Hanna Wootz

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice
    Hanna Wootz
    Department of Neuroscience, Uppsala University, 75123 Uppsala, Sweden
    Neurobiol Dis 37:58-66. 2010
  2. doi request reprint Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model
    Hanna Wootz
    Department of Neuroscience, Uppsala University, 75124 Uppsala, Sweden
    J Comp Neurol 521:1449-69. 2013
  3. ncbi request reprint XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice
    Hanna Wootz
    Department of Neuroscience, Unit of Neurobiology, Uppsala University, Biomedical Centre, Box 587, S 751 23 Uppsala, Sweden
    Exp Cell Res 312:1890-8. 2006
  4. ncbi request reprint Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS
    Hanna Wootz
    Department of Neuroscience, Unit of Neurobiology, Uppsala University, Biomedical Centre, Box 587, S 751 23 Uppsala, Sweden
    Biochem Biophys Res Commun 322:281-6. 2004
  5. ncbi request reprint G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase
    Sylwia Ammoun
    Department of Neuroscience, Unit of Physiology, Uppsala University, Sweden
    J Biol Chem 281:834-42. 2006
  6. pmc Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: what have we learnt about functional glutamatergic neurotransmission?
    Asa Wallen-Mackenzie
    Department of Neuroscience, Unit of Developmental Genetics, Biomedical Center, Box 593, Uppsala University, S 751 24 Uppsala, Sweden
    Ups J Med Sci 115:11-20. 2010
  7. doi request reprint Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders
    Charlotte Israelsson
    Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, PO Box 593, SE 751 24 Uppsala, Sweden
    Eur J Neurosci 31:852-63. 2010
  8. pmc Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model
    Hanna Wootz
    Department of Neuroscience, Uppsala University, 75124 Uppsala, Sweden
    J Comp Neurol 521:1449-69. 2013
  9. ncbi request reprint Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim
    Christine Möller
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Sweden
    Blood 106:1330-6. 2005

Collaborators

Detail Information

Publications9

  1. doi request reprint Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice
    Hanna Wootz
    Department of Neuroscience, Uppsala University, 75123 Uppsala, Sweden
    Neurobiol Dis 37:58-66. 2010
    ..Taken together, this suggests that reduced levels of VGLUT2 decrease motor neuron degeneration but do not prevent loss of motor neuron function in the SOD1(G93A) mouse model for ALS...
  2. doi request reprint Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model
    Hanna Wootz
    Department of Neuroscience, Uppsala University, 75124 Uppsala, Sweden
    J Comp Neurol 521:1449-69. 2013
    ..We conclude that the loss of presynaptic motor axon input on Renshaw cells occurs at early stages of ALS and disconnects the recurrent inhibitory circuit, presumably resulting in diminished control of motor neuron firing...
  3. ncbi request reprint XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice
    Hanna Wootz
    Department of Neuroscience, Unit of Neurobiology, Uppsala University, Biomedical Centre, Box 587, S 751 23 Uppsala, Sweden
    Exp Cell Res 312:1890-8. 2006
    ..The neuroprotective effect of XIAP involves inhibition of caspases and the stabilization of the calpastatin/calpain system that is altered in the ALS mice...
  4. ncbi request reprint Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS
    Hanna Wootz
    Department of Neuroscience, Unit of Neurobiology, Uppsala University, Biomedical Centre, Box 587, S 751 23 Uppsala, Sweden
    Biochem Biophys Res Commun 322:281-6. 2004
    ..Caspase-12 and the ER pathway for cell death may constitute potential novel targets for the treatment of ALS...
  5. ncbi request reprint G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase
    Sylwia Ammoun
    Department of Neuroscience, Unit of Physiology, Uppsala University, Sweden
    J Biol Chem 281:834-42. 2006
    ....
  6. pmc Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: what have we learnt about functional glutamatergic neurotransmission?
    Asa Wallen-Mackenzie
    Department of Neuroscience, Unit of Developmental Genetics, Biomedical Center, Box 593, Uppsala University, S 751 24 Uppsala, Sweden
    Ups J Med Sci 115:11-20. 2010
    ..We review the recent studies in which mouse genetics have been used to characterize the functional role of VGLUT2 in the central nervous system...
  7. doi request reprint Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders
    Charlotte Israelsson
    Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, PO Box 593, SE 751 24 Uppsala, Sweden
    Eur J Neurosci 31:852-63. 2010
    ..It is concluded that the Cxcl10(+) cells appear in the inflamed central nervous system and may represent a novel population of cells that it may be possible to target pharmacologically in a broad range of neurodegenerative conditions...
  8. pmc Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model
    Hanna Wootz
    Department of Neuroscience, Uppsala University, 75124 Uppsala, Sweden
    J Comp Neurol 521:1449-69. 2013
    ..J. Comp. Neurol. 521:1449-1469, 2013. © 2012 Wiley Periodicals, Inc...
  9. ncbi request reprint Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim
    Christine Möller
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Sweden
    Blood 106:1330-6. 2005
    ....