Marika V Nestor

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas
    Marika Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S 751 85 Uppsala, Sweden
    Nucl Med Biol 38:103-12. 2011
  2. doi request reprint Effect of cetuximab treatment in squamous cell carcinomas
    Marika Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Tumour Biol 31:141-7. 2010
  3. doi request reprint Targeted radionuclide therapy in head and neck cancer
    Marika V Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Head Neck 32:666-78. 2010
  4. doi request reprint Characterization of 111In and 177Lu-labeled antibodies binding to CD44v6 using a novel automated radioimmunoassay
    Marika Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    J Mol Recognit 21:179-83. 2008
  5. ncbi request reprint Quantification of CD44v6 and EGFR expression in head and neck squamous cell carcinomas using a single-dose radioimmunoassay
    Marika Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Tumour Biol 28:253-63. 2007
  6. ncbi request reprint In vitro evaluation of the astatinated chimeric monoclonal antibody U36, a potential candidate for treatment of head and neck squamous cell carcinoma
    M Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Eur J Nucl Med Mol Imaging 32:1296-304. 2005
  7. ncbi request reprint Biodistribution of the chimeric monoclonal antibody U36 radioiodinated with a closo-dodecaborate-containing linker. Comparison with other radioiodination methods
    Marika Nestor
    Division of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Bioconjug Chem 14:805-10. 2003
  8. doi request reprint Blocking EGFR in the liver improves the tumor-to-liver uptake ratio of radiolabeled EGF
    Heewa Kareem
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Akademiska sjukhuset, SE 751 85, Uppsala, Sweden
    Tumour Biol 31:79-87. 2010
  9. doi request reprint Targeting CD44v6 expressed in head and neck squamous cell carcinoma: preclinical characterization of an 111In-labeled monoclonal antibody
    Karl Sandström
    Department of Surgical Sciences, Unit of Otolaryngology and Head and Neck Surgery, Uppsala University, Uppsala, Sweden
    Tumour Biol 29:137-44. 2008
  10. ncbi request reprint Radioimmunotherapy with astatine-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma
    Junping Cheng
    Department of Oto Rhino Laryngology and Head and Neck Surgery, Uppsala University Hospital Akademiska sjukhuset, Uppsala, Sweden
    Laryngoscope 117:1013-8. 2007

Detail Information

Publications11

  1. doi request reprint Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas
    Marika Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S 751 85 Uppsala, Sweden
    Nucl Med Biol 38:103-12. 2011
    ..In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed...
  2. doi request reprint Effect of cetuximab treatment in squamous cell carcinomas
    Marika Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Tumour Biol 31:141-7. 2010
    ..In addition, other factors may further influence the long-term treatment response of cetuximab. Moreover, the time-dependent manner of cetuximab response demonstrates the importance of long-term measurements for this substance...
  3. doi request reprint Targeted radionuclide therapy in head and neck cancer
    Marika V Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Head Neck 32:666-78. 2010
    ..In the next few years the use of TRT may offer new opportunities for further improvement of the therapeutic ratio that potentially may obviate or reduce the need for conventional cytotoxics...
  4. doi request reprint Characterization of 111In and 177Lu-labeled antibodies binding to CD44v6 using a novel automated radioimmunoassay
    Marika Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    J Mol Recognit 21:179-83. 2008
    ..The obtained results were in agreement with previously reported findings. In addition the real-time detection and higher time resolution made more detailed studies of the interactions possible...
  5. ncbi request reprint Quantification of CD44v6 and EGFR expression in head and neck squamous cell carcinomas using a single-dose radioimmunoassay
    Marika Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Tumour Biol 28:253-63. 2007
    ..In this study, CD44v6 and EGFR expression was quantified in samples of patients with head and neck squamous cell carcinoma (HNSCC) using a single-dose (SD) radioimmunoassay...
  6. ncbi request reprint In vitro evaluation of the astatinated chimeric monoclonal antibody U36, a potential candidate for treatment of head and neck squamous cell carcinoma
    M Nestor
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Eur J Nucl Med Mol Imaging 32:1296-304. 2005
    ..The purpose of this study was to analyse the properties of the astatinated chimeric MAb (cMAb) U36 as a conjugate to selectively target and eradicate head and neck squamous cell carcinoma (HNSCC)...
  7. ncbi request reprint Biodistribution of the chimeric monoclonal antibody U36 radioiodinated with a closo-dodecaborate-containing linker. Comparison with other radioiodination methods
    Marika Nestor
    Division of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Bioconjug Chem 14:805-10. 2003
    ..Apart from the specific results obtained, these findings also demonstrate how the right linker molecule will provide additional opportunities to further improve the properties of an antibody-radionuclide conjugate...
  8. doi request reprint Blocking EGFR in the liver improves the tumor-to-liver uptake ratio of radiolabeled EGF
    Heewa Kareem
    Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, Akademiska sjukhuset, SE 751 85, Uppsala, Sweden
    Tumour Biol 31:79-87. 2010
    ..We conclude that the Affibody molecule (Z(EGFR:955))(2) shows promise as a blocking agent that could enhance the outcome of radionuclide-based EGFR-expressing tumor diagnostics and imaging...
  9. doi request reprint Targeting CD44v6 expressed in head and neck squamous cell carcinoma: preclinical characterization of an 111In-labeled monoclonal antibody
    Karl Sandström
    Department of Surgical Sciences, Unit of Otolaryngology and Head and Neck Surgery, Uppsala University, Uppsala, Sweden
    Tumour Biol 29:137-44. 2008
    ..i. compared to huA33. We produced a novel radioimmunoconjugate targeting CD44v6 for possible use in the detection of HNSCC. The conjugate demonstrates no adverse effects from labeling and a favorable biodistribution...
  10. ncbi request reprint Radioimmunotherapy with astatine-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma
    Junping Cheng
    Department of Oto Rhino Laryngology and Head and Neck Surgery, Uppsala University Hospital Akademiska sjukhuset, Uppsala, Sweden
    Laryngoscope 117:1013-8. 2007
    ..We aim to evaluate the biodistribution and therapeutic effect of radioimmunotherapy using the alpha emitting, astatine-211-labeled, chimeric monoclonal antibody U36 (U36) on the HNSCC cell line UT-SCC7 in vivo...
  11. ncbi request reprint Tumor-cell targeted epiderimal growth factor liposomes loaded with boronated acridine: uptake and processing
    Erika Bohl Kullberg
    Division of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Rudbeck Laboratory, Uppsala University, S 751 85 Uppsala, Sweden
    Pharm Res 20:229-36. 2003
    ..The liposomes were actively loaded with water-soluble boronated acridine (WSA), primarily developed for boron neutron capture therapy...