Research Topics
| J SundstromSummaryAffiliation: Uppsala University Country: Sweden Publications
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Detail Information
Publications
Left ventricular geometric patterns and adaptations to hemodynamics are similar in elderly men and womenSaid Masiha
Department of Cardiology, Uppsala University Hospital, Uppsala, Sweden
BMC Cardiovasc Disord 11:25. 2011..However, differences between the genders in the relationship of hemodynamics to LV geometry are not well known.The present study aims to investigate differences between the genders in this respect, in a sample of elderly persons...- Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort studyJohan Sundstrom
Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
BMJ 332:878-82. 2006..To find out if the presence of the metabolic syndrome increases the risk of subsequent total and cardiovascular mortality, taking into account established risk factors for cardiovascular disease... 
Blood pressure-independent relations of left ventricular geometry to the metabolic syndrome and insulin resistance: a population-based studyJ Sundstrom
Department of Medical Sciences, Uppsala University Hospital, Entrance 40, 5th Floor, SE 751 85 Uppsala, Sweden
Heart 94:874-8. 2008..This study investigated whether the metabolic syndrome and insulin resistance are related to left ventricular geometry independently of blood pressure...
Cardiac troponin-I and risk of heart failure: a community-based cohort studyJohan Sundstrom
Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
Eur Heart J 30:773-81. 2009..We examined if circulating levels of cardiac troponin-I (cTnI) predict subsequent heart failure in the community...- Risk associated with the metabolic syndrome versus the sum of its individual componentsJohan Sundstrom
Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Diabetes Care 29:1673-4. 2006 - Myocardial biomarkers for prediction of cardiovascular diseaseJohan Sundstrom
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Dis Markers 26:235-46. 2009.... - Association of blood pressure in late adolescence with subsequent mortality: cohort study of Swedish male conscriptsJohan Sundstrom
Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, SE 75185 Uppsala, Sweden
BMJ 342:d643. 2011..To investigate the nature and magnitude of relations of systolic and diastolic blood pressures in late adolescence to mortality... - Serum cystatin C and the risk of Alzheimer disease in elderly menJ Sundelof
Uppsala University, Department of Public Health Geriatrics, Uppsala Science Park, Uppsala, Sweden
Neurology 71:1072-9. 2008..Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD)... - Left ventricular concentric remodeling rather than left ventricular hypertrophy is related to the insulin resistance syndrome in elderly menJ Sundstrom
Department of Public Health, Uppsala University, Sweden
Circulation 101:2595-600. 2000..The purpose of this study was to elucidate these associations through the use of a large sample of elderly men... - Glucose metabolism and the risk of Alzheimer's disease and dementia: a population-based 12 year follow-up study in 71-year-old menE Rönnemaa
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, 751 85 Uppsala, Sweden
Diabetologia 52:1504-10. 2009..The aim of our study was to investigate the longitudinal association of glucose metabolism, insulin secretion and insulin action with the development of Alzheimer's disease and vascular dementia... - Echocardiographic and electrocardiographic diagnoses of left ventricular hypertrophy predict mortality independently of each other in a population of elderly menJ Sundstrom
Departments of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Circulation 103:2346-51. 2001..Methods and.. - Dyslipidemia and an unfavorable fatty acid profile predict left ventricular hypertrophy 20 years laterJ Sundstrom
Departments of Public Health and Caring Sciences J S, B V, H O L and Medical Sciences L L, B A, Uppsala University, Sweden, and Department of Nutrition A A, KTL National Public Health Institute, Helsinki, Finland
Circulation 103:836-41. 2001.... - Insulin sensitivity measured by the euglycaemic insulin clamp and proinsulin levels as predictors of stroke in elderly menB Wiberg
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, Uppsala, Sweden
Diabetologia 52:90-6. 2009..We hypothesised that proinsulin and insulin resistance contributes to an increase of risk for fatal and non-fatal stroke/TIA, independently of diabetes and established risk factors... - Impaired insulin secretion increases the risk of Alzheimer diseaseE Rönnemaa
Uppsala University, Department of Public Health Geriatrics, Uppsala Science Park, Uppsala, Sweden
Neurology 71:1065-71. 2008..However, the underlying causes remain unknown. We investigated the longitudinal associations between midlife insulin secretion, glucose metabolism, and the subsequent development of Alzheimer disease (AD) and dementia... - An echolucent carotid artery intima-media complex is a new and independent predictor of mortality in an elderly male cohortM Wohlin
Department of Public Health and Caring Sciences, Uppsala University, Sweden
Atherosclerosis 205:486-91. 2009..We investigated the prognostic value of intima-media (IM) echogenicity (measured as the grey scale median [GSM]) for mortality compared with intima-media thickness (IMT) in a population-based sample of elderly men... - Myocardial insulin-mediated glucose uptake and left ventricular geometryJ Sundstrom
Department of Public Health and Caring Sciences Geriatrics, Uppsala University Hospital, Uppsala, Sweden
Blood Press 10:27-32. 2001.... - Both cyclooxygenase- and cytokine-mediated inflammation are associated with carotid intima-media thicknessM Wohlin
Department of Public Health and Caring Sciences Geriatrics and Clinical Nutrition, Faculty of Medicine, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
Cytokine 38:130-6. 2007..It is unknown if various modes of inflammation (cyclooxygenase [COX]-mediated, cytokine-mediated), oxidative stress and anti-oxidants are independently related to CCA-IMT... - Impaired insulin sensitivity is an independent predictor of common carotid intima-media thickness in a population sample of elderly menM Wohlin
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Atherosclerosis 170:181-5. 2003..In conclusion, this study is the first to establish impaired insulin sensitivity, measured by the euglycemic hyperinsulinemic clamp test, as an independent predictor of CCA-IMT in a population-based sample of elderly men... - Metabolic syndrome and risk for heart failure in middle-aged menE Ingelsson
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
Heart 92:1409-13. 2006..To explore metabolic syndrome as a possible risk factor for development of heart failure (HF)... - Kidney function and discrimination of cardiovascular risk in middle-aged menI Soveri
Department of Medical Sciences, Uppsala University, Sweden
J Intern Med 266:406-13. 2009..To define the optimal glomerular filtration rate (GFR) cut off for discriminating the risk of myocardial infarction or cardiovascular death... - Insulin resistance, dietary fat intake and blood pressure predict left ventricular diastolic function 20 years laterJohan Arnlov
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Nutr Metab Cardiovasc Dis 15:242-9. 2005.... - Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective studyEva Warensjo
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Am J Clin Nutr 88:203-9. 2008..Desaturase indexes, as markers of endogenous fatty acid desaturation, and a characteristic serum fatty acid (FA) composition are related to cardiovascular and metabolic diseases, but the relation to mortality is poorly investigated... - The apolipoprotein B/AI ratio and the metabolic syndrome independently predict risk for myocardial infarction in middle-aged menLars Lind
Department of Medical Sciences, Uppsala University, Sweden
Arterioscler Thromb Vasc Biol 26:406-10. 2006..Despite this, the apoB/AI ratio and the metabolic syndrome were both independent long-term predictors of MI in a community-based sample of middle-aged men... - Brachial artery hyperaemic blood flow velocity and left ventricular geometryS J Järhult
Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
J Hum Hypertens 26:242-6. 2012..Future studies have to determine if the SDFV ratio is a powerful predictor of future CV events, in addition to LV geometry... - Use of multiple biomarkers to improve the prediction of death from cardiovascular causesBjorn Zethelius
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
N Engl J Med 358:2107-16. 2008..The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly... - Cognitive function and risk of stroke in elderly menB Wiberg
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
Neurology 74:379-85. 2010..We studied the predictive value of cognitive test performance especially related to subcortico-frontal pathways, together with a cognitive screening test, for later incidence of fatal or nonfatal stroke or TIAs and stroke subtypes... - Apolipoprotein E epsilon4 genotype is independently associated with increased intima-media thickness in a recessive patternM Wohlin
Department of Public Health and Caring Sciences Geriatrics and Clinical Nutrition, Faculty of Medicine, Uppsala University, Uppsala Science Park, 751 85, Uppsala, Sweden
Lipids 42:451-6. 2007.... - Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in menEva Warensjo
Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Am J Clin Nutr 84:442-8. 2006..A specific fatty acid (FA) composition in plasma lipid esters is related to the metabolic syndrome (MetS) and may influence the development of the MetS... - Plasma parathyroid hormone and the risk of cardiovascular mortality in the communityEmil Hagström
Uppsala Clinical Research Center, Uppsala University, Sweden
Circulation 119:2765-71. 2009..However, data on the prospective association between circulating PTH levels and cardiovascular mortality in the community are lacking... - Impact of follow-up time and re-measurement of the electrocardiogram and conventional cardiovascular risk factors on their predictive value for myocardial infarctionChristina Strom Moller
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
J Intern Med 260:22-30. 2006.... - Low-grade albuminuria and the incidence of heart failure in a community-based cohort of elderly menErik Ingelsson
Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, Uppsala, Sweden
Eur Heart J 28:1739-45. 2007..To investigate associations of urinary albumin excretion rate (UAER) and heart failure (HF) incidence in a community-based sample... - Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort studyJohan Sundelöf
Uppsala University, Department of Public Health and Geriatrics, Uppsala Science Park, Dag Hammarskölds väg 14B, Uppsala, Sweden
Arch Neurol 65:256-63. 2008..Beta amyloid (Abeta) protein accumulates in the brains of individuals with Alzheimer disease (AD) and is detectable in cerebrospinal fluid and plasma... - Age and follow-up time affect the prognostic value of the ECG and conventional cardiovascular risk factors for stroke in adult menChristina Strom Moller
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala Science Park, SE 751 85 Uppsala, Sweden
J Epidemiol Community Health 61:704-12. 2007..To explore whether the predictive power of mid-life ECG abnormalities and conventional cardiovascular risk factors for future stroke change over a 30-year follow-up period, and whether a repeated examination improves their predictive power... - Serum levels of matrix metalloproteinase-9, tissue inhibitors of metalloproteinase-1 and their ratio are associated with impaired lung function in the elderly: a population-based studyInga S Olafsdóttir
Department of Medical sciences Respiratory Medicine and Allergology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Respirology 15:530-5. 2010..The aim of this study was to investigate the associations of serum MMP-9 and TIMP-1 with lung function... - Brachial artery hyperemic blood flow velocities are related to carotid atherosclerosisSusann J Järhult
Department of Medicine, Uppsala University Hospital, Uppsala 75185, Sweden
Clin Physiol Funct Imaging 29:360-5. 2009..Here, we investigated the relations between SDFV in the brachial artery and different characteristics of carotid atherosclerosis... - The carotid artery plaque size and echogenicity are related to different cardiovascular risk factors in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) studyJessika Andersson
Department of Medicine, Uppsala University Hospital, 75185 Uppsala, Sweden
Lipids 44:397-403. 2009..These results suggest that plaque size and echogenicity are influenced by different risk factors... - Echogenecity of the carotid intima-media complex is related to cardiovascular risk factors, dyslipidemia, oxidative stress and inflammation: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) studyJessika Andersson
Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
Atherosclerosis 204:612-8. 2009..Our aim was therefore to investigate if intima-media echogenecity is related to cardiovascular risk factors, or to markers of inflammation and oxidation in an exploratory investigation... - Diurnal blood pressure pattern and risk of congestive heart failureErik Ingelsson
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
JAMA 295:2859-66. 2006..High blood pressure is the most important risk factor for congestive heart failure (CHF) at a population level, but the relationship of an altered diurnal blood pressure pattern to risk of subsequent CHF is unknown... - Endothelial function in resistance and conduit arteries and 5-year risk of cardiovascular diseaseLars Lind
Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Circulation 123:1545-51. 2011..Little is known of the relations of measures of endothelial function in resistance and conduit arteries to incident cardiovascular disease in the general population, and available techniques have not been compared... - The stroke volume/pulse pressure ratio predicts coronary heart disease mortality in a population of elderly menLars Lind
Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
J Hypertens 22:899-905. 2004..The relations to cardiovascular risk factors and its predictive capacity in the general population are not known... - Relations of serum MMP-9 and TIMP-1 levels to left ventricular measures and cardiovascular risk factors: a population-based studyJonas Hansson
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Eur J Cardiovasc Prev Rehabil 16:297-303. 2009..We hypothesized that circulating MMP-9 and TIMP-1 levels are altered already in persons with the signs of LV remodeling that forego clinical heart failure... - Sleep disturbances independently predict heart failure in overweight middle-aged menErik Ingelsson
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
Eur J Heart Fail 9:184-90. 2007..Sleep disturbances are associated with manifest heart failure (HF). However, the relationship between sleep disturbances and incident HF has been less studied... - Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged menJohan Arnlov
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, SE 751 85 Uppsala, Sweden
Circulation 121:230-6. 2010..The purpose of this study was to investigate associations between combinations of body mass index (BMI) categories and metabolic syndrome (MetS) and the risk of cardiovascular disease and death in middle-aged men... - Plasma vitamin D and mortality in older men: a community-based prospective cohort studyKarl Michaelsson
Department of Surgical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
Am J Clin Nutr 92:841-8. 2010..Vitamin D status is known to be important for bone health but may also affect the development of several chronic diseases, including cancer and cardiovascular diseases, which are 2 major causes of death... - Novel metabolic risk factors for heart failureErik Ingelsson
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
J Am Coll Cardiol 46:2054-60. 2005..Our objectives were to explore novel metabolic risk factors for development of heart failure (HF)... - Circulating biomarkers of extracellular matrix remodeling and risk of atherosclerotic eventsJohan Sundstrom
Department of Medical Sciences and Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
Curr Opin Lipidol 17:45-53. 2006..Altered levels of circulating extracellular matrix markers have frequently been observed in relation to manifestations of atherosclerotic disease and its risk factors... - Insulin resistance and risk of congestive heart failureErik Ingelsson
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
JAMA 294:334-41. 2005..Diabetes and obesity are established risk factors for congestive heart failure (CHF) and are both associated with insulin resistance... - Inflammation, as measured by the erythrocyte sedimentation rate, is an independent predictor for the development of heart failureErik Ingelsson
Public Health and Caring Sciences, Uppsala, Sweden
J Am Coll Cardiol 45:1802-6. 2005..Our objective was to explore inflammation, measured as erythrocyte sedimentation rate (ESR), as a predictor for the development of heart failure (HF)... - Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohortLiisa Byberg
Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE 75185 Uppsala, Sweden
Br J Sports Med 43:482. 2009..To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation... - Inflammatory markers are associated with left ventricular hypertrophy and diastolic dysfunction in a population-based sample of elderly men and womenS Masiha
Department of Cardiology, Uppsala University Hospital, Uppsala, Sweden
J Hum Hypertens 27:13-7. 2013..l-selectin and hsCRP were related to LV diastolic function. Further studies are motivated to investigate a pathogenetic role of inflammation for abnormal LV geometry and function... - Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohortLiisa Byberg
Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE 75185 Uppsala, Sweden
BMJ 338:b688. 2009..To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation... - Homocysteine and heart failure: a review of investigations from the Framingham Heart StudyJohan Sundstrom
Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
Clin Chem Lab Med 43:987-92. 2005.... - Socioeconomic factors as predictors of incident heart failureErik Ingelsson
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
J Card Fail 12:540-5. 2006..Further studies are needed to understand the mechanisms behind these associations... - Biochemical risk factors for development of obesity in first-episode schizophreniaRobert Boden
Department of Neuroscience, Psychiatry Ulleraker, Uppsala University Hospital, S 750 17, Sweden
Schizophr Res 115:141-5. 2009..These observations open a new window to future research on the mechanisms underlying the development of obesity in schizophrenia... - Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controlsJohan Sundelöf
Uppsala University, Department of Public Health Geriatrics, Uppsala, Sweden
J Alzheimers Dis 21:471-8. 2010..Interestingly, cystatin C levels were positively correlated with both tau and Abeta42 levels in CSF independent of age, gender, and APOE genotype... - The validity of a diagnosis of heart failure in a hospital discharge registerErik Ingelsson
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Box 609, SE 75125 Uppsala, Sweden
Eur J Heart Fail 7:787-91. 2005..The accuracy of a diagnosis of heart failure (HF) in hospital discharge registers is largely unknown. We aimed to determine the validity of such a diagnosis in the Swedish hospital discharge register... - Five-year outcome of first-episode psychosis before and after the implementation of a modified assertive community treatment programmeRobert Boden
Department of Neuroscience, Psychiatry Ulleraker, Uppsala University Hospital, 750 17, Uppsala, Sweden
Soc Psychiatry Psychiatr Epidemiol 45:665-74. 2010..We investigated whether the implementation of such a programme would improve symptomatic and functional outcome 5 years later...