M Colonna

Summary

Affiliation: Basel Institute for Immunology
Country: Switzerland

Publications

  1. ncbi Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Immunol 160:3096-100. 1998
  2. ncbi Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Leukoc Biol 66:718-22. 1999
  3. ncbi Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells
    M Colonna
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 30:697-704. 2000
  4. ncbi Specificity and function of immunoglobulin superfamily NK cell inhibitory and stimulatory receptors
    M Colonna
    Basel Institute for Immunology, Switzerland
    Immunol Rev 155:127-33. 1997
  5. ncbi Natural killer cell receptors specific for MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    Curr Opin Immunol 8:101-7. 1996
  6. ncbi Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    M Cella
    Basel Institute for Immunology
    Nat Med 5:919-23. 1999
  7. pmc A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
    M Cella
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 185:1743-51. 1997
  8. pmc A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
    M Colonna
    Basel Institute for Immunology, Basel CH 4005, Switzerland
    J Exp Med 186:1809-18. 1997
  9. ncbi Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:4991-5. 2000
  10. pmc A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
    A Bouchon
    Basel Institute for Immunology, CH-4005 Basel, Switzerland
    J Exp Med 194:1111-22. 2001

Collaborators

Detail Information

Publications42

  1. ncbi Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Immunol 160:3096-100. 1998
    ..ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity...
  2. ncbi Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Leukoc Biol 66:718-22. 1999
    ..Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells...
  3. ncbi Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells
    M Colonna
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 30:697-704. 2000
    ..Thus, the NKC may encode C-type lectin-like receptors expressed not only in NK cells but also in other cells, and at least one of these is of potential importance in regulating DC function...
  4. ncbi Specificity and function of immunoglobulin superfamily NK cell inhibitory and stimulatory receptors
    M Colonna
    Basel Institute for Immunology, Switzerland
    Immunol Rev 155:127-33. 1997
    ..This peculiar strategy allows NK cells to detect loss of MHC class I molecules on autologous transformed and virally infected cells with maximal sensitivity...
  5. ncbi Natural killer cell receptors specific for MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    Curr Opin Immunol 8:101-7. 1996
    ..Despite structural differences, murine and human receptors are diverse and specific for distinct class I ligands. Their characterization provides insight into natural killer cell functions...
  6. ncbi Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    M Cella
    Basel Institute for Immunology
    Nat Med 5:919-23. 1999
    ..Plasmacytoid monocytes may protect other cells from viral infections and promote survival of antigen-activated T cells...
  7. pmc A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
    M Cella
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 185:1743-51. 1997
    ..Thus, ILT3 is a novel inhibitory receptor that can negatively regulate activation of APCs and can be used by APCs for antigen uptake...
  8. pmc A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
    M Colonna
    Basel Institute for Immunology, Basel CH 4005, Switzerland
    J Exp Med 186:1809-18. 1997
    ..These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response...
  9. ncbi Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:4991-5. 2000
    ..To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses...
  10. pmc A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
    A Bouchon
    Basel Institute for Immunology, CH-4005 Basel, Switzerland
    J Exp Med 194:1111-22. 2001
    ..This novel DC activation pathway may regulate DC homeostasis and amplify DC responses to pathogens, explaining the phenotype observed in DAP12-deficient mice...
  11. ncbi Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 167:5517-21. 2001
    ..Thus, CRACC is a unique CD2-like receptor which mediates NK cell activation through a SAP-independent extracellular signal-regulated kinase-mediated pathway...
  12. ncbi Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
    H Nakajima
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 30:3309-18. 2000
    ..Here we show that XLPD patients have a defect of 2B4 receptor-mediated NK cell cytotoxicity. This defect may contribute to the pathogenesis of XLPD by reducing NK cell lysis of EBV-infected B cells...
  13. ncbi TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    A Bouchon
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Nature 410:1103-7. 2001
    ..These results demonstrate a critical function of TREM-1 in acute inflammatory responses to bacteria and implicate TREM-1 as a potential therapeutic target for septic shock...
  14. ncbi Activating interactions in human NK cell recognition: the role of 2B4-CD48
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1676-83. 1999
    ..In T cells and monocytes, ligation of 2B4 does not lead to T cell or monocyte activation. Thus, it appears that the primary function of 2B4 is to modulate other receptor-ligand interactions to enhance leukocyte activation...
  15. ncbi Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain
    H Nakajima
    Basel Institute for Immunology, Switzerland
    J Immunol 162:5-8. 1999
    ..Here we show that ILT1 receptor is selectively expressed on myeloid cells, functions as an activating receptor, and associates with FcepsilonRIgamma rather than DAP12...
  16. ncbi Alternatively spliced forms of human killer inhibitory receptors
    C Döhring
    Basel Institute for Immunology, Grenzacherstrasse 487, Basel CH 4005, Switzerland
    Immunogenetics 44:227-30. 1996
  17. ncbi Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells
    J Dietrich
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:9-12. 2000
    ..Stimulation of this complex induced tyrosine phosphorylation, mitogen-activated protein kinase activation, and cellular activation. Thus, SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells...
  18. ncbi Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways
    J Samaridis
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:660-5. 1997
    ..These cytoplasmic features suggest that ILT1 and ILT2 may mediate novel transmembrane signals by which myeloid and lymphoid cell responses can be either activated or inhibited...
  19. ncbi 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Hum Immunol 61:39-43. 2000
    ..Thus, an interruption of signaling through 2B4 and related molecules may impair NK cell recognition of virally infected cells and contribute to XLP...
  20. ncbi Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex
    K S Campbell
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 28:599-609. 1998
    ....
  21. pmc Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells
    D S Allan
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Exp Med 189:1149-56. 1999
    ..These results suggest that the primary role of HLA-G may be the modulation of myelomonocytic cell behavior in pregnancy...
  22. ncbi A human killer inhibitory receptor specific for HLA-A1,2
    C Döhring
    Basel Institute for Immunology, Switzerland
    J Immunol 156:3098-101. 1996
    ..Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3...
  23. ncbi Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3
    S Radaev
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Immunity 15:1039-49. 2001
    ..Unlike the KIR receptors that recognize a conserved HLA region by a lock-and-key mechanism, NKG2D recognizes diverse ligands by an induced-fit mechanism...
  24. ncbi The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells
    F Navarro
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Eur J Immunol 29:277-83. 1999
    ..Our data demonstrate that NK recognition of cells expressing HLA-G1 involves at least two non-overlapping receptor-ligand systems: the CD94/NKG2 interaction with HLA-E, and the engagement of the ILT2(LIR1) receptor by HLA-G1 molecules...
  25. ncbi Natural killer-type receptors for HLA class I antigens are clonally expressed in lymphoproliferative disorders of natural killer and T-cell type
    T Hoffmann
    Haematological Laboratory, Department of Research, Kantonsspital, Basel Institute for Immunology, Basel, and Division of Haematology, Kantonsspital, Switzerland
    Br J Haematol 110:525-36. 2000
    ..We conclude that NKRs are clonally expressed in lymphoproliferative disorders of NK or T-cell origin. NKR repertoires may represent a novel tool in diagnosing clonal disorders of NK and T-cell type...
  26. ncbi Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization
    J Dietrich
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    J Immunol 166:2514-21. 2001
    ..Thus, ILT2 inhibits both signaling and cellular events involved in the activation of T cells...
  27. ncbi Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation
    B A Binstadt
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Immunity 5:629-38. 1996
    ..These results suggest sequential roles for Lck and SHP-1 in the inhibition of PTK following MHC recognition by NK cells...
  28. ncbi Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells
    M Colonna
    Basel Institute for Immunology, Switzerland
    Science 268:405-8. 1995
    ..The distribution of these cDNAs was clonotypic and correlated with NK cell inhibition by particular class I alleles. Thus, NKAT cDNAs may encode receptors for class I molecules on NK cells...
  29. ncbi Strategies of natural killer cell recognition and signaling
    C A Stewart
    Lab of NK Cells and Innate Immunity, Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, 13288 Marseille, France
    Curr Top Microbiol Immunol 298:1-21. 2006
    ..Recent approaches offer ways to unravel how the integration of complex signaling networks directs the NK response...
  30. pmc BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction
    A Dzionek
    Miltenyi Biotec GmbH, D 51429 Bergisch Gladbach, Germany
    J Exp Med 194:1823-34. 2001
    ....
  31. ncbi Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4
    K S Boles
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Tissue Antigens 54:27-34. 1999
    ..Preliminary functional data suggests that NK-cell interaction with target cells via 2B4 modulates human NK-cell cytolytic activity...
  32. ncbi The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells
    D E Speiser
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunol 167:6165-70. 2001
    ..Thus, 2B4 expression correlates with CD8+ T cell differentiation in vivo...
  33. ncbi Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells
    M Seiffert
    , Department of Internal Medicine II, Division of Hematology, Immunology, and Oncology, , Germany
    Blood 97:2741-9. 2001
    ..The data suggest that the interaction of SIRPalpha with CD47 plays an important role during T-cell activation and induction of antigen-specific cytotoxic T-lymphocyte responses by DCs...
  34. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
    ..These findings demonstrate an important mechanism of immune regulation...
  35. ncbi Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties
    C Chang
    Division of Immunology, Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, United Kingdom
    J Immunol 163:4651-4. 1999
    ..In addition, we identify KAP10 as being able to bind the adapter protein Grb2. Based on our data, we suggest that this molecule is involved in stimulation and costimulation in cells of both myeloid and lymphoid origin...
  36. ncbi Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex
    M Torkar
    Department of Pathology, University of Cambridge, GB
    Eur J Immunol 28:3959-67. 1998
    ..ILT3 and KIRCI were in the same head-to-tail orientation as has been described for other KIR loci which may facilitate addition or loss of genes between different haplotypes...
  37. ncbi Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules
    H T Moins-Teisserenc
    Nuffield Department of Medicine, Institute of Molecular Medicine, Oxford, UK
    Lancet 354:1598-603. 1999
    ..We present evidence for a new aetiology for chronic granulomatous lesions associated with a recessive genetic defect, which is linked to the human leucocyte antigen (HLA) locus...
  38. ncbi Human natural killer cell receptors and signal transduction
    K S Campbell
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int Rev Immunol 20:333-70. 2001
    ..Although the complexities of NK cell signalling are only marginally understood, several overall themes have been defined by characterizing the roles of distinct pathways during NK cell responses...
  39. ncbi Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections
    L Richeldi
    Section of Respiratory Diseases, Dept of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy
    Eur Respir J 24:247-50. 2004
    ....
  40. ncbi Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
    D Jarrossay
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 31:3388-93. 2001
    ..These results reveal a remarkable specialization and complementarity in microbial molecule recognition as well as a flexibility in effector function among myeloid and plasmacytoid DC...
  41. doi Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis
    K Mamegano
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Genes Immun 9:214-23. 2008
    ..Flow cytometry indicated that this isoform was expressed on the surface of monocytes. These findings suggested that LILRA2 Delta 419-421 isoform encoded by the splice site SNP may play a role in SLE and MPA...
  42. ncbi A new Fc receptor homolog, FREB2, found in germinal center B cells
    T J Wilson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Immun 6:341-6. 2005
    ....