Cezmi A Akdis

Summary

Country: Switzerland

Publications

  1. doi request reprint Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:701-21.e1-70. 2011
  2. pmc The biodiversity hypothesis and allergic disease: world allergy organization position statement
    Tari Haahtela
    Skin and Allergy Hospital, Helsinki University Hospital, PO Box 160, 00029, Helsinki, HUCH, Finland
    World Allergy Organ J 6:3. 2013
  3. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  4. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
  5. doi request reprint Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Christine Kühne Center for Allergy Research and Education, Davos, Switzerland
    J Allergy Clin Immunol 131:1479-90. 2013
  6. doi request reprint Therapies for allergic inflammation: refining strategies to induce tolerance
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland
    Nat Med 18:736-49. 2012
  7. pmc Mechanisms of allergen-specific immunotherapy
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Clin Transl Allergy 2:2. 2012
  8. pmc T-cell subset regulation in atopy
    Marek Jutel
    Department of Clinical Immunology, Wroclaw Medical University, T Chalubinskiego 5, 50 368, Wroclaw, Poland
    Curr Allergy Asthma Rep 11:139-45. 2011
  9. doi request reprint New insights into mechanisms of immunoregulation in 2007
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 122:700-9. 2008
  10. doi request reprint Therapeutic manipulation of immune tolerance in allergic disease
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos Platz, Switzerland
    Nat Rev Drug Discov 8:645-60. 2009

Detail Information

Publications84

  1. doi request reprint Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:701-21.e1-70. 2011
    ..We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections...
  2. pmc The biodiversity hypothesis and allergic disease: world allergy organization position statement
    Tari Haahtela
    Skin and Allergy Hospital, Helsinki University Hospital, PO Box 160, 00029, Helsinki, HUCH, Finland
    World Allergy Organ J 6:3. 2013
    ..Data on behavioural means to induce tolerance are outlined and a proposal made for a Global Allergy Plan to prevent and reduce the global allergy burden for affected individuals and the societies in which they live...
  3. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  4. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
    ....
  5. doi request reprint Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Christine Kühne Center for Allergy Research and Education, Davos, Switzerland
    J Allergy Clin Immunol 131:1479-90. 2013
    ....
  6. doi request reprint Therapies for allergic inflammation: refining strategies to induce tolerance
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Switzerland
    Nat Med 18:736-49. 2012
    ..Combination strategies using both of these approaches may also provide a route for addressing the unmet clinical needs in allergic diseases...
  7. pmc Mechanisms of allergen-specific immunotherapy
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Clin Transl Allergy 2:2. 2012
    ..Knowledge of these molecular basis is crucial in the understanding the regulation of immune responses and their possible therapeutic targets in allergic diseases...
  8. pmc T-cell subset regulation in atopy
    Marek Jutel
    Department of Clinical Immunology, Wroclaw Medical University, T Chalubinskiego 5, 50 368, Wroclaw, Poland
    Curr Allergy Asthma Rep 11:139-45. 2011
    ..This review aims to discuss our understanding of the T-cell subset reciprocal interaction in atopy...
  9. doi request reprint New insights into mechanisms of immunoregulation in 2007
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 122:700-9. 2008
    ..This review highlights key advances in immune regulation that were published in the Journal of Allergy and Clinical Immunology...
  10. doi request reprint Therapeutic manipulation of immune tolerance in allergic disease
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos Platz, Switzerland
    Nat Rev Drug Discov 8:645-60. 2009
    ..This Review highlights current knowledge of immunomodulatory therapies for the manipulation of immune tolerance and highlights recent approaches to improve allergen-specific immunotherapy for the treatment of allergic diseases...
  11. ncbi request reprint Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes
    Fariba Karamloo
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 35:3268-76. 2005
    ....
  12. doi request reprint RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter
    Simone Burgler
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Immunol 184:6161-9. 2010
    ..Together, this study identifies RORC2 as a polarizing factor in transcriptional cross-regulation and provides novel viewpoints on the control of immune tolerance versus effector immune responses...
  13. doi request reprint Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells
    Kerstin Siegmund
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Immunol 182:2124-30. 2009
    ..In conclusion, the current study characterizes FOXP3-expressing CD8(+) T cells from human tonsils and shows that in vitro activation leads to FOXP3 expression in CD8(+) T cells and gain of suppressive activity...
  14. ncbi request reprint Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1
    Nadia Ouaked
    Swiss Institute of Allergy and Asthma Research Davos, affiliated with the University of Zurich, Davos Platz, Switzerland
    J Immunol 182:1041-9. 2009
    ..Our data demonstrate a molecular mechanism regulating FOXP3 expression, which is of considerable interest for the development of new drug targets aiming to support anti-inflammatory mechanisms of the immune system...
  15. doi request reprint Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood
    Umut Can Kucuksezer
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 131:875-85. 2013
    ..Breaking of peripheral T-cell tolerance to allergens can lead to the development of allergies, but the mechanisms are not completely understood...
  16. ncbi request reprint Apoptosis and loss of adhesion of bronchial epithelial cells in asthma
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 138:142-50. 2005
    ..Since EC shedding is a histologic hallmark of asthma, the intercellular junction of EC may be a target of pro-inflammatory cytokines...
  17. ncbi request reprint Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    Christian Karagiannidis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 114:1425-33. 2004
    ..The loss of peripheral tolerance against allergens causes diseases that can be therapeutically controlled with glucocorticoids...
  18. doi request reprint IL-10 suppresses CD2-mediated T cell activation via SHP-1
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Mol Immunol 46:622-9. 2009
    ..In conclusion, SHP-1-mediated inhibition of CD2 signaling represents a novel mechanism for direct T cell suppression by IL-10...
  19. doi request reprint Dual nature of T cell-epithelium interaction in chronic rhinosinusitis
    Tomasz M Basinski
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos 7270, Switzerland
    J Allergy Clin Immunol 124:74-80.e1-8. 2009
    ..T-cell infiltration of submucosa, release of proinflammatory cytokines leading to epithelial activation, and contributions to inflammation are observed in chronic rhinosinusitis (CRS)...
  20. doi request reprint Differentiation and functional analysis of human T(H)17 cells
    Simone Burgler
    Swiss Institute for Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:588-95, 595.e1-7. 2009
    ..Regulatory T (Treg) cells, in contrast, suppress inflammatory and allergen-driven responses. Despite these disparate functions, both T-cell subsets have been shown to be dependent on TGF-beta for their development...
  21. doi request reprint Role of Treg in immune regulation of allergic diseases
    Oscar Palomares
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Eur J Immunol 40:1232-40. 2010
    ..The identification of the molecules involved in these processes will contribute to the development of more efficient and safer treatment modalities...
  22. pmc In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    Flurina Meiler
    Swiss Institute of Allergy and Asthma Research, University of Zurich, 7270 Davos, Switzerland
    J Exp Med 205:2887-98. 2008
    ..Thus, rapid switch and expansion of IL-10-producing Tr1 cells and the use of multiple suppressive factors represent essential mechanisms in immune tolerance to a high dose of allergens in nonallergic individuals...
  23. doi request reprint Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases
    Tunc Akkoc
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 121:652-658.e1. 2008
    ..Increased activation and massive infiltration of T cells in the dermis without any evidence for the expansion of their numbers in peripheral blood characterize atopic dermatitis...
  24. doi request reprint Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:1612-21.e8. 2011
    ..Tight junction (TJ) proteins, which are expressed in endothelial and epithelial cells and affect tissue integrity, might exist in other types of cells and display additional functions in the asthmatic lung...
  25. pmc Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms
    Patrycja Konieczna
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    PLoS ONE 8:e62617. 2013
    ..infantis-fed mice. Thus, CD103(+)RALDH(+) LP dendritic cells are important cellular targets for microbiota-associated effects on mucosal immunoregulation...
  26. pmc Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Immunology 117:433-42. 2006
    ..Induction of antigen-specific Tr1 cells can thus re-direct an inappropriate immune response against allergens or auto-antigens using a broad range of suppressor mechanisms...
  27. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
    ..These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy...
  28. doi request reprint TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis
    Maya Zimmermann
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:200-7, 207.e1-10. 2011
    ....
  29. ncbi request reprint A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy
    Fatimah Kussebi
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 115:323-9. 2005
    ..Differences between epitopes of IgE that recognize the 3-dimensional structure of allergens and T cells that recognize linear amino acid sequences provide a suitable tool for novel vaccine development for specific immunotherapy...
  30. pmc Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
    Sven Klunker
    Swiss Institute of Allergy and Asthma Research Davos, University of Zurich, CH 7270 Davos Platz, Switzerland
    J Exp Med 206:2701-15. 2009
    ..Furthermore, FOXP3 and RUNX3 were colocalized in human tonsil T reg cells. These data demonstrate Runx transcription factors as a molecular link in TGF-beta-induced Foxp3 expression in iT reg cell differentiation and function...
  31. ncbi request reprint T cell phenotype in allergic asthma and atopic dermatitis
    Jan G Wohlfahrt
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 131:272-82. 2003
    ..In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pathogenesis of allergic diseases...
  32. doi request reprint Histamine receptor 2 modifies dendritic cell responses to microbial ligands
    Remo Frei
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 132:194-204. 2013
    ..The induction of tolerance and protective immunity to microbes is significantly influenced by host- and microbiota-derived metabolites, such as histamine...
  33. doi request reprint Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4
    Michael B Soyka
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 130:1087-1096.e10. 2012
    ..The regulation of epithelial barrier function and TJ expression has not been extensively studied in patients with CRS and in the paranasal sinus epithelium thus far...
  34. doi request reprint IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis
    Norbert Meyer
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland High altitude Clinic of Davos, Davos Wolfgang, Switzerland
    J Allergy Clin Immunol 125:858-865.e10. 2010
    ..IL-32 is a proinflammatory cytokine that is involved in the inflammatory processes of rheumatoid arthritis, chronic obstructive pulmonary disease, and Crohn disease. Recently, it was shown that upregulation of IL-32 induces apoptosis...
  35. ncbi request reprint T regulatory cells in allergy and health: a question of allergen specificity and balance
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Int Arch Allergy Immunol 135:73-82. 2004
    ..In conclusion, induction of antigen-specific T(Reg) cells may redirect an inappropriate immune response against allergen or autoantigens with the help of a broad range of suppressor mechanisms...
  36. ncbi request reprint A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in
    Sven Klunker
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Immunol 171:1078-84. 2003
    ..Keratinocytes undergoing apoptosis in acute eczematous lesions release chemokines that attract more T cells toward the epidermis, which may further augment the inflammation and keratinocyte apoptosis...
  37. ncbi request reprint Absence of T-regulatory cell expression and function in atopic dermatitis skin
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research, Davos Platz, Switzerland
    J Allergy Clin Immunol 117:176-83. 2006
    ..Increasing the number and activity of regulatory T cells in affected organs has been suggested as a remedy in various inflammatory diseases, including allergy...
  38. ncbi request reprint T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    FASEB J 17:1026-35. 2003
    ..These results define a novel mechanism for peripheral Th2 response in atopic diseases...
  39. ncbi request reprint Histamine in the immune regulation of allergic inflammation
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos
    J Allergy Clin Immunol 112:15-22. 2003
    ..This article highlights novel discoveries in histamine immunobiology and discusses clinical findings or disease models that indicate immune regulation by histamine...
  40. ncbi request reprint TH17 cells in the big picture of immunology
    Carsten B Schmidt-Weber
    Swiss Institute of Allergy and Asthma Research, Switzerland
    J Allergy Clin Immunol 120:247-54. 2007
    ..This review summarizes the recent developments on T(H) cell subsets and integrates these findings into existing concepts of immunopathologic mechanisms...
  41. pmc Portrait of an immunoregulatory Bifidobacterium
    Patrycja Konieczna
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos Platz, Switzerland
    Gut Microbes 3:261-6. 2012
    ..In addition, we discuss the potential DC subset-specific mechanisms, which could contribute to DC(REG) and T(REG) programming by specific gut microbes...
  42. doi request reprint Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema
    Sabine Zeller
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 124:278-85, 285.e1-7. 2009
    ..Atopic eczema (AE) is the most common chronic inflammatory skin disease. Recent data demonstrate the presence of autoreactive serum IgE antibodies correlating with the severity of the disease...
  43. doi request reprint Mechanisms of immune tolerance to allergens
    Hiroyuki Fujita
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Chem Immunol Allergy 96:30-8. 2012
    ..Knowledge of this molecular basis is crucial to understanding the regulation of the immune response and their possible therapeutic applications for allergic diseases...
  44. ncbi request reprint Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Eur J Immunol 33:2717-26. 2003
    ..These results demonstrate that stimulation of TLR-2 by lipopeptides represents a novel way for possible treatment of allergy and asthma by regulating the disrupted cytokine balance...
  45. ncbi request reprint IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 120:76-83. 2007
    ..Specific T-cell activation requires T-cell receptor stimulation and the generation of costimulatory signals. Major costimulatory signals are delivered to T cells by the interaction of CD28 and inducible costimulator (ICOS)...
  46. ncbi request reprint Histamine receptors are hot in immunopharmacology
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Eur J Pharmacol 533:69-76. 2006
    ..This article highlights recent discoveries in histamine immunobiology and discusses their relevance in allergic inflammation...
  47. doi request reprint Regulatory effects of histamine and histamine receptor expression in human allergic immune responses
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 94:67-82. 2008
    ..In addition, differences in affinities of these receptors for histamine are highly decisive for the biological effects of histamine and drugs that target histamine receptors...
  48. pmc GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
    Pierre Yves Mantel
    Swiss Institute of Allergy and Asthma Research Davos SIAF, Davos Platz, Switzerland
    PLoS Biol 5:e329. 2007
    ....
  49. ncbi request reprint Are regulatory T cells the target of venom immunotherapy?
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Curr Opin Allergy Clin Immunol 5:365-9. 2005
    ..T-regulatory (TReg) cells are involved in preventing sensitization to allergens and represent a major target for venom- or other allergen-specific immunotherapy...
  50. ncbi request reprint IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    ..Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens...
  51. ncbi request reprint T regulatory cells in allergen-specific immunotherapy
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Rev Immunol 24:533-48. 2005
    ..Mechanisms underlying allergen-SIT and in particular the role of regulatory T cells will be discussed in this review, based on recent findings and current concepts...
  52. ncbi request reprint Mechanisms of allergen-specific immunotherapy
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:195-203. 2006
    ..By the application of the recent knowledge in mechanisms of allergen-SIT, more rational and safer approaches are awaiting in the future for the prevention and cure of allergic diseases...
  53. ncbi request reprint T cells and effector mechanisms in the pathogenesis of atopic dermatitis
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Allergy Asthma Rep 2:1-3. 2002
  54. doi request reprint IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses
    Willem Van De Veen
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 131:1204-12. 2013
    ..IgG4 is a blocking antibody isotype with anti-inflammatory potential that is induced in human high-dose antigen tolerance models...
  55. doi request reprint TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protection
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 129:1438-49; quiz1450-1. 2012
    ....
  56. doi request reprint Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells
    Patrycja Konieczna
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Zurich, Switzerland
    Gut 61:354-66. 2012
    ..Intestinal homoeostasis is dependent on immunological tolerance to the microbiota...
  57. ncbi request reprint Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos
    J Allergy Clin Immunol 118:152-69. 2006
    ..The consensus report is part of the PRACTALL initiative, which is endorsed by both academies...
  58. pmc Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunology 108:305-12. 2003
    ..Therefore, the CD8low population represent a subset of activated CD8 effector T cells, resulting most probably from a continuous and/or balanced immune response to intracellular pathogens...
  59. ncbi request reprint Apoptosis in tissue inflammation and allergic disease
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 16:717-23. 2004
    ..In individuals with non-atopic monoallergic disease, by contrast, a disturbed balance towards allergen-specific Th2 cells instead of T regulatory type 1 (Tr1) cells characterizes the T cell response...
  60. ncbi request reprint Histamine in allergic inflammation and immune modulation
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 137:82-92. 2005
    ..This article highlights the findings leading to a change of perspective in histamine immunobiology...
  61. ncbi request reprint T regulatory cells and allergy
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Microbes Infect 7:1049-55. 2005
    ..By utilizing multiple secreted cytokines and surface molecules, antigen-specific T(Reg) cells may re-direct an inappropriate immune response against allergens or auto-antigens...
  62. ncbi request reprint Advances in allergen-specific immunotherapy
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research SIAF, CH 7270 Davos, Switzerland
    Expert Opin Biol Ther 5:537-44. 2005
    ....
  63. doi request reprint Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance
    Oscar Palomares
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 129:510-20, 520.e1-9. 2012
    ..Tonsillectomy removes only the palatine tonsils and sometimes adenoids. Lingual tonsil is anatomically big and remains lifelong intact...
  64. ncbi request reprint Targets in allergy-directed immunotherapy
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research, CH 7270 Davos, Switzerland
    Expert Opin Ther Targets 9:217-24. 2005
    ..Recent advances in our knowledge of immunological mechanisms have created several options to comply with these demands. This article will focus on some of the most promising new developments...
  65. doi request reprint Immune regulation by histamine H4 receptors in skin
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Invest Dermatol 128:1615-6. 2008
    ..In this issue, Dijkstra et al., demonstrate the expression and some of the functions of histamine H(4) receptors on inflammatory dendritic cells in atopic dermatitis skin...
  66. doi request reprint Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009
    ..Current strategies for drug development and allergen-specific immunotherapy exploit these observations, with the potential for preventive therapies and cure for allergic diseases...
  67. ncbi request reprint Mechanisms of allergen-specific immunotherapy: T-regulatory cells and more
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunol Allergy Clin North Am 26:207-31, vi. 2006
    ..The application of current knowledge of Treg cells and related mechanisms of peripheral tolerance may soon lead to more rational and safer approaches to the prevention and cure of allergic disease...
  68. doi request reprint Novel immunotherapeutic approaches for allergy and asthma
    Liam O'Mahony
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Autoimmunity 43:493-503. 2010
    ..This review will discuss novel approaches to the management of allergy and asthma by targeting the T regulatory cell via modulation of the commensal microbiota and allergen-SIT...
  69. ncbi request reprint T regulatory cells in allergy
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:159-73. 2006
    ..It is associated with regulation of antibody isotypes and effector cells to the direction of a healthy immune response and opens a window for novel therapies of allergic diseases...
  70. doi request reprint IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma
    Thomas Eiwegger
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Eur J Immunol 41:1535-8. 2011
    ..In conclusion, IL-33 affects both the development of allergic sensitization and the development of lung inflammation in allergic asthma...
  71. doi request reprint Modular antigen-translocation as a novel vaccine strategy for allergen-specific immunotherapy
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Curr Opin Allergy Clin Immunol 9:568-73. 2009
    ..Special emphasis will be given to the approach based on specific targeting of the major histocompatibility complex (MHC) class-II antigen-presentation pathway...
  72. doi request reprint Regulatory cells in allergen-specific immunotherapy
    Michael B Soyka
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Obere Strasse 22, 7270 Davos Platz, Switzerland
    Immunotherapy 4:389-96. 2012
    ....
  73. doi request reprint Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis
    Ana Rebane
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 129:1297-306. 2012
    ..Enhanced apoptosis of keratinocytes is the main cause of eczema and spongiosis in patients with the common inflammatory skin disease atopic dermatitis (AD)...
  74. ncbi request reprint The role of histamine in regulation of immune responses
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:174-87. 2006
    ....
  75. ncbi request reprint Human NK1 and NK2 subsets determined by purification of IFN-gamma-secreting and IFN-gamma-nonsecreting NK cells
    Gunnur Deniz
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 32:879-84. 2002
    ..These results demonstrate that circulating NK cells retain effector subsets in humans with distinct cytokine profiles and may display different inflammatory properties...
  76. ncbi request reprint Mechanisms of allergen-specific immunotherapy
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 119:780-91. 2007
    ..Current understanding of mechanisms of allergen-SIT, particularly the role of Treg cells in peripheral tolerance, may enable novel treatment strategies...
  77. ncbi request reprint Future of allergen-specific immunotherapy: better understanding of the mechanisms, novel treatments, and long-term cure
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos Platz, Switzerland
    Immunol Allergy Clin North Am 26:xiii-xxii. 2006
  78. doi request reprint Regulation of the immune response and inflammation by histamine and histamine receptors
    Liam O'Mahony
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 128:1153-62. 2011
    ....
  79. ncbi request reprint Histamine regulation of innate and adaptive immunity
    Ruth Ferstl
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Front Biosci (Landmark Ed) 17:40-53. 2012
    ..In this review, we discuss histamine receptor expression and differential activation of cells within both the innate and adaptive immune response and the signal transduction mechanisms which influence their activity...
  80. ncbi request reprint T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 116:961-8; quiz 969. 2005
    ..Current strategies for drug development and allergen-specific immunotherapy exploit these observations with the potential to provide cure for allergic diseases...
  81. ncbi request reprint Immune regulation by histamine
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 14:735-40. 2002
    ..Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals...
  82. doi request reprint Mechanisms of allergen-specific immunotherapy
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 127:18-27; quiz 28-9. 2011
    ..New strategies for immune intervention will likely include targeting of the molecular mechanisms of allergen tolerance and reciprocal regulation of effector and Treg cell subsets...
  83. ncbi request reprint The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells
    Carsten B Schmidt-Weber
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 32:1196-204. 2002
    ..These results demonstrate that PTEN negatively controls costimulatory signals by antagonizing PI3 K activity in the absence of TCR engagement...
  84. ncbi request reprint T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 109:329-37. 2002
    ..Asthma is an inflammatory airway disease associated with an infiltration of T cells and eosinophils, increased levels of pro-inflammatory cytokines, and shedding of bronchial epithelial cells (ECs)...