Affiliation: Uppsala University
- [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in ratsJoost Verbeek
Department of Nuclear Medicine and PET Research, Radionuclide Centre, VU University Medical Center, P, O, Box 7057, Amsterdam 1081, HV, The Netherlands
EJNMMI Res 2:36. 2012..abstract:..
- Advances in PET imaging of P-glycoprotein function at the blood-brain barrierStina Syvänen
Department of Public Health and Caring Sciences, Uppsala University, Rudbecklaboratoriet, 751 85 Uppsala, Sweden
ACS Chem Neurosci 4:225-37. 2013..Further, the review summarizes results from PET studies of P-gp function in different central nervous system disorders...
- Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomographyJulia Müllauer
Division of Pharmacology, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands
EJNMMI Res 2:58. 2012..abstract:..
- Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PETStina Syvänen
Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands
J Nucl Med 53:1974-83. 2012....
- Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methodsStina Syvänen
Division of Pharmacology, LACDR, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
Neuroimage 57:928-37. 2011..4 ng · mL(-1) and K(D) values of 7.1 ± 0.8 ng · mL(-1). The main advantage of the full saturation method is that B(max) and K(D) can be obtained from a single PET scan...
- Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainateStina Syvänen
Division of Pharmacology, LACDR, Leiden University, The Netherlands
AAPS J 14:87-96. 2012....
- [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsivenessStina Syvänen
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Nucl Med Biol 40:764-75. 2013..To analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission tomography (PET) radiotracers [(11)C]quinidine and [(11)C]laniquidar...
- [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoproteinFemke E Froklage
Division of Pharmacology, LACDR, Leiden University, PO Box 9502, Leiden, 2300 RA, The Netherlands
EJNMMI Res 2:12. 2012..abstract:..
- (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticusStina Syvänen
Division of Pharmacology, LACDR, Leiden University, P, O, Box 9502, 2300 RA Leiden, The Netherlands
BMC Med Imaging 11:1. 2011..The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate...
- Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugsStina Syvänen
Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24 Uppsala, Sweden
Curr Top Med Chem 10:1799-809. 2010..It is concluded that new imaging probes will be required if the role of PET in studies of the interactions of drugs with efflux transporters is to expand...
- Pharmacokinetic consequences of active drug efflux at the blood-brain barrierStina Syvänen
Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden
Pharm Res 23:705-17. 2006..The objective of this simulation study was to investigate how the nature, location, and capacity of the efflux processes in relation to the permeability properties influence brain concentrations...