H Nakajima

Summary

Affiliation: Basel Institute for Immunology
Country: Switzerland

Publications

  1. ncbi 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Hum Immunol 61:39-43. 2000
  2. ncbi Activating interactions in human NK cell recognition: the role of 2B4-CD48
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1676-83. 1999
  3. ncbi Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
    H Nakajima
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 30:3309-18. 2000
  4. ncbi Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Leukoc Biol 66:718-22. 1999
  5. ncbi Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain
    H Nakajima
    Basel Institute for Immunology, Switzerland
    J Immunol 162:5-8. 1999
  6. ncbi Essential role of Stat5 for IL-5-dependent IgH switch recombination in mouse B cells
    K Horikawa
    Department of Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 167:5018-26. 2001
  7. ncbi Comparison of wasting syndrome in [MRL lpr/lpr-->MRL +/+] chimera and graft versus host disease in [B10.D2-->BALB/c] chimera and an attempt to transfer the wasting syndrome in [MRL lpr/lpr-->MRL +/+] to MRL +/+ mice
    M Aihara
    Department of Dermatology, Yokohama City University School of Medicine, Japan
    J Dermatol Sci 7:107-18. 1994
  8. ncbi Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4
    K S Boles
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Tissue Antigens 54:27-34. 1999
  9. ncbi Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice
    H Nakajima
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Immunol 159:4737-44. 1997
  10. pmc Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis
    T Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Gut 52:683-7. 2003

Collaborators

  • M Cella
  • A Bouchon
  • Thomas Brunner
  • THOMAS GRIFFITH
  • Takashi Saito
  • M Colonna
  • Shinichi Sato
  • Hinobu Matsuo
  • Yusuke Honma
  • H W Davey
  • S E Stepp
  • Shih Sung Chuang
  • K Ozaki
  • Tomoaki Kato
  • I Iwamoto
  • A Suto
  • Y U Katagiri
  • N Kiyokawa
  • Y Saito
  • K Suzuki
  • K Mimori
  • T Sekino
  • J Fujimoto
  • Y Lu
  • S i Kagami
  • W J Leonard
  • M Tsuruga
  • Y Maezawa
  • T Kamisawa
  • K Imada
  • M Saito
  • T Taguchi
  • T Suzuki
  • K Kumano
  • M Kasai
  • Y Kitamura
  • K Horikawa
  • K Kobayashi
  • K Takatsu
  • K S Boles
  • T Kitamura
  • Y Komeno
  • M Kiyono
  • J Kitaura
  • T Oki
  • H Aburatani
  • T Nosaka
  • H Kumagai
  • E Bonfoco
  • S Kubo
  • Y Seto
  • Y C Chang
  • H Karasuyama
  • M Togashi
  • S Ozawa
  • J Magae
  • K Ando
  • N Egawa
  • Y Matsuo
  • K Isoyama
  • K Tsuruta
  • N Funata
  • K Yamada
  • K Amemiya
  • Y Hayashi
  • A Okamoto
  • N Sato
  • N Mizuta
  • K Kurasawa
  • T Yasue
  • A Kobayashi
  • H Kaku
  • T Mori
  • T Takeda
  • K Yamaguchi
  • A Kariyone
  • K Kooguchi
  • A Nakashima
  • S Hashimoto
  • I Miki
  • T Ebata
  • L Hennighausen
  • H Nagata
  • K Ohmi
  • C Katagiri
  • I Fujiwara
  • M Bennett
  • V Kumar
  • P A Mathew
  • G B Udy

Detail Information

Publications29

  1. ncbi 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Hum Immunol 61:39-43. 2000
    ..Thus, an interruption of signaling through 2B4 and related molecules may impair NK cell recognition of virally infected cells and contribute to XLP...
  2. ncbi Activating interactions in human NK cell recognition: the role of 2B4-CD48
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1676-83. 1999
    ..In T cells and monocytes, ligation of 2B4 does not lead to T cell or monocyte activation. Thus, it appears that the primary function of 2B4 is to modulate other receptor-ligand interactions to enhance leukocyte activation...
  3. ncbi Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
    H Nakajima
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 30:3309-18. 2000
    ..Here we show that XLPD patients have a defect of 2B4 receptor-mediated NK cell cytotoxicity. This defect may contribute to the pathogenesis of XLPD by reducing NK cell lysis of EBV-infected B cells...
  4. ncbi Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Leukoc Biol 66:718-22. 1999
    ..Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells...
  5. ncbi Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain
    H Nakajima
    Basel Institute for Immunology, Switzerland
    J Immunol 162:5-8. 1999
    ..Here we show that ILT1 receptor is selectively expressed on myeloid cells, functions as an activating receptor, and associates with FcepsilonRIgamma rather than DAP12...
  6. ncbi Essential role of Stat5 for IL-5-dependent IgH switch recombination in mouse B cells
    K Horikawa
    Department of Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 167:5018-26. 2001
    ..Stat5a and Stat5b are not redundant, but rather are at least partially distinctive in their function...
  7. ncbi Comparison of wasting syndrome in [MRL lpr/lpr-->MRL +/+] chimera and graft versus host disease in [B10.D2-->BALB/c] chimera and an attempt to transfer the wasting syndrome in [MRL lpr/lpr-->MRL +/+] to MRL +/+ mice
    M Aihara
    Department of Dermatology, Yokohama City University School of Medicine, Japan
    J Dermatol Sci 7:107-18. 1994
    ....
  8. ncbi Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4
    K S Boles
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Tissue Antigens 54:27-34. 1999
    ..Preliminary functional data suggests that NK-cell interaction with target cells via 2B4 modulates human NK-cell cytolytic activity...
  9. ncbi Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice
    H Nakajima
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Immunol 159:4737-44. 1997
    ..Thus, gamma c-dependent signals play a role in peripheral T cell deletion, presumably by inducing Fas ligand on activated T cells...
  10. pmc Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis
    T Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Gut 52:683-7. 2003
    ..Autoimmune pancreatitis is a unique clinical entity proposed recently, and is sometimes associated with inflammation of other organs...
  11. ncbi Ligand-switching intermediates for the CO-sensing transcriptional activator CooA measured by pulse radiolysis
    H Nakajima
    School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Nomi-gun, Ishikawa 923-1292, Japan
    J Biol Chem 276:37895-9. 2001
    ..9 ms (k = 3.5 x 10(2) x s(-1)) for wild-type CooA. The ligand exchange between Cys75 and His77 took place during the conversion of the second intermediate into the final reduced form...
  12. ncbi Role of CD4(+) CD25(+) regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways
    A Suto
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Am J Respir Crit Care Med 164:680-7. 2001
    ..These results indicate that CD4(+) CD25(+) T cells modulate the Th1 and Th2 cell balance toward Th2 cells and thus upregulate Th2 cell-mediated allergic inflammation in the airways...
  13. ncbi Monocyte chemoattractant protein-1 enhances HSV-induced encephalomyelitis by stimulating Th2 responses
    H Nakajima
    Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical Branch, Galveston 77555-0435, USA
    J Leukoc Biol 70:374-80. 2001
    ..Furthermore, IL-4 was produced in naive splenic T cells cocultured with CSF-Mphi. These results indicate that the severity of HSM is influenced by MCP-1, which stimulates Th2 responses...
  14. ncbi Characterization of 4-O-methyl-ascochlorin-induced apoptosis in comparison with typical apoptotic inducers in human leukemia cell lines
    M Tsuruga
    Department of Biotechnology, Institute of Research and Innovation, 1201 Takada, Kashiwa, Chiba 277 0861, Japan
    Apoptosis 9:429-35. 2004
    ..These results suggest that 4-O-methyl ascochlorin induces apoptosis through the mechanism distinct from conventional apoptosis inducers...
  15. pmc IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways
    Y Maezawa
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Clin Exp Immunol 135:12-8. 2004
    ....
  16. ncbi Prominent immunogenicity of monosialosyl galactosylgloboside, carrying a stage-specific embryonic antigen-4 (SSEA-4) epitope in the ACHN human renal tubular cell line-a simple method for producing monoclonal antibodies against detergent-insoluble microdom
    Y U Katagiri
    Department of Pathology, National Children's Medical Research Center, 3-35-31, Taisido, Setagaya-ku, Tokyo 154-8509
    Glycoconj J 18:347-53. 2001
    ..Using DIM/raft as immunogens may enable us to easily obtain MAbs for glycolipids...
  17. ncbi Costimulatory signals distinctively affect CD20- and B-cell-antigen-receptor-mediated apoptosis in Burkitt's lymphoma/leukemia cells
    K Mimori
    Department of Developmental Biology, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567, Japan
    Leukemia 17:1164-74. 2003
    ..CD20-mediated apoptosis in BL cells may provide not only a model for understanding the mechanism regulating clonal selection of B cells but a new therapeutic strategy for BL patients...
  18. ncbi T cell vaccination eliminates antigen-specific T cells and prevents antigen-induced eosinophil recruitment into the tissue
    M Kasai
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Int Arch Allergy Immunol 125:59-66. 2001
    ..Together, these results indicate that T cell vaccination prevents antigen-induced eosinophil recruitment into the airways presumably by eliminating antigen-specific T cells...
  19. ncbi Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice
    Y Kitamura
    Department of Intensive Care and Anesthesiology and Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Respir Crit Care Med 163:762-9. 2001
    ..These results indicate that the Fas/FasL system could be important in the pathogenesis of LPS-induced ALI, and proper regulation of the FasL/Fas system might be important for potential treatment of ARDS...
  20. pmc The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis
    H Nakajima
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    J Exp Med 185:189-95. 1997
    ....
  21. pmc Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
    K Imada
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    J Exp Med 188:2067-74. 1998
    ..These data indicate an essential nonredundant role for Stat5b for potent NK cell-mediated proliferation and cytolytic activity...
  22. ncbi Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells
    E Bonfoco
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 9:711-20. 1998
    ..Thus, some immune responses induce FasL in nonlymphoid tissues, which in turn kills activated lymphocytes, leading to peripheral T cell deletion...
  23. ncbi Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity
    H Nakajima
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    J Immunol 162:782-90. 1999
    ....
  24. ncbi Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice
    K Suzuki
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba 260 8670, Japan
    Int Immunol 12:123-32. 2000
    ..These results indicate that Jak3 is absolutely essential for gamma(c)-dependent T cell and B cell development, and for gamma(c)-dependent prevention of thymocyte apoptosis...
  25. ncbi Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue
    S i Kagami
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Blood 95:1370-7. 2000
    ..Blood. 2000;95:1370-1377)..
  26. ncbi Redox properties and coordination structure of the heme in the co-sensing transcriptional activator CooA
    H Nakajima
    School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Nomi-gun, Ishikawa 923-1292, Japan
    J Biol Chem 276:7055-61. 2001
    ..The redox-controlled ligand exchange of the heme between Cys(75) and His(77) is thought to cause the difference between the reduction and oxidation midpoint potentials...
  27. ncbi Activation of the caspase cascade during Stx1-induced apoptosis in Burkitt's lymphoma cells
    N Kiyokawa
    Department of Pathology, National Children's Medical Research Center, Setagaya-ku, Tokyo 154-8509, Japan
    J Cell Biochem 81:128-42. 2001
    ..Our findings should provide new insight into the understanding of the molecular basis of Stx1-mediated cell injury...
  28. ncbi Anti-arthritic effects of KF20444, a new immunosuppressive compound inhibiting dihydroorotate dehydrogenase, on rat collagen-induced arthritis
    K Kobayashi
    Department of Immunology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, Sunto-gun, Shizuoka-ken, Japan
    Inflamm Res 50:24-31. 2001
    ..CONCLUSIONS: KF20444 is a novel immunosuppressant which inhibits DHO-DHase and its effects in CIA suggest that it could be useful in the treatment of rheumatoid arthritis...
  29. ncbi Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD
    Y Lu
    Division of Cellular Therapy, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Leukemia 21:2246-57. 2007
    ..On the other hand, a dominant-negative form of TSC-22 accelerated the growth of Flt3-TKD-transduced 32Dcl.3 cells. Collectively, these results suggest that TSC-22 is a possible target of leukemia therapy...