Michael J Williams

Summary

Country: Sweden

Publications

  1. pmc Comparative genomic analysis of the Tribolium immune system
    Zhen Zou
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Genome Biol 8:R177. 2007
  2. ncbi Drosophila melanogaster Rac2 is necessary for a proper cellular immune response
    Michael J Williams
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    Genes Cells 10:813-23. 2005
  3. ncbi Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells
    Michael J Williams
    Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
    J Cell Sci 120:502-11. 2007
  4. ncbi Drosophila hemopoiesis and cellular immunity
    Michael J Williams
    Umea Centre for Molecular Pathogenesis, Umea University, Umea, Sweden
    J Immunol 178:4711-6. 2007
  5. ncbi Rac1 signalling in the Drosophila larval cellular immune response
    Michael J Williams
    Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
    J Cell Sci 119:2015-24. 2006
  6. pmc A directed screen for genes involved in Drosophila blood cell activation
    Carl Johan Zettervall
    Umea Centre for Molecular Pathogenesis, Byggnad 6L, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 101:14192-7. 2004
  7. ncbi Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs
    Krystle M Veerman
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Immunol 8:532-9. 2007

Collaborators

  • Dan Hultmark
  • S D Rosen
  • Zhen Zou
  • Krystle M Veerman
  • Carl Johan Zettervall
  • Jesus Rivera-Nieves
  • Haobo Jiang
  • Douglas A Carlow
  • Jasmeen S Merzaban
  • Philip Owen
  • Zhiqiang Lu
  • Hermann J Ziltener
  • Niranji Sumathipala
  • Jay D Evans
  • Kenji Uchimura
  • Mark S Singer
  • Picheng Zhao
  • Silvia Naus
  • Charles Hetru
  • Istvan Ando
  • Ruth Palmer
  • Eva Kurucz
  • Ines Anderl

Detail Information

Publications7

  1. pmc Comparative genomic analysis of the Tribolium immune system
    Zhen Zou
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Genome Biol 8:R177. 2007
    ..We have annotated immunity-related genes and compared them with homologous molecules from other species...
  2. ncbi Drosophila melanogaster Rac2 is necessary for a proper cellular immune response
    Michael J Williams
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    Genes Cells 10:813-23. 2005
    ..Finally, larger cells known as lamellocytes attach to the capsule but also fail to spread, and there is a lack of melanization. From these results it appears that Rac2 is necessary for the larval cellular immune response...
  3. ncbi Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells
    Michael J Williams
    Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
    J Cell Sci 120:502-11. 2007
    ..Finally, though dominant negative Rac1 is able to block filopodia formation in the overexpression experiments, only Rac2 is necessary for filopodia formed by hemocytes after parasitization...
  4. ncbi Drosophila hemopoiesis and cellular immunity
    Michael J Williams
    Umea Centre for Molecular Pathogenesis, Umea University, Umea, Sweden
    J Immunol 178:4711-6. 2007
    ..In this review, I will discuss what is currently known about Drosophila hemopoiesis and the cellular immune response and where possible compare it to vertebrate mechanisms...
  5. ncbi Rac1 signalling in the Drosophila larval cellular immune response
    Michael J Williams
    Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
    J Cell Sci 119:2015-24. 2006
    ..From these data we conclude that Rac1 induces Bsk activity and stable actin formation for cellular immune activation, leading to sessile hemocyte release and an increase in the number of circulating hemocytes...
  6. pmc A directed screen for genes involved in Drosophila blood cell activation
    Carl Johan Zettervall
    Umea Centre for Molecular Pathogenesis, Byggnad 6L, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 101:14192-7. 2004
    ..We conclude that the activation of a cellular response is complex and affected by multiple signaling pathways...
  7. ncbi Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs
    Krystle M Veerman
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Immunol 8:532-9. 2007
    ..Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule...