Research Topics
| D AujeskySummaryAffiliation: Centre Hospitalier Universitaire Vaudois Country: Switzerland Publications
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Detail Information
Publications
Derivation and validation of a prognostic model for pulmonary embolismDrahomir Aujesky
Division of General Internal Medicine, Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
Am J Respir Crit Care Med 172:1041-6. 2005..An objective and simple prognostic model for patients with pulmonary embolism could be helpful in guiding initial intensity of treatment...
The pneumonia severity index: a decade after the initial derivation and validationDrahomir Aujesky
Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
Clin Infect Dis 47:S133-9. 2008..Because of its prognostic accuracy, methodological rigor, and effectiveness and safety as a decision aid, the pneumonia severity index has become the reference standard for risk stratification of community-acquired pneumonia...
[The prognosis of pulmonary embolism: are there practical implications for patient management?]D Aujesky
Service de Medecine Interne, BH 10 622, CHUV, Lausanne
Rev Med Suisse 2:281-4. 2006..This article discusses new risk stratification tools for pulmonary embolism such as echocardiography, biomarkers, and clinical prognostic scores, and their potential application for patient management...- Hospital volume and patient outcomes in pulmonary embolismDrahomir Aujesky
Division of Internal Medicine, University of Lausanne, Lausanne, Switzerland
CMAJ 178:27-33. 2008..For patients with pulmonary embolism, the relation between the number of patients treated in a hospital (volume) and patient outcome is unknown... - Reasons why emergency department providers do not rely on the pneumonia severity index to determine the initial site of treatment for patients with pneumoniaDrahomir Aujesky
Division of General Internal Medicine, Department of Medicine, University of Lausanne, Lausanne, Switzerland
Clin Infect Dis 49:e100-8. 2009..We identified the reasons why ED providers hospitalize low-risk patients or manage higher-risk patients as outpatients... - Prognostic value of D-dimer in patients with pulmonary embolismDrahomir Aujesky
Division of Internal Medicine, University of Lausanne, Lausanne, Switzerland
Thromb Haemost 96:478-82. 2006.... - Short-term prognosis of pulmonary embolismD Aujesky
Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
J Thromb Haemost 7:318-21. 2009.... - [Clinical research in general internal medicine: present and future perspectives]D Aujesky
Service de médecine interne CHUV, Lausanne
Rev Med Suisse 2:2534-7. 2006..We briefly describe research topics particularly relevant to general internal medicine such as health technology assessment, quality of care studies, and studies comparing the impact of different systems of care... - African American race was associated with an increased risk of complications following venous thromboembolismDrahomir Aujesky
Division of Internal Medicine, the Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
J Clin Epidemiol 60:410-6. 2007..Limited data exist on the quality of care for patients with venous thromboembolism (VTE), and it is unknown whether the processes and outcomes of care for this illness differ between African Americans and whites... - Validation of a clinical prognostic model to identify low-risk patients with pulmonary embolismD Aujesky
Division of General Internal Medicine, University Outpatient Clinic, Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
J Intern Med 261:597-604. 2007..To validate the Pulmonary Embolism Severity Index (PESI), a clinical prognostic model which identifies low-risk patients with pulmonary embolism (PE)... - Weekend versus weekday admission and mortality after acute pulmonary embolismDrahomir Aujesky
Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
Circulation 119:962-8. 2009..We sought to assess whether associations exist between weekday or weekend admission and mortality and length of hospital stay for patients hospitalized with PE... - Predictors of early hospital readmission after acute pulmonary embolismDrahomir Aujesky
Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Arch Intern Med 169:287-93. 2009..However, it is uncertain which factors are associated with early readmission after PE. We sought to identify predictors of readmission after an admission for PE... - Length of hospital stay and postdischarge mortality in patients with pulmonary embolism: a statewide perspectiveDrahomir Aujesky
Division of Internal Medicine, University of Lausanne, Service de Medecine Interne, BH 10 622, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
Arch Intern Med 168:706-12. 2008..Although reducing LOS is likely to save costs, the effects on patient safety are unclear. We sought to identify patient and hospital factors associated with LOS and assess whether LOS was associated with postdischarge mortality... - Outpatient treatment of pulmonary embolismDrahomir Aujesky
Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Swiss Med Wkly 139:685-90. 2009..Before high quality evidence documenting the safety of an outpatient treatment approach is published, outpatient management of non-massive PE cannot be generally recommended... - Validation of a model to predict adverse outcomes in patients with pulmonary embolismDrahomir Aujesky
Division of General Internal Medicine, The University Outpatient Clinic and The Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
Eur Heart J 27:476-81. 2006..To validate a model for quantifying the prognosis of patients with pulmonary embolism (PE). The model was previously derived from 10 534 US patients... - [The unresolved issue of false-positive D-dimer results in the diagnostic workup of pulmonary embolism]O Hugli
Service des Urgences, CHUV, 1011 Lausanne
Rev Med Suisse 7:1588-92. 2011..Its safety has been confirmed in US emergency departments, but retrospective European studies showed that it would lead to 5-7% of undiagnosed PE. Alternative strategies are needed to reduce the proportion of false-positive DD results... - A prediction rule to identify low-risk patients with pulmonary embolismDrahomir Aujesky
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Arch Intern Med 166:169-75. 2006..A simple prognostic model could help identify patients with pulmonary embolism who are at low risk of death and are candidates for outpatient treatment... - Is atrial fibrillation associated with pulmonary embolism?G Gex
Division of General Internal Medicine, Geneva University Hospital, Geneva, Switzerland
J Thromb Haemost 10:347-51. 2012..A pulmonary embolism (PE) is thought to be associated with atrial fibrillation (AF). Nevertheless, this association is based on weak data... - Pharmacological thromboembolic prophylaxis in a medical ward: room for improvementDrahomir Aujesky
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
J Gen Intern Med 17:788-91. 2002..Quality of care interventions, such as the development of local guidelines, might improve the appropriateness of pharmacological thromboembolic prophylaxis in medical inpatients... - [Venous thromboembolism in the elderly]M Mean
Service de Medecine Interne, CHUV, 1011 Lausanne
Rev Med Suisse 5:2142-4, 2146. 2009..A prospective multicenter Swiss cohort study will examine medical outcomes, quality of life, and medical resource utilization in elderly patients with VTE... - Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolismJacques Donzé
Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
Thromb Haemost 100:943-8. 2008..86). The PESI reliably identifies patients with PE who are at low risk of death and who are potential candidates for outpatient care. The PESI may help physicians make more rational decisions about hospitalization for patients with PE... - [Oral anticoagulation and the risk of major bleeding]Monica Cosma Rochat
Service de médecine interne BH10 622, CHUV, 1011 Lausanne
Rev Med Suisse 3:2461-2, 2464-5. 2007..The role of clinical prediction rules for major bleeding is discussed... - Oral anticoagulation strategies after a first idiopathic venous thromboembolic eventDrahomir Aujesky
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania, USA
Am J Med 118:625-35. 2005..We used decision analysis to evaluate clinical and economic outcomes of different anticoagulation strategies with warfarin... - Hospitalized women experiencing an episode of excessive oral anticoagulation had a higher bleeding risk than menMonica Cosma Rochat
Department of Internal Medicine, University of Lausanne, Lausanne, Switzerland
J Womens Health (Larchmt) 18:321-6. 2009..Overanticoagulated medical inpatients may be particularly prone to bleeding complications. Among medical inpatients with excessive oral anticoagulation (AC), we sought to identify patient and treatment factors associated with bleeding... - Prognostic importance of hyponatremia in patients with acute pulmonary embolismNathalie Scherz
Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
Am J Respir Crit Care Med 182:1178-83. 2010..Although associated with adverse outcomes in other cardiopulmonary conditions, the prognostic value of hyponatremia, a marker of neurohormonal activation, in patients with acute pulmonary embolism (PE) is unknown... - Cost-effectiveness of low-molecular-weight heparin for secondary prophylaxis of cancer-related venous thromboembolismDrahomir Aujesky
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania, USA
Thromb Haemost 93:592-9. 2005..However, because of the substantial pharmacy costs of extended low-molecular-weight heparin prophylaxis in the US, this treatment is relatively expensive compared with warfarin... - Validation of a clinical algorithm to identify low-risk patients with pulmonary embolismC Jakobsson
Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
J Thromb Haemost 8:1242-7. 2010..We previously derived a clinical prognostic algorithm to identify patients with pulmonary embolism (PE) who are at low risk of short-term mortality and who could be safely discharged early or treated entirely in an outpatient setting... - The pulmonary embolism rule-out criteria (PERC) rule does not safely exclude pulmonary embolismO Hugli
Emergency Department, University Hospital Center, University of Lausanne, Lausanne, Switzerland
J Thromb Haemost 9:300-4. 2011..We sought to externally validate the diagnostic performance of the PERC rule alone and combined with clinical probability assessment based on the revised Geneva score... - Cost-effectiveness of low-molecular-weight heparin for treatment of pulmonary embolismDrahomir Aujesky
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, PA, USA
Chest 128:1601-10. 2005..Low-molecular-weight heparin (LMWH) appears to be safe and effective for treating pulmonary embolism (PE), but its cost-effectiveness has not been assessed... - Prospective comparison of three validated prediction rules for prognosis in community-acquired pneumoniaDrahomir Aujesky
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Am J Med 118:384-92. 2005.... - Prevalence and determinants of QT interval prolongation in medical inpatientsM Pasquier
Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
Intern Med J 42:933-40. 2012..QT interval prolongation carries an increased risk of torsade de pointes and death... - [Everyday bioethics in general internal medicine]O Lamy
Service de Medecine Interne, CHUV, Lausanne
Rev Med Suisse 2:2550-4, 2556. 2006.... - Exclusion of pulmonary embolism using C-reactive protein and D-dimer. A prospective comparisonDrahomir Aujesky
Department of Medicine, University Hospital of Lausanne, Switzerland
Thromb Haemost 90:1198-203. 2003..Standard CRP tests alone or combined with clinical probability assessment cannot safely exclude PE... - Using randomized controlled trial data, the agreement between retrospectively and prospectively collected data comprising the pneumonia severity index was substantialDrahomir Aujesky
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
J Clin Epidemiol 58:357-63. 2005..To assess the agreement between prospectively and retrospectively determined variables comprising the Pneumonia Severity Index (PSI), assignment to PSI risk class, and designation as low risk, based on these two methods of data collection... - Diagnosing pulmonary embolism in outpatients with clinical assessment, D-dimer measurement, venous ultrasound, and helical computed tomography: a multicenter management studyArnaud Perrier
Medical Clinic 1, Geneva University Hospital, Switzerland
Am J Med 116:291-9. 2004..To evaluate a diagnostic strategy for pulmonary embolism that combined clinical assessment, plasma D-dimer measurement, lower limb venous ultrasonography, and helical computed tomography (CT)... - Validation of a risk score identifying patients with acute pulmonary embolism, who are at low risk of clinical adverse outcomeMathieu R Nendaz
Medical Clinic 1, Department of Internal Medicine, Geneva University Hospitals, Switzerland
Thromb Haemost 91:1232-6. 2004..Whether this score remains accurate and useful in clinical practice should be determined in a prospective multicentre validation study... - Comparison of two clinical prediction rules and implicit assessment among patients with suspected pulmonary embolismIsabelle Chagnon
Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland
Am J Med 113:269-75. 2002..The Geneva rule appears to be more accurate when combined with clinical judgment, although it does not apply to inpatients... - Clinical usefulness of D-dimer depending on clinical probability and cutoff value in outpatients with suspected pulmonary embolismMarc Righini
Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Arch Intern Med 164:2483-7. 2004.... - Value of D-dimer testing for the exclusion of pulmonary embolism in patients with previous venous thromboembolismGregoire Le Gal
Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
Arch Intern Med 166:176-80. 2006.... - Prediction of pulmonary embolism in the emergency department: the revised Geneva scoreGregoire Le Gal
Brest University Hospital, Brest, France
Ann Intern Med 144:165-71. 2006..Diagnosis of pulmonary embolism requires clinical probability assessment. Implicit assessment is accurate but is not standardized, and current prediction rules have shortcomings... - Racial differences in 30-day mortality for pulmonary embolismSaid A Ibrahim
Veterans Administration Center for Health Equity Research and Promotion, Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
Am J Public Health 96:2161-4. 2006..We used a large statewide database to compare 30-day mortality (defined as death within 30 days from the date of latest hospital admission) for Black and White patients who were hospitalized because of pulmonary embolism... - Gender differences in 30-day mortality for patients hospitalized with acute pulmonary embolismSonya Borrero
University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
J Womens Health (Larchmt) 16:1165-70. 2007..We compared 30-day mortality for men and women hospitalized with PE using a large statewide database... - Clinical usefulness of D-dimer testing in cancer patients with suspected pulmonary embolismMarc Righini
Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Thromb Haemost 95:715-9. 2006..Increasing the cut-off value of D-dimer in cancer patients might increase the test's clinical usefulness... - Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trialMarc Righini
Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
Lancet 371:1343-52. 2008..We compared this combination with a strategy in which both a negative venous ultrasonography of the leg and MSCT were needed to exclude pulmonary embolism... - Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysisNicolas Rodondi
Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
Am J Med 119:541-51. 2006..We performed a systematic review to determine whether subclinical hypothyroidism is associated with CHD in adults...