H S Sharma

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint A new antioxidant compound H-290/51 modulates glutamate and GABA immunoreactivity in the rat spinal cord following trauma
    H S Sharma
    Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden
    Amino Acids 23:261-72. 2002
  2. doi request reprint Exacerbation of brain pathology after partial restraint in hypertensive rats following SiO₂ nanoparticles exposure at high ambient temperature
    Hari S Sharma
    Laboratory of Cerebrovascular Research, Departmen of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Frödingsgatan 12, 75421, Uppsala, Sweden
    Mol Neurobiol 48:368-79. 2013
  3. ncbi request reprint New therapeutic advances in CNS injury and repair
    Hari S Sharma
    Cerebrovascular Research Laboratory, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Expert Rev Neurother 12:901-5. 2012
  4. ncbi request reprint Nanowired drug delivery to enhance neuroprotection in spinal cord injury
    Z Ryan Tian
    Department of Chemistry and Biochemistry, University of Arkansas Fayetteville, Fayetteville, AR 72701, USA
    CNS Neurol Disord Drug Targets 11:86-95. 2012
  5. ncbi request reprint Nanowired drug delivery of antioxidant compound H-290/51 enhances neuroprotection in hyperthermia-induced neurotoxicity
    Dafin F Muresanu
    Department of Neurosciences, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    CNS Neurol Disord Drug Targets 11:50-64. 2012
  6. ncbi request reprint Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals
    Preeti Kumaran Menon
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    CNS Neurol Disord Drug Targets 11:40-9. 2012
  7. ncbi request reprint Diabetes exacerbates nanoparticles induced brain pathology
    Jose Vicente Lafuente
    Lab Clinical and Experimental Neurosciences LaCEN, Dept Neurosciences, University of Basque Country, Box 699, 48080 Bilbao, Spain
    CNS Neurol Disord Drug Targets 11:26-39. 2012
  8. ncbi request reprint Neurotoxicity of engineered nanoparticles from metals
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185, Sweden
    CNS Neurol Disord Drug Targets 11:65-80. 2012
  9. ncbi request reprint Superior neuroprotective effects of cerebrolysin in nanoparticle-induced exacerbation of hyperthermia-induced brain pathology
    Aruna Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    CNS Neurol Disord Drug Targets 11:7-25. 2012
  10. doi request reprint Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors
    Hari Shanker Sharma
    Cerebrovascular Research Laboratory, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:184-203. 2012

Collaborators

Detail Information

Publications90

  1. ncbi request reprint A new antioxidant compound H-290/51 modulates glutamate and GABA immunoreactivity in the rat spinal cord following trauma
    H S Sharma
    Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden
    Amino Acids 23:261-72. 2002
    ..glutamate and GABA are important factors in the breakdown of the BSCB, edema formation and cell changes, and (iii). the antioxidant compound H-290/51 has a potential therapeutic value in the treatment of spinal cord injuries...
  2. doi request reprint Exacerbation of brain pathology after partial restraint in hypertensive rats following SiO₂ nanoparticles exposure at high ambient temperature
    Hari S Sharma
    Laboratory of Cerebrovascular Research, Departmen of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Frödingsgatan 12, 75421, Uppsala, Sweden
    Mol Neurobiol 48:368-79. 2013
    ....
  3. ncbi request reprint New therapeutic advances in CNS injury and repair
    Hari S Sharma
    Cerebrovascular Research Laboratory, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Expert Rev Neurother 12:901-5. 2012
    ....
  4. ncbi request reprint Nanowired drug delivery to enhance neuroprotection in spinal cord injury
    Z Ryan Tian
    Department of Chemistry and Biochemistry, University of Arkansas Fayetteville, Fayetteville, AR 72701, USA
    CNS Neurol Disord Drug Targets 11:86-95. 2012
    ..Thus, nanowired drug delivery to treat SCI may have potential therapeutic value. These aspects of nanowired drug delivery to enhance neuroprotection in SCI are discussed in this review based on our own investigations...
  5. ncbi request reprint Nanowired drug delivery of antioxidant compound H-290/51 enhances neuroprotection in hyperthermia-induced neurotoxicity
    Dafin F Muresanu
    Department of Neurosciences, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    CNS Neurol Disord Drug Targets 11:50-64. 2012
    ..In this review possible mechanisms of nanoparticle-induced exacerbation of heat induced neurotoxicity and brain protection achieved by nanowired drug delivery is discussed that is largely based on our own investigations...
  6. ncbi request reprint Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals
    Preeti Kumaran Menon
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    CNS Neurol Disord Drug Targets 11:40-9. 2012
    ..This indicates that cerebrolysin in higher doses could be a good candidate for treating SCI cases following nanoparticle intoxication. The possible mechanisms and functional significance of these findings are discussed in this review...
  7. ncbi request reprint Diabetes exacerbates nanoparticles induced brain pathology
    Jose Vicente Lafuente
    Lab Clinical and Experimental Neurosciences LaCEN, Dept Neurosciences, University of Basque Country, Box 699, 48080 Bilbao, Spain
    CNS Neurol Disord Drug Targets 11:26-39. 2012
    ..The possible mechanisms and functional significance of these findings are discussed in this review largely based on our own investigations...
  8. ncbi request reprint Neurotoxicity of engineered nanoparticles from metals
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185, Sweden
    CNS Neurol Disord Drug Targets 11:65-80. 2012
    ..The functional significance of these findings and the probable mechanisms of metal nanoparticle-induced neurotoxicity are discussed in this review largely based on our own investigations...
  9. ncbi request reprint Superior neuroprotective effects of cerebrolysin in nanoparticle-induced exacerbation of hyperthermia-induced brain pathology
    Aruna Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    CNS Neurol Disord Drug Targets 11:7-25. 2012
    ..The functional significance and possible mechanisms of drug-induced neuroprotection in nanoparticle-treated, heat-stressed rats are discussed...
  10. doi request reprint Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors
    Hari Shanker Sharma
    Cerebrovascular Research Laboratory, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:184-203. 2012
    ....
  11. doi request reprint 6th Global College of Neuroprotection and Neuroregeneration, annual meeting
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, SE 75185 Uppsala, Sweden
    Expert Rev Neurother 9:941-7. 2009
    ..The GCNN and SSNN conference achieved a new milestone in scientific success in Vienna and established an excellent new working collaboration among the participants in a pleasant, enriched environment with several social gatherings...
  12. doi request reprint Conference Scene: New perspectives on nanoneuroscience, nanoneuropharmacology and nanoneurotoxicology
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala, Sweden
    Nanomedicine (Lond) 4:509-13. 2009
    ..In total, 11 speakers participated in these sessions covering more than 5 h of intensive presentations intermingled with lively discussions from the audience...
  13. doi request reprint Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury
    Hari Shanker Sharma
    Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
    Ann N Y Acad Sci 1139:242-58. 2008
    ....
  14. ncbi request reprint New perspectives for the treatment options in spinal cord injury
    Hari Shanker Sharma
    Uppsala University, University Hospital, Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, SE 75185 Uppsala, Sweden
    Expert Opin Pharmacother 9:2773-800. 2008
    ..This review deals with the key aspects of the latest treatments for SCI and suggests some possible future therapeutic measures to enhance healthcare in clinical situations...
  15. pmc Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy
    Hari S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, University Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
    J Chem Neuroanat 37:18-32. 2009
    ....
  16. doi request reprint 5th Annual Global College of Neuroprotection and Neuroregeneration
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Division of Anesthesiology and Intensive Care Medicine, University Hospital, SE 75185 Uppsala, Sweden
    Expert Rev Neurother 8:881-7. 2008
    ..Thus, these joint meetings of the two societies (GCNN and SSNN) will continue in future in different European cities for the coming 5 years...
  17. ncbi request reprint Antibodies to serotonin attenuate closed head injury induced blood brain barrier disruption and brain pathology
    H S Sharma
    Department of Surgical Sciences, University Hospital, Uppsala University, SE 75421 Uppsala, Sweden
    Ann N Y Acad Sci 1122:295-312. 2007
    ..The plasma and brain serotonin levels continued to remain high. These observations are the first to suggest that antiserum to serotonin when administered into the CSF during the early phase of CHI are capable of inducing neuroprotection...
  18. ncbi request reprint Drug delivery to the spinal cord tagged with nanowire enhances neuroprotective efficacy and functional recovery following trauma to the rat spinal cord
    Hari Shanker Sharma
    Department of Surgical Sciences, University Hospital, Uppsala University, SE 75421 Uppsala, Sweden
    Ann N Y Acad Sci 1122:197-218. 2007
    ..Taken together, our results, probably for the first time, indicate that drug delivery and therapeutic efficacy are enhanced when the compounds are administered with nanowires...
  19. ncbi request reprint Intracerebroventricularly administered neurotrophins attenuate blood cerebrospinal fluid barrier breakdown and brain pathology following whole-body hyperthermia: an experimental study in the rat using biochemical and morphological approaches
    Hari Shanker Sharma
    Department of Surgical Sciences, University Hospital, Uppsala University, SE 75421 Uppsala, Sweden
    Ann N Y Acad Sci 1122:112-29. 2007
    ..Stabilization of BCSFB function is thus one of the crucial factors in achieving neuroprotection in WBH...
  20. ncbi request reprint A select combination of neurotrophins enhances neuroprotection and functional recovery following spinal cord injury
    Hari Shanker Sharma
    Department of Surgical Sciences, University Hospital, Uppsala University, SE 75421 Uppsala, Sweden
    Ann N Y Acad Sci 1122:95-111. 2007
    ..These novel observations suggest that a select group of neurotrophins in combination have potential therapeutic value for the treatment of SCI in clinical situations...
  21. ncbi request reprint Chronic hypertension aggravates heat stress induced cognitive dysfunction and brain pathology: an experimental study in the rat, using growth hormone therapy for possible neuroprotection
    Dafin F Muresanu
    Neurology Department, University of Cluj Napoca, Romania
    Ann N Y Acad Sci 1122:1-22. 2007
    ..These novel observations indicate that patients suffering from various chronic diseases respond differently to various health hazards such as hyperthermia and to other neuroprotective agents...
  22. ncbi request reprint 10th International Conference on Amino Acids and Protein
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Division of Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Expert Rev Neurother 7:1479-84. 2007
  23. ncbi request reprint Interaction between amino acid neurotransmitters and opioid receptors in hyperthermia-induced brain pathology
    Hari Shanker Sharma
    Prog Brain Res 162:295-317. 2007
    ..In addition, opioid receptors play neuromodulatory roles in amino acid neurotransmission in hyperthermia...
  24. doi request reprint Alterations in blood-brain barrier function and brain pathology by morphine in the rat. Neuroprotective effects of antioxidant H-290/51
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Science, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala, Sweden
    Acta Neurochir Suppl 106:61-6. 2010
    ..These observations suggest that psychostimulants and associated oxidative stress are capable to induce brain pathology through modifying the BBB function...
  25. doi request reprint Selected combination of neurotrophins potentiate neuroprotection and functional recovery following spinal cord injury in the rat
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala, Sweden
    Acta Neurochir Suppl 106:295-300. 2010
    ..These observations suggest that a combination of neurotrophins may have added therapeutic value in the treatment of SCI, not reported earlier...
  26. doi request reprint Antibodies to dynorphin a (1-17) attenuate closed head injury induced blood-brain barrier disruption, brain edema formation and brain pathology in the rat
    H S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Science, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala, Sweden
    Acta Neurochir Suppl 106:301-6. 2010
    ..Our work further indicates that dynorphin is actively involved in the cellular and molecular mechanisms of edema formation and BBB breakdown in CHI...
  27. doi request reprint New strategies for CNS injury and repair using stem cells, nanomedicine, neurotrophic factors and novel neuroprotective agents
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Expert Rev Neurother 11:1121-4. 2011
    ..HRH Princess Basma Bint Talal of Jordan inaugurated the congress. The salient new discoveries and recommendations for future strategies discussed during the meeting are summarized in this article...
  28. doi request reprint Cardiac arrest-induced regional blood-brain barrier breakdown, edema formation and brain pathology: a light and electron microscopic study on a new model for neurodegeneration and neuroprotection in porcine brain
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, 75185 Uppsala, Sweden
    J Neural Transm 118:87-114. 2011
    ..These observations strongly suggest that the model could be used to explore new therapeutic agents to enhance neurorepair following cardiac arrest-induced brain damage for therapeutic purposes...
  29. doi request reprint New perspectives on molecular and cellular mechanisms of neuroprotection and neuroregeneration: part II
    Hari Shanker Sharma
    Department of Surgical Sciences, University Hospital, Uppsala University, Uppsala, Sweden
    Expert Rev Neurother 10:1253-7. 2010
    ..The deliberations in this meeting provide new perspectives on the molecular and cellular mechanisms of neuroprotection and neuroregeneration that could be utilized to improve the existing healthcare for the benefit of mankind...
  30. doi request reprint A combination of tumor necrosis factor-alpha and neuronal nitric oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1199:175-85. 2010
    ..This indicates that TNF-alpha and nitric oxide play synergistic roles in the pathophysiology of SCI and combined antibodies therapy has added neuroprotective values in spinal trauma...
  31. doi request reprint Cerebrolysin treatment attenuates heat shock protein overexpression in the brain following heat stress: an experimental study using immunohistochemistry at light and electron microscopy in the rat
    Hari Shanker Sharma
    Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Sweden
    Ann N Y Acad Sci 1199:138-48. 2010
    ..Taken together, these novel observations suggest that upregulation of HSP 72 kD in brain represents neurodestructive signals and a reduction in cellular stress mechanisms leading to decline in HSP expression is neuroprotective in nature...
  32. doi request reprint Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care, University Hospital, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1199:125-37. 2010
    ..Taken together, our observations suggest that Cerebrolysin has potential therapeutic value in TBI...
  33. doi request reprint New perspectives on molecular and cellular mechanisms of neuroprotection and neuroregeneration: part I
    Hari Shanker Sharma
    Cerebrovascular Research Laboratory, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185, Uppsala, Sweden
    Expert Rev Neurother 10:1039-43. 2010
    ..The deliberations in this meeting provide new perspectives on the molecular and cellular mechanisms of neuroprotection and neuroregeneration that could be utilized to improve the existing healthcare for the benefit of mankind...
  34. doi request reprint Conference scene: Nanoneuroprotection and nanoneurotoxicity: recent progress and future perspectives
    Hari Shanker Sharma
    Cerebrovascular Research Laboratory, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185, Uppsala, Sweden
    Nanomedicine (Lond) 5:533-7. 2010
    ..The new developments suggest that more research is needed to understand the potential use of nanoparticles in nanomedicine. Highlights of these presentations are summarized in this article...
  35. doi request reprint Chapter 9 - Nanoparticles influence pathophysiology of spinal cord injury and repair
    Hari Shanker Sharma
    Laboratory of Cerebrovascular and Pain Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Prog Brain Res 180:154-80. 2009
    ....
  36. doi request reprint Influence of nanoparticles on blood-brain barrier permeability and brain edema formation in rats
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Science, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala, Sweden
    Acta Neurochir Suppl 106:359-64. 2010
    ..These observations are the first to suggest that nanoparticles can induce brain edema formation by influencing BBB breakdown in vivo...
  37. doi request reprint A new antioxidant compound H-290/51 attenuates nanoparticle induced neurotoxicity and enhances neurorepair in hyperthermia
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala, Sweden
    Acta Neurochir Suppl 106:351-7. 2010
    ..These observations suggest that nanoparticles aggravate oxidative stress following hyperthermia leading to exacerbation of neurotoxicity through oxidative stress-related mechanisms, not reported earlier...
  38. doi request reprint Nanowired-drug delivery enhances neuroprotective efficacy of compounds and reduces spinal cord edema formation and improves functional outcome following spinal cord injury in the rat
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala, Sweden
    Acta Neurochir Suppl 106:343-50. 2010
    ....
  39. doi request reprint Cerebrolysin attenuates blood-brain barrier and brain pathology following whole body hyperthermia in the rat
    Hari Shanker Sharma
    Laboratory of Carebrovascular Research, Department of Surgical Science, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala, Sweden
    Acta Neurochir Suppl 106:321-5. 2010
    ..These novel observations suggest that cerebrolysin can attenuate WBH induced BBB and BCSFB damage resulting in neuroprotection...
  40. ncbi request reprint Nanoparticles aggravate heat stress induced cognitive deficits, blood-brain barrier disruption, edema formation and brain pathology
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Prog Brain Res 162:245-73. 2007
    ..The possible mechanisms of nanoparticle-induced exacerbation of brain damage in WBH and its functional significance in relation to our current knowledge are discussed in this review...
  41. ncbi request reprint Methods to produce hyperthermia-induced brain dysfunction
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Prog Brain Res 162:173-99. 2007
    ..Since hyperthermia is often associated with profound brain dysfunction, additional methods to examine some crucial parameters of brain injury, e.g., blood-brain barrier (BBB) breakdown and brain edema formation, are also described...
  42. ncbi request reprint Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat
    H S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Division of Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    J Neural Transm 113:521-36. 2006
    ..Further studies using post-injury treatment with H-290/51 is needed to explore its therapeutic potentials in clinical settings...
  43. ncbi request reprint Post-traumatic application of brain-derived neurotrophic factor and glia-derived neurotrophic factor on the rat spinal cord enhances neuroprotection and improves motor function
    H S Sharma
    Laboratory of Cerebrovascular Biology, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:329-34. 2006
    ..These novel observations suggest that neurotrophins in combination have potential therapeutic value for the treatment of SCI in clinical situations...
  44. ncbi request reprint Post-injury treatment with a new antioxidant compound H-290/51 attenuates spinal cord trauma-induced c-fos expression, motor dysfunction, edema formation, and cell injury in the rat
    H S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:322-8. 2006
    ....
  45. ncbi request reprint Histamine receptors influence blood-spinal cord barrier permeability, edema formation, and spinal cord blood flow following trauma to the rat spinal cord
    H S Sharma
    Department of Surgical Sciences, Anesthesiology and Intensive Care, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:316-21. 2006
    ..p.) exacerbated spinal cord pathology. These observations suggest that stimulation of histamine H3 receptors and blockade of histamine H2 receptors is neuroprotective in SCI...
  46. ncbi request reprint Topical application of dynorphin A (1-17) antibodies attenuates neuronal nitric oxide synthase up-regulation, edema formation, and cell injury following focal trauma to the rat spinal cord
    H S Sharma
    Laboratory of Cerebrovascular Research, Department of Anesthesiology and Intensive Care, Institute of Surgical Sciences, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:309-15. 2006
    ....
  47. ncbi request reprint Intracerebral administration of neuronal nitric oxide synthase antiserum attenuates traumatic brain injury-induced blood-brain barrier permeability, brain edema formation, and sensory motor disturbances in the rat
    Hari S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:288-94. 2006
    ....
  48. ncbi request reprint Neuroprotective effects of nitric oxide synthase inhibitors in spinal cord injury-induced pathophysiology and motor functions: an experimental study in the rat
    Hari Shanker Sharma
    Department of Surgical Sciences, Anesthesiology, and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Ann N Y Acad Sci 1053:422-34. 2005
    ..This observation suggests that inhibition of neuronal NOS is important for neuroprotection, and the disturbances in motor function following SCI are associated with the state of spinal cord pathology...
  49. ncbi request reprint Neuroprotective effects of neurotrophins and melanocortins in spinal cord injury: an experimental study in the rat using pharmacological and morphological approaches
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology, and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Ann N Y Acad Sci 1053:407-21. 2005
    ..Taken together, the results indicate that neurotrophins and melanocortins participate in the pathophysiology of spinal cord cell and tissue injury following trauma...
  50. ncbi request reprint Pathophysiology of blood-spinal cord barrier in traumatic injury and repair
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care, University Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
    Curr Pharm Des 11:1353-89. 2005
    ..The probable mechanism(s) of trauma induced BSCB dysfunction and its contribution to cell injuries are discussed...
  51. doi request reprint Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, 75185 Uppsala, Sweden
    J Neural Transm 118:155-76. 2011
    ..It appears that local treatment with new therapeutic agents and nanowired drugs after SCI are needed to enhance neurorepair leading to improved spinal cord cellular functions and the sensory motor performances...
  52. ncbi request reprint Whole-body hyperthermia in the rat disrupts the blood-cerebrospinal fluid barrier and induces brain edema
    H S Sharma
    Laboratory of Cerebrovascular Research, Institute of Surgical Sciences, Department of Anesthesiology and Intensive Care, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:426-31. 2006
    ..These observations suggest that hyperthermia induced by WBH is capable of breaking down the BCSFB and contributing to cell and tissue injury in the central nervous system...
  53. ncbi request reprint Neurotrophic factors in combination: a possible new therapeutic strategy to influence pathophysiology of spinal cord injury and repair mechanisms
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Curr Pharm Des 13:1841-74. 2007
    ..The possible cellular and molecular mechanisms of synergistic effects of some neurotrophins in combination are still speculative and require further investigation...
  54. ncbi request reprint 4th Global College of Neuroprotection and Neuroregeneration meeting
    Hari Shanker Sharma
    Uppsala University, Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, SE 75185 Uppsala, Sweden
    Expert Rev Neurother 7:595-8. 2007
  55. ncbi request reprint A potent serotonin-modulating compound AP-267 attenuates morphine withdrawal-induced blood-brain barrier dysfunction in rats
    Hari S Sharma
    Dr Med Sci, Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Ann N Y Acad Sci 1074:482-96. 2006
    ....
  56. ncbi request reprint Alterations in blood-brain barrier function by morphine and methamphetamine
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Ann N Y Acad Sci 1074:198-224. 2006
    ..These observations suggest that psychostimulants and associated stress are capable to influence the brain function, probably through modifying the BBB function, not reported earlier...
  57. ncbi request reprint Hyperthermia induced brain oedema: current status and future perspectives
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, S 751 85 Uppsala, Sweden
    Indian J Med Res 123:629-52. 2006
    ..The probable mechanisms and functional significance of heat induced brain oedema and BBB damage in relation to neurodegenerative changes are discussed...
  58. ncbi request reprint Neuroprotective effects of melanocortins in CNS injury
    H S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Division of Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Curr Pharm Des 13:1929-41. 2007
    ..This effect of the compounds is related with their ability to attenuate blood-spinal cord barrier permeability. The functional significance and possible therapeutic strategies of these compounds in CNS injury are discussed...
  59. ncbi request reprint Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51
    Hari Shanker Sharma
    Neurochemistry Laboratory, Division of Neurotoxicology, National Centre for Toxicological Research FDA, Jefferson, AR, USA
    Curr Pharm Des 13:1903-23. 2007
    ..The possible mechanisms and functional significance of these findings are discussed...
  60. ncbi request reprint Topical application of TNF-alpha antiserum attenuates spinal cord trauma induced edema formation, microvascular permeability disturbances and cell injury in the rat
    H S Sharma
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 86:407-13. 2003
    ..Taken together, these results suggest that local application of TNF-alpha antiserum is neuroprotective in SCI and that this effect is mediated through NOS regulation...
  61. ncbi request reprint An L-type calcium channel blocker, nimodipine influences trauma induced spinal cord conduction and axonal injury in the rat
    T Winkler
    Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden
    Acta Neurochir Suppl 86:425-32. 2003
    ..These observations suggest that Ca[2+] channels play an important role in the trauma induced alterations in SCEP and axonal injury, and indicate a therapeutic value of Ca[2+] blockers in SCI...
  62. doi request reprint Improved neuroprotective effect of methylene blue with hypothermia after porcine cardiac arrest
    L Wiklund
    Departments of Surgical Sciences Anesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden
    Acta Anaesthesiol Scand 57:1073-82. 2013
    ..We set out to determine if MB administered during CPR could add to the histologic neuroprotective effect of hypothermia...
  63. ncbi request reprint A new antioxidant compound H-290151 attenuates spinal cord injury induced expression of constitutive and inducible isoforms of nitric oxide synthase and edema formation in the rat
    H S Sharma
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 86:415-20. 2003
    ..These results suggest that (i) oxidative stress is involved in SCI induced induction of cNOS and iNOS, (ii) NO plays an important role in the cord pathology, and (iii) that the compound H-290/51 has a potential therapeutic value in SCI...
  64. ncbi request reprint Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord. An immunohistochemical study in the rat
    H S Sharma
    Department of Anatomy, University Hospital, Uppsala University, Sweden
    Amino Acids 14:121-9. 1998
    ..Our data provide new experimental evidences which suggest that BDNF and IGF may exert their potential neuroprotective effects probably via regulation of NOS activity...
  65. ncbi request reprint Neurotrophic factors attenuate microvascular permeability disturbances and axonal injury following trauma to the rat spinal cord
    H S Sharma
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 86:383-8. 2003
    ..This indicates that BSCB opening plays an important role in SCI induced myelin vesiculation and cord pathology...
  66. ncbi request reprint Hyperthermia influences excitatory and inhibitory amino acid neurotransmitters in the central nervous system. An experimental study in the rat using behavioural, biochemical, pharmacological, and morphological approaches
    H S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    J Neural Transm 113:497-519. 2006
    ....
  67. ncbi request reprint Nitric oxide synthase inhibitors influence dynorphin A (1-17) immunoreactivity in the rat brain following hyperthermia
    H S Sharma
    Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden
    Amino Acids 23:247-59. 2002
    ..inhibition of NOS considerably attenuates the dynorphin immunoreaction following heat stress and (iii). upregulation of dynorphin is somehow contributing to hyperthermia induced brain damage, not reported earlier...
  68. ncbi request reprint Neuroprotective effects of melanocortins in experimental spinal cord injury. An experimental study in the rat using topical application of compounds with varying affinity to melanocortin receptors
    H S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Division of Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    J Neural Transm 113:463-76. 2006
    ..Furthermore, compounds acting at melanocortin, MCR4 receptors are capable to induce neuroprotection in spinal cord following trauma...
  69. ncbi request reprint Low molecular weight compounds with affinity to melanocortin receptors exert neuroprotection in spinal cord injury--an experimental study in the rat
    H S Sharma
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 86:399-405. 2003
    ..These observations suggest that the non-peptide compound ME10501 with affinity to the melanocortin receptor MC4 is capable to induce neuroprotection in the spinal cord following trauma not reported earlier...
  70. ncbi request reprint Topical application of dynorphin A (1-17) antiserum attenuates trauma induced alterations in spinal cord evoked potentials, microvascular permeability disturbances, edema formation and cell injury: an experimental study in the rat using electrophysiologic
    T Winkler
    Department of Clinical Neurophysiology, University Hospital, Uppsala
    Amino Acids 23:273-81. 2002
    ..the peptide actively participates in the pathophysiological processes of cell injury in the spinal cord trauma, and (iii). the dynorphin antiserum has potential therapeutic value for the treatment of spinal cord injuries...
  71. ncbi request reprint Involvement of nitric oxide in the pathophysiology of acute heat stress in the rat. Influence of a new antioxidant compound H-290/51
    H S Sharma
    Department of Anatomy, Uppsala University, Sweden
    Ann N Y Acad Sci 813:581-90. 1997
    ..These results suggest that HS has the capacity to induce upregulation of c-NOS, and these effects can be reduced by prior treatment with H-290/51, indicating a possible neuroprotective effect of antioxidants in thermal brain injury...
  72. ncbi request reprint Repeated topical application of growth hormone attenuates blood-spinal cord barrier permeability and edema formation following spinal cord injury: an experimental study in the rat using Evans blue, ([125])I-sodium and lanthanum tracers
    F Nyberg
    Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Amino Acids 23:231-9. 2002
    ....
  73. ncbi request reprint Antioxidant compounds EGB-761 and BN-52021 attenuate brain edema formation and hemeoxygenase expression following hyperthermic brain injury in the rat
    H S Sharma
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 86:313-9. 2003
    ....
  74. ncbi request reprint Neurotrophic factors influence upregulation of constitutive isoform of heme oxygenase and cellular stress response in the spinal cord following trauma. An experimental study using immunohistochemistry in the rat
    H S Sharma
    Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Sweden
    Amino Acids 19:351-61. 2000
    ..These results show that BDNF and IGF-1 attenuate cellular stress response and production of CO following spinal cord injury which seems to be the key factors in neurotrophins induced neuroprotection...
  75. ncbi request reprint Spinal nerve lesion alters blood-spinal cord barrier function and activates astrocytes in the rat
    Torsten Gordh
    Laboratory of Pain Research, Department of Surgical Sciences, Division of Anaesthesiology and Intensive Care Medicine, Uppsala University Hospital, SE 75185, Uppsala, Sweden
    Pain 124:211-21. 2006
    ..These findings may be relevant to our current understanding on the pathophysiology of neuropathic pain...
  76. doi request reprint Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions
    Adriana Miclescu
    Department of Surgical Sciences Anaesthesiology and Critical Care Medicine, Uppsala University, Uppsala, Sweden
    Crit Care Med 38:2199-206. 2010
    ....
  77. ncbi request reprint Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the r
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    J Nanosci Nanotechnol 10:7931-45. 2010
    ..The possible mechanisms and significance of the present findings are discussed...
  78. ncbi request reprint Chronic treatment with nanoparticles exacerbate hyperthermia induced blood-brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired-antioxidant compound H-290/51
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    J Nanosci Nanotechnol 9:5073-90. 2009
    ..Taken together, our observations suggest that nano-wired drug delivery of H-290/51 is a promising approach to induce neuroprotection in hyperthermia induced brain pathology, not reported earlier...
  79. ncbi request reprint Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord
    H S Sharma
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 86:389-94. 2003
    ....
  80. ncbi request reprint Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat
    Hari Shanker Sharma
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Box 571, Biomedical Centre, Uppsala University, SE 75123 Uppsala, Sweden
    Muscle Nerve Suppl 11:S83-91. 2002
    ..These observations suggest that early changes in SCEP reflect secondary injury-induced alterations in the cord microenvironment. Obviously, these changes are crucial in determining the ultimate magnitude and severity of cord pathology...
  81. ncbi request reprint Circulatory arrest as a model for studies of global ischemic injury and neuroprotection
    Lars Wiklund
    Department of Surgical Sciences Anesthesiology and Intensive Care Medicine, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Ann N Y Acad Sci 1053:205-19. 2005
    ..These observations suggest that our model can be used to explore neuroprotective effects of potential therapeutic agents...
  82. ncbi request reprint Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue
    Lars Wiklund
    Department of Surgical Sciences, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Ann N Y Acad Sci 1122:231-44. 2007
    ..The last two effects are recorded as less increase in plasma concentrations of astroglial protein S-100beta, as well as troponin I and creatine kinase isoenzyme MB, respectively...
  83. ncbi request reprint Silicon dioxide nanoparticles (SiO2, 40-50 nm) exacerbate pathophysiology of traumatic spinal cord injury and deteriorate functional outcome in the rat. An experimental study using pharmacological and morphological approaches
    Hari Shanker Sharma
    Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    J Nanosci Nanotechnol 9:4970-80. 2009
    ..These observations are the first to suggest that exposure of nanoparticles enhances the sensitivity of CNS to injuries and alter the effect of neuroprotective drugs...
  84. ncbi request reprint Chronic spinal nerve ligation induces microvascular permeability disturbances, astrocytic reaction, and structural changes in the rat spinal cord
    T Gordh
    Laboratory of Pain Research, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:335-40. 2006
    ..These findings enhance our understanding of the pathophysiology of neuropathic pain and/or other spinal cord disorders...
  85. ncbi request reprint Zinc protoporphyrin IX attenuates closed head injury-induced edema formation, blood-brain barrier disruption, and serotonin levels in the rat
    P Vannemreddy
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Acta Neurochir Suppl 96:151-6. 2006
    ....
  86. ncbi request reprint Blood-cerebrospinal fluid barrier in hyperthermia
    Hari Shanker Sharma
    Laboratory of Cerebrovascular Research, Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care, University Hospital, Uppsala University, SE 75185 Uppsala, Sweden
    Prog Brain Res 162:459-78. 2007
    ..Taken together, these findings suggest that the breaching of the BCSFB in hyperthermia significantly contributes to cell and tissue injuries in the CNS...
  87. doi request reprint Sex differences in cerebral injury after severe haemorrhage and ventricular fibrillation in pigs
    E Semenas
    Department of Surgical Sciences Anesthesiology and Intensive Care, Faculty of Medicine, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Acta Anaesthesiol Scand 54:343-53. 2010
    ..The hypothesis was that cerebral injury is less extensive in female animals, and that this difference is independent of sexual hormones or choice of resuscitative fluid...
  88. ncbi request reprint Hyperthermia induced pathophysiology of the central nervous system
    H S Sharma
    Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Centre, Uppsala University, SE 75123 Uppsala, Sweden
    Int J Hyperthermia 19:325-54. 2003
    ..The probable mechanism(s) underlying hyperthermia induced brain pathology is discussed...
  89. ncbi request reprint Neurodegeneration and neuroregeneration: recent advancements and future perspectives
    Hari Shanker Sharma
    Curr Pharm Des 13:1825-7. 2007
  90. ncbi request reprint Nanoneuroscience: emerging concepts on nanoneurotoxicity and nanoneuroprotection
    Hari Shanker Sharma
    Nanomedicine (Lond) 2:753-8. 2007