A Vahlquist

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint [Burdensome rules for clinical trials are not in proportion to benefits for the patient]
    Anders Vahlquist
    Akademiska sjukhuset, Uppsala
    Lakartidningen 102:1832, 1834; discussion 1834. 2005
  2. doi request reprint Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients
    Anders Vahlquist
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 130:438-43. 2010
  3. doi request reprint Congenital ichthyosis: an overview of current and emerging therapies
    Anders Vahlquist
    Department of Medical Sciences, Section of Dermatology, University Hospital, University of Uppsala, Uppsala, Sweden
    Acta Derm Venereol 88:4-14. 2008
  4. ncbi request reprint Inefficacy of topical thyroid hormone analogue TriAc in plaque psoriasis: results of a double-blind placebo-controlled trial
    A Vahlquist
    Department of Medical Sciences Dermatology, University Hospital, SE 751 85 Uppsala, Sweden
    Br J Dermatol 151:489-91. 2004
  5. ncbi request reprint [The Berzelius symposium on genetic dermatoses: cutaneous gene therapy--potential treatment of severe skin diseases]
    Anders Vahlquist
    Hudkliniken, Akademiska sjukhuset, Uppsala
    Lakartidningen 99:2041-5. 2002
  6. doi request reprint Pleomorphic ichthyosis: proposed name for a heterogeneous group of congenital ichthyoses with phenotypic shifting and mild residual scaling
    Anders Vahlquist
    Department of Medical Sciences Dermatology, Uppsala University, Uppasala, Sweden
    Acta Derm Venereol 90:454-60. 2010
  7. doi request reprint Epidermolysis bullosa care in Scandinavia
    Anders Vahlquist
    Department of Medical Sciences, Uppsala University, University Hospital, Uppsala, Sweden
    Dermatol Clin 28:425-7, xv. 2010
  8. ncbi request reprint The vitamin A metabolism and expression of retinoid-binding proteins differ in HaCaT cells and normal human keratinocytes
    H Torma
    Department of Medical Sciences, University of Uppsala, Sweden
    Arch Dermatol Res 291:339-45. 1999
  9. pmc Congenital ichthyosis: mutations in ichthyin are associated with specific structural abnormalities in the granular layer of epidermis
    J Dahlqvist
    Department of Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, Uppsala, Sweden
    J Med Genet 44:615-20. 2007
  10. doi request reprint Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis
    E Pavez Loriè
    Department of Medical Sciences Dermatology, Uppsala University, SE 751 85 Uppsala, Sweden
    Br J Dermatol 160:26-36. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint [Burdensome rules for clinical trials are not in proportion to benefits for the patient]
    Anders Vahlquist
    Akademiska sjukhuset, Uppsala
    Lakartidningen 102:1832, 1834; discussion 1834. 2005
  2. doi request reprint Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients
    Anders Vahlquist
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 130:438-43. 2010
    ..In conclusion, ALOX12B mutations are the leading cause of SICI in Scandinavia, followed by ALOXE3 mutations, which have not been previously associated with this variant of ARCI...
  3. doi request reprint Congenital ichthyosis: an overview of current and emerging therapies
    Anders Vahlquist
    Department of Medical Sciences, Section of Dermatology, University Hospital, University of Uppsala, Uppsala, Sweden
    Acta Derm Venereol 88:4-14. 2008
    ..This calls for new ideas and intensified efforts to develop future ichthyosis therapies...
  4. ncbi request reprint Inefficacy of topical thyroid hormone analogue TriAc in plaque psoriasis: results of a double-blind placebo-controlled trial
    A Vahlquist
    Department of Medical Sciences Dermatology, University Hospital, SE 751 85 Uppsala, Sweden
    Br J Dermatol 151:489-91. 2004
    ..TriAc (3,3',5-triiodo-thyroacetic acid) is a well-known thyroid hormone analogue with much reduced cardiac thyrotoxic activity compared with the classical thyroid hormones...
  5. ncbi request reprint [The Berzelius symposium on genetic dermatoses: cutaneous gene therapy--potential treatment of severe skin diseases]
    Anders Vahlquist
    Hudkliniken, Akademiska sjukhuset, Uppsala
    Lakartidningen 99:2041-5. 2002
  6. doi request reprint Pleomorphic ichthyosis: proposed name for a heterogeneous group of congenital ichthyoses with phenotypic shifting and mild residual scaling
    Anders Vahlquist
    Department of Medical Sciences Dermatology, Uppsala University, Uppasala, Sweden
    Acta Derm Venereol 90:454-60. 2010
    ..To remind health providers about this heterogeneous group of partially transient disorders of cornification, a new umbrella term, "pleomorphic ichthyosis", is proposed...
  7. doi request reprint Epidermolysis bullosa care in Scandinavia
    Anders Vahlquist
    Department of Medical Sciences, Uppsala University, University Hospital, Uppsala, Sweden
    Dermatol Clin 28:425-7, xv. 2010
    ..A close collaboration with patient organizations and various charity organizations will be very helpful in this respect...
  8. ncbi request reprint The vitamin A metabolism and expression of retinoid-binding proteins differ in HaCaT cells and normal human keratinocytes
    H Torma
    Department of Medical Sciences, University of Uppsala, Sweden
    Arch Dermatol Res 291:339-45. 1999
    ....
  9. pmc Congenital ichthyosis: mutations in ichthyin are associated with specific structural abnormalities in the granular layer of epidermis
    J Dahlqvist
    Department of Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, Uppsala, Sweden
    J Med Genet 44:615-20. 2007
    ..Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of skin disorders. Several mutant genes have been identified in ARCI, but the association between genotype and phenotype is poorly understood...
  10. doi request reprint Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis
    E Pavez Loriè
    Department of Medical Sciences Dermatology, Uppsala University, SE 751 85 Uppsala, Sweden
    Br J Dermatol 160:26-36. 2009
    ..An alternative approach to retinoid therapy is to inhibit the cytochrome P450 (CYP)-mediated catabolism of endogenous all-trans retinoic acid in the skin by applying retinoic acid metabolism blocking agents such as talarozole (R115866)...
  11. ncbi request reprint Phenotypic/genotypic correlations in patients with epidermolytic hyperkeratosis and the effects of retinoid therapy on keratin expression
    M Virtanen
    Department of Medical Sciences, Section of Dermatology, Uppsala University, Sweden
    Acta Derm Venereol 81:163-70. 2001
    ....
  12. doi request reprint Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments
    J C Chamcheu
    Department of Medical Sciences, Dermatology and Venereology, University Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
    Br J Dermatol 164:263-72. 2011
    ..While the aetiology of EI is known, model systems are needed for pathophysiological studies and development of novel therapies...
  13. ncbi request reprint Topical retinoic acid alters the expression of cellular retinoic acid-binding protein-I and cellular retinoic acid-binding protein-II in non-lesional but not lesional psoriatic skin
    T Karlsson
    Department of Medical Sciences, Section of Dermatology and Venereology, Uppsala University, Sweden
    Exp Dermatol 11:143-52. 2002
    ..Whether the high expression of CRABPII in psoriatic skin lesions is due to increased amounts of endogenous retinoids in lesional skin or reflects an abnormal regulation of the CRABPII gene in psoriasis remains to be studied...
  14. doi request reprint X-linked recessive ichthyosis: an impaired barrier function evokes limited gene responses before and after moisturizing treatments
    T Hoppe
    Department of Medical Sciences, Dermatology and Venereology, Uppsala University, SE 75185 Uppsala, Sweden
    Br J Dermatol 167:514-22. 2012
    ..XLRI is characterized by dry, scaly skin and increased skin barrier permeability; patients are often dependent on daily use of moisturizers...
  15. ncbi request reprint Splice site and deletion mutations in keratin (KRT1 and KRT10) genes: unusual phenotypic alterations in Scandinavian patients with epidermolytic hyperkeratosis
    Marie Virtanen
    Department of Medical Sciences, Dermatology Section, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 121:1013-20. 2003
    ....
  16. ncbi request reprint A founder mutation for ichthyosis prematurity syndrome restricted to 76 kb by haplotype association
    M Melin
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 751 85, Sweden
    J Hum Genet 51:864-71. 2006
    ..This region spans four known genes, all of which are expressed in mature epidermal cells. We present the results from the analysis of these four genes and their corresponding transcripts in normal and patient-derived samples...
  17. ncbi request reprint Autosomal recessive congenital ichthyosis in Sweden and Estonia: clinical, genetic and ultrastructural findings in eighty-three patients
    Agneta Gånemo
    Department of Medical Sciences Dermatology, Uppsala University, Uppsala, Sweden
    Acta Derm Venereol 83:24-30. 2003
    ..The transglutaminase-unrelated cases are more heterogeneous, probably reflecting a more varied aetiology...
  18. ncbi request reprint Health-related quality of life among patients with ichthyosis
    Agneta Gånemo
    Department of Medical Sciences, Section of Dermatology, Uppsala University, Sweden
    Eur J Dermatol 14:61-6. 2004
    ..No differences in SF-36 were found between men and women or between the different groups of ichthyosis. The results demonstrate that ichthyosis has an adverse effect on HRQoL...
  19. ncbi request reprint The pH gradient over the stratum corneum differs in X-linked recessive and autosomal dominant ichthyosis: a clue to the molecular origin of the "acid skin mantle"?
    H Ohman
    Department of Biomedicine and Surgery, University Hospital, Linkoping, Sweden
    J Invest Dermatol 111:674-7. 1998
    ..Because corneocyte desquamation involves many pH-dependent enzymes, abnormalities in the transcorneal pH gradient might play a role in the pathogenesis of ichthyosis...
  20. ncbi request reprint What are natural retinoids?
    A Vahlquist
    Section of Dermatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Dermatology 199:3-11. 1999
    ..Inevitably, treatment with such drugs will influence the effects of coexisting natural retinoids. An understanding of the basic principles of these interactions may have major impact on patient outcome...
  21. doi request reprint Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RARalpha
    Marie Virtanen
    Department of Medical Sciences, Uppsala University, Sweden
    Exp Dermatol 19:674-81. 2010
    ..In conclusion, RARalpha agonists elicit a reciprocal modulation of KRT2 and KRT4/KRT13 expression in human epidermis, but whether or not the keratin genes also possess RARalpha-specific regulatory elements is still unclear...
  22. ncbi request reprint Connexin 26 (GJB2) mutations in two Swedish patients with atypical Vohwinkel (mutilating keratoderma plus deafness) and KID syndrome both extensively treated with acitretin
    Marie Louise Bondeson
    Department of Genetics and Pathology, University of Uppsala, Sweden
    Acta Derm Venereol 86:503-8. 2006
    ..Asp50Asn was found in the patient with KID syndrome. The clinical features, particularly a proneness to skin cancer in the patient with Vohwinkel syndrome, are discussed in relation to the identified genotypes...
  23. doi request reprint Sjögren-larsson syndrome: a study of clinical symptoms and dermatological treatment in 34 Swedish patients
    Agneta Gånemo
    Department of Medical Sciences Dermatology, Uppsala University, Uppsala, Sweden
    Acta Derm Venereol 89:68-73. 2009
    ..In conclusion, SLS is a chronic, severely disabling neurocutaneous disease in which optimal dermatological therapy is essential to relieve at least the patient's ichthyosis problem...
  24. doi request reprint Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole
    Elizabeth Pavez Loriè
    Department of Medical Sciences Dermatology, Uppsala University, Uppsala, Sweden
    Acta Derm Venereol 89:12-20. 2009
    ..The results suggest that liarozole exerts a therapeutic effect in lamellar ichthyosis by mildly affecting the expression of retinoid- regulated genes in epidermis...
  25. doi request reprint Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition
    Jean Christopher Chamcheu
    Department of Medical Sciences Dermatology and Venereology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Dermatol Sci 53:198-206. 2009
    ..Despite a vast knowledge about the intermediate filament pathology in this disease, the progress in therapy has been slow. Animal models and well-characterized continuous cell culture models of EBS are needed prior to clinical testing...
  26. pmc Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome
    Joakim Klar
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Am J Hum Genet 85:248-53. 2009
    ..Our results further emphasize the importance of fatty acid metabolism for normal epidermal barrier function illustrated by deficiency of a member in the FATP family of proteins...
  27. doi request reprint Keratinocyte differentiation induced by calcium, phorbol ester or interferon-gamma elicits distinct changes in the retinoid signalling pathways
    Teresa Karlsson
    Department of Medical Sciences, Section of Dermatology and Venereology, Uppsala University, Sweden
    J Dermatol Sci 57:207-13. 2010
    ..The effect of keratinocyte differentiation on expression of nuclear retinoid receptors and on the conversion of retinol into retinoic acid has not been examined earlier in depth...
  28. doi request reprint The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes
    Elizabeth Pavez Loriè
    Department of Medical Sciences, Dermatology and Venereology, Uppsala University, SE 751 85 Uppsala, Sweden
    Biochim Biophys Acta 1791:220-8. 2009
    ..Thus CYP26B1 appears essential for RA catabolism under physiological conditions, whereas CYP26A1 might play a greater role during RA excess...
  29. doi request reprint Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis
    Elizabeth Pavez Loriè
    Department of Medical Sciences, Dermatology and Venereology, Uppsala University, 751 85 Uppsala, Sweden
    Arch Dermatol Res 301:475-85. 2009
    ..e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis...
  30. ncbi request reprint 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands?
    Teresa Karlsson
    Department of Medical Sciences Dermatology and Venereology, University Hospital, Uppsala, Sweden
    Biochem Biophys Res Commun 303:273-8. 2003
    ..e., reduced the formation of dihydrotestosterone and androstandione in vitro. Extrapolated to the in vivo situation, this effect might explain the unique sebosuppressive effect of isotretinoin when treating acne...
  31. ncbi request reprint Immunofluorescence localization of nuclear retinoid receptors in psoriasis versus normal human skin
    Teresa Karlsson
    Department of Medical Sciences, Section of Dermatology and Venereology, Uppsala University, Sweden
    Acta Derm Venereol 84:363-9. 2004
    ..The results support the idea that psoriasis is associated with abnormal retinoid signalling in lesional epidermis...
  32. ncbi request reprint Quality of life in adults with congenital ichthyosis
    Agneta Gånemo
    Department of Medical Sciences, Section of Dermatology, Uppsala University, Uppsala, Sweden
    J Adv Nurs 44:412-9. 2003
    ..Describing life history and quality of life from an individual perspective could increase understanding of living with generalized congenital ichthyosis for nursing staff and others...
  33. ncbi request reprint Differential effects of UV irradiation on nuclear retinoid receptor levels in cultured keratinocytes and melanocytes
    Eva Andersson
    Department of Biomedicine and Surgery, Division of Dermatology, Clinical Research Center, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Exp Dermatol 12:563-71. 2003
    ....