D Aujesky

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. pmc Derivation and validation of a prognostic model for pulmonary embolism
    Drahomir Aujesky
    Division of General Internal Medicine, Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
    Am J Respir Crit Care Med 172:1041-6. 2005
  2. ncbi request reprint Validation of a model to predict adverse outcomes in patients with pulmonary embolism
    Drahomir Aujesky
    Division of General Internal Medicine, The University Outpatient Clinic and The Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
    Eur Heart J 27:476-81. 2006
  3. doi request reprint Predictors of early hospital readmission after acute pulmonary embolism
    Drahomir Aujesky
    Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Arch Intern Med 169:287-93. 2009
  4. ncbi request reprint [The prognosis of pulmonary embolism: are there practical implications for patient management?]
    D Aujesky
    Service de Medecine Interne, BH 10 622, CHUV, Lausanne
    Rev Med Suisse 2:281-4. 2006
  5. doi request reprint The pneumonia severity index: a decade after the initial derivation and validation
    Drahomir Aujesky
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 47:S133-9. 2008
  6. doi request reprint Length of hospital stay and postdischarge mortality in patients with pulmonary embolism: a statewide perspective
    Drahomir Aujesky
    Division of Internal Medicine, University of Lausanne, Service de Medecine Interne, BH 10 622, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Arch Intern Med 168:706-12. 2008
  7. ncbi request reprint Prognostic value of D-dimer in patients with pulmonary embolism
    Drahomir Aujesky
    Division of Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Thromb Haemost 96:478-82. 2006
  8. pmc Hospital volume and patient outcomes in pulmonary embolism
    Drahomir Aujesky
    Division of Internal Medicine, University of Lausanne, Lausanne, Switzerland
    CMAJ 178:27-33. 2008
  9. ncbi request reprint [Clinical research in general internal medicine: present and future perspectives]
    D Aujesky
    Service de médecine interne CHUV, Lausanne
    Rev Med Suisse 2:2534-7. 2006
  10. pmc Weekend versus weekday admission and mortality after acute pulmonary embolism
    Drahomir Aujesky
    Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Circulation 119:962-8. 2009

Detail Information

Publications46

  1. pmc Derivation and validation of a prognostic model for pulmonary embolism
    Drahomir Aujesky
    Division of General Internal Medicine, Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
    Am J Respir Crit Care Med 172:1041-6. 2005
    ..An objective and simple prognostic model for patients with pulmonary embolism could be helpful in guiding initial intensity of treatment...
  2. ncbi request reprint Validation of a model to predict adverse outcomes in patients with pulmonary embolism
    Drahomir Aujesky
    Division of General Internal Medicine, The University Outpatient Clinic and The Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
    Eur Heart J 27:476-81. 2006
    ..To validate a model for quantifying the prognosis of patients with pulmonary embolism (PE). The model was previously derived from 10 534 US patients...
  3. doi request reprint Predictors of early hospital readmission after acute pulmonary embolism
    Drahomir Aujesky
    Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Arch Intern Med 169:287-93. 2009
    ..However, it is uncertain which factors are associated with early readmission after PE. We sought to identify predictors of readmission after an admission for PE...
  4. ncbi request reprint [The prognosis of pulmonary embolism: are there practical implications for patient management?]
    D Aujesky
    Service de Medecine Interne, BH 10 622, CHUV, Lausanne
    Rev Med Suisse 2:281-4. 2006
    ..This article discusses new risk stratification tools for pulmonary embolism such as echocardiography, biomarkers, and clinical prognostic scores, and their potential application for patient management...
  5. doi request reprint The pneumonia severity index: a decade after the initial derivation and validation
    Drahomir Aujesky
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 47:S133-9. 2008
    ..Because of its prognostic accuracy, methodological rigor, and effectiveness and safety as a decision aid, the pneumonia severity index has become the reference standard for risk stratification of community-acquired pneumonia...
  6. doi request reprint Length of hospital stay and postdischarge mortality in patients with pulmonary embolism: a statewide perspective
    Drahomir Aujesky
    Division of Internal Medicine, University of Lausanne, Service de Medecine Interne, BH 10 622, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Arch Intern Med 168:706-12. 2008
    ..Although reducing LOS is likely to save costs, the effects on patient safety are unclear. We sought to identify patient and hospital factors associated with LOS and assess whether LOS was associated with postdischarge mortality...
  7. ncbi request reprint Prognostic value of D-dimer in patients with pulmonary embolism
    Drahomir Aujesky
    Division of Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Thromb Haemost 96:478-82. 2006
    ....
  8. pmc Hospital volume and patient outcomes in pulmonary embolism
    Drahomir Aujesky
    Division of Internal Medicine, University of Lausanne, Lausanne, Switzerland
    CMAJ 178:27-33. 2008
    ..For patients with pulmonary embolism, the relation between the number of patients treated in a hospital (volume) and patient outcome is unknown...
  9. ncbi request reprint [Clinical research in general internal medicine: present and future perspectives]
    D Aujesky
    Service de médecine interne CHUV, Lausanne
    Rev Med Suisse 2:2534-7. 2006
    ..We briefly describe research topics particularly relevant to general internal medicine such as health technology assessment, quality of care studies, and studies comparing the impact of different systems of care...
  10. pmc Weekend versus weekday admission and mortality after acute pulmonary embolism
    Drahomir Aujesky
    Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Circulation 119:962-8. 2009
    ..We sought to assess whether associations exist between weekday or weekend admission and mortality and length of hospital stay for patients hospitalized with PE...
  11. ncbi request reprint Validation of a clinical prognostic model to identify low-risk patients with pulmonary embolism
    D Aujesky
    Division of General Internal Medicine, University Outpatient Clinic, Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
    J Intern Med 261:597-604. 2007
    ..To validate the Pulmonary Embolism Severity Index (PESI), a clinical prognostic model which identifies low-risk patients with pulmonary embolism (PE)...
  12. ncbi request reprint African American race was associated with an increased risk of complications following venous thromboembolism
    Drahomir Aujesky
    Division of Internal Medicine, the Clinical Epidemiology Center, University of Lausanne, Lausanne, Switzerland
    J Clin Epidemiol 60:410-6. 2007
    ..Limited data exist on the quality of care for patients with venous thromboembolism (VTE), and it is unknown whether the processes and outcomes of care for this illness differ between African Americans and whites...
  13. doi request reprint Outpatient treatment of pulmonary embolism
    Drahomir Aujesky
    Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Swiss Med Wkly 139:685-90. 2009
    ..Before high quality evidence documenting the safety of an outpatient treatment approach is published, outpatient management of non-massive PE cannot be generally recommended...
  14. doi request reprint Reasons why emergency department providers do not rely on the pneumonia severity index to determine the initial site of treatment for patients with pneumonia
    Drahomir Aujesky
    Division of General Internal Medicine, Department of Medicine, University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 49:e100-8. 2009
    ..We identified the reasons why ED providers hospitalize low-risk patients or manage higher-risk patients as outpatients...
  15. doi request reprint Short-term prognosis of pulmonary embolism
    D Aujesky
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    J Thromb Haemost 7:318-21. 2009
    ....
  16. doi request reprint Is atrial fibrillation associated with pulmonary embolism?
    G Gex
    Division of General Internal Medicine, Geneva University Hospital, Geneva, Switzerland
    J Thromb Haemost 10:347-51. 2012
    ..A pulmonary embolism (PE) is thought to be associated with atrial fibrillation (AF). Nevertheless, this association is based on weak data...
  17. ncbi request reprint [The unresolved issue of false-positive D-dimer results in the diagnostic workup of pulmonary embolism]
    O Hugli
    Service des Urgences, CHUV, 1011 Lausanne
    Rev Med Suisse 7:1588-92. 2011
    ..Its safety has been confirmed in US emergency departments, but retrospective European studies showed that it would lead to 5-7% of undiagnosed PE. Alternative strategies are needed to reduce the proportion of false-positive DD results...
  18. ncbi request reprint A prediction rule to identify low-risk patients with pulmonary embolism
    Drahomir Aujesky
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Intern Med 166:169-75. 2006
    ..A simple prognostic model could help identify patients with pulmonary embolism who are at low risk of death and are candidates for outpatient treatment...
  19. doi request reprint Prevalence and determinants of QT interval prolongation in medical inpatients
    M Pasquier
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Intern Med J 42:933-40. 2012
    ..QT interval prolongation carries an increased risk of torsade de pointes and death...
  20. pmc Pharmacological thromboembolic prophylaxis in a medical ward: room for improvement
    Drahomir Aujesky
    Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Gen Intern Med 17:788-91. 2002
    ..Quality of care interventions, such as the development of local guidelines, might improve the appropriateness of pharmacological thromboembolic prophylaxis in medical inpatients...
  21. ncbi request reprint [Venous thromboembolism in the elderly]
    M Mean
    Service de Medecine Interne, CHUV, 1011 Lausanne
    Rev Med Suisse 5:2142-4, 2146. 2009
    ..A prospective multicenter Swiss cohort study will examine medical outcomes, quality of life, and medical resource utilization in elderly patients with VTE...
  22. ncbi request reprint Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism
    Jacques Donzé
    Service de Medecine Interne, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Thromb Haemost 100:943-8. 2008
    ..86). The PESI reliably identifies patients with PE who are at low risk of death and who are potential candidates for outpatient care. The PESI may help physicians make more rational decisions about hospitalization for patients with PE...
  23. ncbi request reprint [Oral anticoagulation and the risk of major bleeding]
    Monica Cosma Rochat
    Service de médecine interne BH10 622, CHUV, 1011 Lausanne
    Rev Med Suisse 3:2461-2, 2464-5. 2007
    ..The role of clinical prediction rules for major bleeding is discussed...
  24. doi request reprint Hospitalized women experiencing an episode of excessive oral anticoagulation had a higher bleeding risk than men
    Monica Cosma Rochat
    Department of Internal Medicine, University of Lausanne, Lausanne, Switzerland
    J Womens Health (Larchmt) 18:321-6. 2009
    ..Overanticoagulated medical inpatients may be particularly prone to bleeding complications. Among medical inpatients with excessive oral anticoagulation (AC), we sought to identify patient and treatment factors associated with bleeding...
  25. pmc Prognostic importance of hyponatremia in patients with acute pulmonary embolism
    Nathalie Scherz
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Am J Respir Crit Care Med 182:1178-83. 2010
    ..Although associated with adverse outcomes in other cardiopulmonary conditions, the prognostic value of hyponatremia, a marker of neurohormonal activation, in patients with acute pulmonary embolism (PE) is unknown...
  26. ncbi request reprint Cost-effectiveness of low-molecular-weight heparin for secondary prophylaxis of cancer-related venous thromboembolism
    Drahomir Aujesky
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Thromb Haemost 93:592-9. 2005
    ..However, because of the substantial pharmacy costs of extended low-molecular-weight heparin prophylaxis in the US, this treatment is relatively expensive compared with warfarin...
  27. ncbi request reprint Oral anticoagulation strategies after a first idiopathic venous thromboembolic event
    Drahomir Aujesky
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Am J Med 118:625-35. 2005
    ..We used decision analysis to evaluate clinical and economic outcomes of different anticoagulation strategies with warfarin...
  28. doi request reprint The pulmonary embolism rule-out criteria (PERC) rule does not safely exclude pulmonary embolism
    O Hugli
    Emergency Department, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    J Thromb Haemost 9:300-4. 2011
    ..We sought to externally validate the diagnostic performance of the PERC rule alone and combined with clinical probability assessment based on the revised Geneva score...
  29. doi request reprint Validation of a clinical algorithm to identify low-risk patients with pulmonary embolism
    C Jakobsson
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    J Thromb Haemost 8:1242-7. 2010
    ..We previously derived a clinical prognostic algorithm to identify patients with pulmonary embolism (PE) who are at low risk of short-term mortality and who could be safely discharged early or treated entirely in an outpatient setting...
  30. ncbi request reprint Prospective comparison of three validated prediction rules for prognosis in community-acquired pneumonia
    Drahomir Aujesky
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Med 118:384-92. 2005
    ....
  31. ncbi request reprint Cost-effectiveness of low-molecular-weight heparin for treatment of pulmonary embolism
    Drahomir Aujesky
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, PA, USA
    Chest 128:1601-10. 2005
    ..Low-molecular-weight heparin (LMWH) appears to be safe and effective for treating pulmonary embolism (PE), but its cost-effectiveness has not been assessed...
  32. ncbi request reprint [Everyday bioethics in general internal medicine]
    O Lamy
    Service de Medecine Interne, CHUV, Lausanne
    Rev Med Suisse 2:2550-4, 2556. 2006
    ....
  33. ncbi request reprint Using randomized controlled trial data, the agreement between retrospectively and prospectively collected data comprising the pneumonia severity index was substantial
    Drahomir Aujesky
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Epidemiol 58:357-63. 2005
    ..To assess the agreement between prospectively and retrospectively determined variables comprising the Pneumonia Severity Index (PSI), assignment to PSI risk class, and designation as low risk, based on these two methods of data collection...
  34. ncbi request reprint Exclusion of pulmonary embolism using C-reactive protein and D-dimer. A prospective comparison
    Drahomir Aujesky
    Department of Medicine, University Hospital of Lausanne, Switzerland
    Thromb Haemost 90:1198-203. 2003
    ..Standard CRP tests alone or combined with clinical probability assessment cannot safely exclude PE...
  35. doi request reprint Prospective comparison of clinical prognostic scores in elder patients with a pulmonary embolism
    D Zwierzina
    Division of General Internal Medicine, Bern University Hospital, Bern Clinical Trials Unit Bern, Department of Clinical Research, University of Bern, Bern Division of Angiology and Hemostasis, Geneva University Hospital, Geneva Department of Angiology, Basel University Hospital, Basel Cantonal Hospital of Baden, Baden Department of Internal Medicine, Cantonal Hospital of Frauenfeld, Frauenfeld Emergency Department, Cantonal Hospital of St Gallen, St Gallen Division of Angiology, Bern University Hospital, Bern Cardiovascular Research, Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich Division of Angiology, Cantonal Hospital of Lucerne, Lucerne Service and Central Laboratory of Hematology, Lausanne University Hospital, Lausanne Division of Haematology and Central Haematology Laboratory, Bern University Hospital, Bern Division of Angiology, Lausanne University Hospital, Lausanne Emergency Department, Lausanne University Hospital, Lausanne Division of Angiology, Zurich University Hospital, Zurich Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    J Thromb Haemost 10:2270-6. 2012
    ..66-0.75), respectively (P = 0.47). Conclusions:  In this cohort of elderly patients with PE, the GPS identified a higher proportion of patients as low risk but the PESI and sPESI were more accurate in predicting mortality. ..
  36. ncbi request reprint Comparison of two clinical prediction rules and implicit assessment among patients with suspected pulmonary embolism
    Isabelle Chagnon
    Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland
    Am J Med 113:269-75. 2002
    ..We compared the predictive accuracy and the concordance of the two methods, as well as the Geneva score overridden by implicit clinical judgment...
  37. ncbi request reprint Diagnosing pulmonary embolism in outpatients with clinical assessment, D-dimer measurement, venous ultrasound, and helical computed tomography: a multicenter management study
    Arnaud Perrier
    Medical Clinic 1, Geneva University Hospital, Switzerland
    Am J Med 116:291-9. 2004
    ..To evaluate a diagnostic strategy for pulmonary embolism that combined clinical assessment, plasma D-dimer measurement, lower limb venous ultrasonography, and helical computed tomography (CT)...
  38. ncbi request reprint Validation of a risk score identifying patients with acute pulmonary embolism, who are at low risk of clinical adverse outcome
    Mathieu R Nendaz
    Medical Clinic 1, Department of Internal Medicine, Geneva University Hospitals, Switzerland
    Thromb Haemost 91:1232-6. 2004
    ..Whether this score remains accurate and useful in clinical practice should be determined in a prospective multicentre validation study...
  39. doi request reprint Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    Lancet 371:1343-52. 2008
    ..We compared this combination with a strategy in which both a negative venous ultrasonography of the leg and MSCT were needed to exclude pulmonary embolism...
  40. ncbi request reprint Clinical usefulness of D-dimer depending on clinical probability and cutoff value in outpatients with suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Arch Intern Med 164:2483-7. 2004
    ....
  41. ncbi request reprint Clinical usefulness of D-dimer testing in cancer patients with suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Thromb Haemost 95:715-9. 2006
    ..Increasing the cut-off value of D-dimer in cancer patients might increase the test's clinical usefulness...
  42. ncbi request reprint Gender differences in 30-day mortality for patients hospitalized with acute pulmonary embolism
    Sonya Borrero
    University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    J Womens Health (Larchmt) 16:1165-70. 2007
    ..We compared 30-day mortality for men and women hospitalized with PE using a large statewide database...
  43. ncbi request reprint Prediction of pulmonary embolism in the emergency department: the revised Geneva score
    Gregoire Le Gal
    Brest University Hospital, Brest, France
    Ann Intern Med 144:165-71. 2006
    ..Diagnosis of pulmonary embolism requires clinical probability assessment. Implicit assessment is accurate but is not standardized, and current prediction rules have shortcomings...
  44. ncbi request reprint Value of D-dimer testing for the exclusion of pulmonary embolism in patients with previous venous thromboembolism
    Gregoire Le Gal
    Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    Arch Intern Med 166:176-80. 2006
    ....
  45. pmc Racial differences in 30-day mortality for pulmonary embolism
    Said A Ibrahim
    Veterans Administration Center for Health Equity Research and Promotion, Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    Am J Public Health 96:2161-4. 2006
    ..We used a large statewide database to compare 30-day mortality (defined as death within 30 days from the date of latest hospital admission) for Black and White patients who were hospitalized because of pulmonary embolism...
  46. ncbi request reprint Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis
    Nicolas Rodondi
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Am J Med 119:541-51. 2006
    ..We performed a systematic review to determine whether subclinical hypothyroidism is associated with CHD in adults...