by single-strand conformation polymorphism of four genomic regions
    P M Hauser
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Microbiol 35:3086-91. 1997
    ..Multitarget typing of P. carinii hominis by PCR-SSCP should allow investigation of strain diversity and thus be useful for future epidemiological studies...
  7. pmc Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 40:2300-5. 1996
    ..The assay used in the present study could be implemented with new antifungal agents and is a powerful tool for assigning these substances as putative substrates of multidrug transporters...
  8. pmc Rapid detection of Candida albicans in clinical samples by DNA amplification of common regions from C. albicans-secreted aspartic proteinase genes
    M Flahaut
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Microbiol 36:395-401. 1998
    ..The two false-positive PCR samples came from patients treated with azole antifungal agents, indicating that PCR was probably able to detect damaged organisms that could not be recovered by culture...
  9. ncbi request reprint Comparison of hospital-wide and unit-specific cumulative antibiograms in hospital- and community-acquired infection
    F Lamoth
    Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Infection 38:249-53. 2010
    ..We investigated additional information inferred by aggregating cumulative antibiograms by type of unit or according to the place of acquisition (i.e. community vs. hospital) of the bacteria...
  10. pmc Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 42:241-53. 1998
    ..We speculate that these specific mutations could combine with the effect of multidrug efflux transporters in the clinical isolates and contribute to different patterns and stepwise increases in resistance to azole derivatives...
  11. pmc Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis
    Aimable Nahimana
    Institute of Microbiology, University Hospital of Lausanne, Rue du Bugnon 48, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 48:4301-5. 2004
    ..The results suggest that P. jirovecii populations may evolve under selective pressure from DHFR inhibitors, in particular pyrimethamine, and that DHFR mutations may contribute to P. jirovecii drug resistance...
  12. pmc Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 45:1174-83. 2001
    ..Azole resistance obtained in vitro by HFAR or by agents stimulating mitochondrial loss was at least linked to the upregulation of both CgCDR1 and CgCDR2...
  13. ncbi request reprint Typing methods to approach Pneumocystis carinii genetic heterogeneity
    P M Hauser
    Centre Hospitalier Universitaire Vaudois, Division Autonome de Médecine Préventive Hospitalière, Lausanne, Switzerland
    FEMS Immunol Med Microbiol 22:27-35. 1998
    ..carinii and the frequency of potential co-infections is going to be crucial for a better understanding of its epidemiology, and thus for a better prevention of P. carinii pneumonia in humans...
  14. pmc Matrix-assisted laser desorption ionization-time of flight mass spectrometry as an alternative to 16S rRNA gene sequencing for identification of difficult-to-identify bacterial strains
    A Bizzini
    Institute of Microbiology, University of Lausanne and University Hospital Center, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    J Clin Microbiol 49:693-6. 2011
    ..9% of 410 clinical isolates from 207 different difficult-to-identify species having required 16S rRNA gene sequencing. MALDI-TOF MS might represent an alternative to 16S rRNA gene sequencing...
  15. ncbi request reprint Population pharmacokinetics of fluconazole given for secondary prevention of oropharyngeal candidiasis in HIV-positive patients
    C Csajka
    Division of Clinical Pharmacology, University Hospital, CHUV, Lausanne, Switzerland
    Eur J Clin Pharmacol 57:723-7. 2001
    ....
  16. doi request reprint Interhuman transmission as a potential key parameter for geographical variation in the prevalence of Pneumocystis jirovecii dihydropteroate synthase mutations
    Philippe M Hauser
    Institute of Microbiology, Swiss HIV Cohort Study, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 51:e28-33. 2010
    ..This retrospective study sought to better understand the geographical variation in the prevalence of these mutations...
  17. pmc Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia
    Aimable Nahimana
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Emerg Infect Dis 9:864-7. 2003
    ..The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug...
  18. ncbi request reprint Continuous infusion of ceftazidime with a portable pump is as effective as thrice-a-day bolus in cystic fibrosis children
    I Rappaz
    Department of Paediatrics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Pediatr 159:919-25. 2000
    ..5+/-8.4 microg/ml without any value below the MIC. The mean sputum levels were comparable in both regimens. No CAZ resistant strains of P. aerugino.sa appeared between and directly after the treatments...
  19. ncbi request reprint Genetic diversity of Pneumocystis carinii in HIV-positive and -negative patients as revealed by PCR-SSCP typing
    P M Hauser
    , Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    AIDS 15:461-6. 2001
    ..There was no evidence that in our study population inter-human transmission played a significant role in the epidemiology of P. carinii...
  20. pmc Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae
    I Meneau
    Institute of Microbiology, University Hospital of Lausanne, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 48:2610-6. 2004
    ..jiroveci. Taken together, our results suggest that the DHPS polymorphisms observed in P. jiroveci confer sulfa drug resistance on this pathogen...
  21. ncbi request reprint Molecular epidemiology of predominant clones and sporadic strains of methicillin resistant Staphylococcus aureus in Switzerland and comparison with European epidemic clones
    D S Blanc
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Clin Microbiol Infect 8:419-26. 2002
    ..To assess the molecular epidemiology and risk factors of predominant clones and sporadic strains of methicillin-resistant Staphylococcus aureus (MRSA) in Swiss hospitals and to compare them with European strains of epidemic clones...
  22. ncbi request reprint CRZ1, a target of the calcineurin pathway in Candida albicans
    Mahir Karababa
    Institute of Microbiology, University Hospital Lausanne, CH 1011 Lausanne, Switzerland
    Mol Microbiol 59:1429-51. 2006
    ..Even though this work establishes CRZ1 as a calcineurin target, further studies are needed to identify other calcineurin-dependent elements in C. albicans...
  23. ncbi request reprint Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000
    Oscar Marchetti
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Clin Infect Dis 38:311-20. 2004
    ..krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred...
  24. ncbi request reprint Association between a specific Pneumocystis jiroveci dihydropteroate synthase mutation and failure of pyrimethamine/sulfadoxine prophylaxis in human immunodeficiency virus-positive and -negative patients
    Aimable Nahimana
    Hospital of Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
    J Infect Dis 188:1017-23. 2003
    ..Hospitalization in a specific hospital was an independent risk factor for having P. jiroveci harboring the same DHPS mutation, which indirectly supports that interhuman transmission may affect the dissemination of the mutant strains...
  25. pmc TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2
    Alix T Coste
    Institute of Microbiology, University Hospital Lausanne, Rue du Bugnon 48, CH 1011 Lausanne, Switzerland
    Eukaryot Cell 3:1639-52. 2004
    ..In conclusion, TAC1 appears to be the first C. albicans transcription factor involved in the control of genes mediating antifungal resistance...
  26. ncbi request reprint Pneumocystis jirovecii dihydrofolate reductase polymorphisms associated with failure of prophylaxis
    Aimable Nahimana
    Hospital Preventive Medicine, University Hospital, 1011 Lausanne, Switzerland
    J Eukaryot Microbiol 50:656-7. 2003
  27. pmc Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents
    Dominique Sanglard
    University Hospital Lausanne Chuv, CH 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 47:2404-12. 2003
    ..albicans strain harboring a defective erg11 allele can be obtained in vitro in the presence of amphotericin B. Amphotericin B-resistant strains could therefore be selected by similar mechanisms during antifungal therapy...
  28. ncbi request reprint Epidemiology of methicillin-resistant Staphylococcus aureus: results of a nation-wide survey in Switzerland
    Dominique S Blanc
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Swiss Med Wkly 132:223-9. 2002
    ..To assess the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Switzerland...
  29. ncbi request reprint Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence
    Dominique Sanglard
    Institute of Microbiology, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon 44, CH 1011 Lausanne, Switzerland
    Mol Microbiol 48:959-76. 2003
    ..Finally, calcineurin was found to be necessary for the virulence of C. albicans in a mice model of infection, thus making calcineurin an important element for adequate adaptation to the conditions of the host environment...
  30. ncbi request reprint Single-step extraction of fluconazole from plasma by ultra-filtration for the measurement of its free concentration by high performance liquid chromatography
    Paul Anthony Majcherczyk
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Pharm Biomed Anal 28:645-51. 2002
    ..Ultra-filtration of plasma with cellulose filters permits the extraction of FLC from small volumes (240 microl). The determination of FLC concentrations by HPLC after this single-step procedure is selective, precise and accurate...
  31. pmc Variability of voriconazole plasma levels measured by new high-performance liquid chromatography and bioassay methods
    Andres Pascual
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 51:137-43. 2007
    ..Simple HPLC and bioassay methods offer new tools for monitoring voriconazole therapy...
  32. pmc Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters
    Mahir Karababa
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 48:3064-79. 2004
    ..Upregulated genes in both drug-exposed conditions and clinical strains are drug resistance genes but also genes that could be activated under cell damage conditions...
  33. ncbi request reprint Faucets as a reservoir of endemic Pseudomonas aeruginosa colonization/infections in intensive care units
    D S Blanc
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Intensive Care Med 30:1964-8. 2004
    ..To evaluate the role of faucets as a reservoir for Pseudomonas aeruginosa colonization/infection of patients hospitalized in intensive care units (ICUs)...
  34. pmc A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
    Alix Coste
    Institute of Microbiology, University Hospital Lausanne, Switzerland
    Genetics 172:2139-56. 2006
    ....
  35. pmc Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes
    Oscar Marchetti
    Division of Infectious Diseases, Department of Internal Medicine Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 47:1565-70. 2003
    ..Thus, inhibition of multidrug efflux transporters encoded by CDR1, CDR2, CaMDR1, and FLU1 genes is not responsible for the fungicidal synergism of FLC-CY. Other cellular targets must be considered...
  36. pmc Performance of matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of bacterial strains routinely isolated in a clinical microbiology laboratory
    A Bizzini
    Institute of Microbiology, University of Lausanne, and University Hospital Center, Rue du Bugnon 46, Lausanne 1011, Switzerland
    J Clin Microbiol 48:1549-54. 2010
    ....
  37. ncbi request reprint [New methods for the diagnosis of implant-associated infections]
    A Trampuz
    Service des Maladies Infectieuses, Departement de Medecine Interne, CHUV, 1011 Lausanne
    Rev Med Suisse 6:731-4. 2010
    ..In this article, we describe the conventional and newer diagnostic techniques with their advantages and potential future applications...
  38. doi request reprint Multiplex real-time PCR for the diagnosis of malaria: correlation with microscopy
    L Dormond
    Institute of Microbiology, University Hospital Center and University of Lausanne, Switzerland
    Clin Microbiol Infect 17:469-75. 2011
    ..The quantification obtained by PCR closely correlated with microscopy-based quantification and could be useful for monitoring treatment efficacy, at least in clinical trials...
  39. pmc Prospective determination of plasma imipenem concentrations in critically ill children
    Eric Giannoni
    Department of Pediatrics, CHUV, CH 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 50:2563-8. 2006
    ..To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy...
  40. ncbi request reprint A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance
    Michelle de Micheli
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 44, CH 1011 Lausanne, Switzerland
    Mol Microbiol 43:1197-214. 2002
    ....
  41. pmc Risk for Pneumocystis carinii transmission among patients with pneumonia: a molecular epidemiology study
    Elodie Senggen Manoloff
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Emerg Infect Dis 9:132-4. 2003
    ..Our analysis suggests that transmission from patients with active PCP to susceptible persons caused only a few, if any, PCP cases in our setting...
  42. ncbi request reprint Early diagnosis of invasive candidiasis with mannan antigenemia and antimannan antibodies
    Maura Prella
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Diagn Microbiol Infect Dis 51:95-101. 2005
    ..001). Candidiasis was diagnosed before neutrophil recovery in 78% and 11% of cases with Mn/anti-Mn and radiology, respectively (P < 0.001). Mn and anti-Mn may be useful for early noninvasive diagnosis of IC...
  43. pmc Cefepime versus imipenem-cilastatin for treatment of nosocomial pneumonia in intensive care unit patients: a multicenter, evaluator-blind, prospective, randomized study
    G Zanetti
    Division of Infectious Diseases, Department of Microbiology, and Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 47:3442-7. 2003
    ..aeruginosa. Selection of a single agent for therapy of nosocomial pneumonia should be guided by local resistance patterns...
  44. ncbi request reprint In vitro antimicrobial activity of moxifloxacin against bacterial strains isolated from blood of neutropenic cancer patients
    A Cometta
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Eur J Clin Microbiol Infect Dis 25:537-40. 2006
  45. pmc Typing Listeria monocytogenes isolates from fish products and human listeriosis cases
    P Boerlin
    Institute of Microbiology, University Hospital, Lausanne, Switzerland
    Appl Environ Microbiol 63:1338-43. 1997
    ..None of the 48 subtypes distinguished by the combination of all four typing methods could be found in both populations of human origin and those of fish origin...
  46. ncbi request reprint Value of the comparative enzyme-linked immunofiltration assay for early neonatal diagnosis of congenital Toxoplasma infection
    J Zufferey
    Department of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Pediatr Infect Dis J 18:971-5. 1999
    ....
  47. pmc Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 39:2378-86. 1995
    ..cerevisiae mutants lacking specific multidrug transporters which were rendered hypersusceptible to azole derivatives including fluconazole, itraconazole, and ketoconazole...
  48. pmc Evaluation of a novel medium for screening specimens from hospitalized patients to detect methicillin-resistant Staphylococcus aureus
    D S Blanc
    Hospital Preventive Medicine, Institute of Microbiology, University Hospital of Lausanne CHUV, Lausanne, Switzerland
    J Clin Microbiol 41:3499-502. 2003
    ..aureus. An enrichment broth is still needed to ensure a good sensitivity for the recovery of MRSA, and an incubation time of 48 h is required for primary culture on ORSA medium...
  49. ncbi request reprint Comparison of automated strategies for surveillance of nosocomial bacteremia
    Cristina Bellini
    Service de Médecine Préventive Hospitalière CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Infect Control Hosp Epidemiol 28:1030-5. 2007
    ..Surveillance of nosocomial bloodstream infection (BSI) is recommended, but time-consuming. We explored strategies for automated surveillance...
  50. ncbi request reprint Development of a multiplex real-time quantitative PCR assay to detect Chlamydia pneumoniae, Legionella pneumophila and Mycoplasma pneumoniae in respiratory tract secretions
    Martine Welti
    Institute of Microbiology, University Hospital of Lausanne, Lausanne, Switzerland
    Diagn Microbiol Infect Dis 45:85-95. 2003
    ..Of 19 serology-positive patients, 14 were confirmed by the multiplex real-time PCR to be infected by either one of the three pathogens. All samples from serology-negative patients were negative with the multiplex real-time PCR...
  51. ncbi request reprint A novel real-time PCR to detect Chlamydia trachomatis in first-void urine or genital swabs
    Katia Jaton
    Institute of Microbiology, University of Lausanne, Lausanne, Switzerland
    J Med Microbiol 55:1667-74. 2006
    ..trachomatis. Given its high throughput potential and low costs/laboratory technician time requirement, it may be useful for future use in large C. trachomatis screening programs...
  52. doi request reprint Caspofungin for prevention of intra-abdominal candidiasis in high-risk surgical patients
    Laurence Senn
    Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois CHUV and University of Lausanne UNIL, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Intensive Care Med 35:903-8. 2009
    ..The aim of this study was to explore the efficacy and safety of caspofungin for prevention of intra-abdominal IC in high-risk surgical patients...
  53. pmc First case of bacteremia and multifocal cellulitis due to Helicobacter canis in an immunocompetent patient
    Corinne Leemann
    Infectious Diseases Service, University Hospital, CHUV BH 07 865, 1011 Lausanne, Switzerland
    J Clin Microbiol 44:4598-600. 2006
    ..Here we report on the first human case of H. canis bacteremia in an immunocompetent host. Identification of the organism was made by genetic and phylogenetic analyses of the complete 16S rRNA sequence...
  54. doi request reprint Histoplasma capsulatum var. duboisii infection in a patient with AIDS: rapid diagnosis using polymerase chain reaction-sequencing
    Cyril Pellaton
    Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland
    Diagn Microbiol Infect Dis 64:85-9. 2009
    ..The variety duboisii of Hc was established using DNA sequencing of the polymorphic genomic region OLE. Molecular tools allow diagnosis of histoplasmosis in 24 h, which is drastically shorter than culture procedures...
  55. ncbi request reprint Site-directed mutagenesis of the Saccharomyces cerevisiae dihydropteroate synthase FOL1 gene to study Pneumocystis jirovecii mutations in the orthologue gene FAS
    Isabelle Meneau
    Microbiology Institute, University Hospital, 1011 Lausanne, Switzerland
    J Eukaryot Microbiol 50:652-3. 2003
  56. ncbi request reprint Percentage, bacterial etiology and antibiotic susceptibility of acute respiratory infection and pneumonia among children in rural Senegal
    Pablo Echave
    Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Trop Pediatr 49:28-32. 2003
    ..Comorbidities (tuberculosis, malaria, HIV-AIDS, severe malnutrition) are determinant variables in many ARI cases and carry a high negative prognosis value...
  57. ncbi request reprint [Doctor, I have a lymph node]
    Jacques Bille
    Institut de Microbiologie, Département de pathologie et de médecine de laboratoire, CHUV, 1011 Lausanne
    Rev Med Suisse 5:710-5. 2009
    ..If present, these signs will trigger a biopsy with cyto- or histopathological examination mostly to rule out a malignant tumor. This article reviews the practical steps of an investigation of an isolated adenopathy in an adult patient...
  58. pmc Detection of four Plasmodium species in blood from humans by 18S rRNA gene subunit-based and species-specific real-time PCR assays
    Mathieu Rougemont
    Institute of Microbiology, University Hospital of Lausanne, Switzerland
    J Clin Microbiol 42:5636-43. 2004
    ..This suggests a role of quantitative PCR for the monitoring of patients receiving antimalaria therapy...
  59. ncbi request reprint Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate
    John W Slaven
    School of Medicine, 1 800 Stopford Building, University of Manchester, Oxford Road, Manchester, UK
    Fungal Genet Biol 36:199-206. 2002
    ..atrF is the first ABCT gene cloned from A. fumigatus, whose overexpression is correlated with itraconazole resistance...
  60. doi request reprint 1,3-Beta-D-glucan antigenemia for early diagnosis of invasive fungal infections in neutropenic patients with acute leukemia
    Laurence Senn
    Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 46:878-85. 2008
    ..The aim of the present prospective study was to evaluate the usefulness of monitoring BG in patients undergoing chemotherapy for acute leukemia...
  61. pmc Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis: a global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005
    M A Pfaller
    Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 46:842-9. 2008
    ..parapsilosis to fluconazole and voriconazole may vary by geographic region and clinical service...
  62. doi request reprint Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes
    Andres Pascual
    Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 46:201-11. 2008
    ..Liver disease, age, genetic polymorphism of the cytochrome CYP2C19, and comedications influence voriconazole metabolism. Large variations in voriconazole pharmacokinetics may be associated with decreased efficacy or with toxicity...
  63. pmc Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland
    Marie Frédérique Lartigue
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, Bicetre, France
    Antimicrob Agents Chemother 51:2855-60. 2007
    ..The plasmid-located bla(CTX-M) genes were associated with either ISEcp1 or ISCR1 insertion sequences. This study is the first published report of CTX-M-type beta-lactamases in Switzerland...
  64. pmc SME-2-producing Serratia marcescens isolate from Switzerland
    Laurent Poirel
    Antimicrob Agents Chemother 51:2282-3. 2007
  65. ncbi request reprint Geographical variation in the prevalence of Pneumocystis jirovecii dihydropteroate synthase mutations within Western Europe
    Meja Rabodonirina
    Parasitology Unit, Croix Rousse Hospital, Hospices Civils de Lyon, 103 Grande Rue de la Croix Rousse, 69317 Lyon Cedex 04, France
    J Eukaryot Microbiol 53:S112-3. 2006
  66. pmc Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species
    Frank C Odds
    Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, United Kingdom
    J Clin Microbiol 42:3475-82. 2004
    ....
  67. ncbi request reprint Treatment options of invasive fungal infections in adults
    Ursula Fluckiger
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland
    Swiss Med Wkly 136:447-63. 2006
    ..Amphotericin B deoxycholate is recommended as initial therapy for the empirical therapy in patients with neutropenia and persistent fever with close monitoring of adverse events...
  68. ncbi request reprint Invasive candidiasis: comparison of management choices by infectious disease and critical care specialists
    Philippe Eggimann
    Infection Control Program, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211, Geneva 14, Switzerland
    Intensive Care Med 31:1514-21. 2005
    ..To compare the management of invasive candidiasis between infectious disease and critical care specialists...
  69. pmc Ampicillin-sensitive, imipenem-resistant strains of Enterococcus faecium
    Nagwa El Amin
    J Clin Microbiol 40:738. 2002
  70. pmc Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever
    Cristina Bellini
    Infectious Diseases Unit, University Hospital of Lausanne, Lausanne, Switzerland
    BMC Infect Dis 5:90. 2005
    ..conorii. African tick-bite fever (ATBF) is generally considered as a benign disease and no cases of myocardial involvement due to Rickettsia africae, the agent of ATBF, have yet been described...
  71. ncbi request reprint Disseminated histoplasmosis in Switzerland: an unexpected cause of septic shock and multiple organ dysfunction
    Matthias Cavassini
    Intensive Care Med 28:1501-2. 2002
  72. pmc Bloodstream and endovascular infections due to Abiotrophia defectiva and Granulicatella species
    Laurence Senn
    Infectious Diseases Service, University Hospital, Lausanne, Switzerland
    BMC Infect Dis 6:9. 2006
    ..In this study, we reviewed the clinical manifestations of infections due to A. defectiva and Granulicatella species that occurred at our institution between 1998 and 2004...
  73. pmc Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:15535-9. 2006
    ..The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease...
  74. pmc Clinical implications of Mycobacterium kansasii species heterogeneity: Swiss National Survey
    Caroline Taillard
    Department of Microbiology Division of Infectious Diseases, University Hospital, Lausanne, Switzerland
    J Clin Microbiol 41:1240-4. 2003
    ..5% of patients). Subtyping M. kansasii may improve clinical management by distinguishing pathogenic from nonpathogenic subtypes...
  75. doi request reprint Candida arteritis in patients who have not received organ transplants: case report and review of the literature
    Caroline Chapuis-Taillard
    Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 46:e106-11. 2008
    ..A high index of suspicion, early diagnosis, and prompt antifungal and surgical treatment seem crucial to efforts to avoid life-threatening arterial rupture and hemorrhage...
  76. pmc Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) C
    Ben de Pauw
    Department of Blood Transfusion Service and Transplant Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 46:1813-21. 2008
    ..Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies...