Hakan Melhus

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. pmc Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study
    Helena Hallström
    Research and Development Department, Toxicology Division, National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    Nutr Metab (Lond) 7:12. 2010
  2. pmc Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: a case control study
    Sara Wedren
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 6:R437-49. 2004
  3. pmc Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report
    Jonas Cederberg
    Department of Clinical Chemistry and Pharmacology, Uppsala Academic Hospital, Uppsala, Sweden
    BMC Psychiatry 4:36. 2004
  4. pmc Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study
    Sara Wedren
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    BMC Cancer 8:322. 2008
  5. ncbi request reprint Expression of cellular retinol- and retinoic acid-binding proteins in normal and pathologic human parathyroid glands
    H Melhus
    Department of Medical Sciences, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Endocr Pathol 12:423-7. 2001
  6. ncbi request reprint Plasma 25-hydroxyvitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden
    Hakan Melhus
    Department of Medical Sciences, Uppsala University, SE 75185 Uppsala, Sweden
    J Clin Endocrinol Metab 95:2637-45. 2010
  7. pmc A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men
    H Melhus
    Department of Medical Sciences, University Hospital, Entrance 61, 4th Floor, SE 751 85, Uppsala, Sweden
    Osteoporos Int 19:929-34. 2008
  8. ncbi request reprint Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Sweden
    J Hypertens 22:2321-8. 2004
  9. doi request reprint The relationship between the plasma concentration of irbesartan and the antihypertensive response is disclosed by an angiotensin II type 1 receptor polymorphism: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs. Atenolol (
    Lisa Kurland
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Am J Hypertens 21:836-9. 2008
  10. ncbi request reprint Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:169-73. 2004

Detail Information

Publications86

  1. pmc Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study
    Helena Hallström
    Research and Development Department, Toxicology Division, National Food Administration, Box 622, SE 751 26 Uppsala, Sweden
    Nutr Metab (Lond) 7:12. 2010
    ....
  2. pmc Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: a case control study
    Sara Wedren
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 6:R437-49. 2004
    ..Because breast cancer development is dependent on oestrogenic influence, we have investigated whether polymorphisms in the oestrogen receptor alpha gene (ESR1) are associated with breast cancer risk...
  3. pmc Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report
    Jonas Cederberg
    Department of Clinical Chemistry and Pharmacology, Uppsala Academic Hospital, Uppsala, Sweden
    BMC Psychiatry 4:36. 2004
    ..Serotonin can also cause pruritus when injected into the skin. SSRI-drugs increase serotonin concentrations and are known to have pruritus and other dermal side effects...
  4. pmc Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study
    Sara Wedren
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    BMC Cancer 8:322. 2008
    ..One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial cancer risk...
  5. ncbi request reprint Expression of cellular retinol- and retinoic acid-binding proteins in normal and pathologic human parathyroid glands
    H Melhus
    Department of Medical Sciences, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Endocr Pathol 12:423-7. 2001
    ....
  6. ncbi request reprint Plasma 25-hydroxyvitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden
    Hakan Melhus
    Department of Medical Sciences, Uppsala University, SE 75185 Uppsala, Sweden
    J Clin Endocrinol Metab 95:2637-45. 2010
    ..Blood levels of 25-hydroxyvitamin D [25(OH)D] is the generally accepted indicator of vitamin D status, but no universal reference level has been reached...
  7. pmc A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men
    H Melhus
    Department of Medical Sciences, University Hospital, Entrance 61, 4th Floor, SE 751 85, Uppsala, Sweden
    Osteoporos Int 19:929-34. 2008
    ..This indicates that elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis...
  8. ncbi request reprint Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Sweden
    J Hypertens 22:2321-8. 2004
    ....
  9. doi request reprint The relationship between the plasma concentration of irbesartan and the antihypertensive response is disclosed by an angiotensin II type 1 receptor polymorphism: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs. Atenolol (
    Lisa Kurland
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Am J Hypertens 21:836-9. 2008
    ..The aim of this study was to investigate the effect of the plasma concentration of irbesartan, a specific angiotensin II type 1 receptor (AT1R) antagonist, and the blood pressure response in relation to AT1R gene polymorphisms...
  10. ncbi request reprint Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:169-73. 2004
    ..The TGF-beta1 G + 915C polymorphism is associated with interindividual variation in TGF-beta1 production. No study has yet determined the impact of this polymorphism on the response to antihypertensive treatment...
  11. ncbi request reprint A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response
    Ulrika Liljedahl
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Pharmacogenetics 13:7-17. 2003
    ..Our results highlight the potential of microarray-based technology for SNP genotyping in pharmacogenetics...
  12. doi request reprint Plasma vitamin D and mortality in older men: a community-based prospective cohort study
    Karl Michaelsson
    Department of Surgical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 92:841-8. 2010
    ..Vitamin D status is known to be important for bone health but may also affect the development of several chronic diseases, including cancer and cardiovascular diseases, which are 2 major causes of death...
  13. ncbi request reprint Angiotensinogen gene polymorphisms: relationship to blood pressure response to antihypertensive treatment. Results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial
    Lisa Kurland
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Am J Hypertens 17:8-13. 2004
    ..Our aim was to determine whether specific single nucleotide polymorphisms (SNPs) in RAAS genes were related to the blood pressure (BP) lowering effect of antihypertensive treatment...
  14. ncbi request reprint Cardiovascular diseases and risk of hip fracture
    Ulf Sennerby
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, SE 751 85 Uppsala, Sweden
    JAMA 302:1666-73. 2009
    ..Recent studies indicate common etiologies for cardiovascular disease (CVD) and osteoporotic fractures...
  15. pmc Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Cardiovasc Disord 3:11. 2003
    ..The enzyme seems to be particularly abundant in the heart. Recently, the Arg528-encoding allele of the ALAP gene was shown to be associated with essential hypertension...
  16. doi request reprint Plasma parathyroid hormone and risk of congestive heart failure in the community
    Emil Hagström
    Uppsala Clinical Research Center, Uppsala University, 751 85 Uppsala, Sweden
    Eur J Heart Fail 12:1186-92. 2010
    ..Moreover, increasing PTH is associated with worse prognosis in patients with overt HF. However, the association between PTH and the development HF in the community has not been reported...
  17. pmc Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort
    Liisa Byberg
    Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE 75185 Uppsala, Sweden
    BMJ 338:b688. 2009
    ..To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation...
  18. doi request reprint High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats
    Thomas Lind
    Department of Medical Sciences, Section of Clinical Pharmacology, University Hospital, Uppsala, Sweden
    Bone 48:496-506. 2011
    ..Together these novel findings suggest that a rapid primary effect of excess retinol on bone tissue is the impairment of endosteal/marrow blood flow leading to hypoxia and pathological endosteal mineralization...
  19. ncbi request reprint Prehospital injury deaths--strengthening the case for prevention: nationwide cohort study
    Rolf Gedeborg
    Department of Surgical Sciences Anesthesiology and Intensive Care, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    J Trauma Acute Care Surg 72:765-72. 2012
    ..To determine the frequency and characteristics of prehospital deaths compared with hospital deaths in different subpopulations with severe injuries...
  20. pmc Leisure physical activity and the risk of fracture in men
    Karl Michaelsson
    Section of Orthopaedics, Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    PLoS Med 4:e199. 2007
    ..Data from previous studies are inconsistent, and it is therefore uncertain whether, to what extent, and at what level leisure physical activity influences the risk of osteoporotic fractures in men...
  21. ncbi request reprint Long-term dietary vitamin D intake and risk of fracture and osteoporosis: a longitudinal cohort study of Swedish middle-aged and elderly women
    Greta Snellman
    Department of Surgical Sciences G S, L B, E W L, K M, H Ma, Section of Orthopedics Department of Medical Sciences H Me, Section of Clinical Pharmacology and Department of Surgical Sciences R G, Section of Anesthesiology and Intensive Care, Uppsala University, SE 751 85 Uppsala, Sweden and Department of Nutritional Epidemiology A W, Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Clin Endocrinol Metab 99:781-90. 2014
    ..The importance of dietary vitamin D for osteoporotic fracture prevention is uncertain...
  22. ncbi request reprint Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort
    Liisa Byberg
    Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE 75185 Uppsala, Sweden
    Br J Sports Med 43:482. 2009
    ..To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation...
  23. ncbi request reprint Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    Majd A I Mirza
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Atherosclerosis 207:546-51. 2009
    ..Additional longitudinal studies that evaluate the predictive power of FGF23 and whether FGF23 has additional clinical applications are needed...
  24. doi request reprint Plasma parathyroid hormone and the risk of cardiovascular mortality in the community
    Emil Hagström
    Uppsala Clinical Research Center, Uppsala University, Sweden
    Circulation 119:2765-71. 2009
    ..However, data on the prospective association between circulating PTH levels and cardiovascular mortality in the community are lacking...
  25. pmc Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies
    Karl Michaelsson
    Department of Surgical Sciences, Orthopedics, Uppsala University, Uppsala, Sweden KM and LB the Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden AW the School of Health and Social Studies, Dalarna University, Falun, Sweden JÄ the Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden JÄ and the Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden HM
    Am J Clin Nutr 99:107-14. 2014
    ..A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting...
  26. pmc Simply ask them about their balance--future fracture risk in a nationwide cohort study of twins
    Helene Wagner
    Department of Surgical Sciences, Section of Orthopaedics, University Hospital, Uppsala, Sweden
    Am J Epidemiol 169:143-9. 2009
    ..00 (95% CI: 1.29, 3.11) and 2.39 (95% CI: 1.49, 3.82), respectively. These results imply that self-reported impaired balance is a novel and readily assessed risk factor for future fractures in the elderly...
  27. ncbi request reprint A single nucleotide polymorphism in the promoter region of the osteoprotegerin gene is related to intima-media thickness of the carotid artery in hypertensive patients. The Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA
    H Brändström
    Department of Medical Sciences, Uppsala University, Sweden
    Blood Press 13:152-7. 2004
    ..The present study confirms our previous finding and shows that polymorphism in the promoter region of OPG is associated with vascular morphology in hypertensive subjects...
  28. pmc Effects of pharmacists' interventions on appropriateness of prescribing and evaluation of the instruments' (MAI, STOPP and STARTs') ability to predict hospitalization--analyses from a randomized controlled trial
    Ulrika Gillespie
    Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University and Uppsala University Hospital, Uppsala, Sweden
    PLoS ONE 8:e62401. 2013
    ....
  29. doi request reprint Adamts1 is highly induced in rachitic bones of FGF23 transgenic mice and participates in degradation of non-mineralized bone matrix collagen
    Lijuan Hu
    Department of Medical Sciences, Uppsala University, SE 75185 Uppsala, Sweden
    Biochem Biophys Res Commun 430:901-6. 2013
    ..Thus, Adamts1 potentially contributes to the increased serum levels of CTX in rickets/osteomalacia...
  30. ncbi request reprint Genetic variation in the ATP-binding cassette transporter gene ABCG2 (BCRP) in a Swedish population
    Gunilla Bäckström
    Department of Pharmacy, Uppsala University, P O Box 580, SE 751 23 Uppsala, Sweden
    Eur J Pharm Sci 18:359-64. 2003
    ..This information forms the basis for future association studies to investigate the genetic basis of differences of drug disposition due to sequence variation in the ABCG2 gene...
  31. pmc Seasonal genetic influence on serum 25-hydroxyvitamin D levels: a twin study
    Greta Snellman
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e7747. 2009
    ..We aimed to study the seasonal impact of genetic factors on serum 25-hydroxyvitamin D concentrations...
  32. doi request reprint Serum adiponectin in elderly men does not correlate with fracture risk
    Karl Michaelsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    J Clin Endocrinol Metab 93:4041-7. 2008
    ....
  33. ncbi request reprint Prehospital Trauma Life Support (PHTLS) training of ambulance caregivers and impact on survival of trauma victims
    Jakob Johansson
    Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden
    Resuscitation 83:1259-64. 2012
    ..Still, the effect on injury outcome remains to be established. The objective of this study was to investigate the association between PHTLS training of ambulance crew members and the mortality in trauma patients...
  34. doi request reprint Heritable and environmental factors in the causation of clinical vertebral fractures
    Helene Wagner
    Section of Orthopedics, Department of Surgical Sciences, Uppsala University, 75185, Uppsala, Sweden
    Calcif Tissue Int 90:458-64. 2012
    ....
  35. ncbi request reprint The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopaedics, University Hospital, S 751 85 Uppsala, Sweden
    Bone 39:1343-51. 2006
    ..Numerous studies have examined the association between VDR polymorphism and BMD, but no previous study has examined the joint influence of dietary vitamin D intake and VDR polymorphism on BMD...
  36. doi request reprint Association between repeat length of exon 1 CAG microsatellite in the androgen receptor and bone density in men is modulated by sex hormone levels
    Fredrik Stiger
    Department of Medical Sciences, University Hospital, MMS Ing 40 by, Uppsala SE 75185, Sweden
    Calcif Tissue Int 82:427-35. 2008
    ..In conclusion, there is a positive association between the AR CAG repeat polymorphism and BMD, which is modified by androgen levels in healthy men...
  37. pmc Dietary calcium intake and risk of fracture and osteoporosis: prospective longitudinal cohort study
    Eva Warensjo
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden
    BMJ 342:d1473. 2011
    ..To investigate associations between long term dietary intake of calcium and risk of fracture of any type, hip fractures, and osteoporosis...
  38. pmc Determining vitamin D status: a comparison between commercially available assays
    Greta Snellman
    Section of Orthopaedics, Department of Surgical Sciences, Uppsala University, corrected Uppsala, Sweden
    PLoS ONE 5:e11555. 2010
    ..We therefore aim to investigate the precision, accuracy and clinical consequences of differences in performance between three common commercially available assays...
  39. ncbi request reprint Genetic influence on bone phenotypes and body composition: a Swedish twin study
    Helene Wagner
    Section of Orthopedics, Department of Surgical Sciences, Uppsala University, S75185, Uppsala, Sweden
    J Bone Miner Metab 31:681-9. 2013
    ..Continuing research in this area could reveal the mechanisms behind the strong genetic susceptibility of bone-related phenotypes. ..
  40. ncbi request reprint Plasma-parathyroid hormone is associated with subclinical and clinical atherosclerotic disease in 2 community-based cohorts
    Emil Hagström
    From the Uppsala Clinical Research Center E H, E I, J S, J A, Departments of Radiology T H, H A, L J and Medical Sciences E H, J A, E I, J S, L L, Uppsala University, Uppsala, Sweden and the School of Health and Social Studies, Dalarna University, Falun, Sweden J Ä
    Arterioscler Thromb Vasc Biol 34:1567-73. 2014
    ..However, data on the associations between circulating PTH and peripheral atherosclerosis are limited...
  41. ncbi request reprint Smoking and the risk of fracture in older men
    Helena Olofsson
    Section of Orthopedics, Department of Surgical Sciences, University Hospital, Uppsala, Sweden
    J Bone Miner Res 20:1208-15. 2005
    ..Using time-dependent exposure information and analysis, smoking was detected to be a stronger, dose-dependent and a more long lasting risk factor for fracture than has previously been estimated...
  42. doi request reprint Over-expression of Adamts1 in mice alters bone mineral density
    Lijuan Hu
    Department of Medical Sciences, Section of Clinical Pharmacology, University Hospital, Ing 70 3tr Foa2 Lab22, 75185, Uppsala, Sweden
    J Bone Miner Metab 30:304-11. 2012
    ..These results reveal that Adamts1 has an impact on bone mineral density and thus further confirm Adamts1 as a potent regulator of bone remodeling...
  43. pmc Prediction of fracture risk in men: a cohort study
    Liisa Byberg
    Department of Surgical Sciences, Orthopedics, Uppsala University, Uppsala, Sweden
    J Bone Miner Res 27:797-807. 2012
    ..We conclude that the addition of comorbidity, medication, and behavioral factors to the clinical components of FRAX can substantially improve the ability to identify men at high risk of fracture, especially hip fracture...
  44. pmc Seasonal variations of insulin sensitivity from a euglycemic insulin clamp in elderly men
    Lars Berglund
    Department of Public Health Geriatrics, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 117:35-40. 2012
    ..Seasonal variations in hemoglobin-A1c have been reported in diabetic patients, but the underlying mechanisms have not been elucidated...
  45. ncbi request reprint Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations
    Shwan Khoschnau
    Department of Surgical Sciences, Section of Orthopedics, University Hospital, Uppsala, Sweden
    Am J Sports Med 36:2432-6. 2008
    ..It is well known that polymorphisms in the collagen I gene are associated not only with osteoporosis and osteoporotic fracture risk, but also with osteoarthritis...
  46. pmc Risk of severe knee and hip osteoarthritis in relation to level of physical exercise: a prospective cohort study of long-distance skiers in Sweden
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e18339. 2011
    ..The aim of this study was to determine whether the level of physical exercise is associated with future risk of severe osteoarthritis independent of previous diseases and injuries...
  47. doi request reprint Extent and consequences of misclassified injury diagnoses in a national hospital discharge registry
    Monica Frick Bergström
    Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden
    Inj Prev 17:108-13. 2011
    ..Little is known about the characteristics and consequences of primary coding errors and their consequences for such applications...
  48. ncbi request reprint Digoxin and mortality in atrial fibrillation: a prospective cohort study
    Par Hallberg
    Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, Uppsala University, 751 85, Uppsala, Sweden
    Eur J Clin Pharmacol 63:959-71. 2007
    ..No study has investigated a priori the effect of digoxin on mortality in patients with AF. This study aimed to address this question...
  49. ncbi request reprint Using genotyping to predict responses to anti-hypertensive treatment
    Lisa Kurland
    Department of Medical Sciences, Uppsala University Hospital, 751 85 Uppsala, Sweden
    Trends Pharmacol Sci 26:443-7. 2005
    ..It is therefore necessary to design prospective pharmacogenetic studies that aim to identify a genetic profile that will predict the response to anti-hypertensive treatment...
  50. pmc Vitamin a is a negative regulator of osteoblast mineralization
    Thomas Lind
    Department of Medical Sciences, Section of Clinical Pharmacology, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e82388. 2013
    ..In addition, RA decreased Phex, an osteoblast/osteocyte protein necessary for mineralization. Taken together, our data indicate that vitamin A is a negative regulator of osteoblast mineralization. ..
  51. pmc Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopedics, Uppsala University, SE 751 85 Uppsala, Sweden
    BMJ 346:f228. 2013
    ..To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease...
  52. doi request reprint Microarray profiling of diaphyseal bone of rats suffering from hypervitaminosis A
    Thomas Lind
    Department of Medical Sciences, Section of Clinical Pharmacology, Uppsala University, UAS, Ing 70 3tr Foa2 Lab22, 75185 Uppsala, Sweden
    Calcif Tissue Int 90:219-29. 2012
    ..We specifically identify potential key osteoblast-, Wnt signaling-, and hypoxia-associated genes in the processes leading to spontaneous fractures...
  53. ncbi request reprint Cystatin C vs creatinine as markers of renal function in patients on digoxin treatment
    Par Hallberg
    Department of Medical Sciences, Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden
    Ups J Med Sci 109:247-53. 2004
    ..Serum cystatin C has been suggested to be superior to creatinine for estimation of GFR, which may have relevance for the optimization of treatment with digoxin...
  54. doi request reprint Population density and mortality among individuals in motor vehicle crashes
    Rolf Gedeborg
    Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden
    Inj Prev 16:302-8. 2010
    ..To assess whether higher mortality rates among individuals in motor vehicle crashes in areas with low population density depend on injury type and severity or are related to the performance of emergency medical services (EMS)...
  55. ncbi request reprint Beta1-adrenergic receptor gene polymorphisms and response to beta1-adrenergic receptor blockade in patients with essential hypertension
    J Karlsson
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:347-50. 2004
    ..Both have been associated with altered receptor activity in vitro, and with hypertension and cardiac failure in vivo...
  56. ncbi request reprint Impact of hip fracture on mortality: a cohort study in hip fracture discordant identical twins
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    J Bone Miner Res 29:424-31. 2014
    ..We conclude that both women and men display a higher mortality after hip fracture independent of genes, comorbidity, and lifestyle. © 2014 American Society for Bone and Mineral Research. ..
  57. doi request reprint Prescription and transcription errors in multidose-dispensed medications on discharge from hospital: an observational and interventional study
    Anna Alassaad
    Apoteket Farmaci AB, Hospital Pharmacy, Uppsala University Hospital, Uppsala, Sweden
    J Eval Clin Pract 19:185-91. 2013
    ..The secondary objective was to correct identified errors and suggest measures to promote safe prescribing...
  58. ncbi request reprint Genetic liability to fractures in the elderly
    Karl Michaelsson
    Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Arch Intern Med 165:1825-30. 2005
    ..The genetic impact on the causation of osteoporotic fractures is unclear. A large twin study is ideally suited to determine the genetic liability to categories of fracture at various ages...
  59. ncbi request reprint Dietary calcium and vitamin D intake in relation to osteoporotic fracture risk
    Karl Michaelsson
    Department of Surgical Sciences, Orthopaedics, University Hospital, SE 751 85 Uppsala, Sweden
    Bone 32:694-703. 2003
    ..02 for all fractures (95% CI 0.88-1.17). Dietary calcium or vitamin D intakes estimated at middle and older age do not seem to be of major importance for the primary prevention of osteoporotic fractures in women...
  60. ncbi request reprint Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial
    Lisa Kurland
    Department of Internal Medicine, Uppsala University Hospital, Sweden
    Am J Hypertens 15:389-93. 2002
    ..Our aim was to determine whether the aldosterone synthase (CYP11B2) -344 C/T polymorphism was associated with the blood pressure (BP)-lowering response to antihypertensive treatment...
  61. ncbi request reprint Polymorphisms in the angiotensinogen and angiotensin II type 1 receptor gene are related to change in left ventricular mass during antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (
    Lisa Kurland
    Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
    J Hypertens 20:657-63. 2002
    ..Our aim was to determine if gene polymorphisms in the renin-angiotensin-aldosterone system (RAAS) were related to the degree of change in left ventricular hypertrophy (LVH) during antihypertensive treatment...
  62. ncbi request reprint The CYP2C9 genotype predicts the blood pressure response to irbesartan: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial
    Par Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Hypertens 20:2089-93. 2002
    ..However, its influence on clinical response to treatment with the AT(1) receptor antagonist, irbesartan, has not been investigated...
  63. ncbi request reprint [Pharmacogenetics--pathway to individualized antihypertensive pharmacotherapy]
    Lisa Kurland
    Medicincentrum, Akademiska sjukhuset, Uppsala
    Lakartidningen 100:600-3. 2003
    ..The article gives a background to the field, with emphasis on antihypertensive therapy, and prospects for the future...
  64. ncbi request reprint Common VKORC1 and GGCX polymorphisms associated with warfarin dose
    M Wadelius
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, Uppsala, Sweden
    Pharmacogenomics J 5:262-70. 2005
    ..Genotype-based dose predictions may in future enable personalised drug treatment from the start of warfarin therapy...
  65. ncbi request reprint Vitamin A differentially regulates RANKL and OPG expression in human osteoblasts
    A Jacobson
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Biochem Biophys Res Commun 322:162-7. 2004
    ..In primary cultures we found a threefold induction of RANKL mRNA expression. Thus, the RANKL/OPG ratio was markedly increased, suggesting a potential mechanism of ATRA-induced bone resorption...
  66. ncbi request reprint Single nucleotide polymorphisms in the human gene for osteoprotegerin are not related to bone mineral density or fracture in elderly women
    H Brändström
    Department of Medical Sciences, Uppsala University, Sweden
    Calcif Tissue Int 74:18-24. 2004
    ..Thus, our results show that polymorphisms in the OPG gene, one of which has previously been found to be associated with cardiovascular morphology and function, are not associated with bone mineral density in elderly Swedish women...
  67. ncbi request reprint Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients
    L Kurland
    Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
    J Hypertens 19:1783-7. 2001
    ..To determine whether polymorphisms in the renin-angiotensin system can predict blood pressure-lowering response to antihypertensive treatment; more specifically, in response to treatment with irbesartan or atenolol...
  68. ncbi request reprint Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)
    P Hallberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Cardiol 27:287-90. 2004
    ..No study has yet determined the effect of this polymorphism on the change in blood pressure during antihypertensive treatment...
  69. ncbi request reprint Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors
    M Wadelius
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, Uppsala, Sweden
    Pharmacogenomics J 4:40-8. 2004
    ....
  70. pmc Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring
    Gunilla Englund
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Med 2:8. 2004
    ..The question of whether several P-gp inhibitors may have additive effects has not yet been addressed...
  71. doi request reprint A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial
    Ulrika Gillespie
    Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Arch Intern Med 169:894-900. 2009
    ..The objective of this study was to investigate the effectiveness of interventions performed by ward-based pharmacists in reducing morbidity and use of hospital care among older patients...
  72. ncbi request reprint Serum retinol levels and the risk of fracture
    Karl Michaelsson
    Department of Surgical Sciences, Section of Orthopedics, University Hospital, Uppsala, Sweden
    N Engl J Med 348:287-94. 2003
    ....
  73. ncbi request reprint A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and function
    Helena Brändström
    Department of Medical Sciences, Uppsala University, SE 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 293:13-7. 2002
    ..01) as compared to those with the T allele. Thus, our results show that the polymorphism in the promoter region of OPG is associated with both vascular morphology and function in apparently healthy subjects...
  74. ncbi request reprint Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers
    J Taipalensuu
    Department of Pharmacy, Uppsala University, Uppsala, Sweden
    J Pharmacol Exp Ther 299:164-70. 2001
    ..Also, we tentatively conclude that the Caco-2 cell line is a useful model of jejunal drug efflux, if the low expression of BCRP is taken into account...
  75. ncbi request reprint Polymorphisms in the renin-angiotensin system and endothelium-dependent vasodilation in normotensive subjects
    L Kurland
    Department of Medical Sciences, Uppsala University Hospital, Sweden
    Clin Physiol 21:343-9. 2001
    ..This together with the observation that the AC AT1R genotype is associated with a reduction in both EDV and EIDV, supports the hypothesis that endothelial vasodilatory function is influenced by genes in the renin-angiotensinogen system...
  76. pmc Retinoic acid increases proliferation of human osteoclast progenitors and inhibits RANKL-stimulated osteoclast differentiation by suppressing RANK
    Lijuan Hu
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    PLoS ONE 5:e13305. 2010
    ..In conclusion, our results suggest that retinoic acid increases proliferation of human osteoclast progenitors and that it inhibits RANK-stimulated osteoclast differentiation by suppressing RANK...
  77. ncbi request reprint B2 bradykinin receptor (B2BKR) polymorphism and change in left ventricular mass in response to antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial
    Par Hallberg
    Department of Medical Sciences, Clinical Research Department 2, Uppsala University Hospital, 75185 Uppsala, Sweden
    J Hypertens 21:621-4. 2003
    ..We aimed to clarify whether the processes found in exercise-induced LV growth in normotensive people also occur in pathological LV hypertrophy...
  78. ncbi request reprint Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells
    W Liu
    Department of Surgery, University Hospital, 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 229:922-9. 1996
    ..The present data establish parathyroid gland as a target for retinoids and as a site of synthesis of the hormonal forms of vitamin A (retinol), all-trans- and 9-cis-retinoic acid...
  79. ncbi request reprint Cloning of a novel retinoic acid-inducible mRNA from human osteoblast-like cells
    H Melhus
    Department of Internal Medicine, Universal Hospital, Uppsala, Sweden
    Biochem Mol Biol Int 43:1145-50. 1997
    ..Maximal expression was found after 60 min, suggesting that this may be an early response gene. Expression was found in all tissues examined. No homology to known mRNA sequences was detected...
  80. ncbi request reprint Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture
    H Melhus
    University Hospital, Uppsala, Sweden
    Ann Intern Med 129:770-8. 1998
    ..The highest incidence of osteoporotic fractures is found in northern Europe, where dietary intake of vitamin A (retinol) is unusually high. In animals, the most common adverse effect of toxic doses of retinol is spontaneous fracture...
  81. ncbi request reprint Use of novel bone biopsy system to study molecular effects of growth hormone in human bone--a pilot study
    H Melhus
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    IUBMB Life 48:175-8. 1999
    ..Thus, this pilot study suggests that our novel bone biopsy system may be suitable for in vivo studies of the molecular effects of substances with essential functions in human bone...
  82. ncbi request reprint A genetically engineered purpurin/retinol-binding protein hybrid that binds to transthyretin
    H Melhus
    Department of Cell Research, Uppsala University, Sweden
    Biochem Biophys Res Commun 184:938-44. 1992
    ..These results demonstrate that purpurin does not bind to TTR, that a functional purpurin/RBP hybrid can be constructed, and that the N-terminal coil of RBP is not required for TTR binding...
  83. ncbi request reprint Association between oxidative stress and bone mineral density
    S Basu
    Sections of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S 751 25 Uppsala, Sweden
    Biochem Biophys Res Commun 288:275-9. 2001
    ..Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis...
  84. ncbi request reprint Vitamin A antagonizes calcium response to vitamin D in man
    S Johansson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    J Bone Miner Res 16:1899-905. 2001
    ..In conclusion, an intake of vitamin A corresponding to about one serving of liver antagonizes the rapid intestinal calcium response to physiological levels of vitamin D in man...
  85. ncbi request reprint The loop region around amino acid residue 50, the N-terminal part of the alpha-helix, and the C-terminus of human retinol-binding protein are not located in or close to the transthyretin binding site
    H Melhus
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Biochem Mol Biol Int 37:1147-51. 1995
    ..Our results support the hypothesis that one of the entrance loops is involved in the TTR binding...
  86. ncbi request reprint Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women
    P Gerdhem
    Department of Orthopedics, Lund University, Malmo University Hospital, Malmo, Sweden
    Calcif Tissue Int 74:264-9. 2004
    ..The presence of at least one copy of the "s" allele was associated with lower femoral neck BMD and previous wrist fracture and in addition, it was related to an increased risk for wrist fracture...