Karl Michaelsson

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. ncbi request reprint Plasma 25-hydroxyvitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden
    Hakan Melhus
    Department of Medical Sciences, Uppsala University, SE 75185 Uppsala, Sweden
    J Clin Endocrinol Metab 95:2637-45. 2010
  2. pmc Inorganic phosphate and the risk of cancer in the Swedish AMORIS study
    Wahyu Wulaningsih
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Unit, London, UK
    BMC Cancer 13:257. 2013
  3. pmc Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopedics, Uppsala University, SE 751 85 Uppsala, Sweden
    BMJ 346:f228. 2013
  4. pmc Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study
    Helena Hallström
    Research and Development Department, Toxicology Division, National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    Nutr Metab (Lond) 7:12. 2010
  5. ncbi request reprint Genetic liability to fractures in the elderly
    Karl Michaelsson
    Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Arch Intern Med 165:1825-30. 2005
  6. ncbi request reprint The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopaedics, University Hospital, S 751 85 Uppsala, Sweden
    Bone 39:1343-51. 2006
  7. doi request reprint Plasma vitamin D and mortality in older men: a community-based prospective cohort study
    Karl Michaelsson
    Department of Surgical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 92:841-8. 2010
  8. ncbi request reprint Serum retinol levels and the risk of fracture
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopedics, University Hospital, Uppsala, Sweden
    N Engl J Med 348:287-94. 2003
  9. pmc Leisure physical activity and the risk of fracture in men
    Karl Michaelsson
    Section of Orthopaedics, Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    PLoS Med 4:e199. 2007
  10. pmc Risk of severe knee and hip osteoarthritis in relation to level of physical exercise: a prospective cohort study of long-distance skiers in Sweden
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e18339. 2011

Detail Information

Publications75

  1. ncbi request reprint Plasma 25-hydroxyvitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden
    Hakan Melhus
    Department of Medical Sciences, Uppsala University, SE 75185 Uppsala, Sweden
    J Clin Endocrinol Metab 95:2637-45. 2010
    ..Blood levels of 25-hydroxyvitamin D [25(OH)D] is the generally accepted indicator of vitamin D status, but no universal reference level has been reached...
  2. pmc Inorganic phosphate and the risk of cancer in the Swedish AMORIS study
    Wahyu Wulaningsih
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Unit, London, UK
    BMC Cancer 13:257. 2013
    ..Both dietary and serum levels of inorganic phosphate (Pi) have been linked to development of cancer in experimental studies. This is the first population-based study investigating the relation between serum Pi and risk of cancer in humans...
  3. pmc Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopedics, Uppsala University, SE 751 85 Uppsala, Sweden
    BMJ 346:f228. 2013
    ..To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease...
  4. pmc Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study
    Helena Hallström
    Research and Development Department, Toxicology Division, National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    Nutr Metab (Lond) 7:12. 2010
    ....
  5. ncbi request reprint Genetic liability to fractures in the elderly
    Karl Michaelsson
    Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Arch Intern Med 165:1825-30. 2005
    ..The genetic impact on the causation of osteoporotic fractures is unclear. A large twin study is ideally suited to determine the genetic liability to categories of fracture at various ages...
  6. ncbi request reprint The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopaedics, University Hospital, S 751 85 Uppsala, Sweden
    Bone 39:1343-51. 2006
    ..Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD...
  7. doi request reprint Plasma vitamin D and mortality in older men: a community-based prospective cohort study
    Karl Michaelsson
    Department of Surgical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 92:841-8. 2010
    ..Vitamin D status is known to be important for bone health but may also affect the development of several chronic diseases, including cancer and cardiovascular diseases, which are 2 major causes of death...
  8. ncbi request reprint Serum retinol levels and the risk of fracture
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopedics, University Hospital, Uppsala, Sweden
    N Engl J Med 348:287-94. 2003
    ....
  9. pmc Leisure physical activity and the risk of fracture in men
    Karl Michaelsson
    Section of Orthopaedics, Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    PLoS Med 4:e199. 2007
    ..Data from previous studies are inconsistent, and it is therefore uncertain whether, to what extent, and at what level leisure physical activity influences the risk of osteoporotic fractures in men...
  10. pmc Risk of severe knee and hip osteoarthritis in relation to level of physical exercise: a prospective cohort study of long-distance skiers in Sweden
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e18339. 2011
    ..The aim of this study was to determine whether the level of physical exercise is associated with future risk of severe osteoarthritis independent of previous diseases and injuries...
  11. ncbi request reprint Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:169-73. 2004
    ..The TGF-beta1 G + 915C polymorphism is associated with interindividual variation in TGF-beta1 production. No study has yet determined the impact of this polymorphism on the response to antihypertensive treatment...
  12. doi request reprint Obesity is associated with inferior results after surgery for lumbar spinal stenosis: a study of 2633 patients from the Swedish spine register
    Björn Knutsson
    Department of Surgical Sciences, Uppsala University, Department of Orthopaedics, Sundsvall Hospital, Sweden
    Spine (Phila Pa 1976) 38:435-41. 2013
    ..A cohort study based on the Swedish Spine Register...
  13. ncbi request reprint Cardiovascular diseases and risk of hip fracture
    Ulf Sennerby
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, SE 751 85 Uppsala, Sweden
    JAMA 302:1666-73. 2009
    ..Recent studies indicate common etiologies for cardiovascular disease (CVD) and osteoporotic fractures...
  14. pmc Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cardiovasc Disord 3:11. 2003
    ..The enzyme seems to be particularly abundant in the heart. Recently, the Arg528-encoding allele of the ALAP gene was shown to be associated with essential hypertension...
  15. ncbi request reprint The aluminium content of bone, and mortality risk
    Hans Olov Hellström
    Department of Orthopaedics, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Age Ageing 37:217-20. 2008
  16. doi request reprint Prehospital trauma life support training of ambulance caregivers and the outcomes of traffic-injury victims in Sweden
    Hans Blomberg
    Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden Electronic address
    J Am Coll Surg 217:1010-9.e1-2. 2013
    ..The primary aim of this national study in Sweden was to investigate the association between regional implementation of PHTLS training and mortality after traffic injuries...
  17. doi request reprint Prehospital injury deaths--strengthening the case for prevention: nationwide cohort study
    Rolf Gedeborg
    Department of Surgical Sciences Anesthesiology and Intensive Care, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    J Trauma Acute Care Surg 72:765-72. 2012
    ..To determine the frequency and characteristics of prehospital deaths compared with hospital deaths in different subpopulations with severe injuries...
  18. doi request reprint Plasma parathyroid hormone and the risk of cardiovascular mortality in the community
    Emil Hagström
    Uppsala Clinical Research Center, Uppsala University, Sweden
    Circulation 119:2765-71. 2009
    ..However, data on the prospective association between circulating PTH levels and cardiovascular mortality in the community are lacking...
  19. pmc Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort
    Liisa Byberg
    Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE 75185 Uppsala, Sweden
    BMJ 338:b688. 2009
    ..To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation...
  20. doi request reprint Plasma parathyroid hormone and risk of congestive heart failure in the community
    Emil Hagström
    Uppsala Clinical Research Center, Uppsala University, 751 85 Uppsala, Sweden
    Eur J Heart Fail 12:1186-92. 2010
    ..Moreover, increasing PTH is associated with worse prognosis in patients with overt HF. However, the association between PTH and the development HF in the community has not been reported...
  21. ncbi request reprint Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort
    Liisa Byberg
    Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE 75185 Uppsala, Sweden
    Br J Sports Med 43:482. 2009
    ..To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation...
  22. ncbi request reprint Physical activity and mortality: is the association explained by genetic selection?
    Sofia Carlsson
    Division of Epidemiology, Stockholm Centre of Public Health, Stockholm, Sweden
    Am J Epidemiol 166:255-9. 2007
    ..Results indicate that physical activity is associated with a reduced risk of mortality not due to genetic selection. This finding supports a causal link between physical activity and mortality...
  23. ncbi request reprint Relative importance and conjoint effects of obesity and physical inactivity for the development of insulin resistance
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Eur J Cardiovasc Prev Rehabil 16:28-33. 2009
    ..Obesity and physical inactivity are related to the development of insulin resistance, but their relative importance and conjoint effects are unclear...
  24. pmc Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies
    Karl Michaelsson
    Department of Surgical Sciences, Orthopedics, Uppsala University, Uppsala, Sweden KM and LB the Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden AW the School of Health and Social Studies, Dalarna University, Falun, Sweden JÄ the Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden JÄ and the Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden HM
    Am J Clin Nutr 99:107-14. 2014
    ..A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting...
  25. doi request reprint Cancer death is related to high palmitoleic acid in serum and to polymorphisms in the SCD-1 gene in healthy Swedish men
    Liisa Byberg
    Department of Surgical Sciences Orthopaedics LB, EWL, and KM the Departments of Public Health and Caring Sciences Geriatrics LK and Public Health and Caring Sciences Clinical Nutrition and Metabolism BV, Uppsala University, Uppsala, Sweden and the National Food Agency, Uppsala, Sweden EWL
    Am J Clin Nutr 99:551-8. 2014
    ....
  26. doi request reprint Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women
    Annette Engström
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Bone 50:1372-8. 2012
    ..In separate analyses, dietary and urinary cadmium underestimated the association with bone effects...
  27. pmc Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study
    Jonas Hansson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e16185. 2011
    ..An altered extracellular matrix metabolism has been implicated in a variety of diseases. We investigated relations of serum levels of MMP-9 and TIMP-1 to mortality risk from an etiological perspective...
  28. doi request reprint Long-term cadmium exposure and the association with bone mineral density and fractures in a population-based study among women
    Annette Engström
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Bone Miner Res 26:486-95. 2011
    ..U-Cd at low environmental exposure from food in a general population of women showed modest but significant association with both BMD and fractures, especially in never-smokers, indicating a larger concern than previously known...
  29. ncbi request reprint Smoking and the risk of fracture in older men
    Helena Olofsson
    Section of Orthopedics, Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    J Bone Miner Res 20:1208-15. 2005
    ..Using time-dependent exposure information and analysis, smoking was detected to be a stronger, dose-dependent and a more long lasting risk factor for fracture than has previously been estimated...
  30. pmc No association between the aluminium content of trabecular bone and bone density, mass or size of the proximal femur in elderly men and women
    Hans Olov Hellström
    Department of Orthopaedics, Uppsala University Hospital, Sweden
    BMC Musculoskelet Disord 7:69. 2006
    ..Healthy subjects with normal renal function retain 4% of the aluminium consumed. They might thus also accumulate aluminium and eventually be at risk of long-term low-grade aluminium intoxication that can affect bone health...
  31. doi request reprint Smokers show less improvement than nonsmokers two years after surgery for lumbar spinal stenosis: a study of 4555 patients from the Swedish spine register
    Bengt Sandén
    Section of Orthopedics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Spine (Phila Pa 1976) 36:1059-64. 2011
    ..A cohort study based on the Swedish Spine Register...
  32. ncbi request reprint Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations
    Shwan Khoschnau
    Department of Surgical Sciences, Section of Orthopedics, University Hospital, Uppsala, Sweden
    Am J Sports Med 36:2432-6. 2008
    ..It is well known that polymorphisms in the collagen I gene are associated not only with osteoporosis and osteoporotic fracture risk, but also with osteoarthritis...
  33. doi request reprint Extent and consequences of misclassified injury diagnoses in a national hospital discharge registry
    Monica Frick Bergström
    Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden
    Inj Prev 17:108-13. 2011
    ..Little is known about the characteristics and consequences of primary coding errors and their consequences for such applications...
  34. pmc Simply ask them about their balance--future fracture risk in a nationwide cohort study of twins
    Helene Wagner
    Department of Surgical Sciences, Section of Orthopaedics, University Hospital, Uppsala, Sweden
    Am J Epidemiol 169:143-9. 2009
    ..00 (95% CI: 1.29, 3.11) and 2.39 (95% CI: 1.49, 3.82), respectively. These results imply that self-reported impaired balance is a novel and readily assessed risk factor for future fractures in the elderly...
  35. doi request reprint Serum adiponectin in elderly men does not correlate with fracture risk
    Karl Michaelsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    J Clin Endocrinol Metab 93:4041-7. 2008
    ....
  36. ncbi request reprint Plasma-parathyroid hormone is associated with subclinical and clinical atherosclerotic disease in 2 community-based cohorts
    Emil Hagström
    From the Uppsala Clinical Research Center E H, E I, J S, J A, Departments of Radiology T H, H A, L J and Medical Sciences E H, J A, E I, J S, L L, Uppsala University, Uppsala, Sweden and the School of Health and Social Studies, Dalarna University, Falun, Sweden J Ä
    Arterioscler Thromb Vasc Biol 34:1567-73. 2014
    ..However, data on the associations between circulating PTH and peripheral atherosclerosis are limited...
  37. ncbi request reprint Genetic influence on bone phenotypes and body composition: a Swedish twin study
    Helene Wagner
    Section of Orthopedics, Department of Surgical Sciences, Uppsala University, S75185, Uppsala, Sweden
    J Bone Miner Metab 31:681-9. 2013
    ..Continuing research in this area could reveal the mechanisms behind the strong genetic susceptibility of bone-related phenotypes. ..
  38. doi request reprint Body mass index and mortality: is the association explained by genetic factors?
    Sofia Carlsson
    Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 22:98-103. 2011
    ..Numerous studies have shown that higher body mass index (BMI) is associated with higher mortality. We investigated the extent to which this association might be explained by genetic factors...
  39. ncbi request reprint Survival after hip fracture
    Bahman Y Farahmand
    Institute of Environmental Medicine, Karolinska Institute, Box 210, 17177, Stockholm, Sweden
    Osteoporos Int 16:1583-90. 2005
    ..Hip fracture patients have a substantially increased risk of death that persists for at least 6 years post-fracture. The relative excess mortality is independent of comorbidity and known hip fracture risk factors...
  40. doi request reprint EpiHealth: a large population-based cohort study for investigation of gene-lifestyle interactions in the pathogenesis of common diseases
    Lars Lind
    Department of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden
    Eur J Epidemiol 28:189-97. 2013
    ..Third, the sample is followed for occurrence of outcomes using nationwide medical registers. This overview presents the study design and some baseline characteristics from the first year of data collection in the EpiHealth study...
  41. ncbi request reprint Smokeless tobacco (snus) and risk of heart failure: results from two Swedish cohorts
    Gabriel Arefalk
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Eur J Prev Cardiol 19:1120-7. 2012
    ..Oral moist snuff (snus) is discussed as a safer alternative to smoking, and its use is increasing. Based on its documented effect on blood pressure, we hypothesized that use of snus increases the risk of heart failure...
  42. pmc Seasonal genetic influence on serum 25-hydroxyvitamin D levels: a twin study
    Greta Snellman
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e7747. 2009
    ..We aimed to study the seasonal impact of genetic factors on serum 25-hydroxyvitamin D concentrations...
  43. doi request reprint Dietary cadmium exposure and fracture incidence among men: a population-based prospective cohort study
    Laura D K Thomas
    Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Bone Miner Res 26:1601-8. 2011
    ..This association was independent of smoking and was most pronounced among men with low fruit and vegetable consumption...
  44. doi request reprint Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 206:239-44. 2009
    ..Our aim was to examine relations of serum retinol-binding protein 4 (RBP4) to cardiovascular risk factors, and prevalent metabolic syndrome (MetS) and cardiovascular disease (CVD) in a large community-based sample of elderly...
  45. ncbi request reprint Prehospital Trauma Life Support (PHTLS) training of ambulance caregivers and impact on survival of trauma victims
    Jakob Johansson
    Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden
    Resuscitation 83:1259-64. 2012
    ..Still, the effect on injury outcome remains to be established. The objective of this study was to investigate the association between PHTLS training of ambulance crew members and the mortality in trauma patients...
  46. doi request reprint Heritable and environmental factors in the causation of clinical vertebral fractures
    Helene Wagner
    Section of Orthopedics, Department of Surgical Sciences, Uppsala University, 75185, Uppsala, Sweden
    Calcif Tissue Int 90:458-64. 2012
    ....
  47. pmc Dietary calcium intake and risk of fracture and osteoporosis: prospective longitudinal cohort study
    Eva Warensjo
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden
    BMJ 342:d1473. 2011
    ..To investigate associations between long term dietary intake of calcium and risk of fracture of any type, hip fractures, and osteoporosis...
  48. ncbi request reprint Dietary calcium and vitamin D intake in relation to osteoporotic fracture risk
    Karl Michaelsson
    Department of Surgical Sciences, Orthopaedics, University Hospital, SE 751 85 Uppsala, Sweden
    Bone 32:694-703. 2003
    ..02 for all fractures (95% CI 0.88-1.17). Dietary calcium or vitamin D intakes estimated at middle and older age do not seem to be of major importance for the primary prevention of osteoporotic fractures in women...
  49. pmc Determining vitamin D status: a comparison between commercially available assays
    Greta Snellman
    Section of Orthopaedics, Department of Surgical Sciences, Uppsala University, corrected Uppsala, Sweden
    PLoS ONE 5:e11555. 2010
    ..We therefore aim to investigate the precision, accuracy and clinical consequences of differences in performance between three common commercially available assays...
  50. doi request reprint Association between repeat length of exon 1 CAG microsatellite in the androgen receptor and bone density in men is modulated by sex hormone levels
    Fredrik Stiger
    Department of Medical Sciences, University Hospital, MMS Ing 40 by, Uppsala SE 75185, Sweden
    Calcif Tissue Int 82:427-35. 2008
    ..In conclusion, there is a positive association between the AR CAG repeat polymorphism and BMD, which is modified by androgen levels in healthy men...
  51. ncbi request reprint Long-term dietary vitamin D intake and risk of fracture and osteoporosis: a longitudinal cohort study of Swedish middle-aged and elderly women
    Greta Snellman
    Department of Surgical Sciences G S, L B, E W L, K M, H Ma, Section of Orthopedics Department of Medical Sciences H Me, Section of Clinical Pharmacology and Department of Surgical Sciences R G, Section of Anesthesiology and Intensive Care, Uppsala University, SE 751 85 Uppsala, Sweden and Department of Nutritional Epidemiology A W, Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Clin Endocrinol Metab 99:781-90. 2014
    ..The importance of dietary vitamin D for osteoporotic fracture prevention is uncertain...
  52. pmc Prediction of fracture risk in men: a cohort study
    Liisa Byberg
    Department of Surgical Sciences, Orthopedics, Uppsala University, Uppsala, Sweden
    J Bone Miner Res 27:797-807. 2012
    ..We conclude that the addition of comorbidity, medication, and behavioral factors to the clinical components of FRAX can substantially improve the ability to identify men at high risk of fracture, especially hip fracture...
  53. ncbi request reprint Associations of diet, supplement use, and ultraviolet B radiation exposure with vitamin D status in Swedish women during winter
    Ann Burgaz
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Clin Nutr 86:1399-404. 2007
    ..Vitamin D is produced endogenously after sun exposure but can also be obtained from natural food sources, food fortification, and dietary supplements...
  54. doi request reprint Validation of questionnaire-based long-term dietary exposure to polychlorinated biphenyls using biomarkers
    Charlotte Bergkvist
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Nutr Food Res 56:1748-54. 2012
    ..We validated long-term food frequency questionnaire (FFQ)-based dietary PCB exposure against concentrations of six PCB congeners in serum...
  55. doi request reprint Useful tests of usefulness of new risk factors: tools for assessing reclassification and discrimination
    Johan Sundstrom
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Scand J Public Health 39:439-41. 2011
    ..For that purpose, we provide tools for calculating the net reclassification improvement, NRI, and the integrated discrimination improvement, IDI, using major statistical packages...
  56. doi request reprint Population density and mortality among individuals in motor vehicle crashes
    Rolf Gedeborg
    Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden
    Inj Prev 16:302-8. 2010
    ..To assess whether higher mortality rates among individuals in motor vehicle crashes in areas with low population density depend on injury type and severity or are related to the performance of emergency medical services (EMS)...
  57. ncbi request reprint Identification of incident injuries in hospital discharge registers
    Rolf Gedeborg
    Department of Surgical Sciences, Uppsala Clinical Research Center, Uppsala University Hospital, Uppsala, Sweden
    Epidemiology 19:860-7. 2008
    ..The objective of this study was to develop a prediction model for identifying incident hospital admissions, based on variables derived from a hospital discharge register...
  58. doi request reprint The impact of clinically undiagnosed injuries on survival estimates
    Rolf Gedeborg
    Department of Surgical Sciences, Units for Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden
    Crit Care Med 37:449-55. 2009
    ..To estimate the effect of clinically undiagnosed injuries on injury-specific survival estimates and the accuracy of an injury severity score. To also estimate the potentially preventable mortality attributable to these injuries...
  59. ncbi request reprint Genetic effects on physical activity: results from the Swedish Twin Registry
    Sofia Carlsson
    Division of Epidemiology, Stockholm Centre of Public Health, and Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Med Sci Sports Exerc 38:1396-401. 2006
    ..The aim of this study was to investigate the genetic effects on leisure-time physical activity using data from the Swedish Twin Registry...
  60. doi request reprint Impact of hip fracture on mortality: a cohort study in hip fracture discordant identical twins
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    J Bone Miner Res 29:424-31. 2014
    ..We conclude that both women and men display a higher mortality after hip fracture independent of genes, comorbidity, and lifestyle...
  61. doi request reprint Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study
    Kasper Andersen
    Department of Medical Sciences, Uppsala University Hospital, Entrance 40, 5th Floor, SE 751 85 Uppsala, Sweden
    Eur Heart J 34:3624-31. 2013
    ..We aimed to investigate the association of number of completed races and finishing time with risk of arrhythmias among participants of Vasaloppet, a 90 km cross-country skiing event...
  62. ncbi request reprint Presentation, outcome, and cause of septic arthritis after anterior cruciate ligament reconstruction: a case control study
    Maria Schollin-Borg
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Arthroscopy 19:941-7. 2003
    ..The objective of this study was to examine clinical presentation and medium-term outcome of patients with septic arthritis of the knee after anterior cruciate ligament (ACL) reconstruction...
  63. pmc Instrumentation in lumbar fusion improves back pain but not quality of life 2 years after surgery. A study of 1,310 patients with degenerative disc disease from the Swedish Spine Register SWESPINE
    Yohan Robinson
    Department of Orthopaedics, Institute for Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 84:7-11. 2013
    ..We compared the 2-year results of 3 methods of lumbar fusion when used in degenerative disc disease (DDD), using the Swedish Spine Register (SWESPINE)...
  64. ncbi request reprint Dual X-ray absorptiometry of hip, heel ultrasound, and densitometry of fingers can discriminate male patients with hip fracture from control subjects: a comparison of four different methods
    Anna Ekman
    Department of Surgery, Orthopedic Unit, University Hospital, Uppsala, Sweden
    J Clin Densitom 5:79-85. 2002
    ..Furthermore, ultrasound of the heel and fingers as well as radiographic absorptiometry proved capable of discriminating men with hip fractures from control subjects...
  65. ncbi request reprint Women with palmoplantar pustulosis have disturbed calcium homeostasis and a high prevalence of diabetes mellitus and psychiatric disorders: a case-control study
    Eva Hagforsen
    Department of Medical Sciences Dermatology, University Hospital, S 751 85 Uppsala, Sweden
    Acta Derm Venereol 85:225-32. 2005
    ..Palmoplantar pustulosis is a complex disease with an increased risk for several non-dermatological disorders. The role of the mildly increased serum calcium for the high risk for diabetes and depression deserves to be studied...
  66. doi request reprint Loss of external rotation after open Bankart repair: an important prognostic factor for patient satisfaction
    Hans Rahme
    Department of Surgical Sciences, Section of Orthopaedics, University Hospital, Uppsala, Sweden
    Knee Surg Sports Traumatol Arthrosc 18:404-8. 2010
    ..85 (95% CI 0.20-0.94). We conclude that open Bankart repair with a modified Rowe procedure is an excellent surgical option regarding stability, but restriction in external rotation reduces the likelihood of a satisfied patient...
  67. ncbi request reprint B2 bradykinin receptor (B2BKR) polymorphism and change in left ventricular mass in response to antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial
    Par Hallberg
    Department of Medical Sciences, Clinical Research Department 2, Uppsala University Hospital, 75185 Uppsala, Sweden
    J Hypertens 21:621-4. 2003
    ..We aimed to clarify whether the processes found in exercise-induced LV growth in normotensive people also occur in pathological LV hypertrophy...
  68. pmc Coffee consumption and risk of fracture in the Cohort of Swedish Men (COSM)
    Helena Hallström
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden Risk and Benefit Assessment Department, National Food Agency, Uppsala, Sweden
    PLoS ONE 9:e97770. 2014
    ..Recent research in a large cohort of women showed that coffee consumption is not associated with increased risk of fracture. Whether this is the case also among men is less clear...
  69. ncbi request reprint Persistent mucosal damage and risk of fracture in celiac disease
    Benjamin Lebwohl
    Celiac Disease Center B L, P H R G, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10027 Clinical Epidemiology Unit B L, J F L, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, SE 171 77 Stockholm, Sweden Department of Surgical Sciences K M, Section of Orthopaedics, Uppsala University, SE 751 05 Uppsala, Sweden and Department of Pediatrics J F L, Orebro University Hospital, SE 70185 Orebro, Sweden
    J Clin Endocrinol Metab 99:609-16. 2014
    ..Celiac disease (CD) is associated with an increased fracture risk, an increase that persists after diagnosis. A significant proportion of patients with CD have persistent villous atrophy (VA) on follow-up biopsy...
  70. ncbi request reprint The aluminum content of bone increases with age, but is not higher in hip fracture cases with and without dementia compared to controls
    Hans Olov Hellström
    Department of Orthopedics, Uppsala University Hospital, 7518, Uppsala, Sweden
    Osteoporos Int 16:1982-8. 2005
    ..Thus, our results indicate that we accumulate aluminum in bone over our life span, but this does not seem to be of major pathogenetic significance for the occurrence of hip fracture or dementia...
  71. ncbi request reprint Increased rate of bone loss at the femoral neck in patients with chronic liver disease
    Sif Ormarsdottir
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Eur J Gastroenterol Hepatol 14:43-8. 2002
    ..The aim of this study was to evaluate prospectively the rate of bone loss and potential predictors of increased bone loss in a cohort of patients with CLD...
  72. pmc Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring
    Gunilla Englund
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Med 2:8. 2004
    ..The question of whether several P-gp inhibitors may have additive effects has not yet been addressed...
  73. doi request reprint Circulating levels of persistent organic pollutants associate in divergent ways to fat mass measured by DXA in humans
    Monika Rönn
    Occupational and Environmental Medicine, Department of Medicine, Uppsala University, and Department of Medicine, Uppsala University Hospital, Uppsala, Sweden
    Chemosphere 85:335-43. 2011
    ..Environmental contaminants have recently been implicated in the pathogenesis of obesity...
  74. pmc Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly
    Josefin A Jacobsson
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e20158. 2011
    ..In contrast, this association was not found in elderly men. BMI is a measure of overweight in relation to the individuals' height, but offers no insight into the regional body fat composition or distribution...
  75. ncbi request reprint Long-standing increased bone turnover at the fixation points after anterior cruciate ligament reconstruction: a positron emission tomography (PET) study of 8 patients
    Jens Sorensen
    Department of Nuclear Medicine, University Hospital, Uppsala, Sweden
    Acta Orthop 77:921-5. 2006
    ..In this cross-sectional pilot study, we studied the healing process with positron emission tomography (PET) scanning...