David M Bernstein

Summary

Country: Switzerland

Publications

  1. ncbi Biopersistence of synthetic mineral fibers as a predictor of chronic intraperitoneal injection tumor response in rats
    D M Bernstein
    Joint Research Centre, Institute for Health and Consumer Protection, European Chemicals Bureau, Ispra, Italy
    Inhal Toxicol 13:851-75. 2001
  2. ncbi The toxicological response of Brazilian chrysotile asbestos: a multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response
    David M Bernstein
    Rogers Imaging Corporation, Needham, Massachusetts, USA
    Inhal Toxicol 18:313-32. 2006
  3. ncbi Special-purpose fiber type 475--toxicological assessment
    D M Bernstein
    Inhal Toxicol 19:149-59. 2007
  4. pmc Molecular and cellular mechanism of lung injuries due to exposure to sulfur mustard: a review
    Mostafa Ghanei
    Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Tehran, Iran
    Inhal Toxicol 23:363-71. 2011
  5. ncbi Evaluation of the deposition, translocation and pathological response of brake dust with and without added chrysotile in comparison to crocidolite asbestos following short-term inhalation: interim results
    David M Bernstein
    Consultant in Toxicology, 1208 Geneva, Switzerland Electronic address
    Toxicol Appl Pharmacol 276:28-46. 2014
  6. pmc Health risk of chrysotile revisited
    David Bernstein
    Crit Rev Toxicol 43:154-83. 2013
  7. ncbi The health effects of chrysotile: current perspective based upon recent data
    David M Bernstein
    Regul Toxicol Pharmacol 45:252-64. 2006
  8. ncbi Synthetic vitreous fibers: a review toxicology, epidemiology and regulations
    David M Bernstein
    Crit Rev Toxicol 37:839-86. 2007
  9. pmc A biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles
    D M Bernstein
    University of Edinburgh, ELEGI Colt Laboratory, Edinburgh, Scotland
    Inhal Toxicol 20:1009-28. 2008
  10. doi The pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short-term inhalation exposure: interim results
    D M Bernstein
    Inhal Toxicol 22:937-62. 2010

Collaborators

Detail Information

Publications20

  1. ncbi Biopersistence of synthetic mineral fibers as a predictor of chronic intraperitoneal injection tumor response in rats
    D M Bernstein
    Joint Research Centre, Institute for Health and Consumer Protection, European Chemicals Bureau, Ispra, Italy
    Inhal Toxicol 13:851-75. 2001
    ..In addition, based upon the ip results, there is no statistical difference between the EC and the other fiber exoneration criteria, such as the German Gefahrstoffverordnung of 1999...
  2. ncbi The toxicological response of Brazilian chrysotile asbestos: a multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response
    David M Bernstein
    Rogers Imaging Corporation, Needham, Massachusetts, USA
    Inhal Toxicol 18:313-32. 2006
    ..S. threshold limit value of 0.1 f(WHO)/cm3, chrysotile produces no significant pathological response...
  3. ncbi Special-purpose fiber type 475--toxicological assessment
    D M Bernstein
    Inhal Toxicol 19:149-59. 2007
    ..Following the EC classification criteria, the toxicological data clearly indicate that 475 fibers are appropriately classified in EC category 3...
  4. pmc Molecular and cellular mechanism of lung injuries due to exposure to sulfur mustard: a review
    Mostafa Ghanei
    Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Tehran, Iran
    Inhal Toxicol 23:363-71. 2011
    ..However, according to available evidences there are no such considerable data supporting neither proteolytic activity nor inflammation mechanism as the main underlying pathogenesis in Mustard Lung...
  5. ncbi Evaluation of the deposition, translocation and pathological response of brake dust with and without added chrysotile in comparison to crocidolite asbestos following short-term inhalation: interim results
    David M Bernstein
    Consultant in Toxicology, 1208 Geneva, Switzerland Electronic address
    Toxicol Appl Pharmacol 276:28-46. 2014
    ..These results provide support that brake dust derived from chrysotile containing brake drums would not initiate a pathological response in the lung following short term inhalation...
  6. pmc Health risk of chrysotile revisited
    David Bernstein
    Crit Rev Toxicol 43:154-83. 2013
    ..Since total dose over time decides the likelihood of disease occurrence and progression, they also suggest that the risk of an adverse outcome may be low with even high exposures experienced over a short duration...
  7. ncbi The health effects of chrysotile: current perspective based upon recent data
    David M Bernstein
    Regul Toxicol Pharmacol 45:252-64. 2006
    ..Since total dose over time decides the likelihood of disease occurrence and progression, they also suggest that the risk of an adverse outcome may be low if even any high exposures experienced were of short duration...
  8. ncbi Synthetic vitreous fibers: a review toxicology, epidemiology and regulations
    David M Bernstein
    Crit Rev Toxicol 37:839-86. 2007
    ..IARC (2001) reclassified these fibers from Category 2b to Category 3 (with RCF and special purpose fibers remaining in 2b) an event which has not been common in the history of these monographs...
  9. pmc A biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles
    D M Bernstein
    University of Edinburgh, ELEGI Colt Laboratory, Edinburgh, Scotland
    Inhal Toxicol 20:1009-28. 2008
    ..The increased number of macrophages in the chrysotile/sanded joint exposure group was confirmed histologically, with this being the only exposure-related histological finding reported...
  10. doi The pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short-term inhalation exposure: interim results
    D M Bernstein
    Inhal Toxicol 22:937-62. 2010
    ....
  11. doi Quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite-asbestos following short-term inhalation exposure
    D M Bernstein
    Consultant in Toxicology, Geneva, Switzerland
    Inhal Toxicol 23:372-91. 2011
    ..These results provide confirmation of the important differences between CSP and amphibole asbestos...
  12. ncbi The biopersistence of brazilian chrysotile asbestos following inhalation
    David M Bernstein
    Inhal Toxicol 16:745-61. 2004
    ..These results support the evidence presented by McDonald and McDonald (1997) that the chrysotile fibers are rapidly cleared from the lung in marked contrast to amphibole fibers which persist...
  13. ncbi Biopersistence of synthetic mineral fibers as a predictor of chronic inhalation toxicity in rats
    D M Bernstein
    Joint Research Centre, Institute for Health and Consumer Protection, European Chemicals Bureau, Ispra, Italy
    Inhal Toxicol 13:823-49. 2001
    ..The results show that the clearance half-times set in the EC directive are within the baseline for this parameter...
  14. ncbi The biopersistence of Canadian chrysotile asbestos following inhalation
    David M Bernstein
    Inhal Toxicol 15:1247-74. 2003
    ..Taken in context with the scientific literature to date, this report provides new robust data that clearly support the difference seen epidemiologically between chrysotile and amphibole asbestos...
  15. ncbi Comparison of Calidria chrysotile asbestos to pure tremolite: inhalation biopersistence and histopathology following short-term exposure
    David M Bernstein
    Consultant in Toxicology, 40 chemin de la Petite Boissiere, 1208 Geneva, Switzerland
    Inhal Toxicol 15:1387-419. 2003
    ..As Calidria chrysotile has been certified to have no tremolite fiber, the results of the current study together with the results from toxicological and epidemiological studies indicate that this fiber is not associated with lung disease...
  16. ncbi A review of the influence of particle size, puff volume, and inhalation pattern on the deposition of cigarette smoke particles in the respiratory tract
    David Bernstein
    Consultant in Toxicology, Geneva, Switzerland
    Inhal Toxicol 16:675-89. 2004
    ..The current data therefore suggest that the particle deposition pattern of the smoke within the lung would not change significantly if compensation occurs...
  17. ncbi Comparison of Calidria chrysotile asbestos to pure tremolite: final results of the inhalation biopersistence and histopathology examination following short-term exposure
    David M Bernstein
    Inhal Toxicol 17:427-49. 2005
    ..As Calidria chrysotile has been certified to have no tremolite fiber, the results of the current study together with the results from toxicological and epidemiological studies indicate that this fiber is not associated with lung disease...
  18. ncbi Indices of fiber biopersistence and carcinogen classification for synthetic vitreous fibers (SVFs)
    L Daniel Maxim
    Everest Consulting Associates, Cranbury, New Jersey 08512, USA
    Regul Toxicol Pharmacol 35:357-78. 2002
    ..The WT(1/2) is shown to be directly proportional to the cumulative exposure (fiber days) after the cessation of exposure and also the mean residence time of these fibers in the lung...
  19. ncbi Experience from a long-term carcinogenicity study with intraperitoneal injection of biosoluble synthetic mineral fibers
    Hans G Grimm
    Isover St Gobain, Les Miroirs 18 avenue d Alsace, Cedex 27, 92096 Paris la Défense, France
    Inhal Toxicol 14:855-82. 2002
    ....
  20. ncbi Calibration study on subchronic inhalation toxicity of man-made vitreous fibers in rats
    Bernd Bellmann
    Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Inhal Toxicol 15:1147-77. 2003
    ..In summary, this study demonstrates the importance of fiber dust contamination by granular components. For future subchronic studies a longer posttreatment observation period would be advisable...