Stina Syvänen

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats
    Joost Verbeek
    Department of Nuclear Medicine and PET Research, Radionuclide Centre, VU University Medical Center, P, O, Box 7057, Amsterdam 1081, HV, The Netherlands
    EJNMMI Res 2:36. 2012
  2. pmc Advances in PET imaging of P-glycoprotein function at the blood-brain barrier
    Stina Syvänen
    Department of Public Health and Caring Sciences, Uppsala University, Rudbecklaboratoriet, 751 85 Uppsala, Sweden
    ACS Chem Neurosci 4:225-37. 2013
  3. pmc Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography
    Julia Müllauer
    Division of Pharmacology, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands
    EJNMMI Res 2:58. 2012
  4. doi request reprint Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands
    J Nucl Med 53:1974-83. 2012
  5. doi request reprint Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Neuroimage 57:928-37. 2011
  6. pmc Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, The Netherlands
    AAPS J 14:87-96. 2012
  7. ncbi request reprint [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness
    Stina Syvänen
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Nucl Med Biol 40:764-75. 2013
  8. pmc [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
    Femke E Froklage
    Division of Pharmacology, LACDR, Leiden University, PO Box 9502, Leiden, 2300 RA, The Netherlands
    EJNMMI Res 2:12. 2012
  9. pmc (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, P, O, Box 9502, 2300 RA Leiden, The Netherlands
    BMC Med Imaging 11:1. 2011
  10. ncbi request reprint Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs
    Stina Syvänen
    Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24 Uppsala, Sweden
    Curr Top Med Chem 10:1799-809. 2010

Collaborators

Detail Information

Publications11

  1. pmc [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats
    Joost Verbeek
    Department of Nuclear Medicine and PET Research, Radionuclide Centre, VU University Medical Center, P, O, Box 7057, Amsterdam 1081, HV, The Netherlands
    EJNMMI Res 2:36. 2012
    ..abstract:..
  2. pmc Advances in PET imaging of P-glycoprotein function at the blood-brain barrier
    Stina Syvänen
    Department of Public Health and Caring Sciences, Uppsala University, Rudbecklaboratoriet, 751 85 Uppsala, Sweden
    ACS Chem Neurosci 4:225-37. 2013
    ..Further, the review summarizes results from PET studies of P-gp function in different central nervous system disorders...
  3. pmc Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography
    Julia Müllauer
    Division of Pharmacology, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands
    EJNMMI Res 2:58. 2012
    ..abstract:..
  4. doi request reprint Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands
    J Nucl Med 53:1974-83. 2012
    ....
  5. doi request reprint Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Neuroimage 57:928-37. 2011
    ..4 ng · mL(-1) and K(D) values of 7.1 ± 0.8 ng · mL(-1). The main advantage of the full saturation method is that B(max) and K(D) can be obtained from a single PET scan...
  6. pmc Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, The Netherlands
    AAPS J 14:87-96. 2012
    ....
  7. ncbi request reprint [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness
    Stina Syvänen
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Nucl Med Biol 40:764-75. 2013
    ..To analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission tomography (PET) radiotracers [(11)C]quinidine and [(11)C]laniquidar...
  8. pmc [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
    Femke E Froklage
    Division of Pharmacology, LACDR, Leiden University, PO Box 9502, Leiden, 2300 RA, The Netherlands
    EJNMMI Res 2:12. 2012
    ..abstract:..
  9. pmc (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, P, O, Box 9502, 2300 RA Leiden, The Netherlands
    BMC Med Imaging 11:1. 2011
    ..The aim of this study was to investigate potential changes in P-glycoprotein (P-gp) expression and functionality at an early stage after induction of status epilepticus by kainate...
  10. ncbi request reprint Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs
    Stina Syvänen
    Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24 Uppsala, Sweden
    Curr Top Med Chem 10:1799-809. 2010
    ..It is concluded that new imaging probes will be required if the role of PET in studies of the interactions of drugs with efflux transporters is to expand...
  11. ncbi request reprint Pharmacokinetic consequences of active drug efflux at the blood-brain barrier
    Stina Syvänen
    Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24, Uppsala, Sweden
    Pharm Res 23:705-17. 2006
    ..The objective of this simulation study was to investigate how the nature, location, and capacity of the efflux processes in relation to the permeability properties influence brain concentrations...