S Grad

Summary

Affiliation: AO Research Institute
Country: Switzerland

Publications

  1. ncbi request reprint Chondrocyte gene expression under applied surface motion
    Sibylle Grad
    Biomaterials and Tissue Engineering Program, AO Research Institute, Davos, Switzerland
    Biorheology 43:259-69. 2006
  2. ncbi request reprint Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds
    Sibylle Grad
    AO Research Institute, Davos Platz, Switzerland
    Tissue Eng 12:3171-9. 2006
  3. doi request reprint Sliding motion modulates stiffness and friction coefficient at the surface of tissue engineered cartilage
    S Grad
    AO Research Institute Davos, Switzerland
    Osteoarthritis Cartilage 20:288-95. 2012
  4. doi request reprint [Chondrocytes - one cell type, different subpopulations : characteristics and behavior of different types of chondrocytes and implications for tissue engineering applications]
    S Grad
    AO Forschungsinstitut Davos, Clavadelerstrasse 8, CH 7270, Davos, Schweiz
    Orthopade 38:1038-44. 2009
  5. ncbi request reprint A combination of shear and dynamic compression leads to mechanically induced chondrogenesis of human mesenchymal stem cells
    O Schätti
    AO Research Institute Davos, Clavadelerstrasse 8, Davos Platz, Switzerland
    Eur Cell Mater 22:214-25. 2011
  6. ncbi request reprint Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells
    J V Stoyanov
    AO Research Institute Davos, Clavadelerstrasse, Switzerland
    Eur Cell Mater 21:533-47. 2011
  7. ncbi request reprint Surface motion upregulates superficial zone protein and hyaluronan production in chondrocyte-seeded three-dimensional scaffolds
    Sibylle Grad
    Biochemistry and Cell Biology, AO Research Institute, Davos Platz, Switzerland
    Tissue Eng 11:249-56. 2005
  8. ncbi request reprint Chondrocytes seeded onto poly (L/DL-lactide) 80%/20% porous scaffolds: a biochemical evaluation
    Sibylle Grad
    Biochemistry and Cell Biology, AO Research Institute, 7270 Davos Platz, Switzerland
    J Biomed Mater Res A 66:571-9. 2003
  9. ncbi request reprint Effect of reduced oxygen tension and long-term mechanical stimulation on chondrocyte-polymer constructs
    Ellen Wernike
    Biomaterials and Tissue Engineering Program, AO Research Institute, Clavadelerstrasse 8, Davos Platz, 7270, Switzerland
    Cell Tissue Res 331:473-83. 2008
  10. pmc A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat
    Cynthia R Lee
    Biomaterials and Tissue Engineering Program, AO Research Institute, Clavadelerstrasse 8, 7270, Davos Platz, Switzerland
    Eur Spine J 16:2174-85. 2007

Collaborators

  • Mauro Alini
  • Sylwester Gogolewski
  • Cynthia R Lee
  • Erich Schneider
  • James Iatridis
  • S Ikegawa
  • K M Cheung
  • O Schätti
  • J V Stoyanov
  • Damien O Halloran
  • You Qiang Song
  • Ellen Wernike
  • Markus A Wimmer
  • Jeffery J Maclean
  • J Goldhahn
  • M Baur
  • G Salzmann
  • Z Li
  • A Bertolo
  • M J Stoddart
  • B Gantenbein-Ritter
  • N Aebli
  • John C Y Leong
  • Jaro Karppinen
  • Danny Chan
  • Daniel W H Ho
  • Zhen Li
  • Abhay S Pandit
  • Pak Sham
  • Yuichiro Hirose
  • Kathryn S E Cheah
  • Martin Stoddart
  • Shea Ping Yip
  • Yoshiharu Kawaguchi
  • Anita F Y Yee
  • Keith D K Luk
  • Sandy C S Poon
  • Kazuhiro Chiba
  • Peter Dockery
  • Thomas Kaup
  • Markus Hanni
  • Keita Ito

Detail Information

Publications17

  1. ncbi request reprint Chondrocyte gene expression under applied surface motion
    Sibylle Grad
    Biomaterials and Tissue Engineering Program, AO Research Institute, Davos, Switzerland
    Biorheology 43:259-69. 2006
    ..These results demonstrate the beneficial effect of articular motion not only for stimulation of important lubricating molecules, but also for the preservation of the chondrocytic phenotype...
  2. ncbi request reprint Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds
    Sibylle Grad
    AO Research Institute, Davos Platz, Switzerland
    Tissue Eng 12:3171-9. 2006
    ..It is suggested that the oscillating ball drags the fluid into the joint space, thereby causing biophysical effects similar to those of fluid flow...
  3. doi request reprint Sliding motion modulates stiffness and friction coefficient at the surface of tissue engineered cartilage
    S Grad
    AO Research Institute Davos, Switzerland
    Osteoarthritis Cartilage 20:288-95. 2012
    ..For better understanding of the molecule-function relationships, AFM was complemented with immunohistochemistry...
  4. doi request reprint [Chondrocytes - one cell type, different subpopulations : characteristics and behavior of different types of chondrocytes and implications for tissue engineering applications]
    S Grad
    AO Forschungsinstitut Davos, Clavadelerstrasse 8, CH 7270, Davos, Schweiz
    Orthopade 38:1038-44. 2009
    ..In particular, an overview of recent results from comparative studies is presented, and possible consequences for the design of tissue engineering models are discussed...
  5. ncbi request reprint A combination of shear and dynamic compression leads to mechanically induced chondrogenesis of human mesenchymal stem cells
    O Schätti
    AO Research Institute Davos, Clavadelerstrasse 8, Davos Platz, Switzerland
    Eur Cell Mater 22:214-25. 2011
    ..Histological analysis detected sulphated glycosaminoglycan and collagen II only in the compression and shear group. The results obtained may provide insight into post-operative care after cell therapy involving mesenchymal stromal cells...
  6. ncbi request reprint Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells
    J V Stoyanov
    AO Research Institute Davos, Clavadelerstrasse, Switzerland
    Eur Cell Mater 21:533-47. 2011
    ..Trends in gene expression regulation were confirmed on the protein level using immunohistochemistry. We conclude that hypoxia and GDF5 may be suitable for directing MSCs towards the IVD-like phenotype...
  7. ncbi request reprint Surface motion upregulates superficial zone protein and hyaluronan production in chondrocyte-seeded three-dimensional scaffolds
    Sibylle Grad
    Biochemistry and Cell Biology, AO Research Institute, Davos Platz, Switzerland
    Tissue Eng 11:249-56. 2005
    ..These results indicate that specific stimuli that mimic the kinematics of natural joints, such as articular motion, may promote the development of a functional articular surface-synovial interface...
  8. ncbi request reprint Chondrocytes seeded onto poly (L/DL-lactide) 80%/20% porous scaffolds: a biochemical evaluation
    Sibylle Grad
    Biochemistry and Cell Biology, AO Research Institute, 7270 Davos Platz, Switzerland
    J Biomed Mater Res A 66:571-9. 2003
    ..The limitations of the system are the diffusion of large amounts of matrix molecules into the culture medium and the dedifferentiation of the chondrocytes with prolonged time in culture...
  9. ncbi request reprint Effect of reduced oxygen tension and long-term mechanical stimulation on chondrocyte-polymer constructs
    Ellen Wernike
    Biomaterials and Tissue Engineering Program, AO Research Institute, Clavadelerstrasse 8, Davos Platz, 7270, Switzerland
    Cell Tissue Res 331:473-83. 2008
    ....
  10. pmc A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat
    Cynthia R Lee
    Biomaterials and Tissue Engineering Program, AO Research Institute, Clavadelerstrasse 8, 7270, Davos Platz, Switzerland
    Eur Spine J 16:2174-85. 2007
    ..Future studies using different species are required to evaluate whether the expression of these molecules can be used to characterize NP cells and distinguish them from other chondrocyte-like cells...
  11. ncbi request reprint The use of biodegradable polyurethane scaffolds for cartilage tissue engineering: potential and limitations
    Sibylle Grad
    Biochemistry and Cell Biology Unit, AO Research Institute, 7270 Davos Platz, Switzerland
    Biomaterials 24:5163-71. 2003
    ..However, due to the favourable mechanical properties of the polyurethane scaffold, stimulation of chondrocytes by mechanical loading can be considered in order to improve the formation of a functional cartilage-like extracellular matrix...
  12. ncbi request reprint Tribology approach to the engineering and study of articular cartilage
    Markus A Wimmer
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    Tissue Eng 10:1436-45. 2004
    ..The final design of the bioreactor will include four individual stations in line, which will facilitate the investigation of motion-initiated effects at the contacting surfaces in more detail...
  13. ncbi request reprint Fibrin-polyurethane composites for articular cartilage tissue engineering: a preliminary analysis
    Cynthia R Lee
    Biochemistry and Cell Biology, AO Research Institute, Davos, Switzerland
    Tissue Eng 11:1562-73. 2005
    ..Although further work is needed to optimize this system, the addition of fibrin hydrogel to encapsulate cells in the stiff, macroporous PU scaffold is a step forward in our approach to articular cartilage tissue engineering...
  14. ncbi request reprint Effect of mechanical loading on mRNA levels of common endogenous controls in articular chondrocytes and intervertebral disk
    Cynthia R Lee
    Biochemistry and Cell Biology, AO Research Institute, Davos, Switzerland
    Anal Biochem 341:372-5. 2005
  15. ncbi request reprint Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo
    Jeffery J Maclean
    Department of Mechanical Engineering, University of Vermont, Burlington 05405 0156, USA
    Spine (Phila Pa 1976) 28:973-81. 2003
    ..An in vivo analysis of the intervertebral disc's cellular response to dynamic compression and immobilization was performed using a rat-tail model...
  16. ncbi request reprint An injectable cross-linked scaffold for nucleus pulposus regeneration
    Damien O Halloran
    National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland
    Biomaterials 29:438-47. 2008
    ....
  17. pmc Association of the asporin D14 allele with lumbar-disc degeneration in Asians
    You Qiang Song
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    Am J Hum Genet 82:744-7. 2008
    ..70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD...