Zaal Kokaia

Summary

Affiliation: Wallenberg Neuroscience Center
Country: Sweden

Publications

  1. ncbi Neurogenesis after ischaemic brain insults
    Zaal Kokaia
    Section of Restorative Neurology, Wallenberg Neuroscience Centre, University Hospital, BMC A 11 SE 221 84, Lund, Sweden
    Curr Opin Neurobiol 13:127-32. 2003
  2. pmc The neuronal ceroid lipofuscinosis Cln8 gene expression is developmentally regulated in mouse brain and up-regulated in the hippocampal kindling model of epilepsy
    Liina Lonka
    Neuroscience Center, University of Helsinki, Finland
    BMC Neurosci 6:27. 2005
  3. doi Inflammation regulates functional integration of neurons born in adult brain
    Katherine Jakubs
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 28:12477-88. 2008
  4. ncbi Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Stroke 38:3032-9. 2007
  5. doi Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center A11, University Hospital, Lund, Sweden
    Glia 57:835-49. 2009
  6. ncbi Quantitative analysis of the generation of different striatal neuronal subtypes in the adult brain following excitotoxic injury
    Tove Collin
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 195:71-80. 2005
  7. ncbi Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, University Hospital BMC B10, Klinikgatan 26, SE 221 84 Lund, Sweden
    Eur J Neurosci 26:605-14. 2007
  8. ncbi Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11 SE 221 84, Lund, Sweden
    Neurobiol Dis 14:542-56. 2003
  9. ncbi Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke
    Elin Gustafsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University of Lund, BMC A 11 SE 221 84 Lund, Sweden
    Eur J Neurosci 17:2667-78. 2003
  10. ncbi Stroke-induced neurogenesis in aged brain
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology, University Hospital, The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden
    Stroke 36:1790-5. 2005

Collaborators

Detail Information

Publications47

  1. ncbi Neurogenesis after ischaemic brain insults
    Zaal Kokaia
    Section of Restorative Neurology, Wallenberg Neuroscience Centre, University Hospital, BMC A 11 SE 221 84, Lund, Sweden
    Curr Opin Neurobiol 13:127-32. 2003
    ..Some evidence indicates that these neurons can re-establish connections and contribute to functional recovery...
  2. pmc The neuronal ceroid lipofuscinosis Cln8 gene expression is developmentally regulated in mouse brain and up-regulated in the hippocampal kindling model of epilepsy
    Liina Lonka
    Neuroscience Center, University of Helsinki, Finland
    BMC Neurosci 6:27. 2005
    ..The human phenotype is characterized by epilepsy, progressive psychomotor deterioration and visual loss, while motor neuron degeneration (mnd) mice with a Cln8 mutation show progressive motor neuron dysfunction and retinal degeneration...
  3. doi Inflammation regulates functional integration of neurons born in adult brain
    Katherine Jakubs
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 28:12477-88. 2008
    ....
  4. ncbi Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Stroke 38:3032-9. 2007
    ..We explored whether MCAO leads to hypoxia, changes in vessel density, and angiogenesis in the ipsilateral SVZ and adjacent striatum, and determined the relation between the migrating neuroblasts and the vasculature...
  5. doi Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center A11, University Hospital, Lund, Sweden
    Glia 57:835-49. 2009
    ..The long-term accumulation of microglia with proneurogenic phenotype in the SVZ implies a supportive role of these cells for the continuous neurogenesis after stroke...
  6. ncbi Quantitative analysis of the generation of different striatal neuronal subtypes in the adult brain following excitotoxic injury
    Tove Collin
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, SE 221 84 Lund, Sweden
    Exp Neurol 195:71-80. 2005
    ..Our data show for the first time that an excitotoxic lesion to the striatum can trigger the formation of new striatal neurons with phenotypes of both projection neurons and interneurons...
  7. ncbi Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, University Hospital BMC B10, Klinikgatan 26, SE 221 84 Lund, Sweden
    Eur J Neurosci 26:605-14. 2007
    ..Based on these data, human fetal striatum- and cortex-derived NSCs could be considered potentially safe and viable for transplantation, with strong neurogenic potential, for further exploration in animal models of stroke...
  8. ncbi Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A11 SE 221 84, Lund, Sweden
    Neurobiol Dis 14:542-56. 2003
    ..Our findings also underscore the need for quantitative assessment of long-term neuronal survival and behavioral changes to evaluate the therapeutic potential of factors such as GDNF...
  9. ncbi Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke
    Elin Gustafsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University of Lund, BMC A 11 SE 221 84 Lund, Sweden
    Eur J Neurosci 17:2667-78. 2003
    ..Concomitantly, brain-derived neurotrophic factor potentiates the stroke-induced neurogenic response, at least at early stages...
  10. ncbi Stroke-induced neurogenesis in aged brain
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology, University Hospital, The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden
    Stroke 36:1790-5. 2005
    ..We explored whether stroke influences neurogenesis similarly in the aged brain...
  11. ncbi Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1
    Robert E Iosif
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 28:1574-87. 2008
    ..Our results provide the first evidence that TNF-R1 is a negative regulator of stroke-induced SVZ progenitor proliferation. Blockade of TNF-R1 signaling might be a novel strategy to promote the proliferative response in SVZ after stroke...
  12. ncbi Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery
    Daniel Tornero
    1 Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Centre, University Hospital, SE 221 84 Lund, Sweden
    Brain 136:3561-77. 2013
    ....
  13. ncbi Human fetal cortical and striatal neural stem cells generate region-specific neurons in vitro and differentiate extensively to neurons after intrastriatal transplantation in neonatal rats
    Therése Kallur
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, Lund, Sweden
    J Neurosci Res 84:1630-44. 2006
    ..Our data show that NSCs derived from human fetal cortex and striatum exhibit region-specific differentiation in vitro, and survive, migrate, and form mature neurons to the same extent after intrastriatal transplantation in newborn rats...
  14. ncbi Persistent production of neurons from adult brain stem cells during recovery after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Stem Cells 24:739-47. 2006
    ..These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke...
  15. ncbi Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats
    Tohru Kobayashi
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Stroke 37:2361-7. 2006
    ..We explored whether intrastriatal infusion of glial cell line-derived neurotrophic factor (GDNF) promotes neurogenesis after stroke...
  16. ncbi TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain
    Ursula Heldmann
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Exp Neurol 196:204-8. 2005
    ..The present findings suggest that TNF-alpha, probably acting via its receptor TNFR2, can promote the survival of stroke-generated hippocampal and striatal neurons...
  17. ncbi Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor
    Elin Larsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, BMC A 11 SE 221 84, Lund, Sweden
    Exp Neurol 177:1-8. 2002
    ..Our data indicate that long-term delivery of a neurotrophic factor, which is considered as a novel neuroprotective strategy for human brain diseases, may attenuate intrinsic neuroregenerative responses...
  18. ncbi Regulation of stroke-induced neurogenesis in adult brain--recent scientific progress
    Zaal Kokaia
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, SE 221 84 Lund, Sweden
    Cereb Cortex 16:i162-7. 2006
    ..We also discuss some crucial issues that need to be addressed in the further exploration of this potential self-repair mechanism after damage to the adult brain...
  19. ncbi Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability
    Katherine Jakubs
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Neuron 52:1047-59. 2006
    ..We demonstrate a high degree of plasticity in synaptic inputs to adult-born new neurons, which could act to mitigate pathological brain function...
  20. doi Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain
    Henrik Ahlenius
    Laboratory of Neural Stem Cell Biology, Experimental Epilepsy Group, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 29:4408-19. 2009
    ..These properties are of major importance when considering therapeutic applications of neuronal replacement from endogenous NSCs in the injured, aged brain...
  21. ncbi Intraventricular infusion of TrkB-Fc fusion protein promotes ischemia-induced neurogenesis in adult rat dentate gyrus
    Elin Gustafsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Stroke 34:2710-5. 2003
    ..Here, we investigated whether inhibition of endogenous BDNF alters ischemia-induced neurogenesis in the dentate gyrus...
  22. doi Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone
    Alexandre I Danilov
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Glia 57:136-52. 2009
    ..Our findings indicate that the NSCs in adult rat SVZ give rise directly to neuroblasts. During mitosis, the NSCs disassemble the primary cilium and symmetrically distribute EGFR and PDGFRalpha among their progeny...
  23. ncbi Pax6 promotes neurogenesis in human neural stem cells
    Therése Kallur
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, Lund, Sweden
    Mol Cell Neurosci 38:616-28. 2008
    ..Also, that Pax6 overexpression in striatal NSCs increases the number of neurons but their region-specificity is maintained...
  24. doi Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats
    Yutaka Mine
    Laboratory of Stem Cells and Restorative Neurology, University Hospital, SE 221 84 Lund, Sweden
    Neurobiol Dis 52:191-203. 2013
    ..Our findings support the idea that combination of NSPC transplantation and stimulation of neurogenesis from endogenous NSPCs may become a valuable strategy for functional restoration after stroke...
  25. ncbi Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis
    Robert E Iosif
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 26:9703-12. 2006
    ....
  26. doi Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke
    Ursula Heldmann
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center A11, University Hospital, SE 221 84 Lund, Sweden
    Exp Neurol 229:391-8. 2011
    ..These findings indicate that the Mac-1-expressing microglia in the SVZ do not play a major role either for the number of neuroblasts which exit the SVZ or their migration in the striatum early following stroke...
  27. doi Embryonic stem cell-derived neural stem cells fuse with microglia and mature neurons
    Carlo Cusulin
    Laboratory of Stem Cells and Restorative Neurology, Department of Laboratory Medicine, University Hospital, SE 22184 Lund, Sweden
    Stem Cells 30:2657-71. 2012
    ..It remains to be elucidated how the occurrence of the fused cells will influence the functional outcome after NSC transplantation in the diseased brain...
  28. pmc Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology and Therapy, University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 31:235-42. 2011
    ..These findings, therefore, have direct clinical implications...
  29. doi Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain
    Koichi Oki
    Laboratory of Neural Stem Cell Biology and Therapy, University Hospital, Lund, Sweden
    Stem Cells 30:1120-33. 2012
    ..Our study provides the first evidence that transplantation of human iPSC-derived cells is a safe and efficient approach to promote recovery after stroke and can be used to supply the injured brain with new neurons for replacement...
  30. pmc Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis
    Zhaolu Wang
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, Lund, Sweden
    J Cereb Blood Flow Metab 32:387-98. 2012
    ..Our findings identify METRN as a new factor promoting neurogenesis both in vitro and in vivo by multiple mechanisms. Further work will be needed to translate METRN's actions on endogenous neurogenesis into improved recovery after stroke...
  31. pmc Stem cells in human neurodegenerative disorders--time for clinical translation?
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    J Clin Invest 120:29-40. 2010
    ..In particular, we need to better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment...
  32. doi Stem cell repair of striatal ischemia
    Zaal Kokaia
    Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden
    Prog Brain Res 201:35-53. 2012
    ..Joint efforts of basic researchers and clinicians are needed to develop safe and reproducible NSPC sources, test them in relevant animal models of stroke, and optimize the recovery of impaired functions...
  33. ncbi Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
    ..If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans...
  34. ncbi Human induced pluripotent stem cells improve recovery in stroke-injured aged rats
    Jemal Tatarishvili
    Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, Lund, Sweden
    Restor Neurol Neurosci 32:547-58. 2014
    ..How the aged brain responds to grafted iPSCs is unknown. We determined survival and differentiation of grafted human fibroblast-derived iPSCs and their ability to improve recovery in aged rats after stroke...
  35. ncbi Recovery and rehabilitation in stroke: stem cells
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital BMC A 11, Lund, Sweden
    Stroke 35:2691-4. 2004
    ..In this review we propose a road map to the clinic and describe the different scientific tasks that need to be accomplished to move stem cell-based approaches toward application in stroke patients...
  36. ncbi Stem cell therapy for human brain disorders
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Kidney Int 68:1937-9. 2005
    ....
  37. pmc Inflammation is detrimental for neurogenesis in adult brain
    Christine T Ekdahl
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Biomedical Center A 11, Lund, Sweden
    Proc Natl Acad Sci U S A 100:13632-7. 2003
    ..Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation...
  38. ncbi Stem cell therapy for human neurodegenerative disorders-how to make it work
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Department of Clinical Neuroscience, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Nat Med 10:S42-50. 2004
    ....
  39. ncbi Microglia-derived tumor necrosis factor-alpha exaggerates death of newborn hippocampal progenitor cells in vitro
    Emanuele Cacci
    Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, University Hospital, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Sweden
    J Neurosci Res 80:789-97. 2005
    ..Our data indicate that activated microglia-released TNFalpha might be an important contributor in inflammation-induced exaggeration of death of newly formed HPC in the adult brain after an insult...
  40. doi FoxJ1-expressing cells contribute to neurogenesis in forebrain of adult rats: evidence from in vivo electroporation combined with piggyBac transposon
    Karthikeyan Devaraju
    Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, SE 221 84 Lund, Sweden
    Exp Cell Res 319:2790-800. 2013
    ..These data indicate that in the adult rat brain, FoxJ1-expressing cells contribute to the formation of new neurons in the olfactory bulb but are not involved in the cellular repair after stroke. ..
  41. doi Societal value of stem cell therapy in stroke--a modeling study
    Johanna Svensson
    The Swedish Institute for Health Economics IHE, Lund, Sweden
    Cerebrovasc Dis 33:532-9. 2012
    ..Stem cell therapy (SCT) may promote functional recovery also in stroke patients, thereby improving quality of life and reducing costs. Our aim was to estimate the potential societal value of SCT in stroke patients...
  42. doi Cross-talk between neural stem cells and immune cells: the key to better brain repair?
    Zaal Kokaia
    Lund Stem Cell Center, University Hospital, Lund, Sweden
    Nat Neurosci 15:1078-87. 2012
    ..Better understanding of the dialog between NSPCs and innate and adaptive immune cells is crucial for further development of effective strategies for CNS repair...
  43. doi Stem cell research in stroke: how far from the clinic?
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital, SE 221 84, Lund, Sweden
    Stroke 42:2369-75. 2011
    ..Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke...
  44. doi Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Trends Pharmacol Sci 30:260-7. 2009
    ....
  45. ncbi Stem cells for the treatment of neurological disorders
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Nature 441:1094-6. 2006
    ..The next step is to translate these exciting advances from the laboratory into clinically useful therapies...
  46. doi Isolation and generation of neurosphere cultures from embryonic and adult mouse brain
    Henrik Ahlenius
    Section of Restorative Neurology, Laboratory of Neural Stem Cell Biology, Lund Stem Cell Center, Lund, Sweden
    Methods Mol Biol 633:241-52. 2010
    ..Here we describe methods for dissection, isolation and generation of neurospheres from embryonic ganglionic eminences and adult subventricular zone of mice and rats...
  47. ncbi Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats
    Gunnar Andsberg
    Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    Neurobiol Dis 9:187-204. 2002
    ..We observe that intrastriatal delivery of NGF and BDNF using a viral vector system can mitigate, albeit only moderately, neuronal death following stroke, which leads to detectable functional sparing...