Affiliation: Uppsala University
- Crystalloid vs. hypertonic crystalloid-colloid solutions for induction of mild therapeutic hypothermia after experimental cardiac arrestAdriana Miclescu
Department of Surgical Sciences, Anaesthesiology and Critical Care Medicine, Uppsala University, SE 751 85 Uppsala, Sweden
Resuscitation 84:256-62. 2013....
- Cardio-cerebral and metabolic effects of methylene blue in hypertonic sodium lactate during experimental cardiopulmonary resuscitationAdriana Miclescu
Department of Surgical Sciences Anaesthesiology, Faculty of Medicine, Uppsala University, S 751 85 Uppsala, Sweden
Resuscitation 75:88-97. 2007..As MB precipitates in hypertonic sodium chloride, an alternative mixture of methylene blue in hypertonic sodium lactate (MBL) was developed and investigated during and after cardiopulmonary resuscitation (CPR)...
- Nitric oxide and pain: 'Something old, something new'A Miclescu
Department of Surgical Sciences Anesthesiology and Intensive Care Medicine, Uppsala University Hospital, Uppsala, Sweden
Acta Anaesthesiol Scand 53:1107-20. 2009..Inhibitors of NO synthesis may have analgesic effects and would be of interest for treating inflammatory and neuropathic pain. Unfortunately, only a few of these compounds have reached the stage of clinical pain trials...
- Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptionsAdriana Miclescu
Department of Surgical Sciences Anaesthesiology and Critical Care Medicine, Uppsala University, Uppsala, Sweden
Crit Care Med 38:2199-206. 2010....
- Evidence for time-dependent maximum increase of free radical damage and eicosanoid formation in the brain as related to duration of cardiac arrest and cardio-pulmonary resuscitationSamar Basu
Department of Public Health Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Free Radic Res 37:251-6. 2003..In contrast, the greatest increase of 15-keto-dihydro-PGF2alpha was observed in the 13 min group (VF8 min + CPR5 min). Thus, a time-dependent cerebral oxidative injury occurs in conjunction which cardiac arrest and CPR...
- Methylene blue added to a hypertonic-hyperoncotic solution increases short-term survival in experimental cardiac arrestAdriana Miclescu
Department of Surgical Sciences/Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden
Crit Care Med 34:2806-13. 2006..CONCLUSIONS: MB co-administered with a hypertonic-hyperoncotic solution increased 4-hr survival vs. saline in an experimental porcine model of cardiac arrest and reduced oxidative, inflammatory, myocardial, and neurologic injury...
- Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blueLars Wiklund
Department of Surgical Sciences, Uppsala University Hospital, SE 75185 Uppsala, Sweden
Ann N Y Acad Sci 1122:231-44. 2007..The last two effects are recorded as less increase in plasma concentrations of astroglial protein S-100beta, as well as troponin I and creatine kinase isoenzyme MB, respectively...