Lennart Truedsson

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint The interferon signature in autoimmune diseases
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
    Curr Opin Rheumatol 25:248-53. 2013
  2. pmc Potential role of IFNα in adult lupus
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala University Hospital, Entrance 40, Uppsala, Sweden
    Arthritis Res Ther 12:S3. 2010
  3. pmc The type I interferon system in the etiopathogenesis of autoimmune diseases
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 116:227-37. 2011
  4. ncbi request reprint An etiopathogenic role for the type I IFN system in SLE
    L Ronnblom
    Dept of Medical Sciences, Section of Rheumatology, University Hospital, S 751 85 Uppsala, Sweden
    Trends Immunol 22:427-31. 2001
  5. doi request reprint Type I interferon and lupus
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University Hospital, Uppsala, Sweden
    Curr Opin Rheumatol 21:471-7. 2009
  6. pmc The innate immune system in SLE: type I interferons and dendritic cells
    L Ronnblom
    Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Lupus 17:394-9. 2008
  7. ncbi request reprint Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity
    Lars Rönnblom
    Section of Rheumatology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Autoimmunity 36:463-72. 2003
  8. ncbi request reprint Cytokines as therapeutic targets in SLE
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala SE 751 85, Sweden
    Nat Rev Rheumatol 6:339-47. 2010
  9. pmc Systemic lupus erythematosus and the type I interferon system
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, University Hospital, Uppsala, Sweden
    Arthritis Res Ther 5:68-75. 2003
  10. ncbi request reprint The natural interferon-alpha producing cells in systemic lupus erythematosus
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, University Hospital, Uppsala, Sweden
    Hum Immunol 63:1181-93. 2002

Detail Information

Publications46

  1. doi request reprint The interferon signature in autoimmune diseases
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
    Curr Opin Rheumatol 25:248-53. 2013
    ..We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consequences of this observation...
  2. pmc Potential role of IFNα in adult lupus
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala University Hospital, Entrance 40, Uppsala, Sweden
    Arthritis Res Ther 12:S3. 2010
    ..How produced IFNα can contribute to some clinical manifestations will briefly be described, as well as the possible consequences of this knowledge in clinical practice for disease monitoring and therapy...
  3. pmc The type I interferon system in the etiopathogenesis of autoimmune diseases
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 116:227-37. 2011
    ..Possible mechanisms behind the dysregulated type IFNsystem in autoimmune diseases and how the IFN-α produced can contribute to the development of an autoimmune process will be reviewed...
  4. ncbi request reprint An etiopathogenic role for the type I IFN system in SLE
    L Ronnblom
    Dept of Medical Sciences, Section of Rheumatology, University Hospital, S 751 85 Uppsala, Sweden
    Trends Immunol 22:427-31. 2001
    ..These IFN-alpha inducers consist of complexes of autoantibodies with nucleic-acid-containing autoantigens derived from apoptotic cells...
  5. doi request reprint Type I interferon and lupus
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University Hospital, Uppsala, Sweden
    Curr Opin Rheumatol 21:471-7. 2009
    ..In this review, we summarize the latest information concerning the type I IFN system in lupus...
  6. pmc The innate immune system in SLE: type I interferons and dendritic cells
    L Ronnblom
    Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Lupus 17:394-9. 2008
    ....
  7. ncbi request reprint Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity
    Lars Rönnblom
    Section of Rheumatology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Autoimmunity 36:463-72. 2003
    ..In this review we summarize recent data concerning NIPC/PDC, including their activation, regulation, function and possible role in autoimmune diseases, especially SLE...
  8. ncbi request reprint Cytokines as therapeutic targets in SLE
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala SE 751 85, Sweden
    Nat Rev Rheumatol 6:339-47. 2010
    ..Finally, we provide suggestions for the future of treatment for SLE, including new therapeutic strategies...
  9. pmc Systemic lupus erythematosus and the type I interferon system
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, University Hospital, Uppsala, Sweden
    Arthritis Res Ther 5:68-75. 2003
    ..This hypothesis also indicates new therapeutic targets in this autoimmune disease...
  10. ncbi request reprint The natural interferon-alpha producing cells in systemic lupus erythematosus
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, University Hospital, Uppsala, Sweden
    Hum Immunol 63:1181-93. 2002
    ..This hypothesis furthermore indicates new therapeutic targets...
  11. doi request reprint The type I interferon system in the development of lupus
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
    Semin Immunol 23:113-21. 2011
    ..The possible connection between the type I IFN system and some environmental and genetic risk factors for lupus is also discussed...
  12. ncbi request reprint The type I interferon system in systemic lupus erythematosus
    Lars Rönnblom
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Arthritis Rheum 54:408-20. 2006
  13. doi request reprint Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells
    Maija Leena Eloranta
    Department of Medical Sciences, Uppsala University Hospital, and Uppsala University, Uppsala, Sweden
    Arthritis Rheum 60:2418-27. 2009
    ..We undertook this study to investigate how IFNalpha production induced by RNA-containing immune complexes (ICs) in plasmacytoid dendritic cells (PDCs) is regulated...
  14. pmc A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
    Johanna K Sandling
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Eur J Hum Genet 19:479-84. 2011
    ..Our study suggests additional genes from the type I interferon system in SLE, and highlights genes in this pathway for further functional analysis...
  15. pmc A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5
    Snaevar Sigurdsson
    Molecular Medicine, Department of Medical Sciences, Uppsala University, SE 75185 Uppsala, Sweden
    Hum Mol Genet 17:2868-76. 2008
    ..82-fold risk of SLE with two independent risk alleles of the IRF5 (interferon regulatory factor 5) gene...
  16. ncbi request reprint Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA
    Tanja Lövgren
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 54:1917-27. 2006
    ..To investigate the ability of systemic lupus erythematosus (SLE) autoantigen- and Sjögren's syndrome (SS) autoantigen-associated U1 small nuclear RNA (U1 snRNA) and hY1RNA to induce interferon-alpha (IFNalpha) production...
  17. doi request reprint Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
    Sergey V Kozyrev
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden
    Nat Genet 40:211-6. 2008
    ..The disease-associated variants could contribute to sustained B cell-receptor signaling and B-cell hyperactivity characteristic of this disease...
  18. ncbi request reprint Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG
    Tanja Lövgren
    Immunology V, Biomedical Center, Uppsala University, Uppsala, Sweden
    Arthritis Rheum 50:1861-72. 2004
    ....
  19. pmc Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations
    Chuan Wang
    Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    Eur J Hum Genet 21:994-9. 2013
    ..We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities. ..
  20. doi request reprint Type I interferon system activation and association with disease manifestations in systemic sclerosis
    Maija Leena Eloranta
    Department of Medical Sciences, Clinical Research Department 3, Systemic Autoimmunity Group, Entrance 85, 3rd Floor, Uppsala University Hospital, Uppsala S 75185, Sweden
    Ann Rheum Dis 69:1396-402. 2010
    ..To study the presence of interferogenic autoantibodies in systemic sclerosis (SSc) and their correlation with clinical manifestations, serum levels of interferon alpha (IFNalpha) and chemokines of importance in the disease process...
  21. ncbi request reprint Expression of the markers BDCA-2 and BDCA-4 and production of interferon-alpha by plasmacytoid dendritic cells in systemic lupus erythematosus
    Stina Blomberg
    Immunology V, Biomedical Center, Uppsala University Hospital, Uppsala, Sweden
    Arthritis Rheum 48:2524-32. 2003
    ....
  22. ncbi request reprint Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis
    Snaevar Sigurdsson
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 56:2202-10. 2007
    ..To determine whether genetic variants of the interferon regulatory factor 5 (IRF-5) and Tyk-2 genes are associated with rheumatoid arthritis (RA)...
  23. pmc Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
    Andreas Jönsen
    Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Kioskgatan 3, SE 221 85 Lund, Sweden
    Arthritis Res Ther 13:R206. 2011
    ..Inherited deficiencies of several complement components strongly predispose to systemic lupus erythematosus (SLE) while deficiencies of complement inhibitors are found in kidney diseases such as atypical hemolytic uremic syndrome (aHUS)...
  24. doi request reprint A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus
    Sara E Löfgren
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 62:3404-14. 2010
    ..This study was undertaken to investigate the genetic association of CD226 with susceptibility to systemic lupus erythematosus (SLE) and to assess the functional implications of this association...
  25. pmc Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein
    Angelica M Delgado-Vega
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 751 85, Sweden
    Ann Rheum Dis 71:1219-26. 2012
    ..To perform fine mapping of the autoimmunity susceptibility gene BLK and identify functional variants involved in systemic lupus erythematosus (SLE)...
  26. ncbi request reprint Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE
    Magnus Isaksson
    Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden
    Eur J Immunol 39:2925-35. 2009
    ..In contrast, pDC depletion a week after MOG immunization resulted in more severe clinical signs of EAE. In conclusion, we demonstrate that pDC promote initiation of MOG-induced Th17-cell responses and EAE...
  27. ncbi request reprint Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG
    Ullvi Båve
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
    J Immunol 171:3296-302. 2003
    ..The FcgammaRIIa could therefore have a key function in NIPC/PDC and be a potential therapeutic target in SLE...
  28. ncbi request reprint Endogenous type I interferon inducers in autoimmune diseases
    Doreen Finke
    Section of Rheumatology, Department of Medical Sciences, Uppsala University, SE 75185, Uppsala, Sweden
    Autoimmunity 42:349-52. 2009
    ..This knowledge is important for the development of new therapeutic strategies in autoimmune diseases...
  29. ncbi request reprint A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies
    Maija Leena Eloranta
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 56:3112-24. 2007
    ..To investigate type I interferon (IFN) system activation and its correlation with autoantibodies and organ manifestations in polymyositis (PM), dermatomyositis (DM), and inclusion body myositis...
  30. ncbi request reprint Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism
    Ullvi Båve
    Uppsala University Hospital, Uppsala, Sweden
    Arthritis Rheum 52:1185-95. 2005
    ..In other autoimmune diseases, type I interferon (IFN) may play a pivotal role by triggering and sustaining the disease process. We therefore aimed to determine whether patients with primary SS had an activated type I IFN system...
  31. doi request reprint IFN-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1β and LFA-1
    Niklas Hagberg
    Section of Rheumatology, Department of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden
    J Immunol 186:5085-94. 2011
    ....
  32. ncbi request reprint Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus
    Gunnel Nordmark
    Department of Medical Sciences, Section of Rheumatology, University Hospital, Uppsala, Sweden
    Autoimmunity 38:531-40. 2005
    ..Side effects were mild. We conclude that low dose DHEA treatment improves HRQOL with regard to mental well-being and sexuality and can be offered to women with SLE where mental distress and/or impaired sexuality constitutes a problem...
  33. ncbi request reprint [Burdensome rules for clinical trials are not in proportion to benefits for the patient]
    Anders Vahlquist
    Akademiska sjukhuset, Uppsala
    Lakartidningen 102:1832, 1834; discussion 1834. 2005
  34. ncbi request reprint Platelet activation and anti-phospholipid antibodies collaborate in the activation of the complement system on platelets in systemic lupus erythematosus
    Christian Lood
    Department of Clinical Sciences Lund, Section of Rheumatology, Lund University and Skåne University Hospital, Lund, Sweden
    PLoS ONE 9:e99386. 2014
    ..Further studies are needed to elucidate the role of complement deposition on platelets in development of venous thrombosis. ..
  35. ncbi request reprint Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
    Snaevar Sigurdsson
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Hum Mol Genet 17:872-81. 2008
    ..We have found that the same IRF5 allele also confers risk for inflammatory bowel diseases and multiple sclerosis, suggesting a general role for IRF5 in autoimmune diseases...
  36. ncbi request reprint Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system
    Gunnel Nordmark
    Uppsala University Hospital, Uppsala, Sweden
    Nat Clin Pract Rheumatol 2:262-9. 2006
    ..Several potential therapeutic targets for Sjögren's syndrome exist within the type I IFN system...
  37. ncbi request reprint Gene-environment interactions in the aetiology of systemic lupus erythematosus
    Andreas Jönsen
    Section of Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden
    Autoimmunity 40:613-7. 2007
    ..With increased knowledge on SLE pathogenesis, the role of environmental factors and their genetic interactions may be further elucidated...
  38. ncbi request reprint Single-tube nested quantitative PCR: a rational and sensitive technique for detection of retroviral DNA. Application to RERV-H/HRV-5 and confirmation of its rabbit origin
    Anna Forsman
    Section of Virology, Department of Medical Sciences, Academic Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
    J Virol Methods 111:1-11. 2003
    ..It is concluded that the stnQPCR developed to detect and quantify minute amounts of RERV-H/HRV-5 DNA is a principle which can be applied widely and HRV-5 is a RERV-H. Its presence in a few human blood samples could not be explained...
  39. doi request reprint Complement in the immunopathogenesis of rheumatic disease
    Gunnar Sturfelt
    Section of Rheumatology, Department of Clinical Sciences, Lund University, Kioskgatan 3, SE 221 85 Lund, Sweden gunnar sturfelt med lu se
    Nat Rev Rheumatol 8:458-68. 2012
    ..Potential approaches to therapeutic intervention that focus on regulating complement activities in these disorders are also considered...
  40. doi request reprint Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction
    Kerstin Kronholm Diab
    Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden
    Int Arch Occup Environ Health 82:771-7. 2009
    ....
  41. ncbi request reprint A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
    Ludmila Prokunina
    Institute of Genetics and Pathology, Section for Medical Genetics, Rudbeck Laboratories, University of Uppsala, Dag Hammarsjölds väg 20, 751 85, Uppsala, Sweden
    Nat Genet 32:666-9. 2002
    ....
  42. pmc Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
    Snaevar Sigurdsson
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Am J Hum Genet 76:528-37. 2005
    ..TYK2 binds to the type I IFN receptor complex and IRF5 is a regulator of type I IFN gene expression. Thus, our results support a disease mechanism in SLE that involves key components of the type I IFN system...
  43. ncbi request reprint Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus
    Filip Sköldberg
    Department of Medical Sciences, Uppsala University, University Hospital, 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 291:951-8. 2002
    ..This is the first report that AHNAK can be targeted by the immune system in autoimmune disease...
  44. pmc Multiplex SNP genotyping in pooled DNA samples by a four-colour microarray system
    Katarina Lindroos
    Department of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden
    Nucleic Acids Res 30:e70. 2002
    ....
  45. ncbi request reprint Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation
    Kristina N Ekdahl
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, University Hospital, Uppsala, Sweden
    Br J Haematol 125:74-8. 2004
    ..We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis...