Research Topics
| Mette M BergerSummaryAffiliation: Centre Hospitalier Universitaire Vaudois Country: Switzerland Publications
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Detail Information
Publications
Exudative mineral losses after serious burns: a clue to the alterations of magnesium and phosphate metabolismM M Berger
Anesthesiology and Surgical Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Am J Clin Nutr 65:1473-81. 1997..Mean daily losses of both magnesium and phosphate were more than the recommended dietary allowances. Exudative losses combined with urinary losses largely explained the increased mineral requirements after burn injury...
Impact of a computerized information system on quality of nutritional support in the ICUMette M Berger
Surgical ICU and Burns Center, University Hospital CHUV, Lausanne, Switzerland
Nutrition 22:221-9. 2006..We investigated the effect of computerized information systems (CISs) on quality of nutritional support by comparing two ICUs with or without CIS and burned patients before and after CIS implementation...
Can oxidative damage be treated nutritionally?Mette M Berger
Surgical ICU, Soins Intensifs Chirurgicaux et Centre des Brûlés, CHUV BH08 660, CH 1011 Lausanne, Switzerland
Clin Nutr 24:172-83. 2005..The beneficial effects have been attributed to the reduction of oxidative damage caused by the normal or excessive free radical production. The papers aims at collecting evidence of successful supplementation strategies...
Enteral nutrition in critically ill patients with severe hemodynamic failure after cardiopulmonary bypassMette M Berger
Soins Intensifs Chirurgicaux et Centre des Brûlés, Centre Hospitalier Universitaire Vaudois CHUV BH 08 660, CH 1011 Lausanne, Switzerland
Clin Nutr 24:124-32. 2005..The study was designed to investigate and quantify nutritional support, and particularly enteral nutrition (EN), in critically ill patients with severe hemodynamic failure...
Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patientsMette M Berger
Surgical Intensive Care Unit and Burns Centre, University Hospital, BH 08 660, CH 1011 Lausanne, Switzerland
Am J Clin Nutr 80:410-6. 2004..Acute renal failure is a serious complication in critically ill patients and frequently requires renal replacement therapy, which alters trace element and vitamin metabolism...
[Malnutrition and intensive care: discussion on a difficult case]Mette M Berger
Soins Intensifs Chirurgicaux et Centre des Brûlés, CHUV Lausanne
Rev Med Suisse Romande 123:383-6. 2003..The case illustrates the importance of monitoring daily and cumulated energy balance...
Serum paracetamol concentration: an alternative to X-rays to determine feeding tube location in the critically illMette M Berger
Soins Intensifs Chirurgicaux, Lausanne, Switzerland
JPEN J Parenter Enteral Nutr 27:151-5. 2003..Previous studies suggest that paracetamol absorption is very fast after jejunal administration. The aim was to determine whether paracetamol serum concentration measured by immunoassay can determine the tip position of the feeding tube...
Metabolic and nutritional support in acute cardiac failureMette M Berger
Intensive Care Unit and Burns Centre, University Hospital, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 6:195-201. 2003....
Progression rate of self-propelled feeding tubes in critically ill patientsMette M Berger
Soins Intensifs de Chirurgie et Centre des Brûlés, CHUV BH08 660, 1011 Lausanne, Switzerland
Intensive Care Med 28:1768-74. 2002..Recently, a feeding tube has been introduced that migrates spontaneously into the jejunum in surgical patients. The study aimed at assessing the rate of migration of this tube in critically ill patients...
Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trialM M Berger
Surgical ICU and Burns Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Am J Clin Nutr 68:365-71. 1998....
Intestinal absorption in patients after cardiac surgeryM M Berger
Anesthesiology and Surgical Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
Crit Care Med 28:2217-23. 2000..We designed this study to assess intestinal absorption in patients with adequate or altered hemodynamic status after cardiac surgery and to test clinical tolerance to early enteral nutrition...
Impact of a bicarbonated saline solution on early resuscitation after major burnsM M Berger
Soins intensifs de chirurgie, CHUV, Lausanne, Switzerland
Intensive Care Med 26:1382-5. 2000..The study aimed at assessing the impact of the introduction of a bicarbonated saline solution on total fluid load, weight gain and acid base status during acute burn resuscitation...
Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trialM M Berger
Soins intensifs de chirurgie, CHUV, Lausanne, Switzerland
Intensive Care Med 27:91-100. 2001..To investigate whether early selenium (Se) supplementation can modify the post-traumatic alterations of thyroid hormone metabolism, since the first week after trauma is characterised by low plasma Se and negative Se balances...
Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrationsMette M Berger
Department of Adult Intensive Care Medicine and Burns Center, Lausanne, Switzerland
Am J Clin Nutr 85:1293-300. 2007..After major burns, patients can develop nutritional deficiencies including trace element (TE) deficiencies. Various complications, such as infections and delayed wound healing, influence the clinical course of such patients...
Trace element supplementation after major burns increases burned skin trace element concentrations and modulates local protein metabolism but not whole-body substrate metabolismMette M Berger
Department of Adult Intensive Care Medicine and Burns Centre, Lausanne, Switzerland
Am J Clin Nutr 85:1301-6. 2007..After major burns, patients exhibit an intense catabolism, and the wounds require surgery and grafting for closure. Complications, such as weight loss and delayed wound healing, are worsened by trace element (TE) deficiencies...
Metabolic and physiologic effects of an endotoxin challenge in healthy obese subjectsMarcel Rohrer
Service of Adult Intensive Care Medicine, CHUV, Lausanne, Switzerland
Clin Physiol Funct Imaging 31:371-5. 2011..The aim of this study was to test the physiologic response of healthy obese subjects to a standardized intravenous LPS challenge...
Monitoring the clinical introduction of a glutamine and antioxidant solution in critically ill trauma and burn patientsLudivine Soguel
Department of Intensive Care Medicine and Burns Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Nutrition 24:1123-32. 2008..This study investigated the impact on organ function and clinical outcome of an enteral solution enriched with glutamine and antioxidant micronutrients in patients with trauma and with burns...
Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patientsStéphane Villet
Anesthésiologie, Centre Hospitalier Universitaire Vaudois CHUV, 1011 Lausanne, Switzerland
Clin Nutr 24:502-9. 2005..Critically ill patients with complicated evolution are frequently hypermetabolic, catabolic, and at risk of underfeeding. The study aimed at assessing the relationship between energy balance and outcome in critically ill patients...
Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trialsMette M Berger
Department of Adult Intensive Care Medicine and Burn Centre, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
Crit Care 10:R153. 2006..Burned patients suffer trace element deficiencies and depressed antioxidant and immune defences. This study aimed at determining the effect of trace element supplementation on nosocomial or intensive care unit (ICU)-acquired pneumonia...
Labeled acetate to assess intestinal absorption in critically ill patientsRené L Chioléro
Surgical Intensive Care Unit Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
Crit Care Med 31:853-7. 2003..To compare the absorption of carbon-13(13C) acetate-enriched nutrients with D-xylose absorption...
Update on clinical micronutrient supplementation studies in the critically illMette M Berger
Department of Adult Critical Care Medicine and Burns Center, CHUV, CH 1011 Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 9:711-6. 2006..Selenium is emerging as a particularly important micronutrient. This paper reviews the evidence from trials in the critically ill, putting mechanisms, methods and shortcomings into perspective...
Impact of a pain protocol including hypnosis in major burnsMette M Berger
Service of Intensive Care Medicine and Burns Centre, University Hospital CHUV, Lausanne, Switzerland
Burns 36:639-46. 2010..Pain is a major issue after burns even when large doses of opioids are prescribed. The study focused on the impact of a pain protocol using hypnosis on pain intensity, anxiety, clinical course, and costs...
Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patientsMette M Berger
Department of Intensive Care Medicine and Burns Centre, University Hospital Centre Hospitalier Universitaire Vaudois, CHUV, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
Crit Care 12:R101. 2008..The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit (ICU) patients with conditions characterized by oxidative stress...
Intravenous fish oil blunts the physiological response to endotoxin in healthy subjectsThomas Thi Pluess
Department of Intensive Care Medicine, CHUV, 1011, Lausanne, Switzerland
Intensive Care Med 33:789-97. 2007..To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers...
Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oilYann K Pittet
Service of Adult Intensive Care Medicine and Burns Centre, CHUV, 1011 Lausanne, Switzerland
Intensive Care Med 36:289-95. 2010..To test the dose response effect of infused fish oil (FO) rich in n-3 PUFAs on the inflammatory response to endotoxin (LPS) and on membrane incorporation of fatty acids in healthy subjects...
Lactate and glucose metabolism in severe sepsis and cardiogenic shockJean-Pierre Revelly
Surgical Intensive Care Unit, University Hospital, Lausanne, Switzerland
Crit Care Med 33:2235-40. 2005..Increased lactate production was concomitant to hyperglycemia and increased glucose turnover, suggesting that the latter substantially influences lactate metabolism during critical illness...
Nutritional support of obese critically ill patientsRené L Chioléro
Surgical Intensive Care Unit, Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
Nestle Nutr Workshop Ser Clin Perform Programme 8:187-200; discussion 200-5. 2003
Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteersBurkhard Michaeli
Department of Intensive Care Medicine, CHUV, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
Clin Nutr 26:70-7. 2007..Endotoxin (LPS) has been shown to mimic several aspects of sepsis. The study aimed at testing the effects of oral FO supplements in healthy subjects submitted to intravenous LPS on systemic and endocrine response...
Antioxidant micronutrients in major trauma and burns: evidence and practiceMette M Berger
Department of Intensive Care Medicine and Burns Center, CHUV BH08 660, CH 1011 Lausanne, Switzerland
Nutr Clin Pract 21:438-49. 2006..The IV route seems the only way to deliver the doses required to obtain a clinical effect...
Hypocaloric feeding: pros and consMette M Berger
Department of Adult Intensive Care Medicine and Burns Centre, University Hospital CHUV, Lausanne, Switzerland
Curr Opin Crit Care 13:180-6. 2007..We aim to define hypocaloric feeding based on indirect calorimetric data and to discuss patient-relevant clinical outcomes resulting from hypocaloric feeding...
Vitamin C requirements in parenteral nutritionMette M Berger
Service of Adult Intensive Care Medicine and Burns Centre, University Hospital CHUV, Lausanne, Switzerland
Gastroenterology 137:S70-8. 2009..Future research should distinguish therapeutic use of high-dose ascorbic acid antioxidant therapy from nutritional PN requirements...
[Pre- and intra-hospital over-resuscitation in burns: frequent and deleterious]Mette M Berger
Service de médecine intensive adulte et Centre des brûlés, CHUV, 1011 Lausanne
Rev Med Suisse 6:2410, 2412-5. 2010..The paper analyses the causes of this fluid creep, and the ways to prevent it, which includes rationing prehospital fluid delivery, avoiding early colloids and permissive hypovolemia...
Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failureMarc-Daniel Bollmann
Surgical Intensive Care Unit, University Hospital CHUV, 1011 Lausanne, Switzerland
Intensive Care Med 30:1103-10. 2004..Lactate did not exert undesirable effects, except moderate hyperglycemia, and achieved comparable effects on acid-base balance to bicarbonate...
Nutritional status and food intake in nine patients with chronic low-limb ulcers and pressure ulcers: importance of oral supplementsWassim Raffoul
Chirurgie Plastique et Reconstructive, CHUV, Lausanne, Switzerland
Nutrition 22:82-8. 2006..Meals did not cover energy requirements, while oral supplements covered basic micronutrient requirements and compensated for insufficient oral energy and protein intakes, justifying their use in hospitalized elderly patients...
Antioxidant supplementation in sepsis and systemic inflammatory response syndromeMette M Berger
Department of Intensive Care Medicine and Burns Centre, University Hospital, Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne, Switzerland
Crit Care Med 35:S584-90. 2007....
Key vitamins and trace elements in the critically illMette M Berger
Surgical ICU and Burns Centre, CHUV, Lausanne, Switzerland
Nestle Nutr Workshop Ser Clin Perform Programme 8:99-111; discussion 111-7. 2003
Enteral nutrition and cardiovascular failure: from myths to clinical practiceMette M Berger
Department of Intensive Care Medicine and Burns Centre, University Hospital, Lausanne, Switzerland
JPEN J Parenter Enteral Nutr 33:702-9. 2009..Energy delivery and balance should be monitored, and combined feeding considered when enteral feeds cannot be advanced to target within 4-6 days...
Hypercalcaemia and acute renal failure after major burns: An under-diagnosed conditionBarbara Kohut
Department of Intensive Care Medicine and Burns Centre, University Hospital CHUV, CH 1011 Lausanne, Switzerland
Burns 36:360-6. 2010..Having observed the early onset of hypercalcaemia, the study aimed to determine the frequency and timing of this condition in a European patient cohort...
The role of energy and nutritional support in the intensive care unitMette M Berger
Department of Adult Intensive Care Medicine and Burns Centre, Adult Intensive Care Unit, University Hospital (CHUV, Lausanne, Switzerland
Nat Clin Pract Endocrinol Metab 4:378-9. 2008
Trace element requirements in critically ill burned patientsMette M Berger
Adult Intensive Care Medicine and Burns Centre, CHUV, BH 08 660, CH 1011 Lausanne, Switzerland
J Trace Elem Med Biol 21:44-8. 2007..The intravenous route appears the only way to deliver the doses required to achieve antioxidant and clinical effects. Further research is required to determine the optimal combination and doses for different severities of injury...
Three short perioperative infusions of n-3 PUFAs reduce systemic inflammation induced by cardiopulmonary bypass surgery: a randomized controlled trialMette M Berger
Services of Adult Intensive Care Medicine and Burns, Lausanne University Hospital, Lausanne, Switzerland
Am J Clin Nutr 97:246-54. 2013..Fish oil (FO) has antiinflammatory effects, which might reduce systemic inflammation induced by a cardiopulmonary bypass (CPB)...
Improving nutritional support in critically Ill septic patients: glutamine alone or in combination?René L Chioléro
Surgical Intensive Care Unit, Department of Surgery, University Hospital, CHUV, Lausanne, Switzerland
Nutrition 18:723-4. 2002
Prospective monitoring of cefepime in intensive care unit adult patientsThomas M Chapuis
Department of Ambulatory Medicine and Community Healthcare, University of Lausanne, Rue du Bugnon, Lausanne, Switzerland
Crit Care 14:R51. 2010..We examined these issues in a prospective non-interventional study of 21 consecutive intensive care unit (ICU) adult patients treated with cefepime for nosocomial pneumonia...
Acute endotoxemia inhibits microvascular nitric oxide-dependent vasodilation in humansRolf P Engelberger
Division of Clinical Pathophysiology, Centre Hospitalier Universitaire Vaudois, and University of Lausanne, Switzerland
Shock 35:28-34. 2011..Microvascular NO deficiency might be responsible for the heterogeneity of tissue perfusion observed in sepsis and could be a therapeutic target...
[Thoracic surgery and underfeeding scientific evidences, diagnosis and treatment]Barbara Kohut
Service des soins intensifs chirurgicaux, CHUV, 1011 Lausanne
Rev Med Suisse 1:2940-4. 2005..Therefore preoperative diagnosis of underfeeding is of utmost importance. In case of emergency surgery, the nutritional assessment on admission enables the introduction of early postoperative artificial feeding...
Energy deficit and length of hospital stay can be reduced by a two-step quality improvement of nutrition therapy: the intensive care unit dietitian can make the differenceLudivine Soguel
University of Applied Sciences Western Switzerland HES SO, School of Health Professions Geneva, Nutrition and Dietetics Department, Geneva, Switzerland
Crit Care Med 40:412-9. 2012..Insufficient nutritional support still remains a widespread problem despite guidelines. The aim of this study was to measure the clinical impact of a two-step interdisciplinary quality nutrition program...
Early metabolic and splanchnic responses to enteral nutrition in postoperative cardiac surgery patients with circulatory compromiseJ P Revelly
Surgical Intensive Care Unit, University Hospital CHUV, 1011 Lausanne, Switzerland
Intensive Care Med 27:540-7. 2001..To assess the hemodynamic and metabolic adaptations to enteral nutrition (EN) in patients with hemodynamic compromise...
Importation of Acinetobacter baumannii into a burn unit: a recurrent outbreak of infection associated with widespread environmental contaminationGiorgio Zanetti
Service of Hospital Preventive Medicine, the Service of Infectious Diseases, Department of Medicine, University Hospital, Lausanne, Switzerland
Infect Control Hosp Epidemiol 28:723-5. 2007..Environmental swab samples obtained at this time were inoculated into a minimal mineral broth, and culture results showed widespread contamination. No case of infection occurred after closure of the unit for disinfection...
[Implementing a feeding protocol in an adult ICU (NUTSIA): success and pitfalls]Corinne Longchamp
Service de médecine intensive adulte et Centre des brûlés, CHUV, Lausanne
Rev Med Suisse 3:2844-8. 2007..Potential difficulties and successes are reported. In a complex setting such as the ICU, presence of a dedicated dietician is required for daily application of a feeding protocol...
Bioinformatics assistance of metabolic and nutrition management in the ICUMette M Berger
Service de médecine intensive adulte et Centre des brûlés, University Hospital, Rue du Bugnon 46, Lausanne, Switzerland
Curr Opin Clin Nutr Metab Care 14:202-8. 2011..To review the domains in which computerized information systems have proven beneficial in facilitating the metabolic and nutritional management..
Standardizing the diagnosis of inhalation injury using a descriptive score based on mucosal injury criteriaChristos Ikonomidis
Service of Head and Neck Surgery ENT, University Hospital CHUV, Lausanne, Switzerland
Burns 38:513-9. 2012....
Mass casualty incidents with multiple burn victims: rationale for a Swiss burn planMathieu Potin
Public Health Service, State of Vaud, Lausanne, Switzerland Emergency Service, University Hospital Center CHUV, Lausanne, Switzerland
Burns 36:741-50. 2010..This paper presents an analysis of the published reports with the aim of proposing a rational model for burn rescue and hospital referral for Switzerland...
Fractional hepatic de novo lipogenesis in healthy subjects during near-continuous oral nutrition and bed rest: a comparison with published data in artificially fed, critically ill patientsK Minehira
Institute of Physiology, University of Lausanne, School of Medicine, Switzerland
Clin Nutr 21:345-50. 2002..3%) (range 5.3-15.8%) was markedly higher than in healthy subjects (P<0.001). These data from healthy subjects indicate that fractional hepatic de novo lipogenesis is increased in critically ill patients...
Blood glucose level on postoperative day 1 is predictive of adverse outcomes after cardiovascular surgeryA Frioud
Department of Endocrinology, Diabetology and Metabolism, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Diabetes Metab 36:36-42. 2010..For this reason, we aimed to evaluate the postoperative management of glucose control in patients undergoing cardiovascular surgery, and to assess the impact of glucose levels on in-hospital mortality and morbidity...
Feed the ICU patient 'gastric' first, and go post-pyloric only in case of failureMette M Berger
Service of Adult Intensive Care and Burns Centre, University Hospital CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
Crit Care 14:123. 2010..But the authors' conclusion that gastric is equivalent to post-pyloric is true in only the least severe patients. Given the extra workload and costs, post-pyloric is now clearly indicated in case of gastric feeding failure...
Timing of nutritional supportR L Chiolero
Surgical Intensive Care Unit, Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
Nestle Nutr Workshop Ser Clin Perform Programme 7:151-64; discussion 164-8. 2002
Fish oil after abdominal aorta aneurysm surgeryM M Berger
Department of Intensive Care Medicine, CHUV, Lausanne, Switzerland
Eur J Clin Nutr 62:1116-22. 2008..We aimed at evaluating the clinical impact and safety aspects of a FO containing parenteral nutrition (PN) after AAA surgery...
Nutritional support during renal replacement therapyR Chiolero
Department of Adult Intensive Care Medicine, CHUV, Lausanne, Switzerland
Contrib Nephrol 156:267-74. 2007..Malnutrition is common in critically ill patients with acute renal failure. The aim of this review is to describe the basis for nutritional support during renal replacement therapy...
Major reduction in plasma Lp(a) levels during sepsis and burnsV Mooser
Department of Medicine, CHUV University Hospital, Lausanne, Switzerland
Arterioscler Thromb Vasc Biol 20:1137-42. 2000..Nongenetic factors have a major, acute, and unexpected impact on Lp(a) metabolism in burns and sepsis. Identification of these factors may provide new tools to lower elevated plasma Lp(a) levels...
'Practical guidelines for nutritional management of burn injury and recovery'--a guideline based on expert opinion but not including RCTsMette M Berger
Burns 34:141-3. 2008
Markers of oxidative stress in ICU clinical settings: present and futureTilman Grune
Institute for Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany
Curr Opin Clin Nutr Metab Care 10:712-7. 2007..The paper reviews methods used to determine oxidative stress in clinical situations using routine validated methods or those used by research laboratories...
Is there really a survival benefit of SDD in burns?Philippe Eggimann
Ann Surg 244:325-6; author reply 326-7. 2006
Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patientDaren K Heyland
Department of Medicine, Queen s University, Kingston, Ont, Canada
Intensive Care Med 31:327-37. 2005..We investigated whether supplementing critically ill patients with antioxidants, trace elements, and vitamins improves their survival...
Selenium in intensive care: probably not a magic bullet but an important adjuvant therapyMette M Berger
Crit Care Med 35:306-7. 2007
