Changlian Zhu

Summary

Country: Sweden

Publications

  1. ncbi request reprint The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia
    C Zhu
    Department of Physiology, Goteborg University, Goteborg, Sweden
    Cell Death Differ 12:162-76. 2005
  2. ncbi request reprint Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia
    Changlian Zhu
    Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 90:462-71. 2004
  3. ncbi request reprint Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain
    Changlian Zhu
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 86:306-17. 2003
  4. ncbi request reprint Activation of ERK1/2 after neonatal rat cerebral hypoxia-ischaemia
    Xiaoyang Wang
    Perinatal Center, Departments of Physiology and Pediatrics, Goteborg University, Goteborg, Sweden
    J Neurochem 86:351-62. 2003
  5. ncbi request reprint Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia
    Xiaoyang Wang
    Departments of Physiology, Clinical Neurosciences, Perinatal Center, Sahlgrenska Academy, Goteborg, Sweden
    J Neuropathol Exp Neurol 66:552-61. 2007
  6. ncbi request reprint X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, Box 432, SE 405 30 Goteborg, Sweden
    Eur J Neurosci 26:3402-10. 2007
  7. ncbi request reprint N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    Ann Neurol 61:263-71. 2007
  8. ncbi request reprint Less neurogenesis and inflammation in the immature than in the juvenile brain after cerebral hypoxia-ischemia
    Lin Qiu
    Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 27:785-94. 2007
  9. ncbi request reprint Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia
    Pernilla Svedin
    Department of Neuroscience and Physiology, Perinatal Center, Sahlgrenska Academy, Goteborg University, 405 30 Goteborg, Sweden
    J Neurosci 27:1511-8. 2007
  10. ncbi request reprint Effects of intrauterine inflammation on the developing mouse brain
    Xiaoyang Wang
    Perinatal Center, Dept of Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Brain Res 1144:180-5. 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia
    C Zhu
    Department of Physiology, Goteborg University, Goteborg, Sweden
    Cell Death Differ 12:162-76. 2005
    ..To our knowledge, this is the first report demonstrating developmental regulation of AIF-mediated cell death as well as involvement of autophagy in a model of brain injury...
  2. ncbi request reprint Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia
    Changlian Zhu
    Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 90:462-71. 2004
    ..In summary, nitrotyrosine is an early marker of cellular injury and inhibition of nNOS and iNOS is a promising strategy for neuroprotection after perinatal HI...
  3. ncbi request reprint Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain
    Changlian Zhu
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 86:306-17. 2003
    ..In summary, AIF-mediated cell death may be an important mechanism of HI-induced neuronal loss in the immature brain...
  4. ncbi request reprint Activation of ERK1/2 after neonatal rat cerebral hypoxia-ischaemia
    Xiaoyang Wang
    Perinatal Center, Departments of Physiology and Pediatrics, Goteborg University, Goteborg, Sweden
    J Neurochem 86:351-62. 2003
    ..In summary, ERK1/2 activation occurred early in neurons after HI in the neonatal brain, and mainly in cells displaying signs of damage...
  5. ncbi request reprint Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia
    Xiaoyang Wang
    Departments of Physiology, Clinical Neurosciences, Perinatal Center, Sahlgrenska Academy, Goteborg, Sweden
    J Neuropathol Exp Neurol 66:552-61. 2007
    ....
  6. ncbi request reprint X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, Box 432, SE 405 30 Goteborg, Sweden
    Eur J Neurosci 26:3402-10. 2007
    ....
  7. ncbi request reprint N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    Ann Neurol 61:263-71. 2007
    ..This study evaluated the neuroprotective efficacy of a scavenging agent, N-acetylcysteine (NAC), in a clinically relevant model...
  8. ncbi request reprint Less neurogenesis and inflammation in the immature than in the juvenile brain after cerebral hypoxia-ischemia
    Lin Qiu
    Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 27:785-94. 2007
    ..In summary, contrary to what has been generally assumed, our results indicate that the juvenile brain has a greater capacity for neurogenesis after injury than the immature brain...
  9. ncbi request reprint Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia
    Pernilla Svedin
    Department of Neuroscience and Physiology, Perinatal Center, Sahlgrenska Academy, Goteborg University, 405 30 Goteborg, Sweden
    J Neurosci 27:1511-8. 2007
    ..In contrast, apoptosis does not appear to be a major contributing factor...
  10. ncbi request reprint Effects of intrauterine inflammation on the developing mouse brain
    Xiaoyang Wang
    Perinatal Center, Dept of Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Brain Res 1144:180-5. 2007
    ..Conclusions: Intrauterine inflammation impaired brain development and various brain lesions were produced in both the white and gray matter after intrauterine LPS administration in mice...
  11. ncbi request reprint Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia
    Changlian Zhu
    Arvid Carlsson Institute of Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurochem 96:1016-27. 2006
    ..However, critical sex-dependent differences were demonstrated in vivo with regard to cellular, apoptosis-related mechanisms...
  12. ncbi request reprint The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Goteborg, Sweden
    J Neurochem 91:900-10. 2004
    ..EPO and the nonerythropoietic asialoEPO both provided significant and equal neuroprotection when administered 4 h prior to HI in 7-day-old rats. The protection might be related to reduced ERK activation and up-regulation of SNAP-25...
  13. doi request reprint Reduced liver injury and cytokine release after transplantation of preconditioned intestines
    Mihai Oltean
    Institute for Clinical Sciences, Department of Surgery, University of Gothenburg, Goteborg, Sweden
    J Surg Res 154:30-7. 2009
    ..Because of its pivotal role in inflammation, we investigated if NF-kappaB intragraft inhibition influences the posttransplant inflammatory response and remote organ injury...
  14. pmc Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia
    Changlian Zhu
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, 405 30 Goteborg, Sweden
    J Exp Med 204:1741-8. 2007
    ....
  15. doi request reprint Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury
    Xiaoyang Wang
    Department of Physiology, Perinatal Center, Sahlgrenska Academy, University of Gothenburg, Box 432, S 405 30 Gothenburg, Sweden
    Stroke 41:2050-5. 2010
    ..The aim of this study was to evaluate the neuroprotective effect of a cell-penetrating Bax-inhibiting peptide (BIP) on neonatal mouse HI brain injury...
  16. ncbi request reprint Mitochondria and ischemic reperfusion damage in the adult and in the developing brain
    Klas Blomgren
    Department of Physiology, Perinatal Center, Goteborg University, P O Box 432, SE 405 30 Goteborg, Sweden
    Biochem Biophys Res Commun 304:551-9. 2003
    ..This review will summarize some of the current studies dealing with mitochondria-related mechanisms of ischemic brain damage, with special reference to developmental aspects...
  17. pmc Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine inflammation
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Box 432, S 405 30 Goteborg, Sweden, and The Third Affiliated Hospital of Zhengzhou University, People s Republic of China
    Am J Pathol 169:967-76. 2006
    ....
  18. ncbi request reprint PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury
    Henrik Hagberg
    Perinatal Center, Sahlgrenska University Hospital, Goteborg, Sweden
    J Neurochem 90:1068-75. 2004
    ..The results indicate that hypoxia-ischemia activates Poly(ADP-ribose) polymerase-1 in the neonatal brain and that the sex of the animal strongly influences its role in the pathogenesis of brain injury...
  19. ncbi request reprint Donor pretreatment with FK506 reduces reperfusion injury and accelerates intestinal graft recovery in rats
    Mihai Oltean
    Department of Surgery, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Surgery 141:667-77. 2007
    ..We studied the early outcome after transplantation of intestines from donors pretreated with FK506 compared to grafts from controls treated with saline (154 mM NaCl)...
  20. pmc Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury
    Xiaoyang Wang
    Perinatal Center, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    J Neurosci 29:2588-96. 2009
    ..The role of CypD in HI shifts from a predominantly prosurvival protein in the immature to a cell death mediator in the adult brain...
  21. ncbi request reprint Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo
    Ruijin Shao
    Instiute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, SE 41390 Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 293:E147-58. 2007
    ..We show for the first time that a previously unrecognized localization of ERbeta isoform in rat fallopian tubes can combine with estrogen to individually control the expression of ER beta-isoforms in normal target tissues...
  22. ncbi request reprint Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function
    Ruijin Shao
    Section of Endocrinology, Dept of Physiology and Pharmacology, Sahlgrenska Academy, Goteborg University, SE 40530, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 291:E59-72. 2006
    ....
  23. pmc Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain
    Andrew S Naylor
    Center for Brain Repair and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30, Sweden
    Proc Natl Acad Sci U S A 105:14632-7. 2008
    ....
  24. ncbi request reprint Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia
    Michael J Romanko
    Molecular Medicine Graduate Program, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurochem 103:1121-31. 2007
    ..These studies reveal targets for neuroprotective agents to protect precursors from cell death towards the goal of restoring normal brain development after H/I...
  25. doi request reprint Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy
    Ronald W Oppenheim
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 28:1490-7. 2008
    ..e., caspases and Apaf-1) are perturbed in vivo, developing postmitotic neurons nonetheless undergo quantitatively normal PCD by a caspase-independent pathway involving autophagy and not requiring AIF...
  26. ncbi request reprint Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity
    Christiane Volbracht
    Department of Disease Biology, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    Eur J Neurosci 23:2611-22. 2006
    ..These findings suggest that inhibition of the NMDA-R by memantine is sufficient to block excitotoxicity, while still allowing some degree of signalling...
  27. ncbi request reprint Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia
    Cacha Peeters-Scholte
    Department of Neonatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Neurosci 24:396-404. 2002
    ....
  28. ncbi request reprint Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia
    Michel Ferrand-Drake
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    J Neurochem 85:1431-42. 2003
    ..We conclude that hypoglycemia leads to mitochondrial permeability transition which, upon recovery of energy metabolism, mediates the activation of caspase-3 and calpains, promoting cell death...
  29. ncbi request reprint Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia
    Changlian Zhu
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, PR China
    Brain Res 996:67-75. 2004
    ..These results indicate that hypothermia may, at least partially, act through inhibition of the intrinsic pathway of caspase activation in the neonatal brain, thereby preventing apoptotic cell death...
  30. ncbi request reprint Death mechanisms in status epilepticus-generated neurons and effects of additional seizures on their survival
    Christine T Ekdahl
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, SE 221 84 Lund, Sweden
    Neurobiol Dis 14:513-23. 2003
    ..We propose that the degree of survival of newly generated neurons is determined primarily by the initial SE insult and the ensuing pathology in the tissue environment, whereas spontaneous seizures play a minor role...
  31. ncbi request reprint Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia
    Nikolaus Plesnila
    Laboratory of Experimental Neurosurgery, Institute for Surgical Research, University of Munich, Germany
    J Cereb Blood Flow Metab 24:458-66. 2004
    ....
  32. ncbi request reprint X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia
    Xiaoyang Wang
    Department of Neuroscience, Neurobiology, Uppsala University, Uppsala, SE 751 23, Sweden
    Neurobiol Dis 16:179-89. 2004
    ..These findings provide the first evidence that increased XIAP levels protect the neonatal brain against HI...
  33. ncbi request reprint Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia
    Carsten Culmsee
    Department of Pharmacy, Walter Brendel Center for Experimental Medicine, University of Munich, D 81377 Munich, Germany
    J Neurosci 25:10262-72. 2005
    ..Therefore, caspase-independent cell death signaling may provide a promising novel target for therapeutic interventions in cerebrovascular diseases...
  34. ncbi request reprint Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia-ischemia
    Changlian Zhu
    Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
    Eur J Neurosci 23:387-93. 2006
    ....
  35. ncbi request reprint Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia
    Cacha Peeters-Scholte
    Department of Neonatology, Wilhelmina Children s Hospital, Utrecht, Netherlands
    Stroke 33:2304-10. 2002
    ..The present study examines the neuroprotective properties of neuronal and inducible but not endothelial nitric oxide synthase inhibition by 2-iminobiotin in a piglet model of perinatal hypoxia-ischemia...
  36. doi request reprint Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells
    Inger Johansson
    Laboratory of Experimental Endocrinology, Sahlgrenska Academy, University of Goteborg, SE 413 45 Goteborg, Sweden
    Endocrinology 149:2191-9. 2008
    ..Hexarelin, but not ghrelin, also showed a significant inhibition of apoptosis and necrosis. These results suggest a novel cell protective and proliferative role for GHS in the central nervous system...
  37. pmc Regulation of autophagy by cytoplasmic p53
    Ezgi Tasdemir
    INSERM, U848, France
    Nat Cell Biol 10:676-87. 2008
    ..These results provide evidence of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53...