Changlian Zhu

Summary

Country: Sweden

Publications

  1. pmc Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia
    Q Li
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Cell Death Dis 1:e56. 2010
  2. doi request reprint Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, SE 405 30, Goteborg, Sweden
    Transl Stroke Res 4:201-7. 2013
  3. ncbi request reprint Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia
    Changlian Zhu
    Arvid Carlsson Institute of Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurochem 96:1016-27. 2006
  4. doi request reprint Irradiation to the immature brain attenuates neurogenesis and exacerbates subsequent hypoxic-ischemic brain injury in the adult
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    J Neurochem 111:1447-56. 2009
  5. doi request reprint Age-dependent regenerative responses in the striatum and cortex after hypoxia-ischemia
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Cereb Blood Flow Metab 29:342-54. 2009
  6. pmc Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, 405 30 Goteborg, Sweden
    J Exp Med 204:1741-8. 2007
  7. ncbi request reprint Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia
    C Zhu
    Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    Cell Death Differ 14:775-84. 2007
  8. ncbi request reprint Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia-ischemia
    Changlian Zhu
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
    Eur J Neurosci 23:387-93. 2006
  9. pmc Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Cereb Blood Flow Metab 30:1017-30. 2010
  10. ncbi request reprint Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain
    Changlian Zhu
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 86:306-17. 2003

Collaborators

Detail Information

Publications60

  1. pmc Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia
    Q Li
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Cell Death Dis 1:e56. 2010
    ..The lithium doses used were in the same range as those used in bipolar patients, suggesting that lithium might be safely used for the avoidance of neonatal brain injury...
  2. doi request reprint Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, SE 405 30, Goteborg, Sweden
    Transl Stroke Res 4:201-7. 2013
    ..1%, n.s.). Neither the numbers nor the proliferation rates of neural stem cells in the dentate gyrus were affected by iNO. In summary, intraischemic iNO reduced neonatal HI brain injury in a gender-related manner...
  3. ncbi request reprint Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia
    Changlian Zhu
    Arvid Carlsson Institute of Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurochem 96:1016-27. 2006
    ..However, critical sex-dependent differences were demonstrated in vivo with regard to cellular, apoptosis-related mechanisms...
  4. doi request reprint Irradiation to the immature brain attenuates neurogenesis and exacerbates subsequent hypoxic-ischemic brain injury in the adult
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    J Neurochem 111:1447-56. 2009
    ....
  5. doi request reprint Age-dependent regenerative responses in the striatum and cortex after hypoxia-ischemia
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Cereb Blood Flow Metab 29:342-54. 2009
    ..The biggest ischemia-induced change was the 49-fold increase in P21 striatal microglia, and this was accompanied by increased inflammation, as judged by the size and numbers of CCL2- and interleukin-18-positive cells...
  6. pmc Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, 405 30 Goteborg, Sweden
    J Exp Med 204:1741-8. 2007
    ....
  7. ncbi request reprint Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia
    C Zhu
    Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    Cell Death Differ 14:775-84. 2007
    ....
  8. ncbi request reprint Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia-ischemia
    Changlian Zhu
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
    Eur J Neurosci 23:387-93. 2006
    ....
  9. pmc Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Cereb Blood Flow Metab 30:1017-30. 2010
    ..There were no signs of increased cell death of progenitors or neurons in the hippocampus. These findings show a previously unknown mechanism of neurotoxicity, causing cognitive deficits in a clearly age-dependent manner...
  10. ncbi request reprint Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain
    Changlian Zhu
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 86:306-17. 2003
    ..In summary, AIF-mediated cell death may be an important mechanism of HI-induced neuronal loss in the immature brain...
  11. ncbi request reprint Less neurogenesis and inflammation in the immature than in the juvenile brain after cerebral hypoxia-ischemia
    Lin Qiu
    Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 27:785-94. 2007
    ..In summary, contrary to what has been generally assumed, our results indicate that the juvenile brain has a greater capacity for neurogenesis after injury than the immature brain...
  12. ncbi request reprint Activation of ERK1/2 after neonatal rat cerebral hypoxia-ischaemia
    Xiaoyang Wang
    Perinatal Center, Departments of Physiology and Pediatrics, Goteborg University, Goteborg, Sweden
    J Neurochem 86:351-62. 2003
    ..In summary, ERK1/2 activation occurred early in neurons after HI in the neonatal brain, and mainly in cells displaying signs of damage...
  13. ncbi request reprint Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia
    Changlian Zhu
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, PR China
    Brain Res 996:67-75. 2004
    ..These results indicate that hypothermia may, at least partially, act through inhibition of the intrinsic pathway of caspase activation in the neonatal brain, thereby preventing apoptotic cell death...
  14. pmc Systemic stimulation of TLR2 impairs neonatal mouse brain development
    Xiaonan Du
    Perinatal Center, Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 6:e19583. 2011
    ..The impact of engagement of TLR2 signaling pathways on the neonatal brain is still unclear. The aim of this study was to investigate the potential effect of a TLR2 agonist on neonatal brain development...
  15. pmc Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury
    Xiaoyang Wang
    Perinatal Center, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    J Neurosci 29:2588-96. 2009
    ..The role of CypD in HI shifts from a predominantly prosurvival protein in the immature to a cell death mediator in the adult brain...
  16. ncbi request reprint N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    Ann Neurol 61:263-71. 2007
    ..This study evaluated the neuroprotective efficacy of a scavenging agent, N-acetylcysteine (NAC), in a clinically relevant model...
  17. ncbi request reprint X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, Box 432, SE 405 30 Goteborg, Sweden
    Eur J Neurosci 26:3402-10. 2007
    ....
  18. ncbi request reprint Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia
    Changlian Zhu
    Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 90:462-71. 2004
    ..In summary, nitrotyrosine is an early marker of cellular injury and inhibition of nNOS and iNOS is a promising strategy for neuroprotection after perinatal HI...
  19. pmc Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain
    Andrew S Naylor
    Center for Brain Repair and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30, Sweden
    Proc Natl Acad Sci U S A 105:14632-7. 2008
    ....
  20. pmc Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells
    Hongfu Li
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    J Cereb Blood Flow Metab 31:2106-15. 2011
    ..In summary, lithium conferred impressive, morphological long-term protection against neonatal HI, at least partly by inhibiting inflammation and promoting NSPC proliferation and survival...
  21. ncbi request reprint Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia
    Xiaoyang Wang
    Departments of Physiology, Clinical Neurosciences, Perinatal Center, Sahlgrenska Academy, Goteborg, Sweden
    J Neuropathol Exp Neurol 66:552-61. 2007
    ....
  22. ncbi request reprint Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia-ischemia
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, University of Gothenburg, Gothenburg, Sweden
    Brain Behav Immun 24:822-30. 2010
    ..Furthermore, the Bcl-2 reduction was calpain-dependent, because it could be prevented by the calpain inhibitor CX295 both in vivo and in vitro, suggesting cross-talk between excitotoxic and apoptotic mechanisms...
  23. ncbi request reprint Lithium reduced neural progenitor apoptosis in the hippocampus and ameliorated functional deficits after irradiation to the immature mouse brain
    Kaiming Huo
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
    Mol Cell Neurosci 51:32-42. 2012
    ..It remains to be shown if lithium can be used to prevent the debilitating cognitive late effects seen in children treated with cranial radiotherapy...
  24. doi request reprint The use of the WINROP screening algorithm for the prediction of retinopathy of prematurity in a Chinese population
    Huiqing Sun
    Department of Pediatrics, Zhengzhou Children s Hospital, Zhengzhou, China
    Neonatology 104:127-32. 2013
    ..Timely screening of premature infants could improve visual prognosis. Objective: To evaluate the WINROP algorithm as a method of predicting severe ROP in a Chinese population...
  25. ncbi request reprint Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia
    Pernilla Svedin
    Department of Neuroscience and Physiology, Perinatal Center, Sahlgrenska Academy, Goteborg University, 405 30 Goteborg, Sweden
    J Neurosci 27:1511-8. 2007
    ..In contrast, apoptosis does not appear to be a major contributing factor...
  26. ncbi request reprint Effects of intrauterine inflammation on the developing mouse brain
    Xiaoyang Wang
    Perinatal Center, Dept of Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Brain Res 1144:180-5. 2007
    ..Conclusions: Intrauterine inflammation impaired brain development and various brain lesions were produced in both the white and gray matter after intrauterine LPS administration in mice...
  27. doi request reprint Repeated exposure of the developing rat brain to magnetic resonance imaging did not affect neurogenesis, cell death or memory function
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, University of Gothenburg, Sweden
    Biochem Biophys Res Commun 404:291-6. 2011
    ..In conclusion, repeated exposure to MRI did not appear to affect neurogenesis, cell death or memory function in rats, neither in late gestation (E15-E18) nor in young postnatal (P14-P17) rats...
  28. pmc Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia
    Yanyan Sun
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Mol Neurodegener 7:17. 2012
    ..The caspase-independent apoptosis-inducing factor (AIF) has not been investigated previously in this context...
  29. doi request reprint Systemic hypothermia induced within 10 hours after birth improved neurological outcome in newborns with hypoxic-ischemic encephalopathy
    Tongchuan Li
    Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Hosp Pract (1995) 37:147-52. 2009
    ..To evaluate the efficacy of systemic hypothermia when applied within 10 hours after birth to neonates with hypoxic-ischemic encephalopathy (HIE)...
  30. doi request reprint Electroacupuncture enhances cell proliferation and neuronal differentiation in young rat brains
    Jianfeng Gao
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, Zhengzhou 450052, China
    Neurol Sci 32:369-74. 2011
    ..This finding provides a theoretical basis for the clinical application of acupuncture to cerebral injury rehabilitation in children...
  31. doi request reprint Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury
    Xiaoyang Wang
    Department of Physiology, Perinatal Center, Sahlgrenska Academy, University of Gothenburg, Box 432, S 405 30 Gothenburg, Sweden
    Stroke 41:2050-5. 2010
    ..The aim of this study was to evaluate the neuroprotective effect of a cell-penetrating Bax-inhibiting peptide (BIP) on neonatal mouse HI brain injury...
  32. ncbi request reprint The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 91:900-10. 2004
    ..EPO and the nonerythropoietic asialoEPO both provided significant and equal neuroprotection when administered 4 h prior to HI in 7-day-old rats. The protection might be related to reduced ERK activation and up-regulation of SNAP-25...
  33. doi request reprint Reduced liver injury and cytokine release after transplantation of preconditioned intestines
    Mihai Oltean
    Institute for Clinical Sciences, Department of Surgery, University of Gothenburg, Goteborg, Sweden
    J Surg Res 154:30-7. 2009
    ..Because of its pivotal role in inflammation, we investigated if NF-kappaB intragraft inhibition influences the posttransplant inflammatory response and remote organ injury...
  34. doi request reprint Characteristics of respiratory distress syndrome in infants of different gestational ages
    Huiqing Sun
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China
    Lung 191:425-33. 2013
    ....
  35. pmc Isolation of brain mitochondria from neonatal mice
    Xiaoyang Wang
    Perinatal Center, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    J Neurochem 119:1253-61. 2011
    ..However, method B produced mitochondria that were less contaminated with synaptosomes and associated cytosolic components that suits studies that have a requirement for higher mitochondrial purification...
  36. doi request reprint Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells
    Inger Johansson
    Laboratory of Experimental Endocrinology, Sahlgrenska Academy, University of Goteborg, SE 413 45 Goteborg, Sweden
    Endocrinology 149:2191-9. 2008
    ..Hexarelin, but not ghrelin, also showed a significant inhibition of apoptosis and necrosis. These results suggest a novel cell protective and proliferative role for GHS in the central nervous system...
  37. pmc The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy
    Dan Bi
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, 7 Kangfu Street, 450052 Zhengzhou, China
    J Neuroinflammation 11:100. 2014
    ..The purpose of this study was to analyze IL-6 gene polymorphisms and protein expression and to explore the role of IL-6 in the Chinese CP population...
  38. doi request reprint High-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation plus pressure support in preterm infants with severe respiratory distress syndrome
    Huiqing Sun
    Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Respir Care 59:159-69. 2014
    ....
  39. pmc Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine inflammation
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Box 432, S 405 30 Goteborg, Sweden, and The Third Affiliated Hospital of Zhengzhou University, People s Republic of China
    Am J Pathol 169:967-76. 2006
    ....
  40. ncbi request reprint Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment
    Kaiming Huo
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
    Endocr J 58:355-61. 2011
    ..01). Neurodevelopmental deficits in children with congenital hypothyroidism correlate with the severity of congenital hypothyroidism, TSH normalization time, and parental socioeconomic status...
  41. ncbi request reprint Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy
    Changlian Zhu
    Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
    Pediatrics 124:e218-26. 2009
    ..The purpose of this study was to evaluate the efficacy and safety of erythropoietin in neonatal hypoxic-ischemic encephalopathy (HIE), by using a randomized, prospective study design...
  42. ncbi request reprint Mitochondria and ischemic reperfusion damage in the adult and in the developing brain
    Klas Blomgren
    Department of Physiology, Perinatal Center, Goteborg University, P O Box 432, SE 405 30 Goteborg, Sweden
    Biochem Biophys Res Commun 304:551-9. 2003
    ..This review will summarize some of the current studies dealing with mitochondria-related mechanisms of ischemic brain damage, with special reference to developmental aspects...
  43. doi request reprint Trends in live births in the past 20 years in Zhengzhou, China
    Wei Han
    Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, Zhengzhou, China
    Acta Obstet Gynecol Scand 90:332-7. 2011
    ..To evaluate changing trends in neonatal births and deaths in a provincial women's and children's hospital over the past 20 years. Design: Retrospective longitudinal study...
  44. ncbi request reprint PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury
    Henrik Hagberg
    Perinatal Center, Sahlgrenska University Hospital, Goteborg, Sweden
    J Neurochem 90:1068-75. 2004
    ..The results indicate that hypoxia-ischemia activates Poly(ADP-ribose) polymerase-1 in the neonatal brain and that the sex of the animal strongly influences its role in the pathogenesis of brain injury...
  45. ncbi request reprint Decreased oxidative stress during glycolytic inhibition enables maintenance of ATP production and astrocytic survival
    Christina Nodin
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
    Neurochem Int 61:291-301. 2012
    ....
  46. ncbi request reprint Donor pretreatment with FK506 reduces reperfusion injury and accelerates intestinal graft recovery in rats
    Mihai Oltean
    Department of Surgery, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Surgery 141:667-77. 2007
    ..We studied the early outcome after transplantation of intestines from donors pretreated with FK506 compared to grafts from controls treated with saline (154 mM NaCl)...
  47. ncbi request reprint Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function
    Ruijin Shao
    Section of Endocrinology, Dept of Physiology and Pharmacology, Sahlgrenska Academy, Goteborg University, SE 40530, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 291:E59-72. 2006
    ....
  48. ncbi request reprint The association of apolipoprotein E gene polymorphisms with cerebral palsy in Chinese infants
    Yiran Xu
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqian Street 7, Zhengzhou, 450052, People s Republic of China
    Mol Genet Genomics 289:411-6. 2014
    ..This study provides the first evidence that ApoE gene polymorphisms are a potential risk factor for CP in the Chinese population...
  49. doi request reprint Mortality rates of children aged under five in Henan province, China, 2004-2008
    Kaiming Huo
    Departments of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, Zhengzhou 450052, China
    Paediatr Perinat Epidemiol 24:343-8. 2010
    ..Reducing early newborn death, especially in the rural areas, is a key step to further decreasing mortality in the under-fives. Attention should be paid to perinatal care to prevent preterm birth and congenital anomalies...
  50. ncbi request reprint Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia
    Cacha Peeters-Scholte
    Department of Neonatology, Wilhelmina Children s Hospital, Utrecht, Netherlands
    Stroke 33:2304-10. 2002
    ..The present study examines the neuroprotective properties of neuronal and inducible but not endothelial nitric oxide synthase inhibition by 2-iminobiotin in a piglet model of perinatal hypoxia-ischemia...
  51. doi request reprint Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy
    Ronald W Oppenheim
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 28:1490-7. 2008
    ..e., caspases and Apaf-1) are perturbed in vivo, developing postmitotic neurons nonetheless undergo quantitatively normal PCD by a caspase-independent pathway involving autophagy and not requiring AIF...
  52. ncbi request reprint Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia
    Cacha Peeters-Scholte
    Department of Neonatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Neurosci 24:396-404. 2002
    ....
  53. ncbi request reprint Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia
    Michel Ferrand-Drake
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    J Neurochem 85:1431-42. 2003
    ..We conclude that hypoglycemia leads to mitochondrial permeability transition which, upon recovery of energy metabolism, mediates the activation of caspase-3 and calpains, promoting cell death...
  54. ncbi request reprint Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia
    Nikolaus Plesnila
    Laboratory of Experimental Neurosurgery, Institute for Surgical Research, University of Munich, Germany
    J Cereb Blood Flow Metab 24:458-66. 2004
    ....
  55. ncbi request reprint X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia
    Xiaoyang Wang
    Department of Neuroscience, Neurobiology, Uppsala University, Uppsala, SE 751 23, Sweden
    Neurobiol Dis 16:179-89. 2004
    ..These findings provide the first evidence that increased XIAP levels protect the neonatal brain against HI...
  56. ncbi request reprint Death mechanisms in status epilepticus-generated neurons and effects of additional seizures on their survival
    Christine T Ekdahl
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, SE 221 84 Lund, Sweden
    Neurobiol Dis 14:513-23. 2003
    ..We propose that the degree of survival of newly generated neurons is determined primarily by the initial SE insult and the ensuing pathology in the tissue environment, whereas spontaneous seizures play a minor role...
  57. ncbi request reprint Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia
    Michael J Romanko
    Molecular Medicine Graduate Program, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurochem 103:1121-31. 2007
    ..These studies reveal targets for neuroprotective agents to protect precursors from cell death towards the goal of restoring normal brain development after H/I...
  58. ncbi request reprint Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia
    Carsten Culmsee
    Department of Pharmacy, Walter Brendel Center for Experimental Medicine, University of Munich, D 81377 Munich, Germany
    J Neurosci 25:10262-72. 2005
    ..Therefore, caspase-independent cell death signaling may provide a promising novel target for therapeutic interventions in cerebrovascular diseases...
  59. pmc Regulation of autophagy by cytoplasmic p53
    Ezgi Tasdemir
    INSERM, U848, France
    Nat Cell Biol 10:676-87. 2008
    ..These results provide evidence of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53...
  60. ncbi request reprint Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity
    Christiane Volbracht
    Department of Disease Biology, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    Eur J Neurosci 23:2611-22. 2006
    ..These findings suggest that inhibition of the NMDA-R by memantine is sufficient to block excitotoxicity, while still allowing some degree of signalling...