Research Topics
Species | Christine WennerasSummaryCountry: Sweden Publications
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Publications
Blockade of CD14 increases Shigella-mediated invasion and tissue destructionC Wenneras
Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale, Unité 389, Institut Pasteur, Paris, France
J Immunol 164:3214-21. 2000..Moreover, in vitro blockade of CD14 did not impede bactericidal activity. Thus, anti-CD14 treatment interfered with host defense mechanisms involved with removal/eradication of Shigella...
Blockade of CD14 aggravates experimental shigellosisC Wenneras
Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, Paris, France
J Endotoxin Res 7:442-6. 2001..In contrast, higher quantities of TNF-alpha were observed in the CD14-blocked group. To conclude, anti-CD14 treatment had a detrimental effect on the capacity of Shigella-infected animals to clear the infection...
Prevalence of enterotoxigenic Escherichia coli-associated diarrhoea and carrier state in the developing worldChristine Wenneras
Department of Clinical Bacteriology, Sahlgrenska University Hospital, Goteborg, Sweden
J Health Popul Nutr 22:370-82. 2004..5 diarrhoeal episodes per year caused by ETEC until the age of five years, after which the yearly incidence drops to 0.1. To conclude, ETEC remains an important diarrhoeal pathogen among children in the developing world...
Comparison of a new commercial test, Dermatophyte-PCR kit, with conventional methods for rapid detection and identification of Trichophyton rubrum in nail specimensNahid Kondori
Department of Clinical Bacteriology, Sahlgrenska University Hospital, Goteborg, Sweden
Med Mycol 48:1005-8. 2010..Due to its sensitivity, specificity and rapidity, we conclude that this PCR is an attractive method for routine investigation of nail dermatophytosis in a clinical setting...
Interplay between signaling via the formyl peptide receptor (FPR) and chemokine receptor 3 (CCR3) in human eosinophilsLena Svensson
Department of Clinical Bacteriology, Goteborg University, Goteborg, Sweden
J Leukoc Biol 86:327-36. 2009..Pharmacologic inhibition of signal transduction molecules showed that the release of free oxygen radicals in response to eotaxin-1 compared with fMLP is relatively more dependent on the p38 MAPK pathway...
Human eosinophils selectively recognize and become activated by bacteria belonging to different taxonomic groupsLena Svensson
Department of Clinical Bacteriology, Goteborg University, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
Microbes Infect 7:720-8. 2005..We propose that the presence of defined bacterial species in the normally sterile tissues inhabited by eosinophils may constitute danger signals to eosinophils. This may be of importance in the perpetuation of allergic inflammation...
Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptorAnna Lena Stenfeldt
Department of Rheumatology and Inflammation Research, Guldhedsgatan 10, S 413 46, Goteborg, Sweden
Inflammation 30:224-9. 2007..Based on the difference in potency of cyclosporin H and the two Boc-peptides, we suggest using cyclosporin H as a specific inhibitor for FPR. To specifically inhibit the FPRL1 response the antagonist WRW(4) should be used...
CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2Sofi Johansson
Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10A, 413 46, Goteborg, Sweden
Inflammation 32:65-9. 2009..However, CC16 did not inhibit eosinophil migration towards PGD(2). We therefore propose that CC16 may down-modulate the entry of human eosinophils and neutrophils into the airways during inflammation in the lung...
House dust mite allergen activates human eosinophils via formyl peptide receptor and formyl peptide receptor-like 1Lena Svensson
Department of Clinical Bacteriology, Goteborg University, Goteborg, Sweden
Eur J Immunol 37:1966-77. 2007..This study indicates that FPR and FPRL1 mediate the activation of eosinophils by HDM, whereas birch pollen employs other pathways shared with FPR to activate human eosinophils...
The chemoattractant Trp-Lys-Tyr-Met-Val-D-Met activates eosinophils through the formyl peptide receptor and one of its homologues, formyl peptide receptor-like 1Lena Svensson
Department of Clinical Bacteriology, Sahlgrenska University Hospital, Goteborg, Sweden
J Leukoc Biol 72:810-8. 2002..Different members of the formyl peptide receptor family were preferentially engaged by the peptide in the two classes of granulocytes: the formyl peptide receptor itself in eosinophils and formyl peptide receptor-like 1 in neutrophils...
Allergen extracts directly mobilize and activate human eosinophilsLena Svensson
Department of Clinical Bacteriology, , Gothenburg, Sweden
Eur J Immunol 34:1744-51. 2004..We propose that eosinophil activation in vivo is not exclusively mediated by cytokines and chemokines of the allergic inflammatory reaction, but could partly be the result of direct interaction between allergens and eosinophils...
Danger signals derived from stressed and necrotic epithelial cells activate human eosinophilsAnna-Lena Stenfeldt
Department of Clinical Bacteriology, , Guldhedsgatan 10, , Sweden
Immunology 112:605-14. 2004....
Distinctive blood eosinophilic phenotypes and cytokine patterns in eosinophilic esophagitis, inflammatory bowel disease and airway allergyMarianne Johnsson
Department of Clinical Bacteriology, Sahlgrenska University Hospital, Goteborg, Sweden
J Innate Immun 3:594-604. 2011..We propose that eosinophils acquire varying functional properties as a consequence of distinct patterns of activation signals released from the inflamed tissues in different diseases...
High rate of Exophiala dermatitidis recovery in the airways of patients with cystic fibrosis is associated with pancreatic insufficiencyNahid Kondori
Department of Clinical Bacteriology, Sahlgrenska University Hospital, 40234 Gothenburg, Sweden
J Clin Microbiol 49:1004-9. 2011..In conclusion, E. dermatitidis is a frequent colonizer of the respiratory tract in CF patients in Sweden and appears to be associated with more advanced disease. Whether E. dermatitidis is pathogenic remains to be elucidated...
