A Wallin

Summary

Country: Sweden

Publications

  1. ncbi request reprint Delirium in dementia
    B Robertsson
    Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Mölndal Hospital, Sweden
    Int J Geriatr Psychiatry 13:49-56. 1998
  2. ncbi request reprint [Clinical investigation of cognitive dysfunction by specialists]
    Ake Edman
    Institutionen för klinisk neurovetenskap, Sektionen för psykiatri, Göteborgs Universitet
    Lakartidningen 99:782-5. 2002
  3. ncbi request reprint [Different opinions when it comes to research ethics issues concerning patients with dementia. A questionnaire study among members of research ethics committees]
    Gunbrith Peterson
    Kliniska forskningsavdelningen, Janssen Cilag AB, Sollentuna
    Lakartidningen 101:1810-2. 2004
  4. ncbi request reprint Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology
    Annika Olsson
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Clin Chem 51:336-45. 2005
  5. ncbi request reprint Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 12:255-60. 2007
  6. doi request reprint Characteristic clinical presentation and CSF biomarker pattern in cerebral small vessel disease
    Anders Wallin
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Neurol Sci 322:192-6. 2012
  7. pmc Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
  8. pmc Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mol Neurodegener 5:11. 2010
  9. ncbi request reprint Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson's disease--a rCBF scintigraphy study
    A Wallin
    Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Goteborg University, Molndal, Sweden
    Acta Neurol Scand 116:347-54. 2007
  10. ncbi request reprint Cerebrospinal fluid cytoskeleton proteins in patients with subcortical white-matter dementia
    A Wallin
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, SE 431 80, Molndal, Sweden
    Mech Ageing Dev 122:1937-49. 2001

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Delirium in dementia
    B Robertsson
    Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Mölndal Hospital, Sweden
    Int J Geriatr Psychiatry 13:49-56. 1998
    ..In the two brain disorders that are predominantly cortical, EAD and FTD, the occurrence of delirium was comparatively low...
  2. ncbi request reprint [Clinical investigation of cognitive dysfunction by specialists]
    Ake Edman
    Institutionen för klinisk neurovetenskap, Sektionen för psykiatri, Göteborgs Universitet
    Lakartidningen 99:782-5. 2002
    ..The article also stresses the importance of detecting possible behavioural and psychological signs of dementia, and the importance of collecting information on the premorbid personality of the patient...
  3. ncbi request reprint [Different opinions when it comes to research ethics issues concerning patients with dementia. A questionnaire study among members of research ethics committees]
    Gunbrith Peterson
    Kliniska forskningsavdelningen, Janssen Cilag AB, Sollentuna
    Lakartidningen 101:1810-2. 2004
  4. ncbi request reprint Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology
    Annika Olsson
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Clin Chem 51:336-45. 2005
    ....
  5. ncbi request reprint Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 12:255-60. 2007
    ..Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials...
  6. doi request reprint Characteristic clinical presentation and CSF biomarker pattern in cerebral small vessel disease
    Anders Wallin
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Neurol Sci 322:192-6. 2012
    ..Moreover, monitoring disease modifying treatment effects can be an important application for small vessel disease specific biochemical markers...
  7. pmc Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
    ..These results suggest that TACE activity and soluble TNF receptors may be potential diagnostic candidate biomarkers in AD and MCI...
  8. pmc Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mol Neurodegener 5:11. 2010
    ..82 ([95% CI 0.55-1.24], P = 0.35) was obtained for a positive UCHL1 allele A carrier status. The present study thus do not support a protective effect of the UCHL1 S18Y polymorphism against AD...
  9. ncbi request reprint Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson's disease--a rCBF scintigraphy study
    A Wallin
    Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Goteborg University, Molndal, Sweden
    Acta Neurol Scand 116:347-54. 2007
    ..The aim of the study was to visualize cortical function in Parkinson's patients with various degrees of cognitive impairment...
  10. ncbi request reprint Cerebrospinal fluid cytoskeleton proteins in patients with subcortical white-matter dementia
    A Wallin
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, SE 431 80, Molndal, Sweden
    Mech Ageing Dev 122:1937-49. 2001
    ..No relationship was found between ApoE4 alleles and CSF levels of tau or NFL in this patient group. Besides presenting original data, the disease status of SWD is also discussed...
  11. ncbi request reprint Classification and subtypes of vascular dementia
    Anders Wallin
    Goteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Int Psychogeriatr 15:27-37. 2003
    ..Subcortical VaD has a relatively homogeneous clinical picture for which detailed criteria are suggested. AD + VaD is more difficult to identify but is possible, sometimes with the aid of neuroimaging and/or biological markers...
  12. ncbi request reprint Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia
    Anders Wallin
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 16:200-7. 2003
    ..01) and FTD groups (p < 0.05). No influence of ApoE epsilon4 allele possession on CSF-AChE activity was found. It is suggested that abnormal CSF-AChE activity in patients with SVD reflects a disturbance in the cholinergic system...
  13. doi request reprint Cerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS study
    M Jonsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Eur J Neurol 17:377-82. 2010
    ....
  14. doi request reprint Combination of hippocampal volume and cerebrospinal fluid biomarkers improves predictive value in mild cognitive impairment
    C Eckerström
    Institute of Neuroscience and Physiology, Linguistics and Theory of Science, University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 29:294-300. 2010
    ..Recent findings suggest that hippocampal volumetry and CSF biomarkers can be used to predict which MCI patients have an underlying neurodegenerative disorder...
  15. ncbi request reprint Neurofilament protein in cerebrospinal fluid: a marker of white matter changes
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurosci Res 66:510-6. 2001
    ..Because NFL is located mainly in large myelinated axons, increased CSF NFL in individuals with WMC probably reflects axonal degeneration...
  16. doi request reprint Biomarkers in relation to cognitive reserve in patients with mild cognitive impairment--proof of concept
    S Rolstad
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Dement Geriatr Cogn Disord 27:194-200. 2009
    ..Biomarkers such as total tau (t-tau) and beta-amyloid 42 (Abeta42) may be surrogates for pathology in relation to CR in patients with neurodegenerative disease...
  17. ncbi request reprint CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging
    M Sjogren
    Institute of Clinical Neuroscience, Göbteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    J Neural Transm 107:563-79. 2000
    ..In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms...
  18. ncbi request reprint The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 12:257-64. 2001
    ..The correlations found may reflect a common pathophysiologic process such as axonal degeneration...
  19. ncbi request reprint A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia
    I Skoog
    Department of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
    Neurology 50:966-71. 1998
    ..6 +/- 2.1; p = 0.029) than other individuals. A relative BBB dysfunction is associated with both AD and VAD among very elderly individuals. This finding is possibly found early in the disease before the onset of clinical dementia...
  20. doi request reprint High white matter lesion load is associated with hippocampal atrophy in mild cognitive impairment
    C Eckerström
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Dement Geriatr Cogn Disord 31:132-8. 2011
    ..The objective of the study was to examine hippocampal and WML volumes in MCI patients and to examine if WML were linked to hippocampal atrophy...
  21. ncbi request reprint Evolution of Abeta42 and Abeta40 levels and Abeta42/Abeta40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment
    K Blennow
    Sahlgrenska University Hospital, Goteborg University, Sweden
    J Nutr Health Aging 13:205-8. 2009
    ..To better understand the seemingly contradictory plasma beta-amyloid (Abeta) results in Alzheimer's disease (AD) patients by using a newly developed plasma Abeta assay, the INNO-BIA plasma Abeta forms, in a multicenter study...
  22. ncbi request reprint Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sweden
    Neurology 54:1960-4. 2000
    ..Both proteins have been implicated in the pathophysiology of FTD...
  23. ncbi request reprint Symptoms, vascular risk factors and blood-brain barrier function in relation to CT white-matter changes in dementia
    A Wallin
    Institute of Clinical Neuroscience, Goteborg University, Molndal, Sweden
    Eur Neurol 44:229-35. 2000
    ..BBB dysfunction may be the link between the vasculature and the tissue damage...
  24. pmc Both total and phosphorylated tau are increased in Alzheimer's disease
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital SE 431 80 Mölndal, Sweden
    J Neurol Neurosurg Psychiatry 70:624-30. 2001
    ..As CSF tau protein is increased after stroke, tau may also be implicated in the pathophysiology of vascular dementia, of which subcortical arteriosclerotic encephalopathy (SAE) is a putative subtype...
  25. pmc Age and diagnostic performance of Alzheimer disease CSF biomarkers
    N Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Mo lndal, Sweden
    Neurology 78:468-76. 2012
    ..These biomarkers identify AD already at the predementia stage, but their diagnostic performance might be affected by age-dependent increase of AD-type brain pathology in cognitively unaffected elderly...
  26. ncbi request reprint Occurrence of delirium in different regional brain syndromes
    B Robertsson
    Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Sahlgrenska Universitetssjukhuset Mölndal, Molndal, Sweden
    Dement Geriatr Cogn Disord 10:278-83. 1999
    ..The analyses showed that the rate of delirium was significantly higher when a global brain syndrome was predominant than when any one of the other syndromes predominated...
  27. doi request reprint Cognitive reserve in relation to abeta42 in patients converting from MCI to dementia - a follow-up report
    S Rolstad
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Dement Geriatr Cogn Disord 28:110-5. 2009
    ..However, the interaction between time, biomarkers, neuropsychological performance and CR is yet to be established...
  28. ncbi request reprint Frontotemporal dementia can be distinguished from Alzheimer's disease and subcortical white matter dementia by an anterior-to-posterior rCBF-SPET ratio
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    Dement Geriatr Cogn Disord 11:275-85. 2000
    ..6%. CT/MRI was found to be helpful in the differential diagnosis between FTD and SWD. In FTD patients, the mesial superior frontal gyrus, near the polus frontalis, was found to be the region with the most reduced rCBF values...
  29. ncbi request reprint Longitudinal EEG findings in dementia related to the parietal brain syndrome and the degree of dementia
    A Edman
    Goteborg University, Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Sahlgren Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 9:199-204. 1998
    ..The results suggest that the EEG deterioration in dementia mainly reflects the gradual decline of parietal brain function...
  30. doi request reprint Apathy is a prominent neuropsychiatric feature of radiological white-matter changes in patients with dementia
    M Jonsson
    Institute of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Int J Geriatr Psychiatry 25:588-95. 2010
    ..The objective was to study the relationships between WMCs on MRI/CT and neuropsychiatric symptoms and vascular factors in patients with cognitive impairment...
  31. ncbi request reprint Treatment of Alzheimer's disease with clioquinol
    B Regland
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80 Molndal, Sweden
    Dement Geriatr Cogn Disord 12:408-14. 2001
    ..Clinical ratings showed slight improvement after 3 weeks treatment with clioquinol in this open study...
  32. ncbi request reprint Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values
    M Sjogren
    Institute of Clinical Neuroscience, Psychiatry Section, Goteborg University, SE 431 80 Molndal, Sweden
    Clin Chem 47:1776-81. 2001
    ..For the introduction of these assays in clinical practice, adequate reference values are of importance...
  33. doi request reprint Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Göteborg MCI study
    C Eckerström
    Institute of Neuroscience and Physiology, Goteborg University, Sweden
    J Neurol Sci 272:48-59. 2008
    ....
  34. ncbi request reprint Hyperactivity in the hypothalamic-pituitary-adrenal axis in demented patients with delirium
    B Robertsson
    Department of Psychiatry and Neurochemistry, Institute of Clinical Neuroscience, Sahlgrenska Universitetssjukhuset Mölndal, Sweden
    Int Clin Psychopharmacol 16:39-47. 2001
    ..It is suggested that certain demented individuals have an impaired HPA system and a low delirium threshold and respond to stress with delirium...
  35. doi request reprint High education may offer protection against tauopathy in patients with mild cognitive impairment
    Sindre Rolstad
    Institute of Neuroscience and Physiology, Section for Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 21:221-8. 2010
    ..Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy...
  36. ncbi request reprint The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease
    K Hoglund
    Section of Experimental Neurochemistry, Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    Dement Geriatr Cogn Disord 19:256-65. 2005
    ..The relevance and mechanism between statin treatment and AD has to be further elucidated by using statins of different lipophility in different dosages over a longer period of time...
  37. ncbi request reprint No association between the alpha2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression
    K Blennow
    Department of Clinical Neuroscience, University of Goteborg, Sahlgren s University Hospital, Molndal, Sweden
    J Neural Transm 107:1065-79. 2000
    ..The lack of an association between the A2M-2 allele and AD in the present study, and the lack of abnormalities in the A2M mRNA or protein suggest that the A2M-2 allele is not associated with AD...
  38. doi request reprint No neurochemical evidence of brain injury after blast overpressure by repeated explosions or firing heavy weapons
    K Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Acta Neurol Scand 123:245-51. 2011
    ..Psychiatric and neurological symptoms are common among soldiers exposed to blast without suffering a direct head injury. It is not known whether such symptoms are direct consequences of blast overpressure...
  39. ncbi request reprint Relationship between depressive symptomatology and the subcortical brain syndrome in dementia
    K Lind
    Goteborg University, Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital Molndal, SE 431 80 Molndal, Sweden
    Int J Geriatr Psychiatry 17:774-8. 2002
    ..the aim of the present study was to elucidate a possible relationship between depressive symptomatology and regional brain symptomatology in demented patients...
  40. doi request reprint Association of complement factor H Y402H gene polymorphism with Alzheimer's disease
    Madeleine Zetterberg
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008
    ..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD...
  41. ncbi request reprint Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Mol Med 20:233-9. 2007
    ..018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis...
  42. ncbi request reprint Biological correlates of clinical subgroups of Alzheimer's disease
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    Dement Geriatr Cogn Disord 14:191-7. 2002
    ..For instance, a decreased CSF level of HVA (p < 0.001) was specific to AD type I and decreased rCBF (p < 0.05 to <0.001) in three particular regions was specific to AD type II...
  43. ncbi request reprint Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 13:112-8. 2002
    ..Furthermore, decreased CSF-Abeta42 levels may be common in neurodegenerative disorders possibly reflecting changes in the metabolism of beta-amyloid or axonal degeneration...
  44. ncbi request reprint Objective measurement of the alertness level in dementia
    Ake Edman
    Institute of Clinical Neuroscience, Section of Psychiatry, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 15:212-7. 2003
    ..The intensity of this decrease was proportional to the degree of the dementia. The alertness disturbance was found to be particularly associated with the parietal brain syndrome...
  45. ncbi request reprint Inter-rater reliability of the STEP protocol
    A Edman
    Institute of Clinical Neuroscience, , Sweden
    J Geriatr Psychiatry Neurol 14:140-4. 2001
    ..40, indicating moderate agreement; and for 4 variables, the value was 0.40 or below, indicating poor agreement. Kappa calculations regarding the assessments of four variables were either not possible or were considered inappropriate...
  46. ncbi request reprint Pathophysiological aspects of frontotemporal dementia--emphasis on cytoskeleton proteins and autoimmunity
    M Sjogren
    Institute of Clinical Neuroscience, Psychiatry Section, Goteborg University, Sahlgrenska University Hospital, SE 431 80, Molndal, Sweden
    Mech Ageing Dev 122:1923-35. 2001
    ....
  47. ncbi request reprint Effect of statins on beta-amyloid metabolism in humans: potential importance for the development of senile plaques in Alzheimer's disease
    K Hoglund
    Section of Experimental Neurochemistry, Institute of Clinical Neuroscience, Goteborg University, Sweden
    Acta Neurol Scand Suppl 185:87-92. 2006
    ..The pleiotropic effects of statins should be investigated further. One approach is presented in this review...
  48. pmc Thyroid hormones are associated with poorer cognition in mild cognitive impairment
    Patrick Quinlan
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 30:205-11. 2010
    ..Alterations in interrelated endocrine axes may be related to the pathogenesis of mild cognitive impairment (MCI) and dementia...
  49. ncbi request reprint Cognitive profiles of mild cognitive impairment with and without vascular disease
    Arto Nordlund
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Sweden
    Neuropsychology 21:706-12. 2007
    ..These differences can be largely explained by deficits in speed and attention and in executive function of the MCI subjects with vascular disease...
  50. ncbi request reprint Increased saliva cortisol awakening response in patients with mild cognitive impairment
    Karin Lind
    Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Molndal, Sweden
    Dement Geriatr Cogn Disord 24:389-95. 2007
    ..The aim of the present study was to investigate whether cortisol levels are elevated among patients with MCI and/or whether the individuals have adequate feedback control of their HPA axis...
  51. doi request reprint Reduced levels of amyloid-beta-binding proteins in cerebrospinal fluid from Alzheimer's disease patients
    Sara F Hansson
    Neurochemical Laboratory, Department of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, Molndal, Sweden
    J Alzheimers Dis 16:389-97. 2009
    ..015). Positive correlations between Abeta(1-42) and beta-trace, CysC and TTR, respectively, were seen only in the AD group, suggesting that deficient Abeta-binding capacity in CSF may contribute to the amyloidogenic process in AD...
  52. doi request reprint B-type natriuretic peptide plasma levels are elevated in subcortical vascular dementia
    Daniel Kondziella
    Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Neuroreport 20:825-7. 2009
    ..This probably reflects the larger cardiovascular burden in patients with subcortical vascular dementia...
  53. doi request reprint Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI
    Arto Nordlund
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Int Neuropsychol Soc 14:582-90. 2008
    ..Mild cognitive impairment (MCI) is regarded as the prodromal stage of dementia disorders, such as Alzheimer's disease (AD)...
  54. doi request reprint The Swedish National Adult Reading Test (NART-SWE): a test of premorbid IQ
    Sindre Rolstad
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden
    Scand J Psychol 49:577-82. 2008
    ..It does appear that reading of irregular words is intact in mild Alzheimer's disease...
  55. doi request reprint Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?
    Annika Ohrfelt
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Neurosci Lett 450:332-5. 2009
    ..The lower alpha-syn levels in AD, as well as the association of alpha-syn reduction with AD severity, approximated by MMSE, suggests that it may be a general marker of synapse loss, a hypothesis that warrants further investigation...
  56. doi request reprint Two-year outcome of MCI subtypes and aetiologies in the Göteborg MCI study
    Arto Nordlund
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Neurol Neurosurg Psychiatry 81:541-6. 2010
    ..The objective was to study the 2-year outcome of subjects diagnosed as having mild cognitive impairment (MCI)...
  57. doi request reprint Converging pathways of chromogranin and amyloid metabolism in the brain
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden
    J Alzheimers Dis 20:1039-49. 2010
    ..Cell medium from BACE1-inhibited cells had decreased CgB levels. These results suggest that a large part of AbetaPP in the human central nervous system is processed in the regulated secretory pathway of neurons...
  58. doi request reprint CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    JAMA 302:385-93. 2009
    ....
  59. ncbi request reprint An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, Molndal, Sweden
    Neurosci Lett 409:215-9. 2006
    ..Here, we provide direct evidence that an Abeta fragment signature consisting of Abeta1-16, Abeta1-33, Abeta1-39, and Abeta1-42 in CSF distinguishes sporadic AD patients from non-demented controls with an overall accuracy of 86%...
  60. ncbi request reprint [There is a strong evidence that professional boxing results in chronic brain damage. The more head punches during a boxer's career, the bigger is the risk]
    Kaj Blennow
    Institutionen för klinisk neurovetenskap, Sahlgrenska Universitetssjukhuset Mölndal, Sweden
    Lakartidningen 102:2468-70, 2472-5. 2005
    ..Focus is also set on the interesting similarities in neurochemical changes and pathogenic mechanisms between CTBI-B, acute traumatic brain injury (e.g. road traffic accidents) and Alzheimer's disease...
  61. ncbi request reprint Depressive symptoms and white matter changes in patients with dementia
    Karin Lind
    Institute of Clinical Neuroscience, Goteborg University, Sweden
    Int J Geriatr Psychiatry 21:119-25. 2006
    ..The aim of the present study was to investigate if depressive symptoms in demented patients are associated with white matter changes (WMCs) in the brain...
  62. ncbi request reprint Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease
    Kina Höglund
    Institute of Clinical Neuroscience, Section of Experimental Neurochemistry, Goteborg University, Neurolabb, SU Mölndal, 43180, Molndal, Sweden
    Exp Brain Res 164:205-14. 2005
    ..We also believe that the pleiotropic effects of statins should be investigated further in order to elucidate the connection between Alzheimer's disease and statin treatment...
  63. doi request reprint Subcortical vascular dementia biomarker pattern in mild cognitive impairment
    Maria Bjerke
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 28:348-56. 2009
    ..Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies...
  64. ncbi request reprint The exfoliation syndrome in cognitive impairment of cerebrovascular or Alzheimer's type
    E Linner
    Department of Ophthalmology, Goteborg University, Goteborg, Sweden
    Acta Ophthalmol Scand 79:283-5. 2001
    ..These results suggested that lesions related to the exfoliative process might be located also in the brain of patients suffering from dementia and cognitive impairment...
  65. pmc The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition
    A Nordlund
    Sahlgrenska Academy, Institute of Clinical Neuroscience, Goteborg University, Sweden
    J Neurol Neurosurg Psychiatry 76:1485-90. 2005
    ..Recently other cognitive deficits have been reported. This has led to a modification of MCI criteria...
  66. ncbi request reprint Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype
    M Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, Sweden
    J Neural Transm 108:451-8. 2001
    ..The results primarily suggest a faster rate of decline in the ApoE4 AD compared to the ApoE2-3, but may also reflect that ApoE epsilon4 genotype inheritance is a negative predictor of treatment effect of tacrine in AD patients...
  67. pmc No neurochemical evidence for brain injury caused by heading in soccer
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Br J Sports Med 41:574-7. 2007
    ..The possible injurious effect to the brain of heading in soccer is a matter of discussion...
  68. ncbi request reprint Cystatin C in cerebrospinal fluid and multiple sclerosis
    Sara F Hansson
    Department of Clinical Neuroscience, University of Goteborg, Sahlgrenska University Hospital Molndal, Molndal, Sweden
    Ann Neurol 62:193-6; discussion 205. 2007
    ..A recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5 kDa truncated isoform of cystatin C (CysC) as a specific biomarker for multiple sclerosis (MS)...
  69. doi request reprint Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis
    N Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Mult Scler 15:448-54. 2009
    ..Cell and animal experiments have shown that beta-site APP-cleaving enzyme 1 (BACE1) may be involved in myelination...
  70. ncbi request reprint Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80 Molndal, Sweden
    Dement Geriatr Cogn Disord 16:25-30. 2003
    ..The ADAS-cog score was slightly increased (p < 0.05). The results suggest that simvastatin acts directly on the processing of APP by inhibiting both the alpha- and the beta-secretase pathways...
  71. doi request reprint Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Mech Ageing Dev 131:105-10. 2010
    ..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset...
  72. ncbi request reprint Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
    Elisabeth Tarkowski
    Department of Rheumatology, University of Goteborg, Goteborg, Sweden
    Neurobiol Aging 23:237-43. 2002
    ..In addition, we show in AD and VAD an intrathecal production of TGF-beta, a cytokine exerting on one hand anti-inflammatory and angiogenic properties, but on the other promoting amyloidogenesis...
  73. ncbi request reprint Calcitonin gene-related peptide and calcitonin in the CSF of patients with dementia and depression: possible disease markers
    Aleksander A Mathe
    Institution of Clinical Neuroscience, Karolinska Institutet, St Goran s Hospital, Stockholm, Sweden
    Prog Neuropsychopharmacol Biol Psychiatry 26:41-8. 2002
    ..In contrast, in depression, CT-LI but not CGRP-LI was decreased and the CGRP/CT concentration ratio was increased, which is consistent with a possibility of an altered splicing process favoring CGRP mRNA...
  74. ncbi request reprint Potential biological markers for cerebrovascular disease
    Alexander Kurz
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Int Psychogeriatr 15:89-97. 2003
    ..Among biochemical markers in the CSF, tau protein, phospho-tau, and beta amyloid protein are helpful to differentiate vascular dementia from Alzheimer's disease...
  75. ncbi request reprint Amino-truncated beta-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment
    Hugo Vanderstichele
    Innogenetics NV, Gent, Belgium
    Clin Chem 51:1650-60. 2005
    ..We evaluated whether different beta-amyloid(42) (Abeta42) peptides can add further information to the combined use of tau and Abeta1-42 for predicting risk of progression of MCI to AD...
  76. ncbi request reprint Subcortical ischaemic vascular dementia
    Gustavo C Roman
    University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
    Lancet Neurol 1:426-36. 2002
    ..Treatment is symptomatic and prevention requires control of treatable risk factors...
  77. pmc Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
    Igor Klyubin
    Institute of Neuroscience and Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland
    J Neurosci 28:4231-7. 2008
    ..Abeta monomer isolated from human CSF did not affect long-term potentiation. These results strongly support a strategy of passive immunization against soluble Abeta oligomers in early Alzheimer's disease...
  78. ncbi request reprint Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment
    Zhenyu Zhong
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA
    Arch Gen Psychiatry 64:718-26. 2007
    ..The possible presence of BACE1 in the CSF of patients with AD and MCI has so far gone unreported...
  79. ncbi request reprint Cross-national comparisons of the Cambridge Cognitive Examination-revised: the CAMCOG-R: results from the European Harmonization Project for Instruments in Dementia
    Frans R J Verhey
    Institute Brain and Behaviour, University Hospital of Maastricht, The Netherlands
    Age Ageing 32:534-40. 2003
    ....
  80. ncbi request reprint Cross-national comparison and validation of the Alzheimer's Disease Assessment Scale: results from the European Harmonization Project for Instruments in Dementia (EURO-HARPID)
    Frans R Verhey
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 19:41-50. 2004
    ..The Alzheimer's Disease Assessment Scale (ADAS) is often used in international multicenter trials. Use across countries presupposes correct translation and adaptation of the scale, and maintenance of its psychometric properties...
  81. pmc Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study
    Ana Verdelho
    Neurology Department, Centro de Estudos Egas Moniz, Santa Maria Hospital, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 78:1325-30. 2007
    ..Our aim was to study the influence of vascular risk factors and ARWMC on the neuropsychological performance of an independent elderly population, to see if vascular risk factors impair cognition in addition to the effects of ARWMC...
  82. doi request reprint Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
    Michael Ewers
    Department of Psychiatry, Alzheimer Memorial Center, Ludwig Maximilian University, Munich, Germany
    Brain 131:1252-8. 2008
    ..The assessment of BACE 1 in CSF may provide a sensitive measure to detect in vivo alterations in the amyloidogenic processing potentially modified by the ApoE genotype...
  83. ncbi request reprint White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:834-41. 2006
    ..This study investigates the relationship between location and burden of WMH and lacunes on depressive features in older people...
  84. doi request reprint Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  85. ncbi request reprint Donepezil in Alzheimer's disease: what to expect after 3 years of treatment in a routine clinical setting
    Asa K Wallin
    Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, Malmo, Sweden
    Dement Geriatr Cogn Disord 23:150-60. 2007
    ..Clinical short-term trails have shown positive effects of donepezil treatment in patients with Alzheimer's disease. The outcome of continuous long-term treatment in the routine clinical settings remains to be investigated...
  86. ncbi request reprint Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
    ..Little solid information is available on the possible risks for neuronal injury in amateur boxing...
  87. ncbi request reprint Development of a neuropsychological battery for the Leukoaraiosis and Disability in the Elderly Study (LADIS): experience and baseline data
    Sofia Madureira
    Servico de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
    Neuroepidemiology 27:101-16. 2006
    ..In the LADIS population baseline data, older age and lower educational levels negatively influence neuropsychological performance...
  88. ncbi request reprint Cerebral pattern of pro- and anti-inflammatory cytokines in dementias
    Elisabeth Tarkowski
    Department of Rheumatology, Section of Neurology and Neurochemistry, University of Goteborg, S 413 46 Goteborg, Sweden
    Brain Res Bull 61:255-60. 2003
    ..Our results, which show for the first time strikingly increased CSF levels of TNF-alpha but not of TNF-beta, IL-1beta or IL-6 in AD and VAD, may form a conceptual framework for further studies of neuroprotective mechanisms in dementias...
  89. ncbi request reprint [Guidelines for brain concussion in sports--how are they to be applied in boxing?]
    Henrik Zetterberg
    Lakartidningen 104:1715; author reply 1715-6. 2007
  90. ncbi request reprint Daytime changes in postural stability and repeatability of posturographic measurements
    Pia Forsman
    Finnish Institute of Occupational Health, Helsinki, Finland
    J Occup Environ Med 49:591-6. 2007
    ..The effect of daytime on balance, on posturographic measurements, and on their repeatability was investigated in 30 healthy volunteers as part of our work to develop such a test...
  91. ncbi request reprint Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Anna Maria Basile
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, Hopital Lariboisiere, Paris, France
    Cerebrovasc Dis 21:315-22. 2006
    ..We sought whether such a trend existed in the association of vascular risk factors or comorbidities with the severity of ARWMC aiming particularly at further elucidating the relative roles of hypertension and stroke in this regard...
  92. ncbi request reprint Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
    ..The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the elderly population...
  93. ncbi request reprint Posturographic sleepiness monitoring
    Pia Forsman
    Finnish Institute of Occupational Health, Helsinki, Finland
    J Sleep Res 16:259-61. 2007
    ..These results encourage further work developing posturographic sleepiness monitoring...
  94. ncbi request reprint Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study
    Mani S Krishnan
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 21:983-9. 2006
    ..However, it remains controversial as to whether PVL, DWML, or both are most strongly associated with depression and this was the aim of the current study...
  95. ncbi request reprint White matter hyperintensities and depression--preliminary results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:674-9. 2005
    ..White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood...
  96. doi request reprint Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  97. ncbi request reprint Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
    ..To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients...
  98. ncbi request reprint Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia
    Gustavo C Roman
    Department of Medicine Neurology, University of Texas HSC at San Antonio and the Audie Murphy Veterans Administration Hospital, Mail Code 7883, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Neurol Sci 226:81-7. 2004
    ..It would include specific disease entities such as post-stroke VCI, post-stroke VaD, CADASIL, Binswanger disease, and AD plus CVD. This category explicitly excludes isolated cognitive dysfunctions such as those mentioned above...
  99. ncbi request reprint Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Neuroepidemiology 24:51-62. 2005
    ..The study results may also help to standardize, on an international basis, tools and criteria to identify early stages of disability...
  100. ncbi request reprint National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards
    Vladimir Hachinski
    London Health Sciences Centre, University Campus, London, Ontario, Canada
    Stroke 37:2220-41. 2006
    ....
  101. ncbi request reprint Alzheimer disease ethics--informed consent and related issues in clinical trials: results of a survey among the members of the Research Ethics Committees in Sweden
    Gunbrith Peterson
    Janssen Cilag AB, Sollentuna, Sweden
    Int Psychogeriatr 15:157-70. 2003
    ..However, women and laypersons were in general keener to preserve the patient's integrity and the experts were more willing than the laypersons to allow participation of subjects with dementia in placebo-controlled trials...