Lene Uhrbom

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells
    Maria Ferletta
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Int J Cancer 129:45-60. 2011
  2. pmc Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma
    Maria Kärrlander
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e8536. 2009
  3. ncbi request reprint Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis
    Lene Uhrbom
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res 65:2065-9. 2005
  4. ncbi request reprint Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis
    Maria Ferletta
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory C11, Dag Hammarskjoldsv 20, S 751 85 Uppsala, Sweden
    Mol Cancer Res 5:891-7. 2007
  5. pmc Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging
    Fredrik K Johansson
    Department of Genetics and Pathology, The Rudbeck Laboratory, University Hospital, SE 751 85 Uppsala, Sweden
    Proc Natl Acad Sci U S A 101:11334-7. 2004
  6. pmc miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
    Jelena Polajeva
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Cancer 12:378. 2012
  7. pmc Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12
    Jelena Polajeva
    Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e25222. 2011
  8. pmc PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation
    Yiwen Jiang
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Neoplasia 13:492-503. 2011
  9. ncbi request reprint Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model
    Göran Hesselager
    Department of Genetics and Pathology, Rudbeck Laboratory, University Hospital, SE 75185 Uppsala, Sweden
    Cancer Res 63:4305-9. 2003
  10. pmc On the origin of glioma
    Yiwen Jiang
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 117:113-21. 2012

Collaborators

Detail Information

Publications15

  1. doi request reprint Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells
    Maria Ferletta
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Int J Cancer 129:45-60. 2011
    ..We suggest that Sox21 can negatively regulate Sox2 in glioma. Our findings imply that Sox2 and Sox21 may be interesting targets for the development of novel glioma therapy...
  2. pmc Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma
    Maria Kärrlander
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e8536. 2009
    ..We found that HRG had little effect on tumor incidence but could significantly inhibit the development of malignant glioma and completely prevent the occurrence of grade IV tumors (glioblastoma)...
  3. ncbi request reprint Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis
    Lene Uhrbom
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res 65:2065-9. 2005
    ..Thus, Ink4a and Arf have independent and differential tumor suppressor functions in vivo in the glial cell compartment...
  4. ncbi request reprint Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis
    Maria Ferletta
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory C11, Dag Hammarskjoldsv 20, S 751 85 Uppsala, Sweden
    Mol Cancer Res 5:891-7. 2007
    ..The Sox10 expression was restricted to gliomas and melanomas. All glioma types expressed Sox10, and tumors of low-grade glioma had a much broader distribution of Sox10 compared with high-grade gliomas...
  5. pmc Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging
    Fredrik K Johansson
    Department of Genetics and Pathology, The Rudbeck Laboratory, University Hospital, SE 751 85 Uppsala, Sweden
    Proc Natl Acad Sci U S A 101:11334-7. 2004
    ..Our findings indicate that retroviral tagging with a growth factor-encoding virus may be a powerful means of identifying candidate tumor-causing genes in nonhematopoietic tumors...
  6. pmc miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
    Jelena Polajeva
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Cancer 12:378. 2012
    ..We decided to investigate the expression of the oncogenic miR-21 during normal mouse development and glioma, focusing on PDGF signaling as a potential regulator of miR-21...
  7. pmc Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12
    Jelena Polajeva
    Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e25222. 2011
    ..Moreover, human GBMs were positive for CXCL12 and the infiltrating MCs were positive for CXCR4. In conclusion, we provide the first evidence for a role for MCs in glioma...
  8. pmc PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation
    Yiwen Jiang
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Neoplasia 13:492-503. 2011
    ..Our findings suggest that interfering with PDGF-controlled differentiation could be a therapeutic avenue for patients diagnosed with the PDGF-driven proneural subtype of human glioblastoma...
  9. ncbi request reprint Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model
    Göran Hesselager
    Department of Genetics and Pathology, Rudbeck Laboratory, University Hospital, SE 75185 Uppsala, Sweden
    Cancer Res 63:4305-9. 2003
    ....
  10. pmc On the origin of glioma
    Yiwen Jiang
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 117:113-21. 2012
    ..Thus, it is essential to explore further the role of cellular origin in glioma...
  11. pmc CGGBP1 regulates cell cycle in cancer cells
    Umashankar Singh
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
    BMC Mol Biol 12:28. 2011
    ..Recently we had found CGGBP1 to be a cell cycle regulatory midbody protein required for normal cytokinetic abscission in normal human fibroblasts, which have all the cell cycle regulatory mechanisms intact...
  12. ncbi request reprint Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
    Lene Uhrbom
    Uppsala University, Department of Genetics and Pathology, Rudbeck Laboratory, SE 75185 Uppsala, Sweden
    Nat Med 10:1257-60. 2004
    ..In these platelet-derived growth factor (PDGF)-driven oligodendrogliomas, G1 cell-cycle arrest is generated by blockade of either the PDGF receptor or mTOR using small-molecule inhibitors...
  13. pmc Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures
    Di Yu
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e54952. 2013
    ....
  14. pmc p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3
    Rebecca M Wolf
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 17:476-87. 2003
    ..This evidence strongly suggests that p190 regulates critical components of PDGF oncogenesis and can act as a tumor suppressor in PDGF-induced gliomas by down-regulating Rho activity...
  15. ncbi request reprint Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
    Lene Uhrbom
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:5551-8. 2002
    ..Our data strongly supports the view that one role of loss of Ink4a-Arf in gliomagenesis could be to sensitize astrocytes to transformation through dedifferentiation in response to the appropriate oncogenic stimuli...