Bjorn Zethelius

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp
    B Zethelius
    Department of Public Health and Caring Sciences Geriatrics, P O Box 609, 75125 Uppsala, Sweden
    Diabetologia 48:862-7. 2005
  2. ncbi request reprint Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, University of Uppsala, Uppsala, Sweden
    Circulation 113:1071-8. 2006
  3. ncbi request reprint The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University Hospital, Sweden
    Ups J Med Sci 113:117-29. 2008
  4. ncbi request reprint Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men
    Bjorn Zethelius
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Box 609, SE 75125 Uppsala, Sweden
    Diabetes Care 27:1433-8. 2004
  5. ncbi request reprint Proinsulin is an independent predictor of coronary heart disease: Report from a 27-year follow-up study
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    Circulation 105:2153-8. 2002
  6. ncbi request reprint A new model for 5-year risk of cardiovascular disease in type 2 diabetes, from the Swedish National Diabetes Register (NDR)
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetes Res Clin Pract 93:276-84. 2011
  7. ncbi request reprint Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study
    B Zethelius
    Department of Public Health and Caring Sciences Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetologia 46:20-6. 2003
  8. ncbi request reprint Impact of follow-up time and re-measurement of the electrocardiogram and conventional cardiovascular risk factors on their predictive value for myocardial infarction
    Christina Strom Moller
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    J Intern Med 260:22-30. 2006
  9. ncbi request reprint Risk associated with the metabolic syndrome versus the sum of its individual components
    Johan Sundstrom
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Diabetes Care 29:1673-4. 2006
  10. pmc Age and follow-up time affect the prognostic value of the ECG and conventional cardiovascular risk factors for stroke in adult men
    Christina Strom Moller
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    J Epidemiol Community Health 61:704-12. 2007

Detail Information

Publications69

  1. ncbi request reprint Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp
    B Zethelius
    Department of Public Health and Caring Sciences Geriatrics, P O Box 609, 75125 Uppsala, Sweden
    Diabetologia 48:862-7. 2005
    ..The aim was to determine the longitudinal relationships between Si, intact proinsulin, 32-33 split proinsulin, specific insulin and subsequent CHD...
  2. ncbi request reprint Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, University of Uppsala, Uppsala, Sweden
    Circulation 113:1071-8. 2006
    ..Cardiac TnI concentrations increase with age in subjects free from clinical signs of CHD, suggesting silent myocardial damage. We investigated the association between cTnI and future CHD and mortality in a community-based cohort of men...
  3. ncbi request reprint The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University Hospital, Sweden
    Ups J Med Sci 113:117-29. 2008
    ..The aim was to develop risk models for T2DM and impaired fasting glucose (IFG), reflecting estimates both of AIR and IR, and of their interaction, as predictors over 20 years of follow-up...
  4. ncbi request reprint Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men
    Bjorn Zethelius
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Box 609, SE 75125 Uppsala, Sweden
    Diabetes Care 27:1433-8. 2004
    ....
  5. ncbi request reprint Proinsulin is an independent predictor of coronary heart disease: Report from a 27-year follow-up study
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    Circulation 105:2153-8. 2002
    ....
  6. ncbi request reprint A new model for 5-year risk of cardiovascular disease in type 2 diabetes, from the Swedish National Diabetes Register (NDR)
    Bjorn Zethelius
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetes Res Clin Pract 93:276-84. 2011
    ..We assessed the association between risk factors and cardiovascular disease (CVD) in an observational study of type 2 diabetes patients from the Swedish National Diabetes Register...
  7. ncbi request reprint Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men--report from 27 years of follow-up study
    B Zethelius
    Department of Public Health and Caring Sciences Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetologia 46:20-6. 2003
    ....
  8. ncbi request reprint Impact of follow-up time and re-measurement of the electrocardiogram and conventional cardiovascular risk factors on their predictive value for myocardial infarction
    Christina Strom Moller
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    J Intern Med 260:22-30. 2006
    ....
  9. ncbi request reprint Risk associated with the metabolic syndrome versus the sum of its individual components
    Johan Sundstrom
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Diabetes Care 29:1673-4. 2006
  10. pmc Age and follow-up time affect the prognostic value of the ECG and conventional cardiovascular risk factors for stroke in adult men
    Christina Strom Moller
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    J Epidemiol Community Health 61:704-12. 2007
    ..To explore whether the predictive power of mid-life ECG abnormalities and conventional cardiovascular risk factors for future stroke change over a 30-year follow-up period, and whether a repeated examination improves their predictive power...
  11. doi request reprint Early insulin response and insulin sensitivity are equally important as predictors of glucose tolerance after correction for measurement errors
    Lars Berglund
    Department of Public Health Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetes Res Clin Pract 86:219-24. 2009
    ....
  12. pmc Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort
    Liisa Byberg
    Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE 75185 Uppsala, Sweden
    BMJ 338:b688. 2009
    ..To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation...
  13. doi request reprint Systolic blood pressure and risk of cardiovascular diseases in type 2 diabetes: an observational study from the Swedish national diabetes register
    Jan Cederholm
    Department of Public Health and Caring Sciences Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala, Sweden
    J Hypertens 28:2026-35. 2010
    ..To estimate risks of fatal/nonfatal coronary heart disease (CHD), stroke and cardiovascular disease (CVD) with SBP in an observational study of patients with type 2 diabetes...
  14. doi request reprint Cardiac troponin-I and risk of heart failure: a community-based cohort study
    Johan Sundstrom
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Eur Heart J 30:773-81. 2009
    ..We examined if circulating levels of cardiac troponin-I (cTnI) predict subsequent heart failure in the community...
  15. doi request reprint Seemingly healthy 71-year-old men with minor elevations of cardiac troponin I and at risk of premature death in CVD have elevated levels of NT-proBNP: report from the ULSAM study
    Per Venge
    Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
    Scand J Clin Lab Invest 69:418-24. 2009
    ..Previous findings identifying a group of seemingly healthy elderly men with very minor elevations of cTnI have shown that these men were at risk of premature cardiovascular death...
  16. doi request reprint Use of multiple biomarkers to improve the prediction of death from cardiovascular causes
    Bjorn Zethelius
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    N Engl J Med 358:2107-16. 2008
    ..The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly...
  17. ncbi request reprint Prognostic significance of 24-h ambulatory blood pressure characteristics for cardiovascular morbidity in a population of elderly men
    Kristina Björklund
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    J Hypertens 22:1691-7. 2004
    ..This study aimed to investigate the prognostic significance of 24-h ambulatory systolic (SBP), diastolic (DBP) and pulse pressure (PP), and blood pressure (BP) variability for cardiovascular morbidity in elderly men...
  18. pmc Risk prediction of cardiovascular disease in type 2 diabetes: a risk equation from the Swedish National Diabetes Register
    Jan Cederholm
    Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala, Sweden
    Diabetes Care 31:2038-43. 2008
    ..This study presents a diabetes-specific equation for estimation of the absolute 5-year risk of first incident fatal/nonfatal cardiovascular disease (CVD) in type 2 diabetic patients with use of A1C and clinical characteristics...
  19. ncbi request reprint Evaluation of a scoring scheme, including proinsulin and the apolipoprotein B/apolipoprotein A1 ratio, for the risk of acute coronary events in middle-aged men: Uppsala Longitudinal Study of Adult Men (ULSAM)
    Kristina Dunder
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Am Heart J 148:596-601. 2004
    ....
  20. ncbi request reprint Cardiovascular risk factors for stable angina pectoris versus unheralded myocardial infarction
    Kristina Dunder
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Am Heart J 147:502-8. 2004
    ..This study compared baseline risk factors between subjects in whom stable angina pectoris developed and subjects in whom unheralded fatal or nonfatal MI developed during the follow-up period...
  21. pmc Platelet counts and liver enzymes after bariatric surgery
    Hans Erik Johansson
    Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden
    J Obes 2013:567984. 2013
    ..We investigated alterations in PC, GGT, and ALT after biliopancreatic diversion with duodenal switch (BPD-DS) and Roux-en-Y gastric bypass (RYGBP)...
  22. ncbi request reprint Novel metabolic risk factors for heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    J Am Coll Cardiol 46:2054-60. 2005
    ..Our objectives were to explore novel metabolic risk factors for development of heart failure (HF)...
  23. doi request reprint Effect of tight control of HbA1c and blood pressure on cardiovascular diseases in type 2 diabetes: an observational study from the Swedish National Diabetes Register (NDR)
    Jan Cederholm
    Department of Public Health and Caring Sciences Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala, Sweden
    Diabetes Res Clin Pract 86:74-81. 2009
    ..7 years...
  24. ncbi request reprint Left ventricular concentric remodeling rather than left ventricular hypertrophy is related to the insulin resistance syndrome in elderly men
    J Sundstrom
    Department of Public Health, Uppsala University, Sweden
    Circulation 101:2595-600. 2000
    ..The purpose of this study was to elucidate these associations through the use of a large sample of elderly men...
  25. pmc GDF-15 for prognostication of cardiovascular and cancer morbidity and mortality in men
    Lars Wallentin
    Uppsala Clinical Research Center UCR and Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e78797. 2013
    ..001). In conclusion, in elderly men, GDF-15 improves prognostication of both cardiovascular, cancer mortality and morbidity beyond established risk factors and biomarkers of cardiac, renal dysfunction and inflammation. ..
  26. ncbi request reprint Blood pressure and risk of cardiovascular diseases in type 2 diabetes: further findings from the Swedish National Diabetes Register (NDR-BP II)
    Jan Cederholm
    Department of Public Health and Caring Sciences Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala, Sweden
    J Hypertens 30:2020-30. 2012
    ..Estimate risks of coronary heart disease (CHD), stroke and cardiovascular disease (CVD) with updated mean systolic (SBP) and diastolic (DBP) blood pressure in an observational study of patients with type 2 diabetes...
  27. ncbi request reprint Bileopancreatic diversion with duodenal switch lowers both early and late phases of glucose, insulin and proinsulin responses after meal
    Hans Erik Johansson
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University Hospital, Uppsala Science Park, 75185 Uppsala, Sweden
    Obes Surg 20:549-58. 2010
    ..2 +/- 2.4 kg/m(2)]...
  28. doi request reprint Alterations in proinsulin and insulin dynamics, HDL Cholesterol and ALT after gastric bypass surgery. A 42-months follow-up study
    Hans Erik Johansson
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University Hospital, Uppsala Science Park, 75185, Uppsala, Sweden
    Obes Surg 19:601-7. 2009
    ..Roux-en-Y gastric bypass (RYGBP) powerfully reduces type 2 diabetes (T2DM) incidence. Proinsulin predicts development of T2DM. Adjustable gastric banding is associated with lowered proinsulin but after RYGBP information is scant...
  29. doi request reprint The combined contribution of albuminuria and glomerular filtration rate to the prediction of cardiovascular mortality in elderly men
    Elisabet Nerpin
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Nephrol Dial Transplant 26:2820-7. 2011
    ..Yet, data on whether the combined addition of albuminuria and estimated glomerular filtration rate (eGFR) improves cardiovascular risk prediction in individuals without CVD in the community is scarce...
  30. pmc Seasonal variations of insulin sensitivity from a euglycemic insulin clamp in elderly men
    Lars Berglund
    Department of Public Health Geriatrics, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 117:35-40. 2012
    ..Seasonal variations in hemoglobin-A1c have been reported in diabetic patients, but the underlying mechanisms have not been elucidated...
  31. pmc Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up
    Birgitta Grundmark
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cancer 11:431. 2011
    ..We investigated the relation between s-Se, smoking and non-screening detected PrCa and explored if polymorphisms in two DNA repair genes: OGG1 and MnSOD, influenced any effect of s-Se...
  32. ncbi request reprint Plasma proteome changes in subjects with Type 2 diabetes mellitus with a low or high early insulin response
    Tea Sundsten
    Department of Medical Cell Biology, Uppsala University, SE 751 23 Uppsala, Sweden
    Clin Sci (Lond) 114:499-507. 2008
    ..Four additional unidentified plasma proteins also varied in different ways between the experimental groups. In conclusion, the proteins detected in the present study may be related to the development of beta-cell dysfunction...
  33. ncbi request reprint Vascular risk factors and dementia: 40-year follow-up of a population-based cohort
    Elina Rönnemaa
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Science Park, Uppsala, Sweden
    Dement Geriatr Cogn Disord 31:460-6. 2011
    ..Our aim was to evaluate the longitudinal associations of individual and multiple vascular risk factors with the subsequent development of dementia and Alzheimer's disease (AD)...
  34. pmc Increase in blood glucose concentration during antihypertensive treatment as a predictor of myocardial infarction: population based cohort study
    Kristina Dunder
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, PO Box 609, SE 751 25 Uppsala, Sweden
    BMJ 326:681. 2003
    ..To investigate the impact of an increase in blood glucose on the risk of developing myocardial infarction, with particular emphasis on people taking antihypertensive drugs...
  35. doi request reprint Serum fatty acid composition and insulin resistance are independently associated with liver fat markers in elderly men
    Helena Petersson
    Department of Public Health and Caring Sciences Clinical Nutrition and Metabolism, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden
    Diabetes Res Clin Pract 87:379-84. 2010
    ..To investigate the relationships of serum fatty acid (FA) composition and estimated desaturase activities with the liver fat marker alanine aminotransferase (ALT)...
  36. ncbi request reprint Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men
    Ulf Riserus
    Clinical Nutrition Research Unit, Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetes Care 27:2041-6. 2004
    ..Sagittal abdominal diameter (SAD) or "supine abdominal height" is a simple anthropometric measure previously shown to predict mortality in men, but its association with insulin resistance and hyperproinsulinemia is unknown...
  37. ncbi request reprint Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort
    Liisa Byberg
    Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE 75185 Uppsala, Sweden
    Br J Sports Med 43:482. 2009
    ..To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation...
  38. pmc Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study
    Johan Sundstrom
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    BMJ 332:878-82. 2006
    ..To find out if the presence of the metabolic syndrome increases the risk of subsequent total and cardiovascular mortality, taking into account established risk factors for cardiovascular disease...
  39. doi request reprint Serum adiponectin in elderly men does not correlate with fracture risk
    Karl Michaelsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    J Clin Endocrinol Metab 93:4041-7. 2008
    ....
  40. doi request reprint Insulin sensitivity measured by the euglycaemic insulin clamp and proinsulin levels as predictors of stroke in elderly men
    B Wiberg
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Diabetologia 52:90-6. 2009
    ..We hypothesised that proinsulin and insulin resistance contributes to an increase of risk for fatal and non-fatal stroke/TIA, independently of diabetes and established risk factors...
  41. ncbi request reprint Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men
    A Dahlgren
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Diabetologia 50:1852-7. 2007
    ....
  42. doi request reprint High-sensitive cardiac troponin T and its relations to cardiovascular risk factors, morbidity, and mortality in elderly men
    Kai M Eggers
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden Electronic address
    Am Heart J 166:541-8. 2013
    ..Cardiac troponin is emerging as risk indicator in community-dwelling populations. In this study, we investigated the associations of cardiac troponin T (cTnT) to cardiovascular (CV) disease and outcome in elderly men...
  43. ncbi request reprint Metabolic risk factors for stroke and transient ischemic attacks in middle-aged men: a community-based study with long-term follow-up
    Bernice Wiberg
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Stroke 37:2898-903. 2006
    ..We investigated relations of a comprehensive panel of baseline lipometabolic and glucometabolic variables to incident fatal and nonfatal stroke or transient ischemic attack (TIA), and stroke subtypes...
  44. ncbi request reprint Maximum likelihood estimation of correction for dilution bias in simple linear regression using replicates from subjects with extreme first measurements
    Lars Berglund
    Department of Public Health Geriatrics, Uppsala University, and Uppsala Clinical Research Center, University Hospital, Uppsala, Sweden
    Stat Med 27:4397-407. 2008
    ..MLE was shown to be a robust estimator for non-normal distributions and efficient for small sample situations...
  45. pmc The metabolic syndrome and the risk of prostate cancer under competing risks of death from other causes
    Birgitta Grundmark
    Regional Oncologic Centre, Uppsala University Hospital, Uppsala, Sweden
    Cancer Epidemiol Biomarkers Prev 19:2088-96. 2010
    ..Using the National Cholesterol Education Program Adult Treatment panel III (NCEP) and International Diabetes Federation (IDF) definitions of the MetS, we investigated such associations taking competing risks of death into consideration...
  46. ncbi request reprint Insulin resistance and risk of congestive heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    JAMA 294:334-41. 2005
    ..Diabetes and obesity are established risk factors for congestive heart failure (CHF) and are both associated with insulin resistance...
  47. pmc Circulating levels of phthalate metabolites are associated with prevalent diabetes in the elderly
    P Monica Lind
    Department of Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
    Diabetes Care 35:1519-24. 2012
    ..Because PPAR-γ agonists modulate insulin sensitivity and are used to treat type 2 diabetes, we investigated whether circulating levels of phthalate metabolites are related to prevalent type 2 diabetes...
  48. pmc Persistent ischaemic ECG abnormalities on repeated ECG examination have important prognostic value for cardiovascular disease beyond established risk factors: a population-based study in middle-aged men with up to 32 years of follow-up
    Christina Ström Möller
    AstraZeneca R and D Sodertalje, Sodertalje, Sweden
    Heart 93:1104-10. 2007
    ..To determine the effect of new, persistent or reverted ischaemic ECG abnormalities at ages 50 and 70 years on the risk of subsequent cardiovascular disease...
  49. ncbi request reprint Changes in physical activity are associated with changes in metabolic cardiovascular risk factors
    L Byberg
    Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, P O Box 609, SE 75125 Uppsala, Sweden
    Diabetologia 44:2134-9. 2001
    ..To investigate the effect of changes in physical activity on changes in metabolic cardiovascular risk factors and to investigate what factors affect the association between physical activity and cardiovascular mortality...
  50. doi request reprint Impaired insulin secretion increases the risk of Alzheimer disease
    E Rönnemaa
    Uppsala University, Department of Public Health Geriatrics, Uppsala Science Park, Uppsala, Sweden
    Neurology 71:1065-71. 2008
    ..However, the underlying causes remain unknown. We investigated the longitudinal associations between midlife insulin secretion, glucose metabolism, and the subsequent development of Alzheimer disease (AD) and dementia...
  51. ncbi request reprint Several factors associated with the insulin resistance syndrome are predictors of left ventricular systolic dysfunction in a male population after 20 years of follow-up
    J Arnlov
    Departments of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Am Heart J 142:720-4. 2001
    ..The epidemiologic data on heart failure are scarce. This study aimed at identifying predictors of left ventricular systolic dysfunction in a cohort of middle-aged men with a 20-year follow-up...
  52. ncbi request reprint Echocardiographic and electrocardiographic diagnoses of left ventricular hypertrophy predict mortality independently of each other in a population of elderly men
    J Sundstrom
    Departments of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Circulation 103:2346-51. 2001
    ....
  53. pmc Gastric bypass alters the dynamics and metabolic effects of insulin and proinsulin secretion
    H E Johansson
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University Hospital, Uppsala, Sweden
    Diabet Med 24:1213-20. 2007
    ....
  54. pmc Serum cystatin C and the risk of Alzheimer disease in elderly men
    J Sundelof
    Uppsala University, Department of Public Health Geriatrics, Uppsala Science Park, Uppsala, Sweden
    Neurology 71:1072-9. 2008
    ..Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD)...
  55. ncbi request reprint A new Q/QS pattern on the resting electrocardiogram is associated with impaired insulin secretion and a poor prognosis in elderly men independently of history of myocardial infarction
    K Dunder
    Department of Public Health and Caring Sciences Geriatrics Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden
    J Intern Med 255:221-8. 2004
    ..To evaluate risk factors and prognosis of subjects who had developed a new Q/QS pattern on the resting electrocardiogram (ECG) in relation to history of myocardial infarction (MI)...
  56. doi request reprint Serum and dietary beta-carotene and alpha-tocopherol and incidence of type 2 diabetes mellitus in a community-based study of Swedish men: report from the Uppsala Longitudinal Study of Adult Men (ULSAM) study
    J Arnlov
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Diabetologia 52:97-105. 2009
    ..To investigate the association of serum concentrations and dietary intake of beta-carotene and alpha-tocopherol with type 2 diabetes incidence...
  57. doi request reprint Glucose metabolism and the risk of Alzheimer's disease and dementia: a population-based 12 year follow-up study in 71-year-old men
    E Rönnemaa
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, 751 85 Uppsala, Sweden
    Diabetologia 52:1504-10. 2009
    ..The aim of our study was to investigate the longitudinal association of glucose metabolism, insulin secretion and insulin action with the development of Alzheimer's disease and vascular dementia...
  58. ncbi request reprint Impaired insulin sensitivity is an independent predictor of common carotid intima-media thickness in a population sample of elderly men
    M Wohlin
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Atherosclerosis 170:181-5. 2003
    ..In conclusion, this study is the first to establish impaired insulin sensitivity, measured by the euglycemic hyperinsulinemic clamp test, as an independent predictor of CCA-IMT in a population-based sample of elderly men...
  59. pmc Reducing the noise in signal detection of adverse drug reactions by standardizing the background: a pilot study on analyses of proportional reporting ratios-by-therapeutic area
    Birgitta Grundmark
    Department of Surgical Sciences, Uppsala University, 75185, Uppsala, Sweden
    Eur J Clin Pharmacol 70:627-35. 2014
    ....
  60. doi request reprint Dietary patterns and prostate cancer risk: report from the population based ULSAM cohort study of swedish men
    Erika Ax
    a Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
    Nutr Cancer 66:77-87. 2014
    ..In this study, a LCHP diet was associated with lower prostate cancer incidence. Relations emerged in adequate reporters, underscoring the importance of high-quality dietary data. ..
  61. doi request reprint Serum magnesium status after gastric bypass surgery in obesity
    Hans Erik Johansson
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, Uppsala 75185, Sweden
    Obes Surg 19:1250-5. 2009
    ..However, there is scant information on how magnesium status is affected by RYGBP surgery. Previous bariatric surgery methods, like jejunoileal bypass, are associated with hypomagnesemia...
  62. doi request reprint Circulating levels of perfluoroalkyl substances and prevalent diabetes in the elderly
    Lars Lind
    Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden
    Diabetologia 57:473-9. 2014
    ..We therefore investigated whether other kinds of contaminants, perfluoroalkyl substances (PFAS), also called perfluorinated compounds (PFCs), are also associated with diabetes...
  63. pmc Changes in erythrocyte sedimentation rate, white blood cell count, liver enzymes, and magnesium after gastric bypass surgery
    Hans Erik Johansson
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University Hospital, 75185 Uppsala, Sweden
    J Obes 2011:273105. 2011
    ..while Mg increased by 6%, compared to control group (P = 0.001-0.009). Conclusions. Obese patients treated by RYGBP show sustained reductions in ESR, WBC, ALT, and GGT possibly due to reduced liver steatosis and increased Mg...
  64. ncbi request reprint Isolated ambulatory hypertension predicts cardiovascular morbidity in elderly men
    Kristina Björklund
    Department of Public Health and Caring Sciences Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Circulation 107:1297-302. 2003
    ..This study aimed to investigate the prognostic significance of isolated ambulatory hypertension for cardiovascular morbidity in a population of elderly men...
  65. ncbi request reprint Correction for regression dilution bias using replicates from subjects with extreme first measurements
    Lars Berglund
    Department of Public Health Geriatrics, Uppsala University, Uppsala, Sweden
    Stat Med 26:2246-57. 2007
    ....
  66. doi request reprint Postprandial changes in gut regulatory peptides in gastric bypass patients
    C Holdstock
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Int J Obes (Lond) 32:1640-6. 2008
    ..The aim of this study was to measure the putative satiety peptides peptide YY (PYY), glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP) and pro-neurotensin (pro-NT) in response to fasting and feeding...
  67. ncbi request reprint Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity
    U Riserus
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetologia 47:1016-9. 2004
    ....
  68. doi request reprint Vasoreactivity is rapidly improved in obese subjects after gastric bypass surgery
    L Lind
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Int J Obes (Lond) 33:1390-5. 2009
    ..Obesity is associated with increased risk of cardiovascular disease. We investigated vasoreactivity in conduit and resistance arteries in morbidly obese subjects, and the effect of weight loss after gastric bypass surgery...
  69. doi request reprint Cognitive function and risk of stroke in elderly men
    B Wiberg
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Neurology 74:379-85. 2010
    ..We studied the predictive value of cognitive test performance especially related to subcortico-frontal pathways, together with a cognitive screening test, for later incidence of fatal or nonfatal stroke or TIAs and stroke subtypes...