Henrik Zetterberg

Summary

Country: Sweden

Publications

  1. ncbi request reprint Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Arch Neurol 65:1102-7. 2008
  2. doi request reprint Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 21:1005-12. 2010
  3. pmc Cerebrospinal fluid analysis should be considered in patients with cognitive problems
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, 431 80 Mölndal, Sweden
    Int J Alzheimers Dis 2010:163065. 2010
  4. pmc Discriminatory Analysis of Biochip-Derived Protein Patterns in CSF and Plasma in Neurodegenerative Diseases
    Christoffer Rosén
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg Gothenburg and Mölndal, Sweden
    Front Aging Neurosci 3:1. 2011
  5. pmc Neuroinflammation Screening in Immunotherapy Trials against Alzheimer's Disease
    Niels Andreasen
    Memory Clinic, M51, Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, 17176 Stockholm, Sweden
    Int J Alzheimers Dis 2010:638379. 2010
  6. ncbi request reprint Biomarker evidence for uncoupling of amyloid build-up and toxicity in Alzheimer's disease
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Alzheimers Dement 9:459-62. 2013
  7. ncbi request reprint Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood
    Henrik Zetterberg
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, SE 431 80 Molndal, Sweden
    Nat Rev Neurol 9:201-10. 2013
  8. ncbi request reprint Cerebrospinal fluid biomarkers for Alzheimer's disease: more to come?
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Sweden
    J Alzheimers Dis 33:S361-9. 2013
  9. ncbi request reprint Clinical use of cerebrospinal fluid biomarkers in Alzheimer's disease
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Biomark Med 6:371-6. 2012
  10. pmc Is it time for biomarker-based diagnostic criteria for prodromal Alzheimer's disease?
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, SE 431 80 Molndal, Sweden
    Alzheimers Res Ther 2:8. 2010

Detail Information

Publications158 found, 100 shown here

  1. ncbi request reprint Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Arch Neurol 65:1102-7. 2008
    ....
  2. doi request reprint Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 21:1005-12. 2010
    ..The data presented suggests that the γ-secretase modulator E-2012 alters the cleavage site preference of γ-secretase. The increase in Aβ(1-37) may inhibit Aβ(1-42) oligomerization and toxicity...
  3. pmc Cerebrospinal fluid analysis should be considered in patients with cognitive problems
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, 431 80 Mölndal, Sweden
    Int J Alzheimers Dis 2010:163065. 2010
    ..Here, we argue that a spinal tap should be considered in all patients who seek medical advice for memory problems and list the highly relevant clinical questions CSF analyses can address...
  4. pmc Discriminatory Analysis of Biochip-Derived Protein Patterns in CSF and Plasma in Neurodegenerative Diseases
    Christoffer Rosén
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg Gothenburg and Mölndal, Sweden
    Front Aging Neurosci 3:1. 2011
    ..A multivariate statistical analysis revealed that the pattern of analytes could help to differentiate the conditions, although more studies are required to verify this...
  5. pmc Neuroinflammation Screening in Immunotherapy Trials against Alzheimer's Disease
    Niels Andreasen
    Memory Clinic, M51, Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, 17176 Stockholm, Sweden
    Int J Alzheimers Dis 2010:638379. 2010
    ..Should the two cases have been included and deteriorated, additional investigations might have led to the erroneous conclusion that therapy-induced meningoencephalitis had occurred...
  6. ncbi request reprint Biomarker evidence for uncoupling of amyloid build-up and toxicity in Alzheimer's disease
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Alzheimers Dement 9:459-62. 2013
    ..We argue for the need to describe the molecular natures of Aβ(Cat) and Aβ(Tox) in greater detail as a means to gain success in anti-Aβ disease-modifying drug development. ..
  7. ncbi request reprint Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood
    Henrik Zetterberg
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, SE 431 80 Molndal, Sweden
    Nat Rev Neurol 9:201-10. 2013
    ....
  8. ncbi request reprint Cerebrospinal fluid biomarkers for Alzheimer's disease: more to come?
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Sweden
    J Alzheimers Dis 33:S361-9. 2013
    ....
  9. ncbi request reprint Clinical use of cerebrospinal fluid biomarkers in Alzheimer's disease
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Biomark Med 6:371-6. 2012
    ..Here, we discuss how they may be employed in the clinical evaluation of patients with memory problems. We argue for their proper application and use, and caution against common misinterpretations...
  10. pmc Is it time for biomarker-based diagnostic criteria for prodromal Alzheimer's disease?
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, SE 431 80 Molndal, Sweden
    Alzheimers Res Ther 2:8. 2010
    ..More details are needed, however, on how these biomarkers can be standardized, to allow a general implementation in the clinical routine diagnostic work-up of patients with cognitive disturbances...
  11. doi request reprint Update on amyloid-beta homeostasis markers for sporadic Alzheimer's disease
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Scand J Clin Lab Invest 69:18-21. 2009
    ..This update summarizes the currently available studies that have determined the usefulness of BACE1 and secreted fragments of APP and Abeta as cerebrospinal fluid biomarkers for AD...
  12. ncbi request reprint Biochemical markers in Alzheimer's disease clinical trials
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Biomark Med 4:91-8. 2010
    ....
  13. ncbi request reprint Is plasma amyloid-beta a reliable biomarker for Alzheimer's disease?
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, The Sahlgrenska Academy at Gothenburg University, Sahlgrenska University Hospital Molndal, S 431 80 Molndal, Sweden
    Recent Pat CNS Drug Discov 3:109-11. 2008
    ..This review provides an update on the current status of research on plasma Abeta as a biomarker for AD in the context of recent patents in the field...
  14. doi request reprint Amyloid beta and APP as biomarkers for Alzheimer's disease
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, S 431 80 Molndal, Sweden
    Exp Gerontol 45:23-9. 2010
    ..We also consider their usefulness in clinical practice and in clinical trials...
  15. ncbi request reprint Identification of a beta-amyloid-binding plasma protein, LRP1: implications for biomarker research and therapy in Alzheimer's disease
    Henrik Zetterberg
    Goteborg University, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, S 431 80 Molndal, Sweden
    Biomark Med 1:347-8. 2007
    ..Furthermore, it would be interesting to explore the possibility that reduced sLRP1 levels in plasma may be a specific biochemical sign of incipient AD...
  16. pmc Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, S 431 80 Molndal, Sweden
    Alzheimers Res Ther 2:32. 2010
    ..Such biomarkers may be called 'theragnostic'. Here, we review the literature addressing the prospective value of these biomarkers...
  17. ncbi request reprint Sustained release of neuron-specific enolase to serum in amateur boxers
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Brain Inj 23:723-6. 2009
    ..We assess the potential of a panel of serum biomarkers to identify chronic neuronal injury in amateur boxers as compared to healthy controls without any history of head trauma...
  18. doi request reprint Low incidence of post-lumbar puncture headache in 1,089 consecutive memory clinic patients
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Eur Neurol 63:326-30. 2010
    ..To examine the incidence of post-lumbar puncture headache (PLPH) in patients admitted for cognitive disturbances...
  19. pmc Association of the RAGE G82S polymorphism with Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
    J Neural Transm 117:861-7. 2010
    ..4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD...
  20. ncbi request reprint Association of complement factor H Y402H gene polymorphism with Alzheimer's disease
    Madeleine Zetterberg
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008
    ..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD...
  21. doi request reprint Evaluation of the cerebrospinal fluid amyloid-β1-42/amyloid-β1-40 ratio measured by alpha-LISA to distinguish Alzheimer's disease from other dementia disorders
    Magdalena Nutu
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 36:99-110. 2013
    ..This study aimed to evaluate whether the cerebrospinal fluid (CSF) amyloid-β (Aβ)1-42/Aβ1-40 ratio, measured by a novel method, could improve the differential diagnosis of AD, DLB and PDD...
  22. doi request reprint Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Mech Ageing Dev 131:105-10. 2010
    ..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset...
  23. ncbi request reprint Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Mol Med 20:233-9. 2007
    ..018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis...
  24. ncbi request reprint Kinesin light chain 1 gene haplotypes in three conformational diseases
    Malin von Otter
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 12:229-36. 2010
    ..Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract...
  25. pmc Variability in the kinesin light chain 1 gene may influence risk of age-related cataract
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Vis 13:993-6. 2007
    ..Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis...
  26. doi request reprint Subcortical vascular dementia biomarker pattern in mild cognitive impairment
    Maria Bjerke
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 28:348-56. 2009
    ..Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies...
  27. doi request reprint Low cerebrospinal fluid sulfatide predicts progression of white matter lesions: The LADIS study
    Michael Jonsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Dement Geriatr Cogn Disord 34:61-7. 2012
    ..The neurochemistry of ongoing WML is only partially known. We explored cerebrospinal fluid (CSF) substances as markers of brain tissue damage in relation to progression of WML rated on magnetic resonance imaging...
  28. doi request reprint A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Neural Transm 119:833-42. 2012
    ..However, further investigation of the importance of this SNP for ARC function, ARC processing and the pathology of AD is needed...
  29. ncbi request reprint Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot study
    Sofia Movérare-Skrtic
    Institute of Medicine, Department of Internal Medicine, The Sahlgrenska Academy, University of Gothenburg, S 41345 Gothenburg, Sweden
    Exp Gerontol 47:179-82. 2012
    ..Patients with stable MCI that did not progress to dementia had reduced LTL compared to controls, which might suggest a more marked biological aging as a cause of the cognitive symptoms in this group...
  30. doi request reprint Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuropsychobiology 64:38-46. 2011
    ..In conclusion, this pilot study suggests that reward-related genes are associated with altered personality scores in type 1 alcohol dependence, which warrants future studies of these associations in larger study samples...
  31. doi request reprint Converging pathways of chromogranin and amyloid metabolism in the brain
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden
    J Alzheimers Dis 20:1039-49. 2010
    ..Cell medium from BACE1-inhibited cells had decreased CgB levels. These results suggest that a large part of AbetaPP in the human central nervous system is processed in the regulated secretory pathway of neurons...
  32. doi request reprint Cerebrospinal fluid brain injury biomarkers in children: a multicenter study
    Pashtun Shahim
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Neurochemistry, Sahlgrenska University Hospital Molndal, Sweden
    Pediatr Neurol 49:31-39.e2. 2013
    ....
  33. doi request reprint Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis
    Kristin Augutis
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mult Scler 19:543-52. 2013
    ....
  34. ncbi request reprint Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease
    Gunnar Brinkmalm
    Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Brain Res 1513:117-26. 2013
    ....
  35. doi request reprint Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 33:85-93. 2013
    ..The formation of these AβPP/Aβ peptides may have implications for the use of the 7PA2 cell line as a model for Aβ pathology. The enzyme(s) responsible for this particular BACE1-independent AβPP-processing remains to be identified...
  36. pmc Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts
    Thiemo Rudolph
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Ophthalmic Genet 32:75-9. 2011
    ..A protective role of the p.S18Y polymorphism of the UCHL1 gene has been shown in Parkinson`s disease. The current study aimed to examine possible effects on cataract formation...
  37. doi request reprint Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Exp Neurol 223:351-8. 2010
    ....
  38. ncbi request reprint Association of nAChR gene haplotypes with heavy alcohol use and body mass
    Sara Landgren
    Institute of Neuroscience and Physiology, Department of Pharmacology, University of Gothenburg, Sweden
    Brain Res 1305:S72-9. 2009
    ....
  39. ncbi request reprint No association of VEGF polymorphims with Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 13A, Gothenburg, Sweden
    Neuromolecular Med 12:224-8. 2010
    ..No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD...
  40. ncbi request reprint Genetic variation of the ghrelin signaling system in females with severe alcohol dependence
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Alcohol Clin Exp Res 34:1519-24. 2010
    ....
  41. doi request reprint Cerebrospinal fluid profiles of amyloid β-related biomarkers in Alzheimer's disease
    Christoffer Rosén
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Neuromolecular Med 14:65-73. 2012
    ....
  42. doi request reprint Cerebrospinal fluid matrix metalloproteinases and tissue inhibitor of metalloproteinases in combination with subcortical and cortical biomarkers in vascular dementia and Alzheimer's disease
    Maria Bjerke
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 27:665-76. 2011
    ..The CSF biomarkers reflecting AD pathology (T-tau, P-tau(181), and Aβ(1-42)), white matter lesions (NF-L and MBP) and matrix remodeling (MMP-9 and TIMP-1) perform well in differentiating between SVD and AD patients...
  43. doi request reprint Microglial markers are elevated in the prodromal phase of Alzheimer's disease and vascular dementia
    Bob Olsson
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 33:45-53. 2013
    ..Moreover, YKL-40 differentiates between AD and controls and between stable MCI to AD and those that convert to AD and VaD...
  44. ncbi request reprint Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Ophthalmic Genet 28:47-50. 2007
    ..The purpose of the present study was to determine if hyperhomocysteinemia-associated polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR) are overrepresented in primary open-angle glaucoma...
  45. ncbi request reprint Cerebrospinal fluid biomarkers mirror rate of cognitive decline
    Sindre Rolstad
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, Molndal, Sweden
    J Alzheimers Dis 34:949-56. 2013
    ..CSF predicted subsequent decline in more cognitive domains among MCI cases, but the impact was most pronounced in patients with dementia...
  46. doi request reprint Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 30:767-78. 2012
    ..Knowledge on these biomarkers and their trajectories may facilitate early diagnosis of AD and be useful in future clinical trials to track effects of disease modifying drugs...
  47. doi request reprint Extreme stability of chitotriosidase in cerebrospinal fluid makes it a suitable marker for microglial activation in clinical trials
    Bob Olsson
    Department of Psychiatry and Neurochemistry, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 32:273-6. 2012
    ..Thus, chitotriosidase may be useful in clinical trials where microglia is targeted or as a safety biomarker in other trials where the brain is a bystander organ...
  48. doi request reprint CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    JAMA 302:385-93. 2009
    ....
  49. ncbi request reprint Characterization of tau in cerebrospinal fluid using mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 7:2114-20. 2008
    ..Nineteen tryptic fragments of tau were detected, of which 16 are found in all tau isoforms while 3 represented unique tau isoforms. These results pave the way for clinical CSF studies on the tauopathies...
  50. ncbi request reprint High education may offer protection against tauopathy in patients with mild cognitive impairment
    Sindre Rolstad
    Institute of Neuroscience and Physiology, Section for Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 21:221-8. 2010
    ..Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy...
  51. pmc Increased CSF levels of phosphorylated neurofilament heavy protein following bout in amateur boxers
    Sanna Neselius
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden Institution for Clinical Sciences, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e81249. 2013
    ..The aims of this study were to find other biomarkers of mild TBI, which may help clinicians diagnose and monitor mild TBI, and to calculate the role of APOE ε4 allele genotype which has been associated with poor outcome after TBI...
  52. pmc Evaluating amyloid-β oligomers in cerebrospinal fluid as a biomarker for Alzheimer's disease
    Mikko Hölttä
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    PLoS ONE 8:e66381. 2013
    ..These results indicate that presence of high or measurable Aβo levels in CSF is clearly associated with AD, but the overlap is too large for the test to have any diagnostic potential on its own. ..
  53. doi request reprint Superoxide dismutase gene polymorphisms in patients with age-related cataract
    Dragana Celojevic
    Department of Clinical Neuroscience and Rehabilitation Ophthalmology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Ophthalmic Genet 34:140-5. 2013
    ..In this study, we investigated a number of disease-associated single nucleotide polymorphisms (SNPs) of SOD1, SOD2 and SOD3, in patients with age-related cataract...
  54. doi request reprint Cerebrospinal fluid levels of heart fatty acid binding protein are elevated prodromally in Alzheimer's disease and vascular dementia
    Bob Olsson
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 34:673-9. 2013
    ..In conclusion, HFABP seems to be a stable CSF biomarker that reflects neuronal cell death in several neurodegenerative disorders, including early stages of AD and VaD...
  55. pmc CSF biomarker variability in the Alzheimer's Association quality control program
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Alzheimers Dement 9:251-61. 2013
    ..However, there are large variations in biomarker measurements among and within laboratories...
  56. doi request reprint Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?
    Annika Ohrfelt
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Neurosci Lett 450:332-5. 2009
    ..The lower alpha-syn levels in AD, as well as the association of alpha-syn reduction with AD severity, approximated by MMSE, suggests that it may be a general marker of synapse loss, a hypothesis that warrants further investigation...
  57. doi request reprint Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases
    Magdalena Nutu
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital Molndal, S 431 80, Molndal, Sweden
    Neuromolecular Med 15:169-79. 2013
    ..We found reduced levels of Aβ1-15 in parkinsonian disease groups. The molecular mechanism behind this reduction is at present unknown...
  58. pmc Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease
    Erik Portelius
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 31:335-41. 2012
    ..Our data shows that CSF levels of Aβ(1-15/16) increase during treatment with semagacestat supporting its feasibility as a pharmacodynamic biomarker for drug candidates aimed at inhibiting γ-secretase-mediated AβPP-processing...
  59. doi request reprint The application of cerebrospinal fluid biomarkers in early diagnosis of Alzheimer disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Mölndal Campus, Molndal, Sweden
    Med Clin North Am 97:369-76. 2013
    ..Recent findings in sporadic and genetic preclinical AD are also discussed and, more specifically, what the biomarkers have taught us on the sequence of events in the pathogenic process underlying AD...
  60. doi request reprint Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30, Gothenburg, Sweden
    J Neural Transm 119:789-97. 2012
    ..These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful...
  61. ncbi request reprint Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: from the cell to the patient
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Neurodegener Dis 10:138-40. 2012
    ....
  62. doi request reprint Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Neuromolecular Med 13:151-9. 2011
    ..Microglial markers are unlikely to be useful for AD diagnosis, but might be useful for identification of distinct subgroups of patients, and for the development and implementation of drugs targeting microglial pathology...
  63. ncbi request reprint Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Ophthalmol 143:1059-60. 2007
    ..To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG)...
  64. doi request reprint Reduced levels of amyloid-beta-binding proteins in cerebrospinal fluid from Alzheimer's disease patients
    Sara F Hansson
    Neurochemical Laboratory, Department of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, Molndal, Sweden
    J Alzheimers Dis 16:389-97. 2009
    ..015). Positive correlations between Abeta(1-42) and beta-trace, CysC and TTR, respectively, were seen only in the AD group, suggesting that deficient Abeta-binding capacity in CSF may contribute to the amyloidogenic process in AD...
  65. doi request reprint Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease
    Annika Thorsell
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Brain Res 1362:13-22. 2010
    ..These results together suggest that cerebrospinal fluid neurogranin might be valuable together with the established AD biomarkers in the early diagnosis of AD and warrants further studies to determine the diagnostic value of neurogranin...
  66. ncbi request reprint Complement gene single nucleotide polymorphisms and biomarker endophenotypes of Alzheimer's disease
    Jonny Daborg
    Institute of Neuroscience and Physiology, Department of Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Alzheimers Dis 35:51-7. 2013
    ..023) and Mini-Mental State Examination scores (p = 0.012), both of which may be considered markers of disease intensity/severity...
  67. doi request reprint An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid
    Gunnar Brinkmalm
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Mass Spectrom 47:591-603. 2012
    ..We here describe a detailed characterization of endogenous APP/Aβ peptide species in CSF by using an online top-down MS-based method...
  68. doi request reprint Amyloid-β metabolism in Niemann-Pick C disease models and patients
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Gothenburg, Sweden
    Metab Brain Dis 27:573-85. 2012
    ..The preliminary findings from NPC cats suggest that treatment with cyclodextrin may have an impact on APP processing pathways. CSF Aβ, sAPP and tau biomarkers were dynamically altered over time in human NPC patients...
  69. ncbi request reprint Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Biomark Med 6:409-17. 2012
    ..We describe possible technical approaches, focusing on a selected reaction monitoring mass spectrometry assay as a candidate reference method for quantification of CSF amyloid β42...
  70. ncbi request reprint Proficiency testing programs for Alzheimer's disease cerebrospinal fluid biomarkers
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Biomark Med 6:401-7. 2012
    ..Global proficiency testing for CSF biomarkers is now fully established. It will continue to play an important part in the standardization of measurements that is a prerequisite for the broad-scale future implementation of CSF biomarkers...
  71. ncbi request reprint Proteomic profiling of cerebrospinal fluid in parkinsonian disorders
    Radu Constantinescu
    Institute of Neuroscience and Physiology, Department of Neurology, The Sahlgrenska Academy at the University of Gothenburg, 413 45 Goteborg, Sweden
    Parkinsonism Relat Disord 16:545-9. 2010
    ..However, they could not differentiate PD patients from controls. As none of these changes were APD subgroup-specific, they most likely reflect the intensity and/or extent of the neurodegenerative process in general...
  72. pmc BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    PLoS ONE 7:e31084. 2012
    ..The described CSF Aβ pattern may be used as a pharmacodynamic fingerprint to detect biochemical effects of BACE1-therapies in clinical trials, which might accelerate development of novel therapies...
  73. doi request reprint No association of LOXL1 gene polymorphisms with Alzheimer's disease
    Alexandra Abramsson
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 13:160-6. 2011
    ..No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD...
  74. doi request reprint SILAC zebrafish for quantitative analysis of protein turnover and tissue regeneration
    Ann Westman-Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Sweden
    J Proteomics 75:425-34. 2011
    ..This newly developed SILAC zebrafish model constitutes a novel tool to analyze tissue regeneration in an animal model amenable to genetic and pharmacologic manipulation...
  75. pmc Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mol Neurodegener 5:11. 2010
    ..82 ([95% CI 0.55-1.24], P = 0.35) was obtained for a positive UCHL1 allele A carrier status. The present study thus do not support a protective effect of the UCHL1 S18Y polymorphism against AD...
  76. ncbi request reprint Longitudinal stability of CSF biomarkers in Alzheimer's disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden
    Neurosci Lett 419:18-22. 2007
    ....
  77. doi request reprint Converging molecular pathways in human neural development and degeneration
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Göteborg Mölndal, Sweden
    Neurosci Res 66:330-2. 2010
    ..Tau phosphorylation in Alzheimer's disease may be a physiological response to Alzheimer-associated synaptotoxicity...
  78. pmc Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, SE 431 80 Molndal, Sweden
    Neurodegener Dis 6:258-62. 2009
    ..g. Abeta1-15 and Abeta1-16), and that the levels of these shorter isoforms are elevated in media from cells that have been treated with gamma-secretase inhibitors...
  79. ncbi request reprint Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases
    Ann Westman-Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neuochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Front Biosci (Landmark Ed) 14:1793-806. 2009
    ..In this review we discuss our experience in the field of neuroproteomics/peptidomics, with special focus on biomarker discovery studies that have been performed on CSF samples from well-defined patient and control populations...
  80. pmc Fluid biomarkers in Alzheimer disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Molndal, SE 431 80 Molndal, Sweden
    Cold Spring Harb Perspect Med 2:a006221. 2012
    ..The rationale for the use of CSF biomarkers to identify and monitor the mechanism of action of new drug candidates is also outlined in this chapter...
  81. ncbi request reprint Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 6:4433-9. 2007
    ..Finally, we report the finding of two novel Abeta peptides (Abeta2-17 and Abeta3-17)...
  82. ncbi request reprint Analytical aspects of molecular Alzheimer's disease biomarkers
    Ulf Andreasson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Biomark Med 6:377-89. 2012
    ..In the field of Alzheimer's disease, there are currently three cerebrospinal fluid markers that have been verified in multiple studies and the analytical aspects of measuring them will be discussed...
  83. ncbi request reprint Neurochemical measures co-vary with personality traits: forensic psychiatric findings replicated in a general population sample
    Thomas Nilsson
    Institute of Neuroscience and Physiology, University of Gothenburg, Sweden
    Psychiatry Res 178:525-30. 2010
    ....
  84. pmc Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method
    Annika Ohrfelt
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, S 43180 Mölndal, Sweden
    Neurochem Res 36:2029-42. 2011
    ..Quantification of α-syn in each brain tissue fraction was performed using a novel enzyme-linked immunosorbent assay (ELISA)...
  85. ncbi request reprint Cerebrospinal fluid concentrations of peptides derived from chromogranin B and secretogranin II are decreased in multiple sclerosis
    Niklas Mattsson
    Department of Neurochemistry and Psychiatry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Neurochem 103:1932-9. 2007
    ..Further studies will investigate the involvement of these peptides in MS pathogenesis...
  86. pmc Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women
    Deborah R Gustafson
    The Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Neurol Neurosurg Psychiatry 78:461-4. 2007
    ..It is not known, however, whether these biomarkers may be risk indicators for cognitive decline in otherwise healthy older people...
  87. doi request reprint Is there a CSF biomarker profile related to depression in elderly women?
    Pia Gudmundsson
    Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Sweden
    Psychiatry Res 176:174-8. 2010
    ..This contrasts with the well-characterized pattern of low Abeta42, higher CSF/serum albumin ratio, and higher NFL in Alzheimer's disease...
  88. pmc Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Acta Neuropathol 120:185-93. 2010
    ..No prominent differences in Abeta isoform patterns between FAD and SAD patients were seen, underscoring the similarity in the amyloid pathology of these two disease entities...
  89. doi request reprint Amyloid-β₄₂ is associated with cognitive impairment in healthy elderly and subjective cognitive impairment
    Sindre Rolstad
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 26:135-42. 2011
    ..Aβ₄₂ is associated with cognitive functions from a potentially early to a later disease phase, and T-tau is more indicative of performance in a later disease phase...
  90. doi request reprint Identification of novel APP/Abeta isoforms in human cerebrospinal fluid
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
    Neurodegener Dis 6:87-94. 2009
    ..A lot of research has focused on Abeta production and the neurotoxic 42-amino-acid form of Abeta (Abeta1-42), while less is known about the nonamyloidogenic pathway and how Abeta is degraded...
  91. doi request reprint A novel pathway for amyloid precursor protein processing
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Neurobiol Aging 32:1090-8. 2011
    ....
  92. pmc Neuroinflammation in Lyme neuroborreliosis affects amyloid metabolism
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    BMC Neurol 10:51. 2010
    ..We have previously found altered cerebral amyloid metabolism in other neuroinflammatory conditions. To further elucidate this, we investigated amyloid metabolism in patients with Lyme neuroborreliosis (LNB)...
  93. pmc No neurochemical evidence for brain injury caused by heading in soccer
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Br J Sports Med 41:574-7. 2007
    ..The possible injurious effect to the brain of heading in soccer is a matter of discussion...
  94. pmc The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Alzheimers Dement 7:386-395.e6. 2011
    ..In this article, we present the results from the first two rounds of the program...
  95. doi request reprint The N-terminal domain of α-dystroglycan, released as a 38 kDa protein, is increased in cerebrospinal fluid in patients with Lyme neuroborreliosis
    Camilla Hesse
    Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, The Sahlgrenska Academy, University of Gothenburg, Sweden
    Biochem Biophys Res Commun 412:494-9. 2011
    ..In untreated acute phase LNB patients, 67% showed a significant increase of CSF α-DG-N compared to healthy controls. After treatment with antibiotics the CSF α-DG-N levels were normalized in the LNB patients...
  96. doi request reprint Synaptic retrogenesis and amyloid-beta in Alzheimer's disease
    Pontus Wasling
    Department of Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    J Alzheimers Dis 16:1-14. 2009
    ..Here, we review the literature on the possible physiological roles of Abeta and its precursor protein AbetaPP during development with special focus on electrophysiological findings...
  97. ncbi request reprint An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
    Neurosci Lett 409:215-9. 2006
    ..Here, we provide direct evidence that an Abeta fragment signature consisting of Abeta1-16, Abeta1-33, Abeta1-39, and Abeta1-42 in CSF distinguishes sporadic AD patients from non-demented controls with an overall accuracy of 86%...
  98. doi request reprint Novel cerebrospinal fluid biomarkers of axonal degeneration in frontotemporal dementia
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Sahlgren s University Hospital Mölndal, S 431 80 Molndal, Sweden
    Mol Med Report 1:757-61. 2008
    ..Taken together, these data suggest that differentially-expressed peptides are general markers of axonal degeneration. Further studies are needed to verify their prognostic value in FTD...
  99. ncbi request reprint Cerebrospinal fluid markers for prediction of Alzheimer's disease
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Neurosci Lett 352:67-9. 2003
    ..The usefulness of these markers is further emphasized by the finding of a positive predictive value of 94% and a negative predictive value of 81%...
  100. ncbi request reprint Cerebrospinal fluid biomarkers for Alzheimer's disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 18:413-7. 2009
    ..This paper reviews recent research advances on these CSF biomarkers for use in clinical diagnosis and in clinical trials in AD...