H Jacobs

Summary

Affiliation: Basel Institute for Immunology
Country: Switzerland

Publications

  1. ncbi Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?
    H Jacobs
    Basel Institute for Immunology, Switzerland
    Immunol Today 18:565-9. 1997
  2. pmc Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
    H Jacobs
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 187:1735-43. 1998
  3. pmc Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes
    H Jacobs
    Basel Institute for Immunology, Switzerland
    Philos Trans R Soc Lond B Biol Sci 356:119-25. 2001
  4. ncbi Towards an understanding of somatic hypermutation
    H Jacobs
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005, Basel, Switzerland
    Curr Opin Immunol 13:208-18. 2001
  5. ncbi DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
    L Bross
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Immunity 13:589-97. 2000
  6. pmc PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice
    H Jacobs
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 190:1059-68. 1999
  7. ncbi Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain
    H Jacobs
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    Oncogene 12:2089-99. 1996
  8. ncbi Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants
    G Texido
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 26:1966-9. 1996
  9. ncbi Novel mutation in the TOR1A (DYT1) gene in atypical early onset dystonia and polymorphisms in dystonia and early onset parkinsonism
    J C Leung
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neurogenetics 3:133-43. 2001

Collaborators

  • G Weeda
  • F McBlane
  • H Fujiwara
  • J C Leung
  • L Bross
  • K Rajewsky
  • G Texido
  • C Klein
  • D deLeon
  • T Gasser
  • J Friedman
  • J B Penney
  • P P Pramstaller
  • D P Corey
  • J Jankovic
  • P Vieregge
  • X O Breakefield
  • M Eisengart
  • C Kamm
  • P Kramer
  • S B Bressman
  • D Doheny
  • M F Brin
  • L J Ozelius
  • Y Fukita
  • C Démollière
  • S Gilfillan
  • T W Mak
  • M Meiering
  • R Amakawa
  • W Muller
  • N Yoshida
  • D Mathis
  • C Benoist
  • R Kuhn
  • H Kikutani
  • T Kishimoto
  • J Roes

Detail Information

Publications9

  1. ncbi Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?
    H Jacobs
    Basel Institute for Immunology, Switzerland
    Immunol Today 18:565-9. 1997
    ..Here, Heinz Jacobs proposes a model for the organization of the pre-TCR and discusses its function in signal transduction...
  2. pmc Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
    H Jacobs
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 187:1735-43. 1998
    ..This appears also to be true for mismatch repair, RAD54-dependent double-strand-break repair, and AAG-mediated base excision repair...
  3. pmc Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes
    H Jacobs
    Basel Institute for Immunology, Switzerland
    Philos Trans R Soc Lond B Biol Sci 356:119-25. 2001
    ..Our data suggest that DSBs are reaction intermediates of the mechanism underlying somatic hypermutation...
  4. ncbi Towards an understanding of somatic hypermutation
    H Jacobs
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005, Basel, Switzerland
    Curr Opin Immunol 13:208-18. 2001
    ..These recent findings are key to the identification of the hypermutation mechanism...
  5. ncbi DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
    L Bross
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Immunity 13:589-97. 2000
    ..The introduction of DSBs appears to depend on transcriptional activity. Thus, secondary diversification of rearranged V gene segments relates to an error-prone nonhomologous DSB repair system acting in B cells of the GC...
  6. pmc PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice
    H Jacobs
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 190:1059-68. 1999
    ..Based on these results, we propose that PIM1 functions as an efficient effector of the IL-7 pathway, thereby enabling Rag-deficient pro-T cells to bypass the pre-TCR-controlled checkpoint in T cell development...
  7. ncbi Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain
    H Jacobs
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    Oncogene 12:2089-99. 1996
    ..DeltaV-TCRbeta transgenic mice frequently show an expansion of CD4+8+, IL-2 receptor alpha+ pre-T cells early in life. These cells likely represent the population that is subject to oncogenic transformation...
  8. ncbi Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants
    G Texido
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 26:1966-9. 1996
  9. ncbi Novel mutation in the TOR1A (DYT1) gene in atypical early onset dystonia and polymorphisms in dystonia and early onset parkinsonism
    J C Leung
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neurogenetics 3:133-43. 2001
    ..This 18-bp deletion is the first additional mutation, beyond the GAG-deletion (Glu302/303del), to be found in the TOR1A gene, and is associated with a distinct type of early onset dystonia...