M F Bachmann

Summary

Affiliation: Basel Institute for Immunology
Country: Switzerland

Publications

  1. ncbi Influenza virus: a novel method to assess viral and neutralizing antibody titers in vitro
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    J Immunol Methods 225:105-11. 1999
  2. ncbi Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:291-9. 1999
  3. ncbi The role of B cells in acute and chronic infections
    M F Bachmann
    Basel Institute for Immunology Grenzacherstrasse 487, 4005 Basel, Switzerland
    Curr Opin Immunol 11:332-9. 1999
  4. ncbi Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 28:3110-9. 1998
  5. ncbi Four types of Ca2+ signals in naive CD8+ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists
    M F Bachmann
    Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Canada
    Eur J Immunol 27:3414-9. 1997
  6. ncbi Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:2156-66. 1999
  7. pmc CD2 sets quantitative thresholds in T cell activation
    M F Bachmann
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 190:1383-92. 1999
  8. ncbi The role of T-cell receptor dimerization in T-cell activation
    M F Bachmann
    Basel Institute for Immunology, Grenzacherstr 487, 4005 Basel, Switzerland
    Immunol Today 20:568-76. 1999
  9. ncbi Immune responses in the absence of costimulation: viruses know the trick
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    J Immunol 161:5791-4. 1998
  10. ncbi Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation
    M F Bachmann
    Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Canada
    Eur J Immunol 27:2195-203. 1997

Collaborators

Detail Information

Publications42

  1. ncbi Influenza virus: a novel method to assess viral and neutralizing antibody titers in vitro
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    J Immunol Methods 225:105-11. 1999
    ..This assay made it possible to distinguish between IgM and IgG antibody titers and was about 5-10 fold more sensitive than a classical hemagglutination inhibition assay using fresh chicken blood...
  2. ncbi Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:291-9. 1999
    ....
  3. ncbi The role of B cells in acute and chronic infections
    M F Bachmann
    Basel Institute for Immunology Grenzacherstrasse 487, 4005 Basel, Switzerland
    Curr Opin Immunol 11:332-9. 1999
    ..Current vaccine strategies should take into account this pivotal role of antibodies...
  4. ncbi Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 28:3110-9. 1998
    ..These findings support the model that antagonists are effectively preventing TCR oligomerization and functional TCR triggering...
  5. ncbi Four types of Ca2+ signals in naive CD8+ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists
    M F Bachmann
    Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Canada
    Eur J Immunol 27:3414-9. 1997
    ..Thus, stimulation of naive cytotoxic T cells with a panel of defined altered peptide ligands reveals a consistent picture, where Ca2+ fluxes predict agonist, partial agonist and antagonist properties of peptides...
  6. ncbi Absence of co-stimulation and not the intensity of TCR signaling is critical for the induction of T cell unresponsiveness in vivo
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:2156-66. 1999
    ....
  7. pmc CD2 sets quantitative thresholds in T cell activation
    M F Bachmann
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 190:1383-92. 1999
    ..Thus, CD2 sets quantitative thresholds and fine-tunes T cell activation both in vitro and in vivo...
  8. ncbi The role of T-cell receptor dimerization in T-cell activation
    M F Bachmann
    Basel Institute for Immunology, Grenzacherstr 487, 4005 Basel, Switzerland
    Immunol Today 20:568-76. 1999
    ..This review proposes that TCRs undergo dimerization before activation and that this property might be essential for both T-cell antagonism and T-cell specificity, and may be pivotal for T-cell survival versus T-cell activation...
  9. ncbi Immune responses in the absence of costimulation: viruses know the trick
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    J Immunol 161:5791-4. 1998
    ..This review argues that patterns recognized by both the specific and the innate immune system, together with a high and sustained Ag-load, are responsible for these surprisingly efficient immune responses triggered by pathogens...
  10. ncbi Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation
    M F Bachmann
    Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Canada
    Eur J Immunol 27:2195-203. 1997
    ....
  11. ncbi The antigen dose determines T helper subset development by regulation of CD40 ligand
    C Ruedl
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 30:2056-64. 2000
    ..Thus, we propose that (1) peptide-MHC density and (2) accessory molecules such as LFA-1 determine T helper polarization by regulation of CD40L...
  12. ncbi OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection
    M Kopf
    Basel Institute for Immunology, Basel, Switzerland
    Immunity 11:699-708. 1999
    ..Moreover, the number of CD4+ T cells infiltrating the lungs of influenza virus-infected OX40-/- mice was reduced. These results define a unique role of OX40 in the generation of optimal CD4+ T cell responses in vivo...
  13. ncbi Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells
    M F Bachmann
    Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
    J Immunol 160:95-100. 1998
    ....
  14. ncbi Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration
    K J McKall-Faienza
    Ontario Cancer Institute, Department of Immunology and Medical Biophysics, University of Toronto, Canada
    Int Immunol 10:405-12. 1998
    ..However, the absence of TNFRp55 altered the kinetics and incidence of the disease in a pathogen-dependent fashion...
  15. ncbi T-cell-independent antiviral B cell responses in CD45-deficient mice
    M F Bachmann
    Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
    Cell Immunol 175:12-5. 1997
    ..This demonstrates that the B cell receptor complex is able to generate a functional signal in the absence of CD45, provided the cross-linking stimulus is sufficiently strong...
  16. pmc Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
    M Kopf
    Basel Institute for Immunology, 4005 Basel, Switzerland
    J Exp Med 192:53-61. 2000
    ..Together, our results demonstrate that ICOS regulates both CD28-dependent and CD28-independent CD4(+) subset (Th1 and Th2) responses but not CTL responses in vivo...
  17. ncbi The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens
    M F Bachmann
    Basel Institute for Immunology, Switzerland
    J Immunol 163:137-42. 1999
    ....
  18. ncbi Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered
    M F Bachmann
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 31:450-8. 2001
    ..Thus, CTLA-4 is not involved in the down-regulation of specific T cell responses and peripheral deletion in a T cell-autonomous fashion...
  19. pmc TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
    M F Bachmann
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 189:1025-31. 1999
    ..Moreover, the data suggest that TRANCE/TRANCE-R may be a novel and important target for immune intervention...
  20. ncbi The role of germinal centers for antiviral B cell responses
    M F Bachmann
    Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada
    Immunol Res 17:329-44. 1998
    ..In addition to these well-established functions of GCs, this article presents evidence that they also play a crucial role for the maintenance of specific memory Ig titers and for the prevention of viral antibody escape mutants...
  21. ncbi Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions
    T J Molina
    Ontario Cancer Institute, Toronto, Canada
    J Immunol 151:699-706. 1993
    ..Therefore, these data indicate that p56lck is directly or indirectly crucially involved in in vivo Ag-induced T cell responses...
  22. ncbi Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice
    P Waterhouse
    Amgen Institute, Toronto, Ontario, Canada
    Eur J Immunol 27:1887-92. 1997
    ..These results demonstrate that specific antigen is required for the lymphoproliferation observed in CTLA-4(-/-) mice, and that CTLA-4 deficiency does not lead to a gross defect in negative selection...
  23. ncbi Contribution of LCMV transgenic models to understanding T lymphocyte development, activation, tolerance, and autoimmunity
    L T Nguyen
    Department of Immunology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
    Curr Top Microbiol Immunol 263:119-43. 2002
  24. ncbi Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis
    M F Bachmann
    Department of Medical Biophysics, Ontario Cancer Institute, Canada
    J Immunol 159:4165-70. 1997
    ..The contribution of Fas-mediated cytotoxicity was similar for the full agonist and the APLs. Thus, full agonists, partial agonists, and antagonists trigger similar and not distinct pathways of cytotoxicity...
  25. pmc LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor
    R Schmits
    Amgen Institute, Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Canada
    J Exp Med 183:1415-26. 1996
    ..Thus CD11a deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic infection are normal...
  26. ncbi TNF receptor p55 controls early acute graft-versus-host disease
    D E Speiser
    Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada
    J Immunol 158:5185-90. 1997
    ....
  27. ncbi CTL priming by CD8(+) and CD8(-) dendritic cells in vivo
    C Ruedl
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 29:3762-7. 1999
    ..Here we show that both subsets activate CD8(+) T cells in vitro and induce protective anti-viral CTL responses in vivo. Thus, vaccine strategies using peptide-pulsed DC do not have to take into account DC subsets for priming...
  28. pmc Functional management of an antiviral cytotoxic T-cell response
    M F Bachmann
    Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
    J Virol 71:5764-8. 1997
    ..This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications...
  29. ncbi Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice
    A Rahemtulla
    Amgen Institute, Toronto, Ontario, Canada
    Eur J Immunol 24:2213-8. 1994
    ..These results indicate that CD4 is not absolutely necessary for positive selection or effector function of class II MHC-restricted helper T cells...
  30. ncbi The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation
    J M Penninger
    Amgen Institute, Department of Medical Biophysics and Immunology, University of Toronto, Ontario, Canada
    Eur J Immunol 29:1709-18. 1999
    ..Our data provide the first genetic evidence that Vav is an important effector molecule that relays antigen receptor signaling to IL-2 production and activation of cytotoxic T cells...
  31. pmc Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4
    M F Bachmann
    Department of Pathology, University of Zurich, Switzerland
    J Virol 69:4842-6. 1995
    ....
  32. ncbi Immune responses in interleukin-2-deficient mice
    T M Kundig
    Institute of Experimental Immunology, University of Zurich, Switzerland
    Science 262:1059-61. 1993
    ..Natural killer cell activity was markedly reduced but inducible. These normal in vivo immune responses in IL-2-deficient mice question the importance of IL-2 as defined by in vitro studies...
  33. ncbi Antiviral immune responses of mice lacking MHC class II or its associated invariant chain
    M Battegay
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland
    Cell Immunol 167:115-21. 1996
    ..This suggests that local protein concentrations reached during viral infection in the host are high enough to override the Ii deficiency of antigen-presenting cells in vivo...
  34. ncbi Antiviral B cell memory in the absence of mature follicular dendritic cell networks and classical germinal centers in TNFR1-/- mice
    U Karrer
    Institute of Experimental Immunology, Laboratory for Special Techniques, Department of Pathology, University Hospital of Zurich, Zurich, Switzerland
    J Immunol 164:768-78. 2000
    ..However, about 5-10% of the Ab production remained in the absence of detectable persisting Ag in TNFR1-/- mice, probably either due to immature FDCs being partially functional and/or due to long-lived plasma cells...
  35. ncbi IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2
    M van Den Broek
    Institute for Experimental Immunology, Zurich, Switzerland
    J Immunol 164:371-8. 2000
    ..Thus, our results identify a new role for IL-12 in defense beyond the induction of IFN-gamma and show that IL-4 and IL-10 modulate host protective responses to VV...
  36. ncbi T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype
    M F Bachmann
    Department of Pathology, University of Zurich, Switzerland
    J Immunol 155:3727-33. 1995
    ..These results support the idea that thymic maturation is asymmetrical and strongly biased toward the helper phenotype...
  37. ncbi Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
    M A DeBenedette
    Department of Immunology, University of Toronto, Ontario, Canada
    J Immunol 163:4833-41. 1999
    ..These results further substantiate the idea that different immune responses vary in their dependence on costimulation and suggest a role for 4-1BBL in augmenting suboptimal CTL responses in vivo...
  38. pmc Antiviral immune responses in Itk-deficient mice
    M F Bachmann
    Department of Pathology, University of Zurich, Switzerland
    J Virol 71:7253-7. 1997
    ..Taken together, the results show that CTL responses are reduced in the absence of Itk whereas antiviral B-cell responses are not affected...
  39. pmc Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis
    T Fehr
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Exp Med 185:921-31. 1997
    ....
  40. ncbi Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
    T Holtschke
    Institute of Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Cell 87:307-17. 1996
    ..These results suggest a novel role for ICSBP in regulating the proliferation and differentiation of hematopoietic progenitor cells...
  41. pmc Vav regulates peptide-specific apoptosis in thymocytes
    Y Y Kong
    Amgen Institute, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    J Exp Med 188:2099-111. 1998
    ..Our results indicate that peptide-triggered thymocyte apoptosis is mediated via Vav activation, changes in the actin cytoskeleton, and subsequent activation of a PKC isoform...
  42. ncbi Pattern recognition by B cells: the role of antigen repetitiveness versus Toll-like receptors
    H J Hinton
    Cytos Biotechnology AG, Wagistrasse 25, 8952 Zurich Schlieren, Switzerland
    Curr Top Microbiol Immunol 319:1-15. 2008
    ..Exploiting these characteristics in vaccine design may help us to create vaccines which are as safe as a recombinant vaccine yet still as effective as a virus in inducing B cell responses...