Research Topics
| Ming ZhaoSummaryCountry: Sweden Publications
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Detail Information
Publications
A rapid and sensitive method for determination of sorafenib in human plasma using a liquid chromatography/tandem mass spectrometry assayMing Zhao
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Chromatogr B Analyt Technol Biomed Life Sci 846:1-7. 2007..96. The values for both within day and between day precision and accuracy were well within the generally accepted criteria for analytical methods (<15%)...
A liquid chromatography/tandem mass spectrometry assay to quantitate MS-275 in human plasmaMing Zhao
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Pharm Biomed Anal 43:784-7. 2007..This method was subsequently used to measure concentrations of MS-275 in cancer patients receiving an oral weekly dose of 4 mg/m(2)...- Delayed oxidant-induced cell death involves activation of phospholipase A2M Zhao
Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
FEBS Lett 509:399-404. 2001..This supports a causal association between PLA2 activation and delayed oxidant-induced cell death and suggests that Bcl-2 may suppress apoptosis by preventing PLA2 activation... - Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosisM Zhao
Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
FEBS Lett 509:405-12. 2001..Additional results suggest that, perhaps as a consequence of lysosomal stabilization, Bcl-2 may prevent activation of phospholipase A2, an event potentially important in the ultimate initiation of apoptosis... - Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosisMing Zhao
Faculty of Health Sciences, Linkoping University, Sweden
Eur J Biochem 270:3778-86. 2003..Nonoxidant agonists of apoptosis may, thus, act through oxidant mechanisms... - Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinasesMing Zhao
Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping SE 581 85, Sweden
Arch Biochem Biophys 400:199-207. 2002..These results may have implications for the future design of pharmacologic agents for inhibition of VSMC growth... - Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDLMing Zhao
Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
APMIS 110:458-68. 2002..Our results for the first time demonstrate a regulation of CD36 by p38, and the importance of the p38 pathway in regulation of foam cell formation... - Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2Ming Zhao
Division of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
J Biol Chem 279:49259-67. 2004..These results indicate a novel function for arrestin, which is protection from an excessive oxidative burst, resulting from the sustained stimulation of G-protein-coupled receptors that cause Rac translocation... - Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cellsXiao-hua Guo
Department of Pathophysiology, Southern Medical University, Guangzhou, PR China
APMIS 114:874-83. 2006..The results indicate that ERK and p38 MAPK play important roles in the mediation of AGE-induced EC barrier dysfunction associated with morphological changes of the F-actin... - Novel N-(3-carboxyl-9-benzyl-carboline-1-yl)ethylamino acids: synthesis, anti-proliferation activity and two-step-course of intercalation with calf thymus DNAJianhui Wu
College of Pharmaceutical Sciences, Peking University, Beijing 100083, P R China
Mol Biosyst 3:855-61. 2007..The intercalation itself goes very fast and only has limited contribution to their anticancer activities... - Synthesis and cytotoxic activities of beta-carboline amino acid ester conjugatesMing Zhao
College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, 100054, PR China
Bioorg Med Chem 14:6998-7010. 2006.... 
Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3',4':1,2]pyridin[3,4-b]indol-2-substituted acetates: synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilatorsJiawang Liu
College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China
J Med Chem 51:4715-23. 2008..Actually, the docking adaptabilities of these novel vasodilators to PDE5 were consistent with the conformational requirements of them to MFA and with the crystal conformation of two representatives...- [Effects of hemin and thermal stress exposure on JWA expression]Ming Zhao
Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24:209-13. 2006..CONCLUSION: The hemin and thermal stress may regulate JWA expression via distinct intracellular signal transduction pathways... - Alterations in the rat serum proteome during liver injury from acetaminophen exposureB Alex Merrick
Proteomics Group, National Institute of Environmental Health Sciences, D2 04, P O Box 12233, Research Triangle Park, NC 27709, USA
J Pharmacol Exp Ther 318:792-802. 2006..This study demonstrates that serum proteome alterations probably reflect both liver damage and a concerted, complex response of the body for organ repair and recovery during acute hepatic injury... - Novel 2-substituted nitronyl nitroxides as free radical scavengers: synthesis, biological evaluation and structure-activity relationshipYihui Wu
College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, PR China
Bioorg Med Chem 14:5711-20. 2006..The enhanced radical scavenging capacities of the novel 2-substituted nitronyl nitroxides may be potential drug leads against the deleterious action of ROS (reactive oxygen species)/RNS (reactive nitrogen species)... - Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cellsEdmund S Kassis
Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
J Thorac Cardiovasc Surg 131:298-306. 2006..These findings support further evaluation of DNMT knockdown strategies for cancer therapy... - Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndromeNaEun Cheong
Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6068, USA
J Biol Chem 281:9791-800. 2006..We conclude that ABCA3 is required for lysosomal loading of phosphatidylcholine and conversion of lysosomes to lamellar body-like structures... - The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signalingMing Zhao
Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Mol Cell Biol 26:6197-208. 2006..Taken together, these results indicate that Gli2 mediates hedgehog signaling in osteoblasts and is a powerful activator of BMP-2 gene expression, which is required in turn for normal osteoblast differentiation... - Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen speciesKyra A Gelderman
Section of Medical Inflammation Research, Lund University, Lund, Sweden
J Clin Invest 117:3020-8. 2007..In conclusion, macrophage-derived ROS play a role in T cell selection, maturation, and differentiation, and also a suppressive role in T cell activation, and thereby mediate protection against autoimmune diseases like arthritis... - Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indol-2-substitutedacetatesJiawang Liu
College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China
Bioorg Med Chem 15:7773-88. 2007..The SAR analysis revealed that the benzylester form and the tetracyclic structure of 4a-n were critical for both sensitizing doxorubicin and the cellular anti-proliferative effect... - Transcriptional profiling of human embryonic stem cells and embryoid bodies identifies HESRG, a novel stem cell geneMing Zhao
Cancer Research Institute, Xiang Ya School of Medicine, Central South University, 110 Xiangya Road, Changsha 410078, Hunan, and Department of Neurosurgery, Xiangya Hospital, China
Biochem Biophys Res Commun 362:916-22. 2007..The above suggested an important role for the novel HESRG gene in supporting the undifferentiated state or self-renewal of hES cells... - Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cellsXiao Dan Yu
Department of Pathology, Institute of Basic Medical Sciences, Beijing, China
Cancer J 13:105-13. 2007..In the present study we sought to further define the mechanisms by which FK228 modulates oncoprotein signaling and to ascertain whether altered signal transduction contributes to FK228-mediated apoptosis in lung cancer cells... - Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db miceJia Qing Shao
Department of Endocrinology and Metabolism, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China
Acta Pharmacol Sin 28:246-57. 2007..The aim of this study was to investigate whether and how chronic candesartan treatment can attenuate the deleterious influence of the hyperactive local intra-islet renin-angiotensin system in the diabetes state... - Clinical and molecular responses in lung cancer patients receiving RomidepsinDavid S Schrump
Thoracic Oncology Section Surgery Branch, Center for Cancer Research and Cancer Therapy Evaluation Program, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Clin Cancer Res 14:188-98. 2008..A phase II trial was done to examine clinical and molecular responses mediated by this histone deacetylase inhibitor in lung cancer patients... - Rapid single-step separation of pluripotent mouse embryonic stem cells from mouse feeder fibroblastsZhixin Li
Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Stem Cells Dev 17:383-7. 2008..The method can be readily scaled-up to accommodate large batch preparations, enabling a broad range of processing needs. Overall, this simple technique significantly expedites the recovery and enrichment of mES cells from MEFs... - Identification of label-retaining cells in nasopharyngeal epithelia and nasopharyngeal carcinoma tissuesHong Bo Zhang
Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan 410078, China
Histochem Cell Biol 127:347-54. 2007..More importantly, our data showed that NPC also contained stem cells, which are most likely the cause for NPC spread, metastasis and recurrence... - Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQOMichael M Kim
The John Hopkins University School of Medicine, Head and Neck Cancer Research Division, Department of Otolaryngology--Head and Neck Surgery, 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287-0910, USA
Oral Oncol 42:201-7. 2006..By using a DNA adduct formation and repair model featuring 4NQO and HNSC cell lines, we have implicated faulty mtDNA repair as having a potential role in HNSC... - Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2Ming Zhao
Division of Cancer Biology, La Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, CA 92121, USA
Mol Pharmacol 69:66-75. 2006.... - Evidence for neurogenesis in the adult mammalian substantia nigraMing Zhao
Departments of Neuroscience, Cell and Molecular Biology, Medical Nobel Institute, and Woman and Child Health, Karolinska Institute, SE-171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 100:7925-30. 2003.... - NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitroJian Q Feng
Department of Oral Biology, School of Dentistry, University of Missouri, Kansas City, Missouri 64108, USA
J Biol Chem 278:29130-5. 2003..Therefore, in postnatal growth plate chondrocytes, expression of BMP-2 is regulated by NF-kappaB, which may play an important role in chondrogenesis... - E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiationMing Zhao
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
J Biol Chem 278:27939-44. 2003..Smurf1 therefore appears to be an important regulatory factor in osteoblast differentiation and a potential molecular target for identification of bone anabolic agents... - Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytesLing Yu Chen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla 92037, California 92121, USA
Am J Physiol Lung Cell Mol Physiol 284:L607-13. 2003..These findings provide evidence that LPS-induced NF-kappaB activation and IL-8 gene expression use a signaling pathway requiring protein tyrosine kinase and that such regulation may occur through tyrosine phosphorylation of TLR4... - High efficiency genetic modification of hair follicles and growing hair shaftsNorimitsu Saito
AntiCancer, Inc, San Diego, CA 92111, USA
Proc Natl Acad Sci U S A 99:13120-4. 2002..Most follicles produced GFP-fluorescent growing hair shafts. This technique has produced efficient genetic modification of the hair shaft... - Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotypeMing Zhao
Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
J Bone Miner Res 17:1441-51. 2002..These results suggest that BMP-2 triggers follicle cells to differentiate toward a cementoblast/osteoblast phenotype and that the MAPK pathway is involved... - The relationship between (99m)Tc-MIBI uptakes and tumor cell death/proliferation state under irradiationXiaohua Zhu
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Dadao, 430030, Wuhan, PR China
Cancer Lett 182:217-22. 2002..It is suggested that 99mTc-MIBI uptake of tumor cell correlated with the changes of cell viability after irradiation. 99mTc-MIBI imaging may be a potential method to monitor tumor cell viability or therapeutic response after irradiation... - The zona pellucida in folliculogenesis, fertilization and early developmentMing Zhao
Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
Rev Endocr Metab Disord 3:19-26. 2002 - The human serum proteome: display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteinsRembert Pieper
Large Scale Biology Corporation, 20451 Seneca Meadows Parkway, Germantown, MD 20876, USA
Proteomics 3:1345-64. 2003..Considering that our strategy allows highly parallel protein quantitation on 2-DE gels, it holds promise to accelerate the discovery of novel serum protein biomarkers... - IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptorIngrid U Schraufstatter
Department of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
J Immunol 171:6714-22. 2003..These results indicate that IL-8-induced transactivation of the EGFR is mediated by the CXCR2 and involves cathepsin B, and that this pathway is important for the migratory and tumorigenic effects of IL-8... - Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's diseaseMing Zhao
Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697-4540, USA
Neurobiol Dis 14:391-403. 2003..These findings raise the possibility that the activation of caspase-3 and cleavage of APP may be involved with neuronal degeneration and that pathways characteristic of apoptosis are activated in AD... - Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cellsJulie A Hong
Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1201, USA
Cancer Res 65:7763-74. 2005.... - Stage-specific expression of dynein light chain-1 and its interacting kinase, p21-activated kinase-1, in rodent testes: implications in spermiogenesisRui-An Wang
Department of Molecular and Cellular Oncology. UT-MD Anderson Cancer Center, Houston, TX 77030, USA
J Histochem Cytochem 53:1235-43. 2005..Further, Pak1 may also play a role in spermiogenesis by regulating DLC1 phosphorylation and, consequently, its function... - Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7Ming Zhao
Department of Periodontics, Prevention, and Geriatrics, School of Dentistry and Center for Craniofacial Regeneration, University of Michigan, Ann Arbor, Michigan 48109-1078, USA
J Cell Biochem 95:1-16. 2005..These studies show that dramatic enhancement of osteogenesis can be achieved using gene therapy to express specific combinations of interacting regenerative molecules... - DeltaNp63alpha up-regulates the Hsp70 gene in human cancerGuojun Wu
Department of Otolaryngology-Head and Neck Surgery, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205-2196, USA
Cancer Res 65:758-66. 2005..Our study provides strong evidence for the physiologic association between DeltaNp63alpha and hsp70 in human cancer, thus further supporting the oncogenic potential of DeltaNp63alpha... - Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cellsMing Zhao
Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
Biochemistry 43:12090-104. 2004..Taken together, these data indicate that human and mouse ZP3 proteins are quite similar, and alternative explanations of taxon-specific sperm binding warrant exploration... - Transition nuclear proteins are required for normal chromatin condensation and functional sperm developmentMing Zhao
Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Genesis 38:200-13. 2004..Thus, in mammals TPs are required for normal chromatin condensation, for reducing the number of DNA breaks, and for preventing the formation of secondary defects in spermatozoa, eventual loss of genomic integrity, and sterility... - Gene therapy approaches for bone regenerationRenny T Franceschi
The Center for Craniofacial Regeneration, University of Michigan School of Dentistry, Ann Arbor, Mich, USA
Cells Tissues Organs 176:95-108. 2004..Using these types of approaches, it should be possible to mimic natural processes of bone development and fracture repair and, in so doing, be able to precisely control both the amount and type of bone regenerated... - Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivoMing Zhao
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
J Biol Chem 279:12854-9. 2004..In these transgenic mice, bone formation was significantly reduced during postnatal life. Our results demonstrate for the first time that Smurf1 plays a specific role in osteoblast differentiation and bone formation in vivo... - Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instabilityJiri Neuzil
Department of Pathology II, University Hospital, Linköping 581 85, Sweden
Biochem J 362:709-15. 2002..These findings indicate that lysosomal destabilization may partially or fully explain the induction of apoptosis in cultured cells by alpha-TOS and the mechanism whereby this agent exerts in vivo anti-tumour effects...