Christina Strom Moller

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi Impact of follow-up time and re-measurement of the electrocardiogram and conventional cardiovascular risk factors on their predictive value for myocardial infarction
    Christina Strom Moller
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    J Intern Med 260:22-30. 2006
  2. pmc T wave abnormalities, high body mass index, current smoking and high lipoprotein (a) levels predict the development of major abnormal Q/QS patterns 20 years later. A population-based study
    Christina Strom Moller
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    BMC Cardiovasc Disord 6:10. 2006
  3. pmc Age and follow-up time affect the prognostic value of the ECG and conventional cardiovascular risk factors for stroke in adult men
    Christina Strom Moller
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    J Epidemiol Community Health 61:704-12. 2007
  4. ncbi Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Sweden
    J Hypertens 22:2321-8. 2004
  5. ncbi Insulin resistance, dietary fat intake and blood pressure predict left ventricular diastolic function 20 years later
    Johan Arnlov
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Nutr Metab Cardiovasc Dis 15:242-9. 2005
  6. ncbi Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:169-73. 2004
  7. pmc Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study
    Jonas Hansson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e16185. 2011
  8. pmc Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Uppsala University Hospital, Entrance 70, 3rd Floor, 751 85 Uppsala, Sweden
    BMC Cardiovasc Disord 4:16. 2004
  9. pmc Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cardiovasc Disord 3:11. 2003
  10. ncbi A Doppler-derived index of combined left ventricular systolic and diastolic function is an independent predictor of cardiovascular mortality in elderly men
    Johan Arnlov
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Am Heart J 149:902-7. 2005

Detail Information

Publications98

  1. ncbi Impact of follow-up time and re-measurement of the electrocardiogram and conventional cardiovascular risk factors on their predictive value for myocardial infarction
    Christina Strom Moller
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    J Intern Med 260:22-30. 2006
    ....
  2. pmc T wave abnormalities, high body mass index, current smoking and high lipoprotein (a) levels predict the development of major abnormal Q/QS patterns 20 years later. A population-based study
    Christina Strom Moller
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    BMC Cardiovasc Disord 6:10. 2006
    ..Our aim was to identify factors that could predict the development of ECG markers of CHD, such as abnormal Q/QS patterns, ST segment depression and T wave abnormalities, in 70-year-old men, irrespective of clinical outcome...
  3. pmc Age and follow-up time affect the prognostic value of the ECG and conventional cardiovascular risk factors for stroke in adult men
    Christina Strom Moller
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    J Epidemiol Community Health 61:704-12. 2007
    ..To explore whether the predictive power of mid-life ECG abnormalities and conventional cardiovascular risk factors for future stroke change over a 30-year follow-up period, and whether a repeated examination improves their predictive power...
  4. ncbi Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Sweden
    J Hypertens 22:2321-8. 2004
    ....
  5. ncbi Insulin resistance, dietary fat intake and blood pressure predict left ventricular diastolic function 20 years later
    Johan Arnlov
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Nutr Metab Cardiovasc Dis 15:242-9. 2005
    ....
  6. ncbi Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:169-73. 2004
    ..The TGF-beta1 G + 915C polymorphism is associated with interindividual variation in TGF-beta1 production. No study has yet determined the impact of this polymorphism on the response to antihypertensive treatment...
  7. pmc Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study
    Jonas Hansson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e16185. 2011
    ..An altered extracellular matrix metabolism has been implicated in a variety of diseases. We investigated relations of serum levels of MMP-9 and TIMP-1 to mortality risk from an etiological perspective...
  8. pmc Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Uppsala University Hospital, Entrance 70, 3rd Floor, 751 85 Uppsala, Sweden
    BMC Cardiovasc Disord 4:16. 2004
    ..Dyslipidemia has been associated with hypertension. The present study explored if polymorphisms in genes encoding proteins in lipid metabolism could be used as predictors for the individual response to antihypertensive treatment...
  9. pmc Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cardiovasc Disord 3:11. 2003
    ..The enzyme seems to be particularly abundant in the heart. Recently, the Arg528-encoding allele of the ALAP gene was shown to be associated with essential hypertension...
  10. ncbi A Doppler-derived index of combined left ventricular systolic and diastolic function is an independent predictor of cardiovascular mortality in elderly men
    Johan Arnlov
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Am Heart J 149:902-7. 2005
    ..The novel myocardial performance index (MPI, also denoted as Tei-Doppler index) has been suggested to reflect both left ventricular (LV) systolic and diastolic function...
  11. doi Plasma parathyroid hormone and the risk of cardiovascular mortality in the community
    Emil Hagström
    Uppsala Clinical Research Center, Uppsala University, Sweden
    Circulation 119:2765-71. 2009
    ..However, data on the prospective association between circulating PTH levels and cardiovascular mortality in the community are lacking...
  12. ncbi Prognostic significance of 24-h ambulatory blood pressure characteristics for cardiovascular morbidity in a population of elderly men
    Kristina Björklund
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    J Hypertens 22:1691-7. 2004
    ..This study aimed to investigate the prognostic significance of 24-h ambulatory systolic (SBP), diastolic (DBP) and pulse pressure (PP), and blood pressure (BP) variability for cardiovascular morbidity in elderly men...
  13. doi Plasma parathyroid hormone and risk of congestive heart failure in the community
    Emil Hagström
    Uppsala Clinical Research Center, Uppsala University, 751 85 Uppsala, Sweden
    Eur J Heart Fail 12:1186-92. 2010
    ..Moreover, increasing PTH is associated with worse prognosis in patients with overt HF. However, the association between PTH and the development HF in the community has not been reported...
  14. doi The effects of antihypertensive treatment on the doppler-derived myocardial performance index in patients with hypertensive left ventricular hypertrophy: results from the Swedish irbesartan in left ventricular hypertrophy investigation versus atenolol (SI
    Stefan Liljedahl
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Echocardiography 26:753-8. 2009
    ..To investigate the effects of antihypertensive treatment on the Doppler-derived myocardial performance index (MPI) in patients with hypertensive left ventricular hypertrophy...
  15. ncbi Evaluation of a scoring scheme, including proinsulin and the apolipoprotein B/apolipoprotein A1 ratio, for the risk of acute coronary events in middle-aged men: Uppsala Longitudinal Study of Adult Men (ULSAM)
    Kristina Dunder
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Am Heart J 148:596-601. 2004
    ....
  16. ncbi The apolipoprotein B/AI ratio and the metabolic syndrome independently predict risk for myocardial infarction in middle-aged men
    Lars Lind
    Department of Medical Sciences, Uppsala University, Sweden
    Arterioscler Thromb Vasc Biol 26:406-10. 2006
    ....
  17. ncbi Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men
    Eva Warensjo
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 84:442-8. 2006
    ..A specific fatty acid (FA) composition in plasma lipid esters is related to the metabolic syndrome (MetS) and may influence the development of the MetS...
  18. doi Endothelial function in resistance and conduit arteries and 5-year risk of cardiovascular disease
    Lars Lind
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Circulation 123:1545-51. 2011
    ..Little is known of the relations of measures of endothelial function in resistance and conduit arteries to incident cardiovascular disease in the general population, and available techniques have not been compared...
  19. ncbi Polymorphisms in the estrogen receptor alpha gene and endothelial function in resistance and conduit arteries in the elderly
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Atherosclerosis 199:162-71. 2008
    ..Our aim was to examine the relations of single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) to endothelium-dependent vasodilation...
  20. ncbi Diurnal blood pressure pattern and risk of congestive heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    JAMA 295:2859-66. 2006
    ..High blood pressure is the most important risk factor for congestive heart failure (CHF) at a population level, but the relationship of an altered diurnal blood pressure pattern to risk of subsequent CHF is unknown...
  21. ncbi hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men
    Johan Arnlov
    Department of Public Health and Caring Sciences Geriatrics, PO Box 609, S 75125 Uppsala, Sweden
    Eur J Heart Fail 7:958-65. 2005
    ..The hUNC-93B1 gene has the highest expression in the heart. We aimed to explore relationships between the hUNC-93B1 gene and cardiac function, morbidity and mortality in elderly men...
  22. ncbi Low-grade albuminuria and the incidence of heart failure in a community-based cohort of elderly men
    Erik Ingelsson
    Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Eur Heart J 28:1739-45. 2007
    ..To investigate associations of urinary albumin excretion rate (UAER) and heart failure (HF) incidence in a community-based sample...
  23. ncbi Cardiovascular risk factors for stable angina pectoris versus unheralded myocardial infarction
    Kristina Dunder
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Am Heart J 147:502-8. 2004
    ..This study compared baseline risk factors between subjects in whom stable angina pectoris developed and subjects in whom unheralded fatal or nonfatal MI developed during the follow-up period...
  24. ncbi The Doppler-derived myocardial performance index is determined by both left ventricular systolic and diastolic function as well as by afterload and left ventricular mass
    Lars Lind
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Echocardiography 22:211-6. 2005
    ....
  25. doi A detailed cardiovascular characterization of obesity without the metabolic syndrome
    Lars Lind
    Department of Medical Sciences, Uppsala University, Sweden
    Arterioscler Thromb Vasc Biol 31:e27-34. 2011
    ..To investigate the basis for that increased risk, we studied the impact of obesity without MetS on multiple markers of subclinical CV disease...
  26. ncbi Novel metabolic risk factors for heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    J Am Coll Cardiol 46:2054-60. 2005
    ..Our objectives were to explore novel metabolic risk factors for development of heart failure (HF)...
  27. ncbi Sleep disturbances independently predict heart failure in overweight middle-aged men
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Eur J Heart Fail 9:184-90. 2007
    ..Sleep disturbances are associated with manifest heart failure (HF). However, the relationship between sleep disturbances and incident HF has been less studied...
  28. ncbi Acute elevations of medium- and long-chain fatty acid have different impacts on endothelium-dependent vasodilation in humans
    Peter Steer
    Department of Medical Sciences Internal Medicine, University Hospital, SE 751 85 Uppsala, Sweden
    Lipids 38:15-9. 2003
    ..05). In conclusion, an acute elevation of LCFA attenuated EDV, whereas an elevation of both MCFA and LCFA did not influence EDV. Thus, FA composition seems to be of importance for EDV in healthy humans...
  29. doi Relations of serum MMP-9 and TIMP-1 levels to left ventricular measures and cardiovascular risk factors: a population-based study
    Jonas Hansson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Eur J Cardiovasc Prev Rehabil 16:297-303. 2009
    ..We hypothesized that circulating MMP-9 and TIMP-1 levels are altered already in persons with the signs of LV remodeling that forego clinical heart failure...
  30. ncbi Severity of periodontal disease and number of remaining teeth are related to the prevalence of myocardial infarction and hypertension in a study based on 4,254 subjects
    Anders Holmlund
    Department of Periodontology, The County Hospital of Gävle Sandviken, Center for Research and Development, Uppsala University, Gavle, Sweden
    J Periodontol 77:1173-8. 2006
    ..The aim of this study was to investigate how the severity of periodontal disease and number of remaining teeth relates to myocardial infarction (MI) and hypertension (HT)...
  31. pmc Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men
    Johan Arnlov
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala, Sweden
    Diabetes Care 34:61-5. 2011
    ..We aimed to investigate associations between combinations of BMI categories and metabolic syndrome and risk of type 2 diabetes in middle-aged men...
  32. doi Association between serum cathepsin S and mortality in older adults
    Elisabeth Jobs
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    JAMA 306:1113-21. 2011
    ..However, prospective data concerning a potential association between circulating cathepsin S levels and mortality are lacking...
  33. ncbi Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men
    Johan Arnlov
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, SE 751 85 Uppsala, Sweden
    Circulation 121:230-6. 2010
    ..The purpose of this study was to investigate associations between combinations of body mass index (BMI) categories and metabolic syndrome (MetS) and the risk of cardiovascular disease and death in middle-aged men...
  34. pmc Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study
    Johan Sundstrom
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    BMJ 332:878-82. 2006
    ..To find out if the presence of the metabolic syndrome increases the risk of subsequent total and cardiovascular mortality, taking into account established risk factors for cardiovascular disease...
  35. ncbi Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population
    Helena Petersson
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden
    Atherosclerosis 203:298-303. 2009
    ..This study investigates the associations between serum FA composition, including SCD-1 index, and various inflammatory and endothelial function markers...
  36. ncbi Evaluation of four different methods to measure endothelium-dependent vasodilation in the human peripheral circulation
    Lars Lind
    Department of Internal Medicine, University Hospital, SE 751 85 Uppsala, Sweden
    Clin Sci (Lond) 102:561-7. 2002
    ....
  37. pmc Increase in blood glucose concentration during antihypertensive treatment as a predictor of myocardial infarction: population based cohort study
    Kristina Dunder
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, PO Box 609, SE 751 25 Uppsala, Sweden
    BMJ 326:681. 2003
    ..To investigate the impact of an increase in blood glucose on the risk of developing myocardial infarction, with particular emphasis on people taking antihypertensive drugs...
  38. ncbi A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Pharmacogenetics 13:7-17. 2003
    ..Our results highlight the potential of microarray-based technology for SNP genotyping in pharmacogenetics...
  39. ncbi Metabolic risk factors for stroke and transient ischemic attacks in middle-aged men: a community-based study with long-term follow-up
    Bernice Wiberg
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Stroke 37:2898-903. 2006
    ..We investigated relations of a comprehensive panel of baseline lipometabolic and glucometabolic variables to incident fatal and nonfatal stroke or transient ischemic attack (TIA), and stroke subtypes...
  40. ncbi The stroke volume/pulse pressure ratio predicts coronary heart disease mortality in a population of elderly men
    Lars Lind
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Hypertens 22:899-905. 2004
    ..The relations to cardiovascular risk factors and its predictive capacity in the general population are not known...
  41. ncbi Socioeconomic factors as predictors of incident heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Card Fail 12:540-5. 2006
    ..Further, it is unknown if these factors predict incident HF independently of myocardial infarction and other established risk factors for HF...
  42. pmc Association of the estrogen receptor 1 (ESR1) gene with body height in adult males from two Swedish population cohorts
    Andreas Dahlgren
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 3:e1807. 2008
    ..90 cm taller than individuals with the two other genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort. No association was observed for the females in the PIVUS cohort...
  43. doi Serum levels of matrix metalloproteinase-9, tissue inhibitors of metalloproteinase-1 and their ratio are associated with impaired lung function in the elderly: a population-based study
    Inga S Olafsdóttir
    Department of Medical sciences Respiratory Medicine and Allergology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Respirology 15:530-5. 2010
    ..The aim of this study was to investigate the associations of serum MMP-9 and TIMP-1 with lung function...
  44. ncbi Insulin resistance and risk of congestive heart failure
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    JAMA 294:334-41. 2005
    ..Diabetes and obesity are established risk factors for congestive heart failure (CHF) and are both associated with insulin resistance...
  45. ncbi Hypertension and SNP genotyping in antihypertensive treatment
    Lisa Kurland
    Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden
    Cardiovasc Toxicol 5:133-42. 2005
    ..We also discuss some of the novel results of pharmacodynamic studies in antihypertensive treatment, an area in its infancy...
  46. doi Endothelial function in patients with polycystic ovary syndrome: a long-term follow-up study
    Miriam Hudecova
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Fertil Steril 94:2654-8. 2010
    ..To investigate pulse wave reflection and endothelial-dependent vasodilation in patients with polycystic ovary syndrome (PCOS) and age-matched healthy controls...
  47. ncbi The validity of a diagnosis of heart failure in a hospital discharge register
    Erik Ingelsson
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Box 609, SE 75125 Uppsala, Sweden
    Eur J Heart Fail 7:787-91. 2005
    ..The accuracy of a diagnosis of heart failure (HF) in hospital discharge registers is largely unknown. We aimed to determine the validity of such a diagnosis in the Swedish hospital discharge register...
  48. pmc Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly
    Josefin A Jacobsson
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e20158. 2011
    ..In contrast, this association was not found in elderly men. BMI is a measure of overweight in relation to the individuals' height, but offers no insight into the regional body fat composition or distribution...
  49. doi Reference values for 27 clinical chemistry tests in 70-year-old males and females
    Lena Carlsson
    Department of Medical Sciences, Uppsala University, Sweden
    Gerontology 56:259-65. 2010
    ..These values are not optimal for elderly patients, as many biological markers change over time and adequate reference values are important for correct clinical decisions...
  50. ncbi Increased long-term mortality in patients with repeated visits to the emergency department
    Urban Safwenberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Eur J Emerg Med 17:274-9. 2010
    ..Revisits to the emergency department (ED) are common. It is not clear whether the number of revisits, the time between revisits or the reason for the revisits are associated with increased mortality...
  51. ncbi Isolated ambulatory hypertension predicts cardiovascular morbidity in elderly men
    Kristina Björklund
    Department of Public Health and Caring Sciences Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Circulation 107:1297-302. 2003
    ..This study aimed to investigate the prognostic significance of isolated ambulatory hypertension for cardiovascular morbidity in a population of elderly men...
  52. ncbi Myocardial performance index, a Doppler-derived index of global left ventricular function, predicts congestive heart failure in elderly men
    Johan Arnlov
    Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
    Eur Heart J 25:2220-5. 2004
    ..Myocardial performance index (MPI, also denoted TEI-Doppler index) reflects both left ventricular (LV) systolic and diastolic function...
  53. pmc Persistent ischaemic ECG abnormalities on repeated ECG examination have important prognostic value for cardiovascular disease beyond established risk factors: a population-based study in middle-aged men with up to 32 years of follow-up
    Christina Ström Möller
    AstraZeneca R and D Sodertalje, Sodertalje, Sweden
    Heart 93:1104-10. 2007
    ..To determine the effect of new, persistent or reverted ischaemic ECG abnormalities at ages 50 and 70 years on the risk of subsequent cardiovascular disease...
  54. ncbi A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and function
    Helena Brändström
    Department of Medical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 293:13-7. 2002
    ..01) as compared to those with the T allele. Thus, our results show that the polymorphism in the promoter region of OPG is associated with both vascular morphology and function in apparently healthy subjects...
  55. ncbi Skeletal muscle magnesium content is correlated with plasma glucose concentration in patients with essential hypertension treated with lisinopril or bendrofluazide
    Arvo Haenni
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    Am J Hypertens 15:735-8. 2002
    ..However, the Mg concentration in skeletal muscle did not significantly predict the insulin sensitivity or glucose tolerance...
  56. ncbi The majority of nondipping men do not have increased cardiovascular risk: a population-based study
    Kristina Björklund
    Department of Public Health and Caring Sciences Section of Geriatrics, University of Uppsala, Uppsala, Sweden
    J Hypertens 20:1501-6. 2002
    ..To investigate whether nondipping and diabetes are independently related to metabolic risk profile and prevalence of target organ damage in a population setting...
  57. ncbi Different metabolic predictors of white-coat and sustained hypertension over a 20-year follow-up period: a population-based study of elderly men
    Kristina Björklund
    Department of Public Health and Caring Sciences Section of Geriatrics, University of Uppsala, Sweden
    Circulation 106:63-8. 2002
    ..The clinical significance of white-coat hypertension is still unclear. Moreover, no study has examined metabolic predictors of white-coat versus sustained hypertension...
  58. ncbi Magnesium infusion improves endothelium-dependent vasodilation in the human forearm
    Arvo Haenni
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Sweden
    Am J Hypertens 15:10-5. 2002
    ..In conclusion, this in vivo study showed that intraarterial magnesium infusion increased EDV in the infused human forearm, which is in accordance with findings in previous in vitro and animal experiments...
  59. ncbi Inflammation, as measured by the erythrocyte sedimentation rate, is an independent predictor for the development of heart failure
    Erik Ingelsson
    Public Health and Caring Sciences, Uppsala, Sweden
    J Am Coll Cardiol 45:1802-6. 2005
    ..Our objective was to explore inflammation, measured as erythrocyte sedimentation rate (ESR), as a predictor for the development of heart failure (HF)...
  60. ncbi The CYP2C9 genotype predicts the blood pressure response to irbesartan: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Hypertens 20:2089-93. 2002
    ..However, its influence on clinical response to treatment with the AT(1) receptor antagonist, irbesartan, has not been investigated...
  61. ncbi The effect of a mixed meal on endothelium-dependent vasodilation is dependent on fat content in healthy humans
    Peter Steer
    Department of Medical Sciences Internal Medicine, University Hospital, SE 751 85 Uppsala, Sweden
    Clin Sci (Lond) 105:81-7. 2003
    ..Our findings indicate that a dietary fat content of 20 E% or less might be beneficial to endothelial vasodilatory function...
  62. ncbi Relations of growth-differentiation factor-15 to biomarkers reflecting vascular pathologies in a population-based sample of elderly subjects
    Kai M Eggers
    Department of Medical Sciences Cardiology and Clinical Chemistry and Clinical Research Center, Uppsala University, Uppsala, Sweden
    Scand J Clin Lab Invest 72:45-51. 2012
    ..GDF-15 is commonly related to cardiovascular risk factors, inflammatory activity and cardiac abnormalities. However, it is not clear whether it might be an indicator of vascular pathologies as well...
  63. pmc Circulating levels of persistent organic pollutants (POPs) and carotid atherosclerosis in the elderly
    P Monica Lind
    Occupational and Environmental Medicine, Department of Medicine, Uppsala University, Uppsala, Sweden
    Environ Health Perspect 120:38-43. 2012
    ..Because myocardial infarction is an atherosclerotic disease, we investigated, in a cross-sectional study, whether POP levels are related to atherosclerosis...
  64. ncbi Improvement in central arterial pressure waveform during hemodialysis is related to a reduction in asymmetric dimethylarginine (ADMA) levels
    Inga Soveri
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Nephron Clin Pract 106:c180-6. 2007
    ..Therefore, we aimed to study changes in ADMA levels and central arterial pressure waveform during HD...
  65. doi Circulating levels of persistent organic pollutants associate in divergent ways to fat mass measured by DXA in humans
    Monika Rönn
    Occupational and Environmental Medicine, Department of Medicine, Uppsala University, and Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Chemosphere 85:335-43. 2011
    ..Environmental contaminants have recently been implicated in the pathogenesis of obesity...
  66. ncbi Influence of nervous blockade on insulin-mediated glucose uptake in the human forearm
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Metabolism 52:413-7. 2003
    ....
  67. ncbi The effect of smoking on endothelial vasodilatory function evaluated by local infusion of metacholine in the forearm is dependent on the duration of smoking
    Lars Lind
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Nicotine Tob Res 5:125-30. 2003
    ....
  68. ncbi The dioxin-like pollutant PCB 126 (3,3',4,4',5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats
    P Monica Lind
    Karolinska Institutet, Institute of Environmental Medicine, Nobels vag 13, plan 3, P O Box 210, 171 77 Stockholm, Sweden
    Toxicol Lett 150:293-9. 2004
    ..Of these effects of PCB 126, the increase in blood pressure was dependent on estrogen status...
  69. ncbi Analysis of endothelium-dependent vasodilation by use of the radial artery pulse wave obtained by applanation tonometry
    Lars Lind
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 23:50-7. 2003
    ....
  70. ncbi Endothelium-dependent vasodilation in normotensive subjects with a familial history of essential hypertension and in young subjects with borderline hypertension
    Jonas Millgård
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Blood Press 11:279-84. 2002
    ..To investigate if young normotensive subjects with a familial history of essential hypertension (FHH) or young borderline-hypertensive (BHT) subjects have a defect endothelial function...
  71. ncbi Vasodilation in resistance arteries is related to the apolipoprotein B/A1 ratio in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, AstraZeneca R and D Molndal, 751 85 Uppsala, Sweden
    Atherosclerosis 190:378-84. 2007
    ..The present study aims to relate apoB/A1 to endothelium-dependent vasodilation, an early marker of atherosclerosis, in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study...
  72. ncbi Cyclooxygenase inhibition improves endothelium-dependent vasodilatation in patients with chronic renal failure
    Margus Annuk
    Department of Medical Science, University Hospital, Uppsala, Sweden
    Nephrol Dial Transplant 17:2159-63. 2002
    ..The aim of the present study was to investigate the acute effects of L-arginine and diclofenac on endothelium-dependent vasodilatation (EDV) and endothelium-independent vasodilatation (EIDV) in patients with chronic renal failure (CRF)...
  73. ncbi Endothelium-dependent vasodilation is impaired in apparently healthy subjects with a family history of myocardial infarction
    Lars Lind
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    J Cardiovasc Risk 9:53-7. 2002
    ..To investigate whether endothelial-dependent vasodilation is altered in healthy subjects with a family history of myocardial infarction...
  74. ncbi Endothelial function, CRP and oxidative stress in chronic kidney disease
    Margus Annuk
    Department of Medical Sciences, Uppsala University, Uppsala Sweden
    J Nephrol 18:721-6. 2005
    ..Our aim was to investigate the relationship between high sensitivity C-reactive protein (CRP), endothelium dependent vasodilation (EDV) and oxidative stress markers in patients with CKD K/DOQI stage 3-5...
  75. ncbi Lipids and endothelium-dependent vasodilation--a review
    Lars Lind
    Department of Medicine, Uppsala University Hospital and AstraZeneca R and D, Möndal, Sweden
    Lipids 37:1-15. 2002
    ..Furthermore, discrepancies regarding the role of triglycerides and fat content in food may be explained by divergent effects of different fatty acids on the endothelium...
  76. ncbi Insulin-mediated vasodilatation, but not glucose uptake or endothelium-mediated vasodilatation, is enhanced in young females compared with males
    Lars Lind
    Department of Internal Medicine, University Hospital, S 751 85 Uppsala, Sweden
    Clin Sci (Lond) 102:241-6. 2002
    ..However, no differences between the sexes were seen with regard to insulin-mediated glucose uptake and the ability of insulin to enhance endothelium-dependent vasodilatation...
  77. doi Prognostic value of ambulatory heart rate revisited in 6928 subjects from 6 populations
    Tine W Hansen
    Research Center for Prevention and Health and Department of Clinical Physiology, Faculty of Health Sciences, Hvidovre University Hospital, Copenhagen, Denmark
    Hypertension 52:229-35. 2008
    ..With the exception of the night:day heart rate ratio, heart rate did not add to the risk stratification for fatal combined with nonfatal cardiovascular events. Thus, heart rate adds little to the prediction of cardiovascular risk...
  78. doi Is blood pressure during the night more predictive of cardiovascular outcome than during the day?
    Yan Li
    Department of Cardiovascular Diseases, Division of Hypertension and Cardiovascular Rehabilitation, Studies Coordinating Centre, University of Leuven, Leuven, Belgium
    Blood Press Monit 13:145-7. 2008
    ..The increased mortality in patients with higher NDR probably indicates reverse causality. Our findings support recording the ambulatory BP during the whole day...
  79. doi The relationship between the plasma concentration of irbesartan and the antihypertensive response is disclosed by an angiotensin II type 1 receptor polymorphism: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs. Atenolol (
    Lisa Kurland
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Am J Hypertens 21:836-9. 2008
    ..The aim of this study was to investigate the effect of the plasma concentration of irbesartan, a specific angiotensin II type 1 receptor (AT1R) antagonist, and the blood pressure response in relation to AT1R gene polymorphisms...
  80. ncbi Charlson Comorbidity Index can add prognostic information to Rapid Emergency Medicine Score as a predictor of long-term mortality
    Thomas Olsson
    Department of Internal Medicine, Uppsala University, Akademiska sjukhuset
    Eur J Emerg Med 12:220-4. 2005
    ....
  81. ncbi Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
    Masahiro Kikuya
    Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Circulation 115:2145-52. 2007
    ..Current diagnostic thresholds for ambulatory blood pressure (ABP) mainly rely on statistical parameters derived from reference populations. We determined an outcome-driven reference frame for ABP measurement...
  82. ncbi Endothelium-dependent vasodilation, insulin resistance and the metabolic syndrome in an elderly cohort: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Atherosclerosis 196:795-802. 2008
    ..In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, different techniques to assess vasodilation in conduit and resistance arteries were evaluated in relation to the MetS and insulin resistance...
  83. ncbi Vasodilation and visceral fat in elderly subjects: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Atherosclerosis 194:e64-71. 2007
    ..In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, we related VAT and other obesity indices to endothelium-dependent vasodilation in both capacitance and resistance arteries...
  84. ncbi Baroreceptor sensitivity is impaired in elderly subjects with metabolic syndrome and insulin resistance
    Karin Lindgren
    AstraZeneca R and D, Molndal, Sweden
    J Hypertens 24:143-50. 2006
    ..This study aimed to investigate whether altered baroreflex sensitivity (BRS), a measure of cardiovascular autonomic control, is related to metabolic syndrome and insulin resistance...
  85. ncbi Arterial compliance influences the measurement of flow-mediated vasodilation, but not acetylcholine-mediated forearm blood flow. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital and AstraZeneca R and D Mölndal, 751 85 Uppsala, Sweden
    Atherosclerosis 190:212-5. 2007
    ..Using data from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, we investigated if a reduced arterial distensibility could influence FMD measurements...
  86. ncbi A comparison of three different methods to determine arterial compliance in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Sweden
    J Hypertens 24:1075-82. 2006
    ..This study aimed to evaluate the feasibility and relation to cardiac risk of three of these techniques in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study...
  87. ncbi Systolic and diastolic hypertension impair endothelial vasodilatory function in different types of vessels in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala and AstraZeneca R and D, Molndal, Sweden
    J Hypertens 24:1319-27. 2006
    ..Endothelium-dependent vasodilation (EDV) is known to be impaired in middle-aged hypertensive individuals, but less is known regarding hypertension in the elderly...
  88. ncbi Erythropoietin impairs endothelial vasodilatory function in patients with renal anemia and in healthy subjects
    Margus Annuk
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Nephron Clin Pract 102:c30-4. 2006
    ..The aim of the present study was to investigate the effects of epoetin alfa on endothelial vasodilatory function in patients with renal anemia and in healthy subjects...
  89. ncbi A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Molndal, Sweden
    Arterioscler Thromb Vasc Biol 25:2368-75. 2005
    ..This study aimed to evaluate the feasibility and usefulness of these techniques in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study...
  90. doi Effects of Intrabrachial metacholine infusion on muscle capillary recruitment and forearm glucose uptake during physiological hyperinsulinemia in obese, insulin-resistant individuals
    Giuseppe Murdolo
    Department of Internal Medicine, Section of Internal Medicine, Endocrine and Metabolic Sciences, Perugia University, Via Enrico Dal Pozzo I, Perugia, Italy
    J Clin Endocrinol Metab 93:2764-73. 2008
    ..Impairment of insulin-mediated capillary recruitment in skeletal muscle contributes to a hampered glucose uptake in obesity...
  91. doi Hyperaemic blood-flow velocities in systole and diastole relate to coronary risk in divergent ways
    Susann J Järhult
    Department of Medicine, Uppsala University Hospital, Sweden
    Clin Physiol Funct Imaging 28:189-95. 2008
    ..The present study aimed to investigate the relative importance of hyperaemic systolic and diastolic blood-flow velocity in the forearm regarding both FMD and cardiovascular risk factors...
  92. ncbi Rapid Emergency Medicine Score can predict long-term mortality in nonsurgical emergency department patients
    Thomas Olsson
    Research and Development Unit, Department of Internal Medicine, Ostersund Hospital, SE 831 83 Ostersund, Sweden
    Acad Emerg Med 11:1008-13. 2004
    ..To examine the Rapid Emergency Medicine Score (REMS) as a predictor of long-term (4.7 years) mortality in the nonsurgical emergency department (ED)...
  93. doi Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
    Masahiro Kikuya
    The Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Blood Press Monit 12:393-5. 2007
    ..In conclusion, population-based outcome-driven thresholds for optimal and normal ABP are lower than those currently proposed by hypertension guidelines...
  94. ncbi Brachial artery intima-media thickness and echogenicity in relation to lipids and markers of oxidative stress in elderly subjects:--the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) Study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Lipids 43:133-41. 2008
    ..Thus, both thickness and echogenicity of the brachial artery intima-media complex might be useful biomarkers in the future...
  95. ncbi C-reactive protein and e-selectin levels are related to vasodilation in resistance, but not conductance arteries in the elderly: the prospective investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Atherosclerosis 199:129-37. 2008
    ..The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries...
  96. ncbi Impaired endothelial function of forearm resistance arteries in CADASIL patients
    Anna Stenborg
    Department of Medical Sciences, University and University Hospital of Uppsala, Sweden
    Stroke 38:2692-7. 2007
    ..Mice expressing the mutated protein display early dysfunction in vasoreactivity in resistance arteries, but studies of patients have been inconclusive so far...
  97. ncbi The International Database of Ambulatory Blood Pressure in relation to Cardiovascular Outcome (IDACO): protocol and research perspectives
    Lutgarde Thijs
    Studies Coordinating Centre, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Blood Press Monit 12:255-62. 2007
    ..We are constructing a new resource of longitudinal population studies to investigate with great precision to what extent the ambulatory blood pressure improves risk stratification...
  98. ncbi Risk associated with the metabolic syndrome versus the sum of its individual components
    Johan Sundstrom
    Department of Medical Sciences, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Diabetes Care 29:1673-4. 2006