Olle Lindvall

Summary

Affiliation: Wallenberg Neuroscience Center
Country: Sweden

Publications

  1. ncbi request reprint Cell therapy and transplantation in Parkinson's disease
    O Lindvall
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Clin Chem Lab Med 39:356-61. 2001
  2. ncbi request reprint Stem cell therapy for human neurodegenerative disorders-how to make it work
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Department of Clinical Neuroscience, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Nat Med 10:S42-50. 2004
  3. ncbi request reprint Recovery and rehabilitation in stroke: stem cells
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital BMC A 11, Lund, Sweden
    Stroke 35:2691-4. 2004
  4. pmc Cell therapy in Parkinson's disease
    Olle Lindvall
    Wallenberg Neuroscience Center and Lund Strategic Center for Stem Cell Biology and Cell Therapy, BMC A11, SE 221 84 Lund, Sweden
    NeuroRx 1:382-93. 2004
  5. ncbi request reprint Role of cell therapy in Parkinson disease
    Olle Lindvall
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Neurosurg Focus 13:e2. 2002
  6. ncbi request reprint Stem cells for cell therapy in Parkinson's disease
    Olle Lindvall
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Pharmacol Res 47:279-87. 2003
  7. doi request reprint Inflammation regulates functional integration of neurons born in adult brain
    Katherine Jakubs
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 28:12477-88. 2008
  8. ncbi request reprint Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke
    Elin Gustafsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University of Lund, BMC A 11 SE 221 84 Lund, Sweden
    Eur J Neurosci 17:2667-78. 2003
  9. ncbi request reprint Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Stroke 38:3032-9. 2007
  10. doi request reprint Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center A11, University Hospital, Lund, Sweden
    Glia 57:835-49. 2009

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Cell therapy and transplantation in Parkinson's disease
    O Lindvall
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Clin Chem Lab Med 39:356-61. 2001
    ..The possibility to generate dopamine neurons from such cells is now being explored using different approaches. However, so far the generated neurons have survived poorly after transplantation in animals...
  2. ncbi request reprint Stem cell therapy for human neurodegenerative disorders-how to make it work
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Department of Clinical Neuroscience, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Nat Med 10:S42-50. 2004
    ....
  3. ncbi request reprint Recovery and rehabilitation in stroke: stem cells
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital BMC A 11, Lund, Sweden
    Stroke 35:2691-4. 2004
    ..In this review we propose a road map to the clinic and describe the different scientific tasks that need to be accomplished to move stem cell-based approaches toward application in stroke patients...
  4. pmc Cell therapy in Parkinson's disease
    Olle Lindvall
    Wallenberg Neuroscience Center and Lund Strategic Center for Stem Cell Biology and Cell Therapy, BMC A11, SE 221 84 Lund, Sweden
    NeuroRx 1:382-93. 2004
    ..The stem cell technology may provide a virtually unlimited source of DA neurons, but several scientific issues need to be addressed before stem cell-based therapies can be tested in PD patients...
  5. ncbi request reprint Role of cell therapy in Parkinson disease
    Olle Lindvall
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Neurosurg Focus 13:e2. 2002
    ..Several scientific issues need to be addressed before stem cell-based therapies can be tested in PD patients...
  6. ncbi request reprint Stem cells for cell therapy in Parkinson's disease
    Olle Lindvall
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Pharmacol Res 47:279-87. 2003
    ..Several scientific issues need to be addressed before stem cell-based therapies can be tested in PD patients...
  7. doi request reprint Inflammation regulates functional integration of neurons born in adult brain
    Katherine Jakubs
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 28:12477-88. 2008
    ....
  8. ncbi request reprint Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke
    Elin Gustafsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University of Lund, BMC A 11 SE 221 84 Lund, Sweden
    Eur J Neurosci 17:2667-78. 2003
    ..Concomitantly, brain-derived neurotrophic factor potentiates the stroke-induced neurogenic response, at least at early stages...
  9. ncbi request reprint Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Stroke 38:3032-9. 2007
    ..We explored whether MCAO leads to hypoxia, changes in vessel density, and angiogenesis in the ipsilateral SVZ and adjacent striatum, and determined the relation between the migrating neuroblasts and the vasculature...
  10. doi request reprint Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center A11, University Hospital, Lund, Sweden
    Glia 57:835-49. 2009
    ..The long-term accumulation of microglia with proneurogenic phenotype in the SVZ implies a supportive role of these cells for the continuous neurogenesis after stroke...
  11. ncbi request reprint Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability
    Katherine Jakubs
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Neuron 52:1047-59. 2006
    ..We demonstrate a high degree of plasticity in synaptic inputs to adult-born new neurons, which could act to mitigate pathological brain function...
  12. ncbi request reprint Quantitative analysis of the generation of different striatal neuronal subtypes in the adult brain following excitotoxic injury
    Tove Collin
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 195:71-80. 2005
    ..Our data show for the first time that an excitotoxic lesion to the striatum can trigger the formation of new striatal neurons with phenotypes of both projection neurons and interneurons...
  13. ncbi request reprint Long-term neuronal replacement in adult rat hippocampus after status epilepticus despite chronic inflammation
    Sara Bonde
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84, Lund, Sweden
    Eur J Neurosci 23:965-74. 2006
    ....
  14. doi request reprint Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
    Agnete Kirkeby
    Department of Experimental Medical Science, Lund University, SE 221 84 Lund, Sweden
    Cell Rep 1:703-14. 2012
    ..VM-patterned but not forebrain-patterned neurons released dopamine and reversed motor deficits in an animal model of Parkinson's disease...
  15. ncbi request reprint Status epilepticus severity influences the long-term outcome of neurogenesis in the adult dentate gyrus
    Paul Mohapel
    Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Neurobiol Dis 15:196-205. 2004
    ....
  16. ncbi request reprint Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11 SE 221 84, Lund, Sweden
    Neurobiol Dis 14:542-56. 2003
    ..Our findings also underscore the need for quantitative assessment of long-term neuronal survival and behavioral changes to evaluate the therapeutic potential of factors such as GDNF...
  17. ncbi request reprint Stroke-induced neurogenesis in aged brain
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology, University Hospital, The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden
    Stroke 36:1790-5. 2005
    ..We explored whether stroke influences neurogenesis similarly in the aged brain...
  18. doi request reprint Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1
    Robert E Iosif
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 28:1574-87. 2008
    ..Our results provide the first evidence that TNF-R1 is a negative regulator of stroke-induced SVZ progenitor proliferation. Blockade of TNF-R1 signaling might be a novel strategy to promote the proliferative response in SVZ after stroke...
  19. ncbi request reprint Human fetal cortical and striatal neural stem cells generate region-specific neurons in vitro and differentiate extensively to neurons after intrastriatal transplantation in neonatal rats
    Therése Kallur
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, Lund, Sweden
    J Neurosci Res 84:1630-44. 2006
    ..Our data show that NSCs derived from human fetal cortex and striatum exhibit region-specific differentiation in vitro, and survive, migrate, and form mature neurons to the same extent after intrastriatal transplantation in newborn rats...
  20. ncbi request reprint Persistent production of neurons from adult brain stem cells during recovery after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Stem Cells 24:739-47. 2006
    ..These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke...
  21. doi request reprint Adaptor protein LNK is a negative regulator of brain neural stem cell proliferation after stroke
    Henrik Ahlenius
    Laboratory of Neural Stem Cell Biology and Therapy, Lund University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 32:5151-64. 2012
    ..Our findings identify LNK as a stroke-specific, endogenous negative regulator of NSPC proliferation, and suggest that LNK signaling is a novel mechanism influencing plastic responses in postischemic brain...
  22. ncbi request reprint Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats
    Tohru Kobayashi
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Stroke 37:2361-7. 2006
    ..We explored whether intrastriatal infusion of glial cell line-derived neurotrophic factor (GDNF) promotes neurogenesis after stroke...
  23. doi request reprint Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Mov Disord 25:1091-6. 2010
    ..Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra...
  24. ncbi request reprint Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor
    Young Hwan Ahn
    Wallenberg Neuroscience Center, Section for Neuronal Survival, BMC A10, SE 221 84 Lund, Sweden
    Brain Res Bull 66:135-42. 2005
    ..We suggest that continuous and safe delivery of GDNF to the brain could be a potential way to optimize neural transplantation as a therapy for Parkinson's disease...
  25. ncbi request reprint Regulation of stroke-induced neurogenesis in adult brain--recent scientific progress
    Zaal Kokaia
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, SE 221 84 Lund, Sweden
    Cereb Cortex 16:i162-7. 2006
    ..We also discuss some crucial issues that need to be addressed in the further exploration of this potential self-repair mechanism after damage to the adult brain...
  26. ncbi request reprint TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain
    Ursula Heldmann
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Exp Neurol 196:204-8. 2005
    ..The present findings suggest that TNF-alpha, probably acting via its receptor TNFR2, can promote the survival of stroke-generated hippocampal and striatal neurons...
  27. ncbi request reprint Intraventricular infusion of TrkB-Fc fusion protein promotes ischemia-induced neurogenesis in adult rat dentate gyrus
    Elin Gustafsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Stroke 34:2710-5. 2003
    ..Here, we investigated whether inhibition of endogenous BDNF alters ischemia-induced neurogenesis in the dentate gyrus...
  28. ncbi request reprint Death mechanisms in status epilepticus-generated neurons and effects of additional seizures on their survival
    Christine T Ekdahl
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, SE 221 84 Lund, Sweden
    Neurobiol Dis 14:513-23. 2003
    ..We propose that the degree of survival of newly generated neurons is determined primarily by the initial SE insult and the ensuing pathology in the tissue environment, whereas spontaneous seizures play a minor role...
  29. ncbi request reprint Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor
    Elin Larsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, BMC A 11 SE 221 84, Lund, Sweden
    Exp Neurol 177:1-8. 2002
    ..Our data indicate that long-term delivery of a neurotrophic factor, which is considered as a novel neuroprotective strategy for human brain diseases, may attenuate intrinsic neuroregenerative responses...
  30. doi request reprint Functional properties of the human ventral mesencephalic neural stem cell line hVM1
    Jan Tønnesen
    Experimental Epilepsy Group, Wallenberg Neuroscience Center, Lund University Hospital, 221 84, Lund, Sweden
    Exp Neurol 223:653-6. 2010
    ..However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions...
  31. ncbi request reprint Suppressed kindling epileptogenesis and perturbed BDNF and TrkB gene regulation in NT-3 mutant mice
    E Elmer
    Department of Clinical Neuroscience, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Exp Neurol 145:93-103. 1997
    ..These results indicate that endogenous NT-3 levels can influence the rate of epileptogenesis, and suggest a link between NT-3 and BDNF gene regulation in dentate granule cells...
  32. doi request reprint Pax6 promotes neurogenesis in human neural stem cells
    Therése Kallur
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, Lund, Sweden
    Mol Cell Neurosci 38:616-28. 2008
    ..Also, that Pax6 overexpression in striatal NSCs increases the number of neurons but their region-specificity is maintained...
  33. doi request reprint Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone
    Alexandre I Danilov
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Glia 57:136-52. 2009
    ..Our findings indicate that the NSCs in adult rat SVZ give rise directly to neuroblasts. During mitosis, the NSCs disassemble the primary cilium and symmetrically distribute EGFR and PDGFRalpha among their progeny...
  34. doi request reprint Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain
    Henrik Ahlenius
    Laboratory of Neural Stem Cell Biology, Experimental Epilepsy Group, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 29:4408-19. 2009
    ..These properties are of major importance when considering therapeutic applications of neuronal replacement from endogenous NSCs in the injured, aged brain...
  35. doi request reprint Research in motion: the enigma of Parkinson's disease pathology spread
    Patrik Brundin
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, SE 221 84 Lund, Sweden
    Nat Rev Neurosci 9:741-5. 2008
    ..We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease...
  36. doi request reprint Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats
    Yutaka Mine
    Laboratory of Stem Cells and Restorative Neurology, University Hospital, SE 221 84 Lund, Sweden
    Neurobiol Dis 52:191-203. 2013
    ..Our findings support the idea that combination of NSPC transplantation and stimulation of neurogenesis from endogenous NSPCs may become a valuable strategy for functional restoration after stroke...
  37. ncbi request reprint Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts
    Andreas Toft Sørensen
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A 11, Lund University, Lund, Sweden
    Eur J Neurosci 21:2793-9. 2005
    ..Our findings define specific electrophysiological characteristics of transplanted fetal dopaminergic neurons, and we provide the first direct evidence of functional synaptic integration of these neurons into host neural circuitries...
  38. pmc Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult
    Johanna Jackson
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, Lund, Sweden
    PLoS ONE 7:e35557. 2012
    ....
  39. pmc Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model
    Jan Tønnesen
    Experimental Epilepsy Group, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    PLoS ONE 6:e17560. 2011
    ....
  40. doi request reprint Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke
    Ursula Heldmann
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center A11, University Hospital, SE 221 84 Lund, Sweden
    Exp Neurol 229:391-8. 2011
    ..These findings indicate that the Mac-1-expressing microglia in the SVZ do not play a major role either for the number of neuroblasts which exit the SVZ or their migration in the striatum early following stroke...
  41. ncbi request reprint Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis
    Robert E Iosif
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 26:9703-12. 2006
    ....
  42. ncbi request reprint Endogenous neurotrophin-3 regulates short-term plasticity at lateral perforant path-granule cell synapses
    M Kokaia
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85 Lund, Sweden
    J Neurosci 18:8730-9. 1998
    ..Because NT-3 expression is reduced after focal seizures, impaired short-term facilitation may represent a protective response that limits the propagation of epileptiform activity from the entorhinal cortex to the hippocampus...
  43. doi request reprint Embryonic stem cell-derived neural stem cells fuse with microglia and mature neurons
    Carlo Cusulin
    Laboratory of Stem Cells and Restorative Neurology, Department of Laboratory Medicine, University Hospital, SE 22184 Lund, Sweden
    Stem Cells 30:2657-71. 2012
    ..It remains to be elucidated how the occurrence of the fused cells will influence the functional outcome after NSC transplantation in the diseased brain...
  44. doi request reprint Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain
    Koichi Oki
    Laboratory of Neural Stem Cell Biology and Therapy, University Hospital, Lund, Sweden
    Stem Cells 30:1120-33. 2012
    ..Our study provides the first evidence that transplantation of human iPSC-derived cells is a safe and efficient approach to promote recovery after stroke and can be used to supply the injured brain with new neurons for replacement...
  45. pmc Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis
    Zhaolu Wang
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, Lund, Sweden
    J Cereb Blood Flow Metab 32:387-98. 2012
    ..Our findings identify METRN as a new factor promoting neurogenesis both in vitro and in vivo by multiple mechanisms. Further work will be needed to translate METRN's actions on endogenous neurogenesis into improved recovery after stroke...
  46. pmc Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology and Therapy, University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 31:235-42. 2011
    ..These findings, therefore, have direct clinical implications...
  47. doi request reprint Functional integration of new hippocampal neurons following insults to the adult brain is determined by characteristics of pathological environment
    James C Wood
    Laboratory of Neurogenesis and Cell Therapy, Lund University Hospital, SE 221 84 Lund, Sweden
    Exp Neurol 229:484-93. 2011
    ..This study provides further evidence that following insults to the adult brain, the pattern of synaptic alterations at afferent inputs to newly generated neurons is dependent on the characteristics of the pathological environment...
  48. pmc Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2
    A Nanobashvili
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 97:12312-7. 2000
    ..Our data suggest that GDNF and NRTN may modulate seizure susceptibility by altering the function of hilar neuropeptide Y-containing interneurons and entorhinal cortical afferents at dentate granule cell synapses...
  49. ncbi request reprint Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling
    I Ferencz
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Neuroscience 80:389-99. 1997
    ....
  50. doi request reprint Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery
    Daniel Tornero
    1 Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Centre, University Hospital, SE 221 84 Lund, Sweden
    Brain 136:3561-77. 2013
    ....
  51. ncbi request reprint Neurogenesis after ischaemic brain insults
    Zaal Kokaia
    Section of Restorative Neurology, Wallenberg Neuroscience Centre, University Hospital, BMC A 11 SE 221 84, Lund, Sweden
    Curr Opin Neurobiol 13:127-32. 2003
    ..Some evidence indicates that these neurons can re-establish connections and contribute to functional recovery...
  52. ncbi request reprint Upregulation of p75 neurotrophin receptor after stroke in mice does not contribute to differential vulnerability of striatal neurons
    G Andsberg
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 85 Lund, Sweden
    Exp Neurol 169:351-63. 2001
    ..These quantitative data demonstrate that striatal neurons in the mouse are differentially susceptible to ischemic damage and argue against a significant role of p75(NTR) for the high resistance of cholinergic interneurons...
  53. doi request reprint Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Nat Med 14:501-3. 2008
    ..However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief...
  54. doi request reprint Efficient induction of functional neurons from adult human fibroblasts
    Ulrich Pfisterer
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Cell Cycle 10:3311-6. 2011
    ..Thus, this technology is an attractive alternative to iPS cells for generating patient- and disease-specific neurons suitable for disease modeling and autologous transplantation...
  55. pmc Stem cells in human neurodegenerative disorders--time for clinical translation?
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    J Clin Invest 120:29-40. 2010
    ..In particular, we need to better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment...
  56. pmc Direct conversion of human fibroblasts to dopaminergic neurons
    Ulrich Pfisterer
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, SE 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 108:10343-8. 2011
    ..Such subtype-specific induced neurons derived from human somatic cells could be valuable for disease modeling and cell replacement therapy...
  57. ncbi request reprint Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus
    Christine T Ekdahl
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, 221 84 Lund, Sweden
    Eur J Neurosci 16:1463-71. 2002
    ..Our data indicate that caspase-mediated cell death pathways are active in progenitor cell progeny generated by status epilepticus and compromise survival during neuronal differentiation...
  58. ncbi request reprint Dyskinesias following neural transplantation in Parkinson's disease
    Peter Hagell
    Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Nat Neurosci 5:627-8. 2002
    ....
  59. ncbi request reprint Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
    ..If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans...
  60. pmc Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma
    O Lindvall
    Department of Neurology, University Hospital, Lund, Sweden
    Proc Natl Acad Sci U S A 89:648-52. 1992
    ..If the changes of mRNA expression lead to alterations in the relative availability of neurotrophic factors, this could influence functional outcome and neuronal necrosis following ischemic and hypoglycemic insults...
  61. doi request reprint FoxJ1-expressing cells contribute to neurogenesis in forebrain of adult rats: evidence from in vivo electroporation combined with piggyBac transposon
    Karthikeyan Devaraju
    Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, SE 221 84 Lund, Sweden
    Exp Cell Res 319:2790-800. 2013
    ..These data indicate that in the adult rat brain, FoxJ1-expressing cells contribute to the formation of new neurons in the olfactory bulb but are not involved in the cellular repair after stroke. ..
  62. doi request reprint Stem cell repair of striatal ischemia
    Zaal Kokaia
    Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden
    Prog Brain Res 201:35-53. 2012
    ..Joint efforts of basic researchers and clinicians are needed to develop safe and reproducible NSPC sources, test them in relevant animal models of stroke, and optimize the recovery of impaired functions...
  63. doi request reprint Clinical translation of stem cells in neurodegenerative disorders
    Olle Lindvall
    Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Cell Stem Cell 10:151-5. 2012
    ..We discuss here the challenges and potential for the translation of stem-cell-based approaches into treatments for Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis...
  64. pmc Inflammation is detrimental for neurogenesis in adult brain
    Christine T Ekdahl
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Biomedical Center A 11, Lund, Sweden
    Proc Natl Acad Sci U S A 100:13632-7. 2003
    ..Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation...
  65. doi request reprint Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Trends Pharmacol Sci 30:260-7. 2009
    ....
  66. ncbi request reprint Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning
    Paul Mohapel
    Section of Restorative Neurology, Wallenberg Neuroscience Centre, BMC A11, SE 221 84 Lund, Sweden
    Neurobiol Aging 26:939-46. 2005
    ....
  67. ncbi request reprint Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus
    C T Ekdahl
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, SE-221 84 Lund, Sweden
    Eur J Neurosci 14:937-45. 2001
    ..Furthermore, although previous studies have indicated that increased neuronal death can trigger neurogenesis, we show here that reduction in apoptotic death may be associated with increased neurogenesis...
  68. ncbi request reprint Suppressed epileptogenesis in BDNF mutant mice
    M Kokaia
    Department of Neurology, University Hospital, Lund, Sweden
    Exp Neurol 133:215-24. 1995
    ..These results show that BDNF plays an important role in establishing hyperexcitability during epileptogenesis, probably by increasing efficacy in stimulated synapses...
  69. doi request reprint Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease
    Zuzanna Kurowska
    Wallenberg Neuroscience Center, Lund
    J Parkinsons Dis 1:83-92. 2011
    ..2% of them contain Lewy bodies. In conclusion, our results show that grafted dopaminergic neurons can survive for more than two decades. However, over time an increasing proportion of grafted neurons exhibit signs of degeneration. ..
  70. doi request reprint Societal value of stem cell therapy in stroke--a modeling study
    Johanna Svensson
    The Swedish Institute for Health Economics IHE, Lund, Sweden
    Cerebrovasc Dis 33:532-9. 2012
    ..Stem cell therapy (SCT) may promote functional recovery also in stroke patients, thereby improving quality of life and reducing costs. Our aim was to estimate the potential societal value of SCT in stroke patients...
  71. doi request reprint Why is it taking so long to develop clinically competitive stem cell therapies for CNS disorders?
    Olle Lindvall
    Lund Stem Cell Center, University Hospital, SE 221 84 Lund, Sweden
    Cell Stem Cell 10:660-2. 2012
    ..Here I discuss some of the underlying problems and how they could be overcome...
  72. doi request reprint Stem cell research in stroke: how far from the clinic?
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital, SE 221 84, Lund, Sweden
    Stroke 42:2369-75. 2011
    ..Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke...
  73. ncbi request reprint Stem cell therapy for human brain disorders
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Kidney Int 68:1937-9. 2005
    ....
  74. ncbi request reprint Stereological assessment of vulnerability of immunocytochemically identified striatal and hippocampal neurons after global cerebral ischemia in rats
    E Larsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, University Hospital, SE 221 84, Lund, Sweden
    Brain Res 913:117-32. 2001
    ....
  75. ncbi request reprint Stroke induces widespread changes of gene expression for glial cell line-derived neurotrophic factor family receptors in the adult rat brain
    A Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, University Hospital, SE 221 84 Lund, Sweden
    Neuroscience 106:27-41. 2001
    ..These changes could enhance neuroprotective and neuroregenerative responses both to endogenous and exogenous GDNF ligands...
  76. ncbi request reprint N-methyl-D-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke
    A Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, University Hospital, SE 221 84, Lund, Sweden
    Eur J Neurosci 14:10-8. 2001
    ..This modulatory effect may be mediated through changes in the levels of several growth factors, which occur after stroke, and could influence various regulatory steps of neurogenesis...
  77. ncbi request reprint Delayed kindling development after rapidly recurring seizures: relation to mossy fiber sprouting and neurotrophin, GAP-43 and dynorphin gene expression
    E Elmer
    Department of Neurology, University Hospital, Lund, Sweden
    Brain Res 712:19-34. 1996
    ....
  78. ncbi request reprint Protective effect of platelet-derived growth factor against 6-hydroxydopamine-induced lesion of rat dopaminergic neurons in culture
    K Pietz
    Restorative Neurology Unit, Department of Neurology, University Hospital, Sweden
    Neurosci Lett 204:101-4. 1996
    ..We conclude that PDGF-BB can counteract 6-OHDA-induced degeneration of mesencephalic DA neurons...
  79. pmc Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures
    J Bengzon
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 94:10432-7. 1997
    ..We hypothesize that these processes, occurring early during epileptogenesis, are primary events in the development of hippocampal pathology in animals and possibly also in patients suffering from temporal lobe epilepsy...
  80. ncbi request reprint Increased synaptic inhibition in dentate gyrus of mice with reduced levels of endogenous brain-derived neurotrophic factor
    K Olofsdotter
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85, Lund, Sweden
    Neuroscience 101:531-9. 2000
    ..This will have consequences for the recruitment of hippocampal neural circuitries both under physiological and pathological conditions, such as epileptogenesis...
  81. ncbi request reprint Basal forebrain neurons suppress amygdala kindling via cortical but not hippocampal cholinergic projections in rats
    I Ferencz
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85 Lund, Sweden
    Eur J Neurosci 12:2107-16. 2000
    ..These data indicate that basal forebrain cholinergic neurons suppress kindling elicited from amygdala, and that this dampening effect is mediated via cortical but not hippocampal projections...
  82. ncbi request reprint Afferent-specific modulation of short-term synaptic plasticity by neurotrophins in dentate gyrus
    F Asztely
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85 Lund, Sweden
    Eur J Neurosci 12:662-9. 2000
    ..Our data suggest that BDNF and NT-3 differentially regulate the synaptic impact of different afferent inputs onto single target neurons in the CNS...
  83. ncbi request reprint GDNF family ligands and receptors are differentially regulated after brain insults in the rat
    Z Kokaia
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Eur J Neurosci 11:1202-16. 1999
    ..g. those underlying the development of epileptic syndromes...
  84. ncbi request reprint Epileptogenesis induced by rapidly recurring seizures in genetically fast- but not slow-kindling rats
    E Elmer
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Brain Res 789:111-7. 1998
    ..We hypothesize that long seizure episodes may be necessary to trigger the cascade of gene changes regulating the development of epilepsy...
  85. ncbi request reprint Suppression of kindling epileptogenesis in rats by intrahippocampal cholinergic grafts
    I Ferencz
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Eur J Neurosci 10:213-20. 1998
    ..These results provide further evidence that the intrinsic basal forebrain cholinergic system dampens kindling epileptogenesis and demonstrate that this function can be exerted also by grafted cholinergic neurones...
  86. ncbi request reprint Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons
    I Ferencz
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85, Lund, Sweden
    Neuroscience 102:819-32. 2001
    ..This shows that, depending on the location of the primary epileptic focus, i.e. the site of stimulation, basal forebrain cholinergic neurons operate through different subsystems to counteract seizure development in kindling...
  87. pmc Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
    M Kokaia
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 98:14006-11. 2001
    ..These data provide evidence that ectopically overexpressed galanin can be released and dampen the development of epilepsy by means of receptor-mediated action, at least partly by reducing glutamate release from mossy fibers...
  88. ncbi request reprint Generalization of rapidly recurring seizures is suppressed in mice lacking glial cell line-derived neurotrophic factor family receptor alpha2
    A Nanobashvili
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A 11, University Hospital, SE 221 84 Lund, Sweden
    Neuroscience 118:845-52. 2003
    ..Our findings provide evidence that signaling through the GFRalpha2 receptor contributes to seizure generalization in rapid kindling...
  89. ncbi request reprint Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition
    J Bengzon
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, S 221 85 Lund, Sweden
    Eur J Neurosci 11:916-22. 1999
    ..The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor subunit composition determines the progression of experimental epilepsy...
  90. doi request reprint Cross-talk between neural stem cells and immune cells: the key to better brain repair?
    Zaal Kokaia
    Lund Stem Cell Center, University Hospital, Lund, Sweden
    Nat Neurosci 15:1078-87. 2012
    ..Better understanding of the dialog between NSPCs and innate and adaptive immune cells is crucial for further development of effective strategies for CNS repair...
  91. pmc Cell therapeutics in Parkinson's disease
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital, SE 22184 Lund, Sweden
    Neurotherapeutics 8:539-48. 2011
    ..Finally, we discuss the scientific and clinical advancements that will be necessary to develop a competitive cell therapy for PD patients...
  92. ncbi request reprint Stem cells for the treatment of neurological disorders
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Nature 441:1094-6. 2006
    ..The next step is to translate these exciting advances from the laboratory into clinically useful therapies...
  93. ncbi request reprint Generation of human cortical neurons from a new immortal fetal neural stem cell line
    E Cacci
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, BMC B10, Klinikgatan 26, University Hospital, SE 221 84 Lund, Sweden
    Exp Cell Res 313:588-601. 2007
    ..Taking advantage of its clonality and homogeneity, this cell line will also be a valuable experimental tool to study the regulatory role of intrinsic and extrinsic factors in human NSC biology...
  94. ncbi request reprint Neuronal apoptosis after brief and prolonged seizures
    Johan Bengzon
    Department of Neurosurgery, University Hospital, S 221 85 Lund, Sweden
    Prog Brain Res 135:111-9. 2002
    ....
  95. ncbi request reprint Health status measurement in Parkinson's disease: validity of the PDQ-39 and Nottingham Health Profile
    Peter Hagell
    Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, Lund, Sweden
    Mov Disord 18:773-83. 2003
    ..Although promising, both questionnaires warrant further developmental work and stronger support of measurement validity before they could be considered fully suitable for valid use in PD, in particular in earlier stages of the disease...
  96. pmc Brain repair by cell replacement and regeneration
    Olle Lindvall
    Wallenberg Neuroscience Center, Department of Clinical Neuroscience, University Hospital, Solvegatan 17 BMC A 11, 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 100:7430-1. 2003
  97. ncbi request reprint Encapsulated cell biodelivery of GDNF: a novel clinical strategy for neuroprotection and neuroregeneration in Parkinson's disease?
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84, Lund, Sweden
    Exp Neurol 209:82-8. 2008
    ..Finally, we describe the different scientific and regulatory issues that need to be addressed in order to reach the clinic and start the first trial in patients...
  98. doi request reprint Medical innovation versus stem cell tourism
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, and Lund Stem Cell Center, University Hospital, SE 221 84 Lund, Sweden
    Science 324:1664-5. 2009
    ..Here we discuss these issues and articulate conditions under which "unproven" therapies may be offered to patients outside of regular clinical trials...
  99. ncbi request reprint Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats
    Gunnar Andsberg
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Neurobiol Dis 9:187-204. 2002
    ..We observe that intrastriatal delivery of NGF and BDNF using a viral vector system can mitigate, albeit only moderately, neuronal death following stroke, which leads to detectable functional sparing...
  100. doi request reprint Brain inflammation and adult neurogenesis: the dual role of microglia
    C T Ekdahl
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Neuroscience 158:1021-9. 2009
    ..We conclude that microglia activation, as an indicator of inflammation, is not pro- or antineurogenic per se but the net outcome is dependent on the balance between secreted molecules with pro- and antiinflammatory action...
  101. pmc Use and interpretation of on/off diaries in Parkinson's disease
    J Reimer
    Division of Neurology, Department of Clinical Neuroscience, University Hospital, Lund, Sweden
    J Neurol Neurosurg Psychiatry 75:396-400. 2004
    ..To explore the use and interpretation of self reported on/off diary data for assessment of daily motor fluctuations in Parkinson's disease...